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VAEAGGGPISVIARHMQLIRDDFISELFDKMKAEIRGLDYDARMADLWRASITENFVTAVHYLDRDTPQS LVEAPAAALAYARAAAQRDIPLSGLVRAHRLGHARFLEVAMQYVSLLEPADRVSTIIELVNRSARLVDLV ADQLIVAYEHEHDRWLSRRSGLQQQWVSELLADTPVDVPRAERALGYRLDGVHIAAVVWVDSAVPIGDVV AQFDQVRCLLAGELGPELGPVANSLMVPTDEREARLWFSPAPTRAFAPSRIRAAFESAGIRARLACGRVG DGLRGFRASLKQAERVKALALAGGARPGGRVMFYDDVAPVALLADDLEELRRFVTDVLGDLSVDDERNSW LRETLREFLLRNRSYVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAVLRA KQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1464 | - | - | 100% (422) | hypothetical protein Mb1464 |
| M. bovis AF2122 / 97 | Mb1488 | - | 4e-16 | 27.09% (299) | transcriptional activator protein |
| M. bovis AF2122 / 97 | Mb1226c | - | 6e-16 | 26.64% (289) | hypothetical protein Mb1226c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4621 | - | 6e-39 | 28.98% (421) | hypothetical protein Mflv_4621 |
| M. tuberculosis H37Rv | Rv1429 | - | 0.0 | 100.00% (422) | hypothetical protein Rv1429 |
| M. leprae Br4923 | MLBr_01052 | - | 8e-17 | 26.92% (312) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_2657c | - | 3e-17 | 30.09% (319) | hypothetical protein MAB_2657c |
| M. marinum M | MMAR_1582 | - | 4e-51 | 33.76% (391) | hypothetical protein MMAR_1582 |
| M. avium 104 | MAV_4933 | - | 8e-06 | 24.11% (365) | hypothetical protein MAV_4933 |
| M. smegmatis MC2 155 | MSMEG_4044 | - | 7e-10 | 28.29% (205) | GAF domain-containing protein |
| M. thermoresistible (build 8) | TH_2938 | - | 2e-47 | 35.14% (387) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3452 | - | 1e-49 | 32.56% (390) | hypothetical protein MUL_3452 |
| M. vanbaalenii PYR-1 | Mvan_4407 | - | 2e-07 | 31.35% (185) | putative GAF sensor protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1464|M.bovis_AF2122/97 --------------------------------------------------
Rv1429|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1582|M.marinum_M --------------------------------------------------
MUL_3452|M.ulcerans_Agy99 --------------------------------------------------
TH_2938|M.thermoresistible__bu --------------------------------------------------
Mflv_4621|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_01052|M.leprae_Br4923 --------------------------------------------------
MAB_2657c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4933|M.avium_104 --------------------------------------------------
MSMEG_4044|M.smegmatis_MC2_155 MSVRSDPLRAWMSAVTAISRTVNAAEPLETVLDDIAQMGCDLVGFDYCGV
Mvan_4407|M.vanbaalenii_PYR-1 --------------------MSEPRSVIAAQTALIAALRDVVSARSVADV
Mb1464|M.bovis_AF2122/97 --------------------------------------------------
Rv1429|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1582|M.marinum_M --------------------------------------------------
MUL_3452|M.ulcerans_Agy99 --------------------------------------------------
TH_2938|M.thermoresistible__bu --------------------------------------------------
