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AWQQPSPRIRELIREGARIALNPSPEWIEELDRATIAANPAIANDPVLAKVVQTANRANLVYWAAANLRD PGARVPANLGTEPLRMARDLVRRGLDTVAFNIYRTGEHIGWRFWMGIAFELTSDPQELRELLDVSARSVN DFIEATLTGIAAQVQSEHDELTRSTHAERLEVVGLILDGAPISPERAEAKLGYPLSRAHTAAIIWSDELD GDHSYLDRAADLFCHAVGSTRPLTVVAGAASRWAWVTDADGLDIDTVQAAVDNAPGARIAIGTTANGVEG FRRSHLEALITQRTLSRLRSTQRVAFFADVKMVALISQNPDAASEFITSTLGDLESASPDLQTALLTFIN EQCNASRAAKRLHTHRNTFLRRLESAQRLLPRPLDHTSVHVAVALEALQWRGNKAHALSSPGRRSNSVPA *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1194c | - | - | 100% (421) | hypothetical protein Rv1194c |
| M. tuberculosis H37Rv | Rv2370c | - | e-151 | 63.70% (405) | hypothetical protein Rv2370c |
| M. tuberculosis H37Rv | Rv1453 | - | e-149 | 64.18% (402) | transcriptional activator protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1226c | - | 0.0 | 100.00% (421) | hypothetical protein Mb1226c |
| M. gilvum PYR-GCK | Mflv_4621 | - | 7e-14 | 24.56% (342) | hypothetical protein Mflv_4621 |
| M. leprae Br4923 | MLBr_01052 | - | 1e-170 | 69.83% (421) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_2657c | - | 1e-74 | 36.45% (406) | hypothetical protein MAB_2657c |
| M. marinum M | MMAR_4242 | - | 0.0 | 75.77% (421) | transcriptional regulatory protein |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_1456 | - | 2e-08 | 24.38% (283) | hypothetical protein MSMEG_1456 |
| M. thermoresistible (build 8) | TH_3143 | - | 4e-20 | 26.58% (395) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_0944 | - | 0.0 | 74.82% (421) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_1323 | - | 3e-06 | 27.54% (138) | transcriptional regulator, CdaR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4621|M.gilvum_PYR-GCK -------------------MLDSSEVQDTPGHAVHHLFRDLGDLVREL--
TH_3143|M.thermoresistible__bu -------------------VVVSGYNADDISSTVALIVDRLLENSGED--
Rv1194c|M.tuberculosis_H37Rv --------------------MAWQQPSPRIRELIREGARIALNPSPEW--
Mb1226c|M.bovis_AF2122/97 --------------------MAWQQPSPRIRELIREGARIALNPSPEW--
MMAR_4242|M.marinum_M --------------------MPWQRPSSRIRELIREGARRALNAGPEW--
MUL_0944|M.ulcerans_Agy99 --------------------MPWQRPSSRIRELIREGARRALNAGPEW--
MLBr_01052|M.leprae_Br4923 --------------------MARQHPSPRVRELIREGARIALNPTQEW--
MAB_2657c|M.abscessus_ATCC_199 ----MNEGSERVHTQSMTPDQLWPDASEPVRRLIRELAEKMLARSGEV--
MSMEG_1456|M.smegmatis_MC2_155 MTAPPIDSGRMTVRGLLDESLMAGSRIVAGEDLLDEELTWVLPLNEVLSQ
