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VAEAGGGPISVIARHMQLIRDDFISELFDKMKAEIRGLDYDARMADLWRASITENFVTAVHYLDRDTPQS LVEAPAAALAYARAAAQRDIPLSGLVRAHRLGHARFLEVAMQYVSLLEPADRVSTIIELVNRSARLVDLV ADQLIVAYEHEHDRWLSRRSGLQQQWVSELLADTPVDVPRAERALGYRLDGVHIAAVVWVDSAVPIGDVV AQFDQVRCLLAGELGPELGPVANSLMVPTDEREARLWFSPAPTRAFAPSRIRAAFESAGIRARLACGRVG DGLRGFRASLKQAERVKALALAGGARPGGRVMFYDDVAPVALLADDLEELRRFVTDVLGDLSVDDERNSW LRETLREFLLRNRSYVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAVLRA KQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1429 | - | - | 100% (422) | hypothetical protein Rv1429 |
| M. tuberculosis H37Rv | Rv1453 | - | 4e-16 | 27.09% (299) | transcriptional activator protein |
| M. tuberculosis H37Rv | Rv1194c | - | 6e-16 | 26.64% (289) | hypothetical protein Rv1194c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1464 | - | 0.0 | 100.00% (422) | hypothetical protein Mb1464 |
| M. gilvum PYR-GCK | Mflv_4621 | - | 6e-39 | 28.98% (421) | hypothetical protein Mflv_4621 |
| M. leprae Br4923 | MLBr_01052 | - | 8e-17 | 26.92% (312) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_2657c | - | 3e-17 | 30.09% (319) | hypothetical protein MAB_2657c |
| M. marinum M | MMAR_1582 | - | 4e-51 | 33.76% (391) | hypothetical protein MMAR_1582 |
| M. avium 104 | MAV_4933 | - | 8e-06 | 24.11% (365) | hypothetical protein MAV_4933 |
| M. smegmatis MC2 155 | MSMEG_4044 | - | 7e-10 | 28.29% (205) | GAF domain-containing protein |
| M. thermoresistible (build 8) | TH_2938 | - | 2e-47 | 35.14% (387) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3452 | - | 1e-49 | 32.56% (390) | hypothetical protein MUL_3452 |
| M. vanbaalenii PYR-1 | Mvan_4407 | - | 2e-07 | 31.35% (185) | putative GAF sensor protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1429|M.tuberculosis_H37Rv -----------------------------MAEAGGGPISVIARH------
Mb1464|M.bovis_AF2122/97 -----------------------------MAEAGGGPISVIARH------
MMAR_1582|M.marinum_M ----------------------MAERNRTDDAAVSKIAVEVVDR------
MUL_3452|M.ulcerans_Agy99 ----------------------MAERNRTDDAVVGKIVVEVVYR------
TH_2938|M.thermoresistible__bu --------------------------------------------------
Mflv_4621|M.gilvum_PYR-GCK ----------------------MLDSSEVQDTPG-HAVHHLFRD------
MLBr_01052|M.leprae_Br4923 ------------------------MARQHPSPRVRELIREGARI------
MAB_2657c|M.abscessus_ATCC_199 --------MNEGSERVHTQSMTPDQLWPDASEPVRRLIRELAEK------
MAV_4933|M.avium_104 -----------------MKDFRAPVNGVDGDSASALVAVPKSQG------
MSMEG_4044|M.smegmatis_MC2_155 ------MSVRSDPLRAWMSAVTAISRTVNAAEPLETVLDDIAQMGCDLVG
Mvan_4407|M.vanbaalenii_PYR-1 MSEPRSVIAAQTALIAALRDVVSARSVADVESATLAAVRSLLSADAAFWM
Rv1429|M.tuberculosis_H37Rv -------------------------------------MQLIRDDFISELF
Mb1464|M.bovis_AF2122/97 -------------------------------------MQLIRDDFISELF
MMAR_1582|M.marinum_M -------------------------------------LSAQLAEATASIQ
MUL_3452|M.ulcerans_Agy99 -------------------------------------LSAQLAEATASIQ
TH_2938|M.thermoresistible__bu -----------------------------------------VGYGPGSRQ
