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LDSSEVQDTPGHAVHHLFRDLGDLVRELPESIHGLLIEQVAELAADQQLKELLSDTVAANVDTWFSVVRH SIPFDRMESPTAALEHARRMAQREVPVNALLRAYRLGHQYGLNLIIAGLRSADLPPEEKLALIEHITRVS FRYIDWMSEQVLETYQTERAEWDERRRSLRAQAIRDILNGRDVDLTEASSAMRYFLGATHVALMVWLDRD AGADTDEFIAMERFMQHAVSATGAKQSVYFSIDRLVGCAWMTVHRPSDYLSQLRDFVRAQPDGPRLSVGE PLPGIEGFRRTYRQAEQARVVAVAADGSSRHRIVAARDPGVALASMLMTDDATLKEWIHDVLGPLAQNTA SDQRLRDTLRVFLRAGSSFKAAANELQIHANTVKYRVNRALERRGRPIAAERLDVEVALLMCYWLGEVAL NPTQALGRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4621 | - | - | 100% (430) | hypothetical protein Mflv_4621 |
| M. gilvum PYR-GCK | Mflv_2780 | - | 2e-05 | 29.63% (135) | hypothetical protein Mflv_2780 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1464 | - | 5e-39 | 28.98% (421) | hypothetical protein Mb1464 |
| M. tuberculosis H37Rv | Rv1429 | - | 5e-39 | 28.98% (421) | hypothetical protein Rv1429 |
| M. leprae Br4923 | MLBr_01052 | - | 2e-15 | 24.86% (346) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_2657c | - | 1e-18 | 23.76% (404) | hypothetical protein MAB_2657c |
| M. marinum M | MMAR_1603 | - | 4e-96 | 44.17% (403) | hypothetical protein MMAR_1603 |
| M. avium 104 | MAV_2195 | - | 2e-07 | 34.31% (137) | hypothetical protein MAV_2195 |
| M. smegmatis MC2 155 | MSMEG_4324 | - | 2e-06 | 30.71% (140) | hypothetical protein MSMEG_4324 |
| M. thermoresistible (build 8) | TH_2938 | - | 1e-97 | 48.03% (381) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3434 | - | 1e-96 | 44.42% (403) | hypothetical protein MUL_3434 |
| M. vanbaalenii PYR-1 | Mvan_3753 | - | 4e-06 | 22.44% (361) | hypothetical protein Mvan_3753 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1603|M.marinum_M ----------------MAADRQQDSV---DTWAVEIVTRLGDLMTSLVDT
MUL_3434|M.ulcerans_Agy99 ----------------MAADRQQDSV---DTWAVEIVTRLGDLMTSLVDT
TH_2938|M.thermoresistible__bu --------------------------------------------------
Mflv_4621|M.gilvum_PYR-GCK ---------------MLDSSEVQDTP---GHAVHHLFRDLGDLVRELPES
Mb1464|M.bovis_AF2122/97 ---------------------MAEAG---GGPISVIARHMQLIRDDFISE
Rv1429|M.tuberculosis_H37Rv ---------------------MAEAG---GGPISVIARHMQLIRDDFISE
MLBr_01052|M.leprae_Br4923 ----------------MARQHPSPRV---RELIREGARIALNPTQEWIDQ
MAB_2657c|M.abscessus_ATCC_199 MNEGSERVHTQSMTPDQLWPDASEPV---RRLIRELAEKMLARSGEVAGD
MSMEG_4324|M.smegmatis_MC2_155 ----------------MPDNRFVP-----PKSTVEVLEAVPDSLLRRLKQ
Mvan_3753|M.vanbaalenii_PYR-1 ----------------MTDNRFIP-----PRSTVEVLENVPESTLRRLKQ
MAV_2195|M.avium_104 ----------------MNDNPFAGPFAKHPRSPLETLDTVPESVLRRLKQ
