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SVRSDPLRAWMSAVTAISRTVNAAEPLETVLDDIAQMGCDLVGFDYCGVMLDDVTHEVMQIAGSSGLRKR YLDLVRSEGWLEIHPADFSADLPATKAYRELTTIVVPDVYAENSERLHRFAAAQGYRSVLTAPLRVGKDN VGILAGYFRDPHDYEPEEIELAKLLAEQSANAIRTAQLRAAQQATINDLSAVNDELRRRRASLDWADQQH RRLMRLVLNDIGMDGLVAALADMLQASATVLDSAERVLAEASAGEYIDPPKLDRKTRSKWEDTGRYEALL IDRQAAETWLIPIVLSGEVAGWLWVITEPSEPDAGRQRLIEHFALVVGLEILKQRHIVEVQERLCGDLMV DLLRTSDVPPSTMLIQRAEALGHDLTTPHWLAVFAGEFGPKLDQVALTVREAAPRQETLVGVYASSVVML IPCDRDPLRIVQRTLTRITESSGGGRLAVALSPPVERLADYPVNYQTGVRTTQLRLAAGAGGLVDLRRVP LTSLLLLNSTVPDQLRRFAENLIEPLESHDEQRETDLVATLRTWLVEGFSAAATGNRLTVHVNTVGYRLA KIQSLLGLDLRKADVRLELQLAVIVWDIMRGEQA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4044 | - | - | 100% (595) | GAF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6492 | - | 3e-61 | 31.09% (595) | GAF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2971 | - | 2e-13 | 23.64% (440) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1464 | - | 7e-10 | 28.29% (205) | hypothetical protein Mb1464 |
| M. gilvum PYR-GCK | Mflv_0356 | - | 4e-09 | 28.05% (164) | purine catabolism PurC domain-containing protein |
| M. tuberculosis H37Rv | Rv1429 | - | 7e-10 | 28.29% (205) | hypothetical protein Rv1429 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0291 | - | 1e-14 | 28.67% (300) | hypothetical protein MAB_0291 |
| M. marinum M | MMAR_2601 | - | 3e-07 | 29.11% (237) | hypothetical protein MMAR_2601 |
| M. avium 104 | MAV_4933 | - | 3e-11 | 34.13% (126) | hypothetical protein MAV_4933 |
| M. thermoresistible (build 8) | TH_2137 | - | 6e-09 | 44.93% (69) | putative DNA-binding protein |
| M. ulcerans Agy99 | MUL_3452 | - | 4e-05 | 31.82% (110) | hypothetical protein MUL_3452 |
| M. vanbaalenii PYR-1 | Mvan_5765 | - | 7e-51 | 29.01% (586) | transcriptional regulator, CdaR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1464|M.bovis_AF2122/97 --------------------------------------------------
Rv1429|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3452|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2601|M.marinum_M --------------------------------------------------
MAV_4933|M.avium_104 --------------------------------------------------
Mflv_0356|M.gilvum_PYR-GCK ---MPLTLADVIALPVVQRGRPEVLSSRRWDDTIRWVHVSDLADLSTLLQ
Mvan_5765|M.vanbaalenii_PYR-1 ------------------------MSSRTLSTALPFEHWLSALAEIGEAV