Mflv_4621|M.gilvum_PYR-GCK -------------------------------------LGDLVRELPESIH
MLBr_01052|M.leprae_Br4923 -------------------------------------ALNPTQEWIDQLD
MAB_2657c|M.abscessus_ATCC_199 -------------------------------------MLARSGEVAGDLT
MAV_4933|M.avium_104 -------------------------------------AQTIRPDSVSRLV
MSMEG_4044|M.smegmatis_MC2_155 FDYCGVMLDDVTHEVMQIAGSSGLRKRYLDLVRSEGWLEIHPADFSADLP
Mvan_4407|M.vanbaalenii_PYR-1 DRVDDGFAMTALSG-------------LIQPESHELSLVPPGAGLAAEIV
Rv1429|M.tuberculosis_H37Rv DKMKAEI--------RGLDYDARMADLWRASITENFVTAVHYLDRDTP--
Mb1464|M.bovis_AF2122/97 DKMKAEI--------RGLDYDARMADLWRASITENFVTAVHYLDRDTP--
MMAR_1582|M.marinum_M GTLEREI--------VELRGDAQLLDLLHASVEGNVAAVLNAIHYDIP--
MUL_3452|M.ulcerans_Agy99 GTLEREI--------VELRGDVQLLDLLHASVEGNVAAVLNAIHYDIP--
TH_2938|M.thermoresistible__bu G-----------------SGCRQLLELLRDSVEGNIDTIFSAIQHDIP--
Mflv_4621|M.gilvum_PYR-GCK GLLIEQV--------AELAADQQLKELLSDTVAANVDTWFSVVRHSIP--
MLBr_01052|M.leprae_Br4923 RATFAAN--------PAIANDPVLAKVVRRASRAHLVHWATANLRDPG--
MAB_2657c|M.abscessus_ATCC_199 AASLEDPR------YRTIADDPVIAEVDARLTVSNLKHWLTSNISEPG--
MAV_4933|M.avium_104 GALLDDHAAVVGRVRSVIRSRLPVYRSVADEALEAELEWVLRSAVGGR--
MSMEG_4044|M.smegmatis_MC2_155 ATKAYRELTTIVVPDVYAENSERLHRFAAAQGYRSVLTAPLRVGKDNVGI
Mvan_4407|M.vanbaalenii_PYR-1 ANDAPASS------SDYTVDPRAIPAFAAMFRRENIRSTAGAPMRSSEG-
:
Rv1429|M.tuberculosis_H37Rv ------------------QSLVEAP-AAALAYARAAAQRDIPLSGLVRAH
Mb1464|M.bovis_AF2122/97 ------------------QSLVEAP-AAALAYARAAAQRDIPLSGLVRAH
MMAR_1582|M.marinum_M ------------------IERVESP-TAALEYARRLAQRGVPVNALVRAY
MUL_3452|M.ulcerans_Agy99 ------------------IERVESP-TAALEYARRLAQRGVPVNALVRAY
TH_2938|M.thermoresistible__bu ------------------IEEVAPP-TAALEYARRLARHGVEPHALLRAY
Mflv_4621|M.gilvum_PYR-GCK ------------------FDRMESP-TAALEHARRMAQREVPVNALLRAY
MLBr_01052|M.leprae_Br4923 ------------------APVPAHLGPEPLTMARDLVRRGRDVLALD-IY
MAB_2657c|M.abscessus_ATCC_199 ------------------HRVRPATGSAMRTYARDVVLRGLTTDDIQ-SW
MAV_4933|M.avium_104 ------------------EALHEPQIAGLAAIGEARARDGVPVDDMLRAW
MSMEG_4044|M.smegmatis_MC2_155 LAGYFRDPHDYEPEEIELAKLLAEQSANAIRTAQLRAAQQATINDLSAVN
Mvan_4407|M.vanbaalenii_PYR-1 -----------------VVGVLFVFARRSREFTEDEMQLLMSIAGVARAL
. :
Rv1429|M.tuberculosis_H37Rv RLGHAR--------FLEVAMQYVS--LLEPADRVSTIIELVNRSARLVDL
Mb1464|M.bovis_AF2122/97 RLGHAR--------FLEVAMQYVS--LLEPADRVSTIIELVNRSARLVDL
MMAR_1582|M.marinum_M RLGHKE--------MLERIIDGVQEAGADPALSLDVFNRISEVTFNYIDW
MUL_3452|M.ulcerans_Agy99 RLGHKE--------MLERIIDGVQEAGADPALSLDVFNRISEVTFNYIDW
TH_2938|M.thermoresistible__bu RLGQQK--------LLDIVLHEIRSLDWEREVSLEFVVGVTNATFGYIDG
Mflv_4621|M.gilvum_PYR-GCK RLGHQY--------GLNLIIAGLRSADLPPEEKLALIEHITRVSFRYIDW
MLBr_01052|M.leprae_Br4923 RVGQYT--------AWRRWMEIAFTLTSDPQELREILNVSAQSINEYVAA
MAB_2657c|M.abscessus_ATCC_199 RAVQRV--------GWKWWLAACFQVTDDKEQLCELIEVTSNSLTTFVDD
MAV_4933|M.avium_104 RIGVEV--------VVECAREAARRLGVDDAR----VLELVQSALAWSDI
MSMEG_4044|M.smegmatis_MC2_155 DELRRRRASLDWADQQHRRLMRLVLNDIGMDGLVAALADMLQASATVLDS
Mvan_4407|M.vanbaalenii_PYR-1 RERLREGEFQRELLEQERSRAAAGDRLLRAAETFSSSMLRGQPLAAGLEA
.
Rv1429|M.tuberculosis_H37Rv VADQLIVAYE-----------HEHDRWLSR--------------------
Mb1464|M.bovis_AF2122/97 VADQLIVAYE-----------HEHDRWLSR--------------------
MMAR_1582|M.marinum_M ISQQVVAAYE-----------AERDRWLEN--------------------
MUL_3452|M.ulcerans_Agy99 ISQQVVAAYE-----------AERDRWLEN--------------------
TH_2938|M.thermoresistible__bu ISQRVVEVYQ-----------QERERWLEN--------------------
Mflv_4621|M.gilvum_PYR-GCK MSEQVLETYQ-----------TERAEWDER--------------------
MLBr_01052|M.leprae_Br4923 TLEAIATHMQ-----------LERDELTRS--------------------
MAB_2657c|M.abscessus_ATCC_199 SIAELAEHVR-----------RVREELAGG--------------------
MAV_4933|M.avium_104 AMATSAKAHR-----------RTERALALE--------------------
MSMEG_4044|M.smegmatis_MC2_155 AERVLAEASAGEYIDPPKLDRKTRSKWEDTGRYEALLIDRQAAETWLIPI
Mvan_4407|M.vanbaalenii_PYR-1 ASDELGVRLHVRGLPAPGSPTSHMLPIEDAPTVSSGPEARIPG-------
Rv1429|M.tuberculosis_H37Rv --------------------RSGLQQQWVSELLADTPVDVPRAERALGYR
Mb1464|M.bovis_AF2122/97 --------------------RSGLQQQWVSELLADTPVDVPRAERALGYR
MMAR_1582|M.marinum_M --------------------RSRVRNVRIAEILDGGDIDTDAMTRSIRYP
MUL_3452|M.ulcerans_Agy99 --------------------RSRVRNVRIAEILDGGDIDTDAMTKSIRYP
TH_2938|M.thermoresistible__bu --------------------RNSLRAMRVRELLDGGEVDVDTASATVGYP
Mflv_4621|M.gilvum_PYR-GCK --------------------RRSLRAQAIRDILNGRDVDLTEASSAMRYF
MLBr_01052|M.leprae_Br4923 --------------------THAERLEVVDLILEGAPVTQERAEARLGYR
MAB_2657c|M.abscessus_ATCC_199 --------------------SQLQRYATVELLLQGADIAPARAEAQLGYA
MAV_4933|M.avium_104 --------------------AEESDAEFVRGALMG---SLPAAELRMHAE
MSMEG_4044|M.smegmatis_MC2_155 VLSGEVAGWLWVITEPSEPDAGRQRLIEHFALVVGLEILKQRHIVEVQER
Mvan_4407|M.vanbaalenii_PYR-1 ----------ADLAVLSADGALPEMQLALLAQLIGIDFRRQRVELETELA
: .
Rv1429|M.tuberculosis_H37Rv LDGVHIAAVVWVDSAVPIGDVVAQFDQVRC-------------------L
Mb1464|M.bovis_AF2122/97 LDGVHIAAVVWVDSAVPIGDVVAQFDQVRC-------------------L
MMAR_1582|M.marinum_M LRKVHLALVLWFPDDA-TDGNEFERLER----------------------
MUL_3452|M.ulcerans_Agy99 LRKVHLALVLWFPDDA-TDGNEFERLER----------------------
TH_2938|M.thermoresistible__bu LRRTHLAVCVWTPDGS-AGDNELDRLQR----------------------
Mflv_4621|M.gilvum_PYR-GCK LGATHVALMVWLDRDAGADTDEFIAMER----------------------
MLBr_01052|M.leprae_Br4923 LGLTHTAAVIWSDDLDGDHGYLDQAAEA----------------------
MAB_2657c|M.abscessus_ATCC_199 LTGSHIGAVVWVDSEK-EIAALERASEQ----------------------
MAV_4933|M.avium_104 LRGLDPGAEYVAVRARLGGDGPHLRLEQS---------------------
MSMEG_4044|M.smegmatis_MC2_155 LCGDLMVDLLRTSDVPPSTMLIQRAEALGHDLTTPHWLAVFAGEFGPKLD
Mvan_4407|M.vanbaalenii_PYR-1 LTDQMVHSLLTGDFQELERLWSRTALLGMNPAVPRVLVSIGRDRPVDRML
*
Rv1429|M.tuberculosis_H37Rv LAGELGPELGPVANSLMVPTDEREARLWFSPAPTRA-FAPSRIRAAFESA
Mb1464|M.bovis_AF2122/97 LAGELGPELGPVANSLMVPTDEREARLWFSPAPTRA-FAPSRIRAAFESA
MMAR_1582|M.marinum_M FLDELAEHLGT-GNALFVAADRVTGWGWIPLRVNDA-GLAERVRRFVAGH
MUL_3452|M.ulcerans_Agy99 FLDELAEHLGT-GNALFVAADRITGWGWIPLRANDA-GLTGRVRRFVAGH
TH_2938|M.thermoresistible__bu YVRGLAEALGAPGDSLFIALDRLTGCGWIPLPGDAATGAVAGVRRYAAEH
Mflv_4621|M.gilvum_PYR-GCK FMQHAVSATGA-KQSVYFSIDRLVGCAWMTVHRPSD--YLSQLRDFVRAQ
MLBr_01052|M.leprae_Br4923 -----FSHVVESTQQLIVVASAATRWVWLADALALD---VPEVQKALLNL
MAB_2657c|M.abscessus_ATCC_199 -----VMRACGADRRLTVVAGTVALWLWIPAKTTPT---VAVLMDSLGRR
MAV_4933|M.avium_104 ---LGFQDPAHSRRGLCALLDGDLAGFLIEPPRDVEG-------------
MSMEG_4044|M.smegmatis_MC2_155 QVALTVREAAPRQETLVGVYASSVVMLIPCDRDPLRIVQRTLTRITESSG
Mvan_4407|M.vanbaalenii_PYR-1 LDRIRREMRSRISGGYSTTYGGDVVLLCPVPEVEQEAKLVGQVESIVTAC
Rv1429|M.tuberculosis_H37Rv -GIRARLACGRVGDGLRGFRASLKQAERVKALALAG--GARPGGRVMFYD
Mb1464|M.bovis_AF2122/97 -GIRARLACGRVGDGLRGFRASLKQAERVKALALAG--GARPGGRVMFYD
MMAR_1582|M.marinum_M -TDAPHVALGQALPGVEGFRRAHRQARNAHRVGVAV-GASAPAVVAVSDE
MUL_3452|M.ulcerans_Agy99 -TDAPHVALGQALPGVEGFRRAHRQARNAHRVGVAV-GASAPAVMAVSDE
TH_2938|M.thermoresistible__bu -PDGPHLALGDPLPGLDGFRRSYRQALRTRAVAVAA-GASAPRVTAAADP
Mflv_4621|M.gilvum_PYR-GCK -PDGPRLSVGEPLPGIEGFRRTYRQAEQARVVAVAADGSSRHRIVAARDP
MLBr_01052|M.leprae_Br4923 -S-KARVAIGTSSAGIEGFRRSHLEALTAQRTLARL----KSHQQVAFFA
MAB_2657c|M.abscessus_ATCC_199 -S-GVRVALGRAATGMAGFRRTHMDAAAAQRLLARL----GSPLSVVRYE
MAV_4933|M.avium_104 -----VVGFGPPRP-LTRLSESYRMAARALVTAEAC-----GLRGAYDIA
MSMEG_4044|M.smegmatis_MC2_155 -GGRLAVALSPPVERLADYPVNYQTGVRTTQLRLAA--GAGGLVDLRRVP
Mvan_4407|M.vanbaalenii_PYR-1 RPERLTAGIGPVCRKADDYPLGVREALFARQVAAQS--RTGKAVVSSAEL
. . . .
Rv1429|M.tuberculosis_H37Rv DVAPVALLADDLEELRRFVTDVLGDLSVDDE-RNSWLRETLREFLLRNRS
Mb1464|M.bovis_AF2122/97 DVAPVALLADDLEELRRFVTDVLGDLSVDDE-RNSWLRETLREFLLRNRS
MMAR_1582|M.marinum_M GLSAAALMGADLPEAGAWVRETLGPLSTDSD-NDAVLRETLRVFLREGGS
MUL_3452|M.ulcerans_Agy99 GLSAAALMGADLPDAGAWVRETLGPLSTDSD-NDAVLRETLRVFLREGGS
TH_2938|M.thermoresistible__bu GLSAAALLTGDLAEARTWVQEVLGPLSADTK-NDARLRETLGVFLRHGSS
Mflv_4621|M.gilvum_PYR-GCK GVALASMLMTDDATLKEWIHDVLGPLAQNTA-SDQRLRDTLRVFLRAGSS
MLBr_01052|M.leprae_Br4923 DVQLVSLITQNPEDAKEFITSTLGDFESAS----PALQQTLLTFINEQCN
MAB_2657c|M.abscessus_ATCC_199 DVHLMDLLSADPASADQFVTDVLGEFQSAS----PVLHQTVLTYVEEALN
MAV_4933|M.avium_104 ALGLRTAVAIDADVGELLRKRYLEPLSVGG--SSRELIATVRTYLACGMH
MSMEG_4044|M.smegmatis_MC2_155 LTSLLLLNSTVPDQLRRFAENLIEPLESHDEQRETDLVATLRTWLVEGFS
Mvan_4407|M.vanbaalenii_PYR-1 GMYRLFAHVGGTDALLGAVLETLGPLLDADGRDGSDLLNTLHAFLEHDRR
: : * *: ::
Rv1429|M.tuberculosis_H37Rv YVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMA
Mb1464|M.bovis_AF2122/97 YVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMA
MMAR_1582|M.marinum_M YKAAAERLHLHYNSVKYRVARAVERRGRPIDD--ERLDVEMALLVCQWFG
MUL_3452|M.ulcerans_Agy99 YKAAAERLHLHYNSVKYRVARAVERRGRPIDD--ERLDVEMALLVCQWFG
TH_2938|M.thermoresistible__bu YTAAADELNLHFNTVKYRVQRAVERRGRPIVP--DRLDVELALLICQWFG
Mflv_4621|M.gilvum_PYR-GCK FKAAANELQIHANTVKYRVNRALERRGRPIAA--ERLDVEVALLMCYWLG
MLBr_01052|M.leprae_Br4923 ASRAAKRLFTHRNTLLRRIESAEKLLPRPLDH--TSVHIAVALEALQWRG
MAB_2657c|M.abscessus_ATCC_199 RTSTAERLYTHRNTIDRRLARVDELLPKPFAR--NPIEVAAALTLLRVRA
MAV_4933|M.avium_104 VERTATRLFVHQNTVRYRLARFEELTGASLRDTEVVTEVWWVLELAAMRL
MSMEG_4044|M.smegmatis_MC2_155 AAATGNRLTVHVNTVGYRLAKIQSLLGLDLRKADVRLELQLAVIVWDIMR
Mvan_4407|M.vanbaalenii_PYR-1 IAETARALHLHVNTLRYRVDRIARLLKTDLDDPEKRFFILLALRLRGVVG
:. : * *:: *: : : .:
Rv1429|M.tuberculosis_H37Rv PAVLRAKQ----------
Mb1464|M.bovis_AF2122/97 PAVLRAKQ----------
MMAR_1582|M.marinum_M AVVLGPER----------
MUL_3452|M.ulcerans_Agy99 AVVPGPER----------
TH_2938|M.thermoresistible__bu AAVLRPQR----------
Mflv_4621|M.gilvum_PYR-GCK EVALNPTQALGRS-----
MLBr_01052|M.leprae_Br4923 DQTNTSGPRAGRNDGVPA
MAB_2657c|M.abscessus_ATCC_199 GR----------------
MAV_4933|M.avium_104 ------------------
MSMEG_4044|M.smegmatis_MC2_155 GEQA--------------
Mvan_4407|M.vanbaalenii_PYR-1 LGPNDSRQAPSSAGENVQ