MMAR_1603|M.marinum_M VEAEVVSEV--GELREDALLTRLLHDSIRANIETVFSA-IRHGIRIENVE
MUL_3434|M.ulcerans_Agy99 VEAEVVSEV--GELREDALLTRLLHDSIRANIETVFSA-IRHGIRIENVE
TH_2938|M.thermoresistible__bu VGYGPGSRQ--GSGCR--QLLELLRDSVEGNIDTIFSA-IQHDIPIEEVA
Mflv_4621|M.gilvum_PYR-GCK IHGLLIEQV--AELAADQQLKELLSDTVAANVDTWFSV-VRHSIPFDRME
Mb1464|M.bovis_AF2122/97 LFDKMKAEI--RGLDYDARMADLWRASITENFVTAVHY-LDRDTPQSLVE
Rv1429|M.tuberculosis_H37Rv LFDKMKAEI--RGLDYDARMADLWRASITENFVTAVHY-LDRDTPQSLVE
MLBr_01052|M.leprae_Br4923 LDRATFAAN--PAIANDPVLAKVVRRASRAHLVHWATANLRDPGAPVPAH
MAB_2657c|M.abscessus_ATCC_199 LTAASLEDPRYRTIADDPVIAEVDARLTVSNLKHWLTSNISEPGHRVRPA
MSMEG_4324|M.smegmatis_MC2_155 YSGRLATEAVHAMEQRLPFFAELDASQRASVQLVVQTAVVNFVEWMRNPE
Mvan_3753|M.vanbaalenii_PYR-1 YSGRLATQAVHAMEERLPFFAELDASQRASVQLVVQTAVVNFAEWMRDPR
MAV_2195|M.avium_104 YSGRLATEAVSVMQDRLPFFADLEASQRASVSLVVQTAVVNFAEWMQDPK
: : :
MMAR_1603|M.marinum_M PPTAALEHARRLAQREVSVNSLVRSYRLGHKAVLDVARGQVRALKLDQGL
MUL_3434|M.ulcerans_Agy99 PPTAALEHARRLAQREVSVNSLVRSYRLGHKAVLDVARGQVRALKLDQGL
TH_2938|M.thermoresistible__bu PPTAALEYARRLARHGVEPHALLRAYRLGQQKLLDIVLHEIRSLDWEREV
Mflv_4621|M.gilvum_PYR-GCK SPTAALEHARRMAQREVPVNALLRAYRLGHQYGLNLIIAGLRSADLPPEE
Mb1464|M.bovis_AF2122/97 APAAALAYARAAAQRDIPLSGLVRAHRLGHARFLEVAMQYVSLLEPADR-
Rv1429|M.tuberculosis_H37Rv APAAALAYARAAAQRDIPLSGLVRAHRLGHARFLEVAMQYVSLLEPADR-
MLBr_01052|M.leprae_Br4923 LGPEPLTMARDLVRRGRDVLALD-IYRVGQYTAWRRWMEIAFTLTSDPQE
MAB_2657c|M.abscessus_ATCC_199 TGSAMRTYARDVVLRGLTTDDIQ-SWRAVQRVGWKWWLAACFQVTDDKEQ
MSMEG_4324|M.smegmatis_MC2_155 SNVGYTAQAFEVVPQDLRRRVALRQSVEMVRTSMEFFEEAVPLLARSEEQ
Mvan_3753|M.vanbaalenii_PYR-1 SNVSYTAQAFEVVPQDLRRRIALRQSVEMVRVTMEFFEEVVPLLARSEDQ
MAV_2195|M.avium_104 SNVRHTAQAFELVPQDLARRIALRHSVEMVRVTMEFFEEVVPLLARSEEQ
* . :
MMAR_1603|M.marinum_M SLDVFGRIEQVTFGYVDHITQEVVNTYQSEHDRWTENRNSLRALRVREVL
MUL_3434|M.ulcerans_Agy99 ILDVFGRIEQVTFGYVDHITQEVVNTYQSEHDRWTENRNSLRALRVREVL
TH_2938|M.thermoresistible__bu SLEFVVGVTNATFGYIDGISQRVVEVYQQERERWLENRNSLRAMRVRELL
Mflv_4621|M.gilvum_PYR-GCK KLALIEHITRVSFRYIDWMSEQVLETYQTERAEWDERRRSLRAQAIRDIL
Mb1464|M.bovis_AF2122/97 -VSTIIELVNRSARLVDLVADQLIVAYEHEHDRWLSRRSGLQQQWVSELL
Rv1429|M.tuberculosis_H37Rv -VSTIIELVNRSARLVDLVADQLIVAYEHEHDRWLSRRSGLQQQWVSELL
MLBr_01052|M.leprae_Br4923 LREILNVSAQSINEYVAATLEAIATHMQLERDELTRSTHAERLEVVDLIL
MAB_2657c|M.abscessus_ATCC_199 LCELIEVTSNSLTTFVDDSIAELAEHVRRVREELAGGSQLQRYATVELLL
MSMEG_4324|M.smegmatis_MC2_155 ----LTALTAGILRYSRDLAFAAASAYADQAEARGAWDIRMEANIVDAVV
Mvan_3753|M.vanbaalenii_PYR-1 ----LAAMTAGILRYSRDLAFAAATAYADQAEARGAWDTRMEANLVDAVV