Mvan_1323|M.vanbaalenii_PYR-1 ---MRHDDDRMTVAGLLDESLMSGAHVLTGADRLDQQVHWVLPLSEVMSR
:
Mflv_4621|M.gilvum_PYR-GCK PESIHGLLIEQV--AELAADQQLKELLSDTVAANVDT------WFSV-VR
TH_3143|M.thermoresistible__bu VERIQRRILADI--DELRSDPRLVELLRSSVAGNVET------VLTV-IR
Rv1194c|M.tuberculosis_H37Rv IEELDRATIAAN--PAIANDPVLAKVVQTANRANLVY------WAAANLR
Mb1226c|M.bovis_AF2122/97 IEELDRATIAAN--PAIANDPVLAKVVQTANRANLVY------WAAANLR
MMAR_4242|M.marinum_M IEELDRETVSAN--PTIANDPVLAKVVKRANRANLVH------WAAANVR
MUL_0944|M.ulcerans_Agy99 IEELDRETVSAN--PTIANDPVLAKVVKRVNRANLVH------WAAANVR
MLBr_01052|M.leprae_Br4923 IDQLDRATFAAN--PAIANDPVLAKVVRRASRAHLVH------WATANLR
MAB_2657c|M.abscessus_ATCC_199 AGDLTAASLEDPRYRTIADDPVIAEVDARLTVSNLKH------WLTSNIS
MSMEG_1456|M.smegmatis_MC2_155 HDRLDAVAVYARPESLTARASTLSALAARGATTLLVDGVAPPDLG--GLP
Mvan_1323|M.vanbaalenii_PYR-1 HDALDGVAVYTRPEALLGNGGTLAPLAARGATALLVDGTVPADFPTAAVP
: . : : : :
Mflv_4621|M.gilvum_PYR-GCK HSIPFDRMESPTAALEHARRMAQREVPVNALLRAYRLGHQY---------
TH_3143|M.thermoresistible__bu YGIDLDRVEPPTAALEYARRAAQHGIALSALIRAYRLGQQE---------
Rv1194c|M.tuberculosis_H37Rv DPGARVPANLGTEPLRMARDLVRRGLDTVAFN-IYRTGEHI---------
Mb1226c|M.bovis_AF2122/97 DPGARVPANLGTEPLRMARDLVRRGLDTVAFN-IYRTGEHI---------
MMAR_4242|M.marinum_M HPGAPVPANLGGEPLRMARDLVRRGLETLTLD-IYRIGQYI---------
MUL_0944|M.ulcerans_Agy99 HPGAPVPANLGGEPLRMARDLVRRGLEALTLD-IYRIGQYI---------
MLBr_01052|M.leprae_Br4923 DPGAPVPAHLGPEPLTMARDLVRRGRDVLALD-IYRVGQYT---------
MAB_2657c|M.abscessus_ATCC_199 EPGHRVRPATGSAMRTYARDVVLRGLTTDDIQ-SWRAVQRV---------
MSMEG_1456|M.smegmatis_MC2_155 AGLVVVELGIPVGFAALNRLLAERALSQEVHVMRYSTHVHATLAGLFHRG
Mvan_1323|M.vanbaalenii_PYR-1 ADMVVVEMAFPVGFAALNRLLAERALSQEVHAMRYATHVHASLAGLFHRG
* . : :
Mflv_4621|M.gilvum_PYR-GCK -GLNLIIAGLRSADLPPEEKLALIEHITRV--------------------
TH_3143|M.thermoresistible__bu -MLERILREVRETELDPDLRLSVYERISST--------------------
Rv1194c|M.tuberculosis_H37Rv -GWRFWMGIAFELTSDPQELRELLDVSARS--------------------
Mb1226c|M.bovis_AF2122/97 -GWRFWMGIAFELTSDPQELRELLDVSARS--------------------
MMAR_4242|M.marinum_M -AWRLWINIAFDLTSDPQELRELLDVSAKS--------------------
MUL_0944|M.ulcerans_Agy99 -AWRLWINIAFDLTSDPQELHELLDVSAKS--------------------
MLBr_01052|M.leprae_Br4923 -AWRRWMEIAFTLTSDPQELREILNVSAQS--------------------
MAB_2657c|M.abscessus_ATCC_199 -GWKWWLAACFQVTDDKEQLCELIEVTSNS--------------------
MSMEG_1456|M.smegmatis_MC2_155 AGLQILVREVSNLARNPAVALDARGHVVAHHGLPPEAVAALADSVSRMLA