MSMEG_4044|M.smegmatis_MC2_155 ----------------------------MSVRSDPLRAWMSAVTAISRTV
MAB_0291|M.abscessus_ATCC_1997 MTDIQVGGAREGVPSAGPSALSVLRLLASGTAPDVFEARLKEMARESSPP
TH_2137|M.thermoresistible__bu ---------VVTLDRLVNVLGSYGVRLQFCPVPRSTEVRSVALHENAGGL
Mb1464|M.bovis_AF2122/97 --------------MAEAG-------GGPISVIAR-HMQLIRDDFISELF
Rv1429|M.tuberculosis_H37Rv --------------MAEAG-------GGPISVIAR-HMQLIRDDFISELF
MUL_3452|M.ulcerans_Agy99 --------------MAERNRTDDAVVGKIVVEVVY-RLSAQLAEATASIQ
MMAR_2601|M.marinum_M ---------MELQWPPACDAEAQRVWQRVLVPLAA-EMGTQAADLAQRAV
MAV_4933|M.avium_104 ---------MKDFRAPVNGVDGDSASALVAVPKSQ-GAQTIRPDSVSRLV
Mflv_0356|M.gilvum_PYR-GCK GGELVLTTGAAMARSPRTYLRGLAEAGAVGVVVEVGAVVPEVPPGVGGIA
Mvan_5765|M.vanbaalenii_PYR-1 GGDEPVAEVLDRVARTACTLLGYDFCAVFLPDEQGRALTIEGSYGLSADY
MSMEG_4044|M.smegmatis_MC2_155 NAAEPLETVLDDIAQMGCDLVGFDYCGVMLDDVTHEVMQIAGSSGLRKRY
MAB_0291|M.abscessus_ATCC_1997 WSAADLHRARGYAERIYGLIEGQNQREARLSNLVGIGIDLLGCHGLDEAS
TH_2137|M.thermoresistible__bu RVTGDVLLAVGAESVAEAVRWAETAQAVVVLTRAGPDASRSCSDGAVAVL
Mb1464|M.bovis_AF2122/97 DKMKA----EIRGLDYDAR----------MADLWRASITENFVTAVHYLD
Rv1429|M.tuberculosis_H37Rv DKMKA----EIRGLDYDAR----------MADLWRASITENFVTAVHYLD
MUL_3452|M.ulcerans_Agy99 GTLER----EIVELRGDVQ----------LLDLLHASVEGNVAAVLNAIH
MMAR_2601|M.marinum_M ARMQA----EVPQLFPDEQ----------TVKENLVSTEASLRQLAQVIE
MAV_4933|M.avium_104 GALLD----DHAAVVGRVRSV-IRSRLPVYRSVADEALEAELEWVLRSAV
Mflv_0356|M.gilvum_PYR-GCK EQLDL----ALVVLHRTVRFV-EVTEAVHRMIVAEQYDVVEFDRRVHETF
Mvan_5765|M.vanbaalenii_PYR-1 IAQVN----ANRPILLDVRGD-HEAPTSLAYRTGDVVTLEDIELVPDFTW
MSMEG_4044|M.smegmatis_MC2_155 LDLVR----SEGWLEIHPADFSADLPATKAYRELTTIVVPDVYAENSERL
MAB_0291|M.abscessus_ATCC_1997 TTLVKR---ARIMLDADFSFISVRDDSEPETRHHVRYVDGPTTAINHGLY
TH_2137|M.thermoresistible__bu TVEPEVSWSELAAVVYGLVLEGRETESGRGPTDLFALADNLADAVGGPVT
:
Mb1464|M.bovis_AF2122/97 RDTPQSL---------VEAP----AAALAYARAAAQRDIPLSGLVRAHRL
Rv1429|M.tuberculosis_H37Rv RDTPQSL---------VEAP----AAALAYARAAAQRDIPLSGLVRAHRL
MUL_3452|M.ulcerans_Agy99 YDIPIER---------VESP----TAALEYARRLAQRGVPVNALVRAYRL
MMAR_2601|M.marinum_M AGADPRQ---------VELP----PSTQAIARAAVPRQVALADLLRFYRL
MAV_4933|M.avium_104 GGREALH---------EPQI----AGLAAIGEARARDGVPVDDMLRAWRI
Mflv_0356|M.gilvum_PYR-GCK TDLSMKR---------ASLSGIVDAAAKLLGEHVVLEDLSHQALVASTGI
Mvan_5765|M.vanbaalenii_PYR-1 GGVAQEQGYRALISAPLRRPGTVVGALNGYRTAPHRFDRAEVSLVTTLAT
MSMEG_4044|M.smegmatis_MC2_155 HRFAAAQGYRSVLTAPLRVGKDNVGILAGYFRDPHDYEPEEIELAKLLAE