MAV_2195|M.avium_104 ----LTALTVGVLKYSRDLAFTAATAYADAAEARGTWDSRMEASVVDAVV
. . : ::
MMAR_1603|M.marinum_M DGAQ-LDVDAMTTEIRYPLNLIHLATVMWF--DGPALGNELAIMQR---V
MUL_3434|M.ulcerans_Agy99 DGAQ-LDVDAMTTEIRYPLNLIHLATVMWF--DGPALGNELAIMQR---V
TH_2938|M.thermoresistible__bu DGGE-VDVDTASATVGYPLRRTHLAVCVWTP-DGSAGDNELDRLQR---Y
Mflv_4621|M.gilvum_PYR-GCK NGRD-VDLTEASSAMRYFLGATHVALMVWLDRDAGADTDEFIAMER---F
Mb1464|M.bovis_AF2122/97 ADTP-VDVPRAERALGYRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLL
Rv1429|M.tuberculosis_H37Rv ADTP-VDVPRAERALGYRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLL
MLBr_01052|M.leprae_Br4923 EGAP-VTQERAEARLGYRLGLTHTAAVIWSD----DLDGDHGYLDQ----
MAB_2657c|M.abscessus_ATCC_199 QGAD-IAPARAEAQLGYALTGSHIGAVVWVD----SEK-EIAALER----
MSMEG_4324|M.smegmatis_MC2_155 RGDTGPELQSQAAALNWDATAPATVIVGLPR----ADR------------
Mvan_3753|M.vanbaalenii_PYR-1 RGGTRPELQSQAAALNWDATAPATVIVGMPR----PDR------------
MAV_2195|M.avium_104 RGDTGPELLSRAAALNWDTTAPATVVVGTPA----PGRDGSTGPGD----
. : :
MMAR_1603|M.marinum_M IRQFGQSVGASASPLFIPVDRLTGWAWVPLTTDTARNAVTEIREFARERT
MUL_3434|M.ulcerans_Agy99 IRQFGQSVGASASPLFIPVDRLTGWAWVPLTTDTARNAVTEIREFARERT
TH_2938|M.thermoresistible__bu VRGLAEALGAPGDSLFIALDRLTGCGWIPLPGDAATGAVAGVRRYAAEHP
Mflv_4621|M.gilvum_PYR-GCK MQHAVSATGAKQS-VYFSIDRLVGCAWMTVHR--PSDYLSQLRDFVRAQP
Mb1464|M.bovis_AF2122/97 AGELGPELGPVANSLMVPTDEREARLWFSPAP-TRAFAPSRIRAAFESAG
Rv1429|M.tuberculosis_H37Rv AGELGPELGPVANSLMVPTDEREARLWFSPAP-TRAFAPSRIRAAFESAG
MLBr_01052|M.leprae_Br4923 AAEAFSHVVESTQQLIVVASAATRWVWLADAL---ALDVPEVQKALLNLS
MAB_2657c|M.abscessus_ATCC_199 ASEQVMRACGADRRLTVVAGTVALWLWIPAKT---TPTVAVLMDSLGRRS
MSMEG_4324|M.smegmatis_MC2_155 IEMARDDVHAVVRRNDRAALSDVHGTWLVTIVSGPLSATDRFLADLMSVF
Mvan_3753|M.vanbaalenii_PYR-1 AEFAGDDVHEVADRNGRTALSDVHGTWLVAIISGGLSPTDRFLSELMTVF
MAV_2195|M.avium_104 SERASQHVRDIAAQHGRAALTDVHGTWLVAIVSGQLSPTDKFLGDLLEAF
*. .
MMAR_1603|M.marinum_M DIPWIAVGDPLPHVAGFRRSHWQARDARSVAIVL-GSNAHRVTAAGDPGL
MUL_3434|M.ulcerans_Agy99 DIPWIAVGDPLPHVAGFRRSHWQARDARSVAIVL-GSNAHRVTAAGDPGL
TH_2938|M.thermoresistible__bu DGPHLALGDPLPGLDGFRRSYRQALRTRAVAVAA-GASAPRVTAAADPGL
Mflv_4621|M.gilvum_PYR-GCK DGPRLSVGEPLPGIEGFRRTYRQAEQARVVAVAADGSSRHRIVAARDPGV
Mb1464|M.bovis_AF2122/97 IRARLACGRVGDGLRGFRASLKQAERVKALALAGGARPGGRVMFYDD--V
Rv1429|M.tuberculosis_H37Rv IRARLACGRVGDGLRGFRASLKQAERVKALALAGGARPGGRVMFYDD--V
MLBr_01052|M.leprae_Br4923 -KARVAIGTSSAGIEGFRRSHLEALTAQRTLARL--KSHQQVAFFAD--V
MAB_2657c|M.abscessus_ATCC_199 -GVRVALGRAATGMAGFRRTHMDAAAAQRLLARL--GSPLSVVRYED--V
MSMEG_4324|M.smegmatis_MC2_155 ADGPVVIGPTTPTLTAAHRSATEAISGMNAVAGWPSAPRP----VSAREL