Mflv_4621|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_01052|M.leprae_Br4923 --------------------------------------------------
MAB_2657c|M.abscessus_ATCC_199 ------------------------------------------MNEGSERV
MAV_4933|M.avium_104 --------------------------------------------MKDFRA
MSMEG_4044|M.smegmatis_MC2_155 MLDDVTHEVMQIAGSSGLRKRYLDLVRSEGWLEIHPADFSADLPATKAYR
Mvan_4407|M.vanbaalenii_PYR-1 ESATLAAVRSLLSADAAFWMDRVDDGFAMTALSGLIQPESHELSLVPPGA
Mb1464|M.bovis_AF2122/97 -------------MAEAGGGPISVIARHMQLIRDDFISELFDKMKAEI--
Rv1429|M.tuberculosis_H37Rv -------------MAEAGGGPISVIARHMQLIRDDFISELFDKMKAEI--
MMAR_1582|M.marinum_M ------MAERNRTDDAAVSKIAVEVVDRLSAQLAEATASIQGTLEREI--
MUL_3452|M.ulcerans_Agy99 ------MAERNRTDDAVVGKIVVEVVYRLSAQLAEATASIQGTLEREI--
TH_2938|M.thermoresistible__bu --------------------------------VGYGPGSRQG--------
Mflv_4621|M.gilvum_PYR-GCK ------MLDSSEVQDTPG-HAVHHLFRDLGDLVRELPESIHGLLIEQV--
MLBr_01052|M.leprae_Br4923 --------MARQHPSPRVRELIREGARIALNPTQEWIDQLDRATFAAN--
MAB_2657c|M.abscessus_ATCC_199 HTQSMTPDQLWPDASEPVRRLIRELAEKMLARSGEVAGDLTAASLEDPRY
MAV_4933|M.avium_104 PVNGVDGDSASALVAVPKSQGAQTIRPDSVSRLVGALLDDHAAVVGRVRS
MSMEG_4044|M.smegmatis_MC2_155 ELTTIVVPDVYAENSERLHRFAAAQGYRSVLTAPLRVGKDNVGILAGYFR
Mvan_4407|M.vanbaalenii_PYR-1 GLAAEIVANDAPASSSDYTVDPRAIPAFAAMFRRENIRSTAGAPMRSS-E
.
Mb1464|M.bovis_AF2122/97 RGLDYDARMADLWRASITENFVTAVHYLDRDTPQSLVEAP-AAALAYARA
Rv1429|M.tuberculosis_H37Rv RGLDYDARMADLWRASITENFVTAVHYLDRDTPQSLVEAP-AAALAYARA
MMAR_1582|M.marinum_M VELRGDAQLLDLLHASVEGNVAAVLNAIHYDIPIERVESP-TAALEYARR
MUL_3452|M.ulcerans_Agy99 VELRGDVQLLDLLHASVEGNVAAVLNAIHYDIPIERVESP-TAALEYARR
TH_2938|M.thermoresistible__bu ---SGCRQLLELLRDSVEGNIDTIFSAIQHDIPIEEVAPP-TAALEYARR
Mflv_4621|M.gilvum_PYR-GCK AELAADQQLKELLSDTVAANVDTWFSVVRHSIPFDRMESP-TAALEHARR
MLBr_01052|M.leprae_Br4923 PAIANDPVLAKVVRRASRAHLVHWATANLRDPGAPVPAHLGPEPLTMARD
MAB_2657c|M.abscessus_ATCC_199 RTIADDPVIAEVDARLTVSNLKHWLTSNISEPGHRVRPATGSAMRTYARD
MAV_4933|M.avium_104 VIRSRLPVYRSVADEALEAELEWVLRSAVGG-REALHEPQIAGLAAIGEA
MSMEG_4044|M.smegmatis_MC2_155 DPHDYEPEEIELAKLLAEQSANAIRTAQLRAAQQATINDLSAVNDELRRR
Mvan_4407|M.vanbaalenii_PYR-1 GVVGVLFVFARRSREFTEDEMQLLMSIAGVARALRERLREGEFQRELLEQ
.
Mb1464|M.bovis_AF2122/97 AAQRDIPLSGLVRAHRLGH-ARFLEVAMQYVS--LLEPADRVSTIIELVN
Rv1429|M.tuberculosis_H37Rv AAQRDIPLSGLVRAHRLGH-ARFLEVAMQYVS--LLEPADRVSTIIELVN
MMAR_1582|M.marinum_M LAQRGVPVNALVRAYRLGH-KEMLERIIDGVQEAGADPALSLDVFNRISE
MUL_3452|M.ulcerans_Agy99 LAQRGVPVNALVRAYRLGH-KEMLERIIDGVQEAGADPALSLDVFNRISE
TH_2938|M.thermoresistible__bu LARHGVEPHALLRAYRLGQ-QKLLDIVLHEIRSLDWEREVSLEFVVGVTN
Mflv_4621|M.gilvum_PYR-GCK MAQREVPVNALLRAYRLGH-QYGLNLIIAGLRSADLPPEEKLALIEHITR
MLBr_01052|M.leprae_Br4923 LVRRGRDVLALD-IYRVGQ-YTAWRRWMEIAFTLTSDPQELREILNVSAQ
MAB_2657c|M.abscessus_ATCC_199 VVLRGLTTDDIQ-SWRAVQ-RVGWKWWLAACFQVTDDKEQLCELIEVTSN
MAV_4933|M.avium_104 RARDGVPVDDMLRAWRIGV-EVVVECAREAARRLGVDDAR----VLELVQ
MSMEG_4044|M.smegmatis_MC2_155 RASLDWADQQHRRLMRLVLNDIGMDGLVAALADMLQASATVLDSAERVLA
Mvan_4407|M.vanbaalenii_PYR-1 ERSRAAAGDRLLRAAETFSSSMLRGQPLAAGLEAASDELGVRLHVRGLPA
.
Mb1464|M.bovis_AF2122/97 RSAR----------------LVDLVADQLIVAYEHEHDRWLS--------
Rv1429|M.tuberculosis_H37Rv RSAR----------------LVDLVADQLIVAYEHEHDRWLS--------
MMAR_1582|M.marinum_M VTFN----------------YIDWISQQVVAAYEAERDRWLE--------
MUL_3452|M.ulcerans_Agy99 VTFN----------------YIDWISQQVVAAYEAERDRWLE--------
TH_2938|M.thermoresistible__bu ATFG----------------YIDGISQRVVEVYQQERERWLE--------
Mflv_4621|M.gilvum_PYR-GCK VSFR----------------YIDWMSEQVLETYQTERAEWDE--------
MLBr_01052|M.leprae_Br4923 SINE----------------YVAATLEAIATHMQLERDELTR--------
MAB_2657c|M.abscessus_ATCC_199 SLTT----------------FVDDSIAELAEHVRRVREELAG--------
MAV_4933|M.avium_104 SALA----------------WSDIAMATSAKAHRRTERALAL--------
MSMEG_4044|M.smegmatis_MC2_155 EASAGEYIDPPKLDRKTRSKWEDTGRYEALLIDRQAAETWLIPIVLSGEV
Mvan_4407|M.vanbaalenii_PYR-1 PGSP----------TSHMLPIEDAPTVSSGPEARIPGADLAVLS------
.
Mb1464|M.bovis_AF2122/97 -------------RRSGLQQQWVSELLADTPVDVPRAERALGYRLDGVHI
Rv1429|M.tuberculosis_H37Rv -------------RRSGLQQQWVSELLADTPVDVPRAERALGYRLDGVHI
MMAR_1582|M.marinum_M -------------NRSRVRNVRIAEILDGGDIDTDAMTRSIRYPLRKVHL
MUL_3452|M.ulcerans_Agy99 -------------NRSRVRNVRIAEILDGGDIDTDAMTKSIRYPLRKVHL
TH_2938|M.thermoresistible__bu -------------NRNSLRAMRVRELLDGGEVDVDTASATVGYPLRRTHL
Mflv_4621|M.gilvum_PYR-GCK -------------RRRSLRAQAIRDILNGRDVDLTEASSAMRYFLGATHV
MLBr_01052|M.leprae_Br4923 -------------STHAERLEVVDLILEGAPVTQERAEARLGYRLGLTHT
MAB_2657c|M.abscessus_ATCC_199 -------------GSQLQRYATVELLLQGADIAPARAEAQLGYALTGSHI
MAV_4933|M.avium_104 -------------EAEESDAEFVRGALMG---SLPAAELRMHAELRGLDP
MSMEG_4044|M.smegmatis_MC2_155 AGWLWVITEPSEPDAGRQRLIEHFALVVGLEILKQRHIVEVQERLCGDLM
Mvan_4407|M.vanbaalenii_PYR-1 -----------ADGALPEMQLALLAQLIGIDFRRQRVELETELALTDQMV
: . *
Mb1464|M.bovis_AF2122/97 AAVVWVDSAVPIGDVVAQFDQVRC-------------------LLAGELG
Rv1429|M.tuberculosis_H37Rv AAVVWVDSAVPIGDVVAQFDQVRC-------------------LLAGELG
MMAR_1582|M.marinum_M ALVLWFPDDA-TDGNEFERLER----------------------FLDELA
MUL_3452|M.ulcerans_Agy99 ALVLWFPDDA-TDGNEFERLER----------------------FLDELA
TH_2938|M.thermoresistible__bu AVCVWTPDGS-AGDNELDRLQR----------------------YVRGLA
Mflv_4621|M.gilvum_PYR-GCK ALMVWLDRDAGADTDEFIAMER----------------------FMQHAV
MLBr_01052|M.leprae_Br4923 AAVIWSDDLDGDHGYLDQAAEA---------------------------F
MAB_2657c|M.abscessus_ATCC_199 GAVVWVDSEK-EIAALERASEQ---------------------------V
MAV_4933|M.avium_104 GAEYVAVRARLGGDGPHLRLEQS------------------------LGF
MSMEG_4044|M.smegmatis_MC2_155 VDLLRTSDVPPSTMLIQRAEALGHDLTTPHWLAVFAGEFGPKLDQVALTV
Mvan_4407|M.vanbaalenii_PYR-1 HSLLTGDFQELERLWSRTALLGMNPAVPRVLVSIGRDRPVDRMLLDRIRR
Mb1464|M.bovis_AF2122/97 PELGPVANSLMVPTDEREARLWFSPAPTRA-FAPSRIRAAFESA-GIRAR
Rv1429|M.tuberculosis_H37Rv PELGPVANSLMVPTDEREARLWFSPAPTRA-FAPSRIRAAFESA-GIRAR
MMAR_1582|M.marinum_M EHLGT-GNALFVAADRVTGWGWIPLRVNDA-GLAERVRRFVAGH-TDAPH
MUL_3452|M.ulcerans_Agy99 EHLGT-GNALFVAADRITGWGWIPLRANDA-GLTGRVRRFVAGH-TDAPH
TH_2938|M.thermoresistible__bu EALGAPGDSLFIALDRLTGCGWIPLPGDAATGAVAGVRRYAAEH-PDGPH
Mflv_4621|M.gilvum_PYR-GCK SATGA-KQSVYFSIDRLVGCAWMTVHRPSD--YLSQLRDFVRAQ-PDGPR
MLBr_01052|M.leprae_Br4923 SHVVESTQQLIVVASAATRWVWLADALALD---VPEVQKALLNL-S-KAR
MAB_2657c|M.abscessus_ATCC_199 MRACGADRRLTVVAGTVALWLWIPAKTTPT---VAVLMDSLGRR-S-GVR
MAV_4933|M.avium_104 QDPAHSRRGLCALLDGDLAGFLIEPPRDVEG------------------V
MSMEG_4044|M.smegmatis_MC2_155 REAAPRQETLVGVYASSVVMLIPCDRDPLRIVQRTLTRITESSG-GGRLA
Mvan_4407|M.vanbaalenii_PYR-1 EMRSRISGGYSTTYGGDVVLLCPVPEVEQEAKLVGQVESIVTACRPERLT
Mb1464|M.bovis_AF2122/97 LACGRVGDGLRGFRASLKQAERVKALALAG--GARPGGRVMFYDDVAPVA
Rv1429|M.tuberculosis_H37Rv LACGRVGDGLRGFRASLKQAERVKALALAG--GARPGGRVMFYDDVAPVA
MMAR_1582|M.marinum_M VALGQALPGVEGFRRAHRQARNAHRVGVAV-GASAPAVVAVSDEGLSAAA
MUL_3452|M.ulcerans_Agy99 VALGQALPGVEGFRRAHRQARNAHRVGVAV-GASAPAVMAVSDEGLSAAA
TH_2938|M.thermoresistible__bu LALGDPLPGLDGFRRSYRQALRTRAVAVAA-GASAPRVTAAADPGLSAAA
Mflv_4621|M.gilvum_PYR-GCK LSVGEPLPGIEGFRRTYRQAEQARVVAVAADGSSRHRIVAARDPGVALAS
MLBr_01052|M.leprae_Br4923 VAIGTSSAGIEGFRRSHLEALTAQRTLARL----KSHQQVAFFADVQLVS
MAB_2657c|M.abscessus_ATCC_199 VALGRAATGMAGFRRTHMDAAAAQRLLARL----GSPLSVVRYEDVHLMD
MAV_4933|M.avium_104 VGFGPPRP-LTRLSESYRMAARALVTAEAC-----GLRGAYDIAALGLRT
MSMEG_4044|M.smegmatis_MC2_155 VALSPPVERLADYPVNYQTGVRTTQLRLAA--GAGGLVDLRRVPLTSLLL
Mvan_4407|M.vanbaalenii_PYR-1 AGIGPVCRKADDYPLGVREALFARQVAAQS--RTGKAVVSSAELGMYRLF
. . . .
Mb1464|M.bovis_AF2122/97 LLADDLEELRRFVTDVLGDLSVDDE-RNSWLRETLREFLLRNRSYVATAD
Rv1429|M.tuberculosis_H37Rv LLADDLEELRRFVTDVLGDLSVDDE-RNSWLRETLREFLLRNRSYVATAD
MMAR_1582|M.marinum_M LMGADLPEAGAWVRETLGPLSTDSD-NDAVLRETLRVFLREGGSYKAAAE
MUL_3452|M.ulcerans_Agy99 LMGADLPDAGAWVRETLGPLSTDSD-NDAVLRETLRVFLREGGSYKAAAE
TH_2938|M.thermoresistible__bu LLTGDLAEARTWVQEVLGPLSADTK-NDARLRETLGVFLRHGSSYTAAAD
Mflv_4621|M.gilvum_PYR-GCK MLMTDDATLKEWIHDVLGPLAQNTA-SDQRLRDTLRVFLRAGSSFKAAAN
MLBr_01052|M.leprae_Br4923 LITQNPEDAKEFITSTLGDFESAS----PALQQTLLTFINEQCNASRAAK
MAB_2657c|M.abscessus_ATCC_199 LLSADPASADQFVTDVLGEFQSAS----PVLHQTVLTYVEEALNRTSTAE
MAV_4933|M.avium_104 AVAIDADVGELLRKRYLEPLSVGG--SSRELIATVRTYLACGMHVERTAT
MSMEG_4044|M.smegmatis_MC2_155 LNSTVPDQLRRFAENLIEPLESHDEQRETDLVATLRTWLVEGFSAAATGN
Mvan_4407|M.vanbaalenii_PYR-1 AHVGGTDALLGAVLETLGPLLDADGRDGSDLLNTLHAFLEHDRRIAETAR
: : * *: :: :.
Mb1464|M.bovis_AF2122/97 AMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAVLRA
Rv1429|M.tuberculosis_H37Rv AMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAVLRA
MMAR_1582|M.marinum_M RLHLHYNSVKYRVARAVERRGRPIDD--ERLDVEMALLVCQWFGAVVLGP
MUL_3452|M.ulcerans_Agy99 RLHLHYNSVKYRVARAVERRGRPIDD--ERLDVEMALLVCQWFGAVVPGP
TH_2938|M.thermoresistible__bu ELNLHFNTVKYRVQRAVERRGRPIVP--DRLDVELALLICQWFGAAVLRP
Mflv_4621|M.gilvum_PYR-GCK ELQIHANTVKYRVNRALERRGRPIAA--ERLDVEVALLMCYWLGEVALNP
MLBr_01052|M.leprae_Br4923 RLFTHRNTLLRRIESAEKLLPRPLDH--TSVHIAVALEALQWRGDQTNTS
MAB_2657c|M.abscessus_ATCC_199 RLYTHRNTIDRRLARVDELLPKPFAR--NPIEVAAALTLLRVRAGR----
MAV_4933|M.avium_104 RLFVHQNTVRYRLARFEELTGASLRDTEVVTEVWWVLELAAMRL------
MSMEG_4044|M.smegmatis_MC2_155 RLTVHVNTVGYRLAKIQSLLGLDLRKADVRLELQLAVIVWDIMRGEQA--
Mvan_4407|M.vanbaalenii_PYR-1 ALHLHVNTLRYRVDRIARLLKTDLDDPEKRFFILLALRLRGVVGLGPNDS
: * *:: *: : : .:
Mb1464|M.bovis_AF2122/97 KQ----------
Rv1429|M.tuberculosis_H37Rv KQ----------
MMAR_1582|M.marinum_M ER----------
MUL_3452|M.ulcerans_Agy99 ER----------
TH_2938|M.thermoresistible__bu QR----------
Mflv_4621|M.gilvum_PYR-GCK TQALGRS-----
MLBr_01052|M.leprae_Br4923 GPRAGRNDGVPA
MAB_2657c|M.abscessus_ATCC_199 ------------
MAV_4933|M.avium_104 ------------
MSMEG_4044|M.smegmatis_MC2_155 ------------
Mvan_4407|M.vanbaalenii_PYR-1 RQAPSSAGENVQ