Mvan_1323|M.vanbaalenii_PYR-1 AGLQLLVREVSNLARNPAMALDARGNVVAHNGFTAETAAALTESILPLLT
. :
Mflv_4621|M.gilvum_PYR-GCK --------------------------------------------------
TH_3143|M.thermoresistible__bu --------------------------------------------------
Rv1194c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1226c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4242|M.marinum_M --------------------------------------------------
MUL_0944|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01052|M.leprae_Br4923 --------------------------------------------------
MAB_2657c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_1456|M.smegmatis_MC2_155 ADLPASERRHDGHDTRTQQVTGPEDSRWTCVASAIRLGKSFEGWVAVLVP
Mvan_1323|M.vanbaalenii_PYR-1 ADLPAAARLSAHHDTRVERFGAPGGGVWTVISTAIRLGKAFEGWVLVVVP
Mflv_4621|M.gilvum_PYR-GCK ----------------SFRYIDWMSEQVLETYQTERAEWDERRRSLRAQA
TH_3143|M.thermoresistible__bu ----------------SFAYIDWISQQVSDTYDTERERWLEHRNNIRAVR
Rv1194c|M.tuberculosis_H37Rv ----------------VNDFIEATLTGIAAQVQSEHDELTRSTHAERLEV
Mb1226c|M.bovis_AF2122/97 ----------------VNDFIEATLTGIAAQVQSEHDELTRSTHAERLEV
MMAR_4242|M.marinum_M ----------------VNEFIEATLAGIAAQVQLEHDELTRGNHADRLEV
MUL_0944|M.ulcerans_Agy99 ----------------VNEFIEATLAGIAAQVQLEHDELTRGNHADRLEV
MLBr_01052|M.leprae_Br4923 ----------------INEYVAATLEAIATHMQLERDELTRSTHAERLEV
MAB_2657c|M.abscessus_ATCC_199 ----------------LTTFVDDSIAELAEHVRRVREELAGGSQLQRYAT
MSMEG_1456|M.smegmatis_MC2_155 TLAPDHADGPSKHDLARHEVLTEQATAIIGSEMLRQRSVDEAEERARGDF
Mvan_1323|M.vanbaalenii_PYR-1 SAE------PGGHDLARHIVVTEQATAIIGSEMLRQHSVDEAEERARGDF
: : : . *
Mflv_4621|M.gilvum_PYR-GCK IRDILNGRD-VDLTEASSAMRYFLGATHVALMVWLDRDA----GADTDEF
TH_3143|M.thermoresistible__bu VREILDSDEPIDIDTASAALGYPLRGRHLALVLWMTR-S----DLPGGEL
Rv1194c|M.tuberculosis_H37Rv VGLILDGAP-ISPERAEAKLGYPLSRAHTAAIIWSDE--------LDGDH
Mb1226c|M.bovis_AF2122/97 VGLILDGAP-ISPERAEAKLGYPLSRAHTAAIIWSDE--------LDGDH
MMAR_4242|M.marinum_M VGHLLEGAP-ISRERAETRLGYSLIRAHTAAIIWSDD--------FDGDH
MUL_0944|M.ulcerans_Agy99 VGHLLEGAP-ISRERAETRLGYSLIRAHTAAIIWSDD--------FDGDH
MLBr_01052|M.leprae_Br4923 VDLILEGAP-VTQERAEARLGYRLGLTHTAAVIWSDD--------LDGDH
MAB_2657c|M.abscessus_ATCC_199 VELLLQGAD-IAPARAEAQLGYALTGSHIGAVVWVDS--------EK-EI
MSMEG_1456|M.smegmatis_MC2_155 VQALVHGSFSSEHDMRARAEHHDIELDARFGVFVAPGVLPRGPDSPTTPM
Mvan_1323|M.vanbaalenii_PYR-1 VQALVHGHFSSEHDMRARADYHEIDIDSVFGVFVAPGAVPRGVDNPAASM
: ::.. : : :.