MAB_0291|M.abscessus_ATCC_1997 FPIGDDVG-----LVSLYRPGQGPVWTADYPSDTRFSRASDGDAAMRSEG
TH_2137|M.thermoresistible__bu IEDRMSRVLAYSQRQQHADPARAQTILARQAPEPLRRLFEQLGVSEHLAA
Mb1464|M.bovis_AF2122/97 GHARFLEVAMQYVSLL-----------------------EPADRVSTIIE
Rv1429|M.tuberculosis_H37Rv GHARFLEVAMQYVSLL-----------------------EPADRVSTIIE
MUL_3452|M.ulcerans_Agy99 GHKEMLERIIDGVQEAGA---------------------DPALSLDVFNR
MMAR_2601|M.marinum_M AQELVWQWMFGRITADSR---------------------DAAEQAKAVEL
MAV_4933|M.avium_104 GVEVVVECAREAARRLGV---------------------DDAR----VLE
Mflv_0356|M.gilvum_PYR-GCK PADLLTDWARRSRRSPGGGAGAEPW--------------SATDVGPRFEQ
Mvan_5765|M.vanbaalenii_PYR-1 QVAIALGTAQLRAKEQATIRELRRA--------------EEVHTLLTATA
MSMEG_4044|M.smegmatis_MC2_155 QSANAIRTAQLRAAQQATINDLSAVNDELRRRRASLDWADQQHRRLMRLV
MAB_0291|M.abscessus_ATCC_1997 VHSLMVMPMEHEDQHFGNLYVGSRTVR--------SFSAAERSLFASLCS
TH_2137|M.thermoresistible__bu GDDPLFIAARPGHDLTGR---------------------TVIAVRAGREL
Mb1464|M.bovis_AF2122/97 LVNRSARLVDLVADQLIVAYEHEHDRWLSR--------------------
Rv1429|M.tuberculosis_H37Rv LVNRSARLVDLVADQLIVAYEHEHDRWLSR--------------------
MUL_3452|M.ulcerans_Agy99 ISEVTFNYIDWISQQVVAAYEAERDRWLEN--------------------
MMAR_2601|M.marinum_M ATGWIFGYVDAALMRAERAYDVEREAWLRG--------------------
MAV_4933|M.avium_104 LVQSALAWSDIAMATSAKAHRRTERALALE--------------------
Mflv_0356|M.gilvum_PYR-GCK WGRLVVPYAPADATRAATVLERAAAALAMHRMVEQN--------------
Mvan_5765|M.vanbaalenii_PYR-1 LRGEGVSGVAAALSELLGRGVLIEDVYDEPLTDANW--------------
MSMEG_4044|M.smegmatis_MC2_155 LNDIGMDGLVAALADMLQASATVLDSAERVLAEASAGEYIDPP-------
MAB_0291|M.abscessus_ATCC_1997 FAGIALARASEFSSNTEQISALERRLELRSILLDTGAGPGGMDGFVLTAG
TH_2137|M.thermoresistible__bu LGSVWVVTPEPLDDGRRRALADGARTVALHLLRSR---------------
Mb1464|M.bovis_AF2122/97 -----------------------RSGLQQQWVSELLADTPV---DVPRAE
Rv1429|M.tuberculosis_H37Rv -----------------------RSGLQQQWVSELLADTPV---DVPRAE
MUL_3452|M.ulcerans_Agy99 -----------------------RSRVRNVRIAEILDGGDI---DTDAMT
MMAR_2601|M.marinum_M -----------------------ATVARASAIDDIVAERER---DPQRAS
MAV_4933|M.avium_104 -----------------------AEESDAEFVRGALMG------SLPAAE
Mflv_0356|M.gilvum_PYR-GCK -------------------RTGLQHQAQSGLIDDVLRGRVVDDRDAAARA
Mvan_5765|M.vanbaalenii_PYR-1 -------------------TAPDPRAQDHVVATVTLDGSPVARIHVAASD
MSMEG_4044|M.smegmatis_MC2_155 -KLDRKTRSKWEDTGRYEALLIDRQAAETWLIPIVLSGEVAGWLWVITEP
MAB_0291|M.abscessus_ATCC_1997 EQLGVAMRVTGHDGSEIASYKWEPDTQNILTTALTVGDDYHGELSVASLD