Mvan_3753|M.vanbaalenii_PYR-1 ADGPVVIGPTAPTLGAAHRSATEAIAGMNAVAGWAGAPRP----VSAREL
MAV_2195|M.avium_104 SDGPVVVGPTAPMLTAAYHSASEAISGMNAVGGWRGAPRP----VLAREL
: * : . : :* :
MMAR_1603|M.marinum_M SMAGLLGRNIEDAAAWVGQILGPLASQTDSDERLRETLRAFLRSGSSFKA
MUL_3434|M.ulcerans_Agy99 SMAGLLGRNIEDAAAWVGQILGPLASQTDSDERLRETLRAFLRSGSSFKA
TH_2938|M.thermoresistible__bu SAAALLTGDLAEARTWVQEVLGPLSADTKNDARLRETLGVFLRHGSSYTA
Mflv_4621|M.gilvum_PYR-GCK ALASMLMTDDATLKEWIHDVLGPLAQNTASDQRLRDTLRVFLRAGSSFKA
Mb1464|M.bovis_AF2122/97 APVALLADDLEELRRFVTDVLGDLSVDDERNSWLRETLREFLLRNRSYVA
Rv1429|M.tuberculosis_H37Rv APVALLADDLEELRRFVTDVLGDLSVDDERNSWLRETLREFLLRNRSYVA
MLBr_01052|M.leprae_Br4923 QLVSLITQNPEDAKEFITSTLGDFESAS---PALQQTLLTFINEQCNASR
MAB_2657c|M.abscessus_ATCC_199 HLMDLLSADPASADQFVTDVLGEFQSAS---PVLHQTVLTYVEEALNRTS
MSMEG_4324|M.smegmatis_MC2_155 LPERALLGDADAVTALETEVMRPLADAG---PALTETLDAFLDSGGAIEA
Mvan_3753|M.vanbaalenii_PYR-1 LPERALLGDATAGAALEAEVMRPLSDAG---PALMETLDAYLDSGGAIEA
MAV_2195|M.avium_104 LPERALMGDASAIVALHTDVMGPLADAG---PTLIETLDAFLDSGGAIEA
: : . : : * :*: ::
MMAR_1603|M.marinum_M AAEELHLHHNSVKYRVQRAIKRRGRPLTD--DRLDVEVALLLCHWYGAAV
MUL_3434|M.ulcerans_Agy99 AAEELHLHHNSVKYRVQRAIKRRGRPLTA--DRLDVEVALLLCHWYGAAV
TH_2938|M.thermoresistible__bu AADELNLHFNTVKYRVQRAVERRGRPIVP--DRLDVELALLICQWFGAAV
Mflv_4621|M.gilvum_PYR-GCK AANELQIHANTVKYRVNRALERRGRPIAA--ERLDVEVALLMCYWLGEVA
Mb1464|M.bovis_AF2122/97 TADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAV
Rv1429|M.tuberculosis_H37Rv TADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAV
MLBr_01052|M.leprae_Br4923 AAKRLFTHRNTLLRRIESAEKLLPRPLDH--TSVHIAVALEALQWRGDQT
MAB_2657c|M.abscessus_ATCC_199 TAERLYTHRNTIDRRLARVDELLPKPFAR--NPIEVAAALTLLRVRAGR-
MSMEG_4324|M.smegmatis_MC2_155 CARKLFVHPNTVRYRLRRIADFTGRDPAVPRDAYVLRVASTVGRLSKHAY
Mvan_3753|M.vanbaalenii_PYR-1 CARKLFVHPNTVRYRLKRIADFTGRDPTVPRDAYVLRVASSVGRLARQAH
MAV_2195|M.avium_104 CARKLFVHPNTVRYRLKRITDFTGRDPMQPRDAYVLRVAATVGQLNYPTH
* : * *:: *: . : : *
MMAR_1603|M.marinum_M LG------------------------
MUL_3434|M.ulcerans_Agy99 LG------------------------
TH_2938|M.thermoresistible__bu LRPQR---------------------
Mflv_4621|M.gilvum_PYR-GCK LNPTQALGRS----------------
Mb1464|M.bovis_AF2122/97 LRAKQ---------------------
Rv1429|M.tuberculosis_H37Rv LRAKQ---------------------
MLBr_01052|M.leprae_Br4923 NTSGPRAGRNDGVPA-----------
MAB_2657c|M.abscessus_ATCC_199 --------------------------
MSMEG_4324|M.smegmatis_MC2_155 RASTINSAVSVVPTIRPATSAGSRGT
Mvan_3753|M.vanbaalenii_PYR-1 LSAAPAAASAQAIGVASVTSPENLGT
MAV_2195|M.avium_104 PPSAAGAAMPAVPLPVNGAARGQSGG