Mflv_4621|M.gilvum_PYR-GCK IAMERFMQHAVSATGAKQS------VYFSIDRLVGCAWMTV-HRPSDYLS
TH_3143|M.thermoresistible__bu LRLERFARAVAEAFQLRNTP-----LFVAEDTVSGWAWLAINHVVTEPVR
Rv1194c|M.tuberculosis_H37Rv SYLDRAADLFCHAVGSTRP------LTVVAGAASRWAWVTDADGLD--ID
Mb1226c|M.bovis_AF2122/97 SYLDRAADLFCHAVGSTRP------LTVVAGAASRWAWVTDADGLD--ID
MMAR_4242|M.marinum_M SNLDRAADAFCHAVGSSQD------LTVVANAATRWVWLAEATNLD--ID
MUL_0944|M.ulcerans_Agy99 SNLDRAADAFCHAVGSSQD------LTVVANAATRWVWLAEATNLD--ID
MLBr_01052|M.leprae_Br4923 GYLDQAAEAFSHVVESTQQ------LIVVASAATRWVWLADALALD--VP
MAB_2657c|M.abscessus_ATCC_199 AALERASEQVMRACGADRR------LTVVAGTVALWLWIPAKTTPT--VA
MSMEG_1456|M.smegmatis_MC2_155 VRLARYAAGVAAHPSVHAYVTVIGDVLVVVRTLRGEDAAAMRSEMAEYAE
Mvan_1323|M.vanbaalenii_PYR-1 VRLARYAANVAPDPAVRSYVTVLGDVLVVVRSLRGADDTAMRKEMTRYAE
: : : . .
Mflv_4621|M.gilvum_PYR-GCK QLRDFVR-AQPDGPRLSVGEPLPGIEGFRRTYRQAEQARVVAVAADGSSR
TH_3143|M.thermoresistible__bu TIRELAE-TADNGVHVALGTVDDGLEGFRRSHRRARDARKVAAAS--AIP
Rv1194c|M.tuberculosis_H37Rv TVQAAVD-NAP-GARIAIGTTANGVEGFRRSHLEALITQRTLSRLR----
Mb1226c|M.bovis_AF2122/97 TVQAAVD-NAP-GARIAIGTTANGVEGFRRSHLEALITQRTLSRLR----
MMAR_4242|M.marinum_M TIEQAVD-NAS-DARIAIGTKASGIEGFRRSHLEALTTQRTLARLK----
MUL_0944|M.ulcerans_Agy99 TIEQAVD-NAS-DARIAIGTKASGIEGFRRSHLEALTTQRTLARLK----
MLBr_01052|M.leprae_Br4923 EVQKALL-NLS-KARVAIGTSSAGIEGFRRSHLEALTAQRTLARLK----
MAB_2657c|M.abscessus_ATCC_199 VLMDSLG-RRS-GVRVALGRAATGMAGFRRTHMDAAAAQRLLARLG----
MSMEG_1456|M.smegmatis_MC2_155 AMSGELQRRRGLPAPVAYGRPALGAGEVRESYREARVALGIARRLH----
Mvan_1323|M.vanbaalenii_PYR-1 AMADELQNRRGTPAAVAYSRPARGAQEVAGSYREARIALGIARRLG----
: :: . * . :: * :
Mflv_4621|M.gilvum_PYR-GCK HRIVAARDPGVALASMLMTDDAT--LKEWIHDVLGPLAQNTASDQRLRDT
TH_3143|M.thermoresistible__bu PRITAADDYGISVSALLTENLAD--TRRWVLDTLGPLASDTANDARLRET
Rv1194c|M.tuberculosis_H37Rv STQRVAFFADVKMVALISQNPDA--ASEFITSTLGDLESASP---DLQTA
Mb1226c|M.bovis_AF2122/97 STQRVAFFADVKMVALISQNPDA--ASEFITSTLGDLESASP---DLQTA