TH_2137|M.thermoresistible__bu ----------------------ASADLERQVESDLVLRLLEGTSDAAGAA
:
Mb1464|M.bovis_AF2122/97 RALG-YRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLLAGELGPELGPV
Rv1429|M.tuberculosis_H37Rv RALG-YRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLLAGELGPELGPV
MUL_3452|M.ulcerans_Agy99 KSIR-YPLRKVHLALVLWFPDDATDGNEFERLERFLDELAEHLG-----T
MMAR_2601|M.marinum_M KRLR-YDVSTQHLAVIAWIDRLPEDGDAQPLLGRVVADLARATA-----A
MAV_4933|M.avium_104 LRMH-AELRGLDPGAEYVAVRARLGGD------GPHLRLEQSLG------
Mflv_0356|M.gilvum_PYR-GCK QALG-LRSNAQYLPVVVRVARPAEIDDPVAGHRRNVAVLDAVAHTVNACG
Mvan_5765|M.vanbaalenii_PYR-1 SELSRLDVRAVEHATVVTALELLRARTAAEVEQRIRGSLVADLLSSDDAG
MSMEG_4044|M.smegmatis_MC2_155 SEPDAGRQRLIEHFALVVGLEILKQRHIVEVQERLCGDLMVDLLRTSDVP
MAB_0291|M.abscessus_ATCC_1997 DQPVSVYPLKIEDLATTAAVVMCGDNRMSLSVSQLRNDLLHDVLDYRQRD
TH_2137|M.thermoresistible__bu ARLG-LPQEALRIIAVRARSGVDRQGPLLLAFEHATTGFGWSRAGRSALA
:
Mb1464|M.bovis_AF2122/97 ANSLMVPT-----DEREARLWFSPAPTRAFAPSRIRAAFES---------
Rv1429|M.tuberculosis_H37Rv ANSLMVPT-----DEREARLWFSPAPTRAFAPSRIRAAFES---------
MUL_3452|M.ulcerans_Agy99 GNALFVAA-----DRITGWGWIPLRANDAGLTGRVRRFVAG---------
MMAR_2601|M.marinum_M QSTLVHTL-----GSLAVAGWVSGRGS--LSVRDAQDGVAG---------
MAV_4933|M.avium_104 ---FQDPA-----HSR--------RGLCALLDGDLAGFLIE---------
Mflv_0356|M.gilvum_PYR-GCK HTGLFSLR-----GDGEVGAVLSLKDSRTRSVDQALGALARRIH---TEI
Mvan_5765|M.vanbaalenii_PYR-1 IPALLDRARRLGWDLSGVQSLIALRPADERTLAAADRFTAGVTP---HPL
MSMEG_4044|M.smegmatis_MC2_155 PSTMLIQRAEALGHDLTTPHWLAVFAGEFGPKLDQVALTVREAAPRQETL
MAB_0291|M.abscessus_ATCC_1997 SRLVQIYARRLALDLNQPHVVVIVRPERGGLDRASLWSASFASRVG----
TH_2137|M.thermoresistible__bu GDTVYTVLP--ADHAATARRWVEGLQAALPSEVTVSAGISG---------
.
Mb1464|M.bovis_AF2122/97 ----AGIRARLACGRVGDG--------------------------LRGFR
Rv1429|M.tuberculosis_H37Rv ----AGIRARLACGRVGDG--------------------------LRGFR
MUL_3452|M.ulcerans_Agy99 ----HTDAPHVALGQALPG--------------------------VEGFR
MMAR_2601|M.marinum_M ----APAGVRLAVGDPARG--------------------------LKGFR
MAV_4933|M.avium_104 ----PPRDVEGVVGFGPPRP-------------------------LTRLS
Mflv_0356|M.gilvum_PYR-GCK RRVDGSDRVVVTLGPSARNV-------------------------TDAIA
Mvan_5765|M.vanbaalenii_PYR-1 VALHRGDLVFVWPADTGPAVPVAHRLLEFLNAATIPEAPTAAVSRQAAAR
MSMEG_4044|M.smegmatis_MC2_155 VGVYASSVVMLIPCDRDPLRIVQRTLTRITESSGGGRLAVALSPPVERLA
MAB_0291|M.abscessus_ATCC_1997 GLRATQDEVVVLLIPGSDAGRIAQTVWDETTAHLRMPVTVSSAGPSERIE