MMAR_4242|M.marinum_M SDQRVAFFSDVQIVALITQNPQA--ADEFITSTLGELESAAP---ELQAT
MUL_0944|M.ulcerans_Agy99 SDQRVAFFSDVQIVALITQNTQA--ANEFITSTLGELESAAP---ELQAT
MLBr_01052|M.leprae_Br4923 SHQQVAFFADVQLVSLITQNPED--AKEFITSTLGDFESASP---ALQQT
MAB_2657c|M.abscessus_ATCC_199 SPLSVVRYEDVHLMDLLSADPAS--ADQFVTDVLGEFQSASP---VLHQT
MSMEG_1456|M.smegmatis_MC2_155 -RTGATSYQQLRGFTVLAQVAETEDSRQLVRDVLGPLRSSPD----LLET
Mvan_1323|M.vanbaalenii_PYR-1 -HTGAVSYQDLRSFTVLADVADTDQSRALVADVLGPLRSAPD----LLDF
.. : :: : ..** : . . *
Mflv_4621|M.gilvum_PYR-GCK LRVFLRAGSSFKAAANELQIHANTVKYRVNRALERRGRPIAAERLDVEVA
TH_3143|M.thermoresistible__bu LLVFLHVGSSYTAAAERLLLHPNSVRYRVNRAVERRARPIGEDRLEVELA
Rv1194c|M.tuberculosis_H37Rv LLTFINEQCNASRAAKRLHTHRNTFLRRLESAQRLLPRPLDHTSVHVAVA
Mb1226c|M.bovis_AF2122/97 LLTFINEQCNASRAAKRLHTHRNTFLRRLESAQRLLPRPLDHTSVHVAVA
MMAR_4242|M.marinum_M LLMFINEQCNASRAAKRLYTHRNTLLRRIEAAQRLLPRPLAHTSVHVAVA
MUL_0944|M.ulcerans_Agy99 LLMFINEQCNASRAAKRLYTHRNTLLRRIEAAQRLLPRPLAHTSVHVAVA
MLBr_01052|M.leprae_Br4923 LLTFINEQCNASRAAKRLFTHRNTLLRRIESAEKLLPRPLDHTSVHIAVA
MAB_2657c|M.abscessus_ATCC_199 VLTYVEEALNRTSTAERLYTHRNTIDRRLARVDELLPKPFARNPIEVAAA
MSMEG_1456|M.smegmatis_MC2_155 LEAYLSEGGNINATARTLNVHRNTMLAKLDRISRMLGMDVRDPEHQFTVW
Mvan_1323|M.vanbaalenii_PYR-1 LIGYLAHGGNVNATARALNVHRNTMLTKLDRVSRATGLDIRLPDNQFTVW
: :: . . :*. * * *:. :: . . ..
Mflv_4621|M.gilvum_PYR-GCK LLMCYWLGEVALNPTQALGRS-----
TH_3143|M.thermoresistible__bu LLACRHFQQAVLQPAD----------
Rv1194c|M.tuberculosis_H37Rv LEALQWRGNKAHALSSPGRRSNSVPA
Mb1226c|M.bovis_AF2122/97 LEALQWRGNKAHALSSPGRRSNSVPA
MMAR_4242|M.marinum_M LEALQWRGDNIAKLPTPTSQDDEVPA
MUL_0944|M.ulcerans_Agy99 LEALQWRGDNIAKLPTPTSQDDEVPA
MLBr_01052|M.leprae_Br4923 LEALQWRGDQTNTSGPRAGRNDGVPA
MAB_2657c|M.abscessus_ATCC_199 LTLLRVRAGR----------------
MSMEG_1456|M.smegmatis_MC2_155 LAIRLDLLDEVHSAVEREASFR----
Mvan_1323|M.vanbaalenii_PYR-1 LAIRLDMLTEVHAAVDREAKFR----
*