TH_2137|M.thermoresistible__bu ----IADHTELPDARREAD---------------------------ECLA
Mb1464|M.bovis_AF2122/97 ASLKQAERVKALALAGGARPGGRVMFYDD--VAPVALLADDL-EELRRFV
Rv1429|M.tuberculosis_H37Rv ASLKQAERVKALALAGGARPGGRVMFYDD--VAPVALLADDL-EELRRFV
MUL_3452|M.ulcerans_Agy99 RAHRQARNAHRVGVAVGASAPAVMAVSDEG-LSAAALMGADL-PDAGAWV
MMAR_2601|M.marinum_M RSYLEATYAHRVASLMGRR-ADAVTLYRG--VAVAALASADR-DHAVFFA
MAV_4933|M.avium_104 ESYRMAARALVTAEACGLRGAYDIAALGL-----RTAVAIDA-DVGELLR
Mflv_0356|M.gilvum_PYR-GCK GLAEAIDTAEVALSLRGDVRDFYRTSDIRL-RGLISLLRDDP-RIRRFAE
Mvan_5765|M.vanbaalenii_PYR-1 ELPGIFRTVRGALDLAGDRDTATVIDLDEPTIDHLLLQLDDP-ARLRDFA
MSMEG_4044|M.smegmatis_MC2_155 DYPVNYQTGVRTTQLRLAAGAGGLVDLRRVPLTSLLLLNSTVPDQLRRFA
MAB_0291|M.abscessus_ATCC_1997 SIEDTYQDAMRCLDAMSALGALGTAAAAHELGFLGVLLSRHQ--DVEGFV
TH_2137|M.thermoresistible__bu LHDALHDARPDTGSPDSDSDALAAVVYDESWHDVLLQRLRTAARAGRIPS
Mb1464|M.bovis_AF2122/97 TDVLG-DLSVDDERNSWLRETLREFLLRNRSYVATADAMILHRNTIQYRV
Rv1429|M.tuberculosis_H37Rv TDVLG-DLSVDDERNSWLRETLREFLLRNRSYVATADAMILHRNTIQYRV
MUL_3452|M.ulcerans_Agy99 RETLG-PLSTDSDNDAVLRETLRVFLREGGSYKAAAERLHLHYNSVKYRV
MMAR_2601|M.marinum_M TRVLG-GLAAADEDTYRIATTLAVFLAENRSRTRAAKRLNVHPNTVSYRV
MAV_4933|M.avium_104 KRYLE-PLSVGG-SSRELIATVRTYLACGMHVERTATRLFVHQNTVRYRL
Mflv_0356|M.gilvum_PYR-GCK TELRA-LLAHDAGAEPSNISVLREYLRLAGNKSALAERLHMSRPALYKRL
Mvan_5765|M.vanbaalenii_PYR-1 SAVLGPAVDYDRTRSTELLHTVRVLLEHGLDRRAAAQALHLHPNTVAQRV
MSMEG_4044|M.smegmatis_MC2_155 ENLIEPLESHDEQRETDLVATLRTWLVEGFSAAATGNRLTVHVNTVGYRL
MAB_0291|M.abscessus_ATCC_1997 RSMVGPVIDYDEDRDTDLLQTLDVYFSVGASPTRAAKILHTHPNTVVRRL
TH_2137|M.thermoresistible__bu RGPIAALHEHDLRHATQYVATLRSWLAAQGDPAAAGAVLGVHENTVRYRL
.: : . : :: *:
Mb1464|M.bovis_AF2122/97 IQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAVLRAKQ
Rv1429|M.tuberculosis_H37Rv IQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAVLRAKQ
MUL_3452|M.ulcerans_Agy99 ARAVERRGRPIDD--ERLDVEMALLVCQWFGAVVPGPER
MMAR_2601|M.marinum_M NQAEAILGRAVDADVLELSVALALLPVLPGLAQGRSGEL
MAV_4933|M.avium_104 ARFEELTGASLRDTEVVTEVWWVLELAAMRL--------
Mflv_0356|M.gilvum_PYR-GCK RGIEDALGVDLDDGESMTSLHVAVMVLDSLTGSG-----
Mvan_5765|M.vanbaalenii_PYR-1 RRLEELTGLSLARPADLLRLTAALTVSRIASLS------
MSMEG_4044|M.smegmatis_MC2_155 AKIQSLLGLDLRKADVRLELQLAVIVWDIMRGEQA----
MAB_0291|M.abscessus_ATCC_1997 DRVNELLGDGWQDAERLLDTQLAIKLWKVRGSLLTRQTG
TH_2137|M.thermoresistible__bu RKMTAVTQLDLQDPDKRLAMMIELAAIEGPPILSG----
: