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SEPRSVIAAQTALIAALRDVVSARSVADVESATLAAVRSLLSADAAFWMDRVDDGFAMTALSGLIQPESH ELSLVPPGAGLAAEIVANDAPASSSDYTVDPRAIPAFAAMFRRENIRSTAGAPMRSSEGVVGVLFVFARR SREFTEDEMQLLMSIAGVARALRERLREGEFQRELLEQERSRAAAGDRLLRAAETFSSSMLRGQPLAAGL EAASDELGVRLHVRGLPAPGSPTSHMLPIEDAPTVSSGPEARIPGADLAVLSADGALPEMQLALLAQLIG IDFRRQRVELETELALTDQMVHSLLTGDFQELERLWSRTALLGMNPAVPRVLVSIGRDRPVDRMLLDRIR REMRSRISGGYSTTYGGDVVLLCPVPEVEQEAKLVGQVESIVTACRPERLTAGIGPVCRKADDYPLGVRE ALFARQVAAQSRTGKAVVSSAELGMYRLFAHVGGTDALLGAVLETLGPLLDADGRDGSDLLNTLHAFLEH DRRIAETARALHLHVNTLRYRVDRIARLLKTDLDDPEKRFFILLALRLRGVVGLGPNDSRQAPSSAGENV Q*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4407 | - | - | 100% (562) | putative GAF sensor protein |
| M. vanbaalenii PYR-1 | Mvan_5765 | - | 7e-16 | 24.63% (471) | transcriptional regulator, CdaR |
| M. vanbaalenii PYR-1 | Mvan_1323 | - | 8e-12 | 35.11% (131) | transcriptional regulator, CdaR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1218c | - | 1e-08 | 29.41% (221) | hypothetical protein Mb1218c |
| M. gilvum PYR-GCK | Mflv_5015 | - | 6e-08 | 25.40% (189) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv1186c | - | 1e-08 | 29.41% (221) | hypothetical protein Rv1186c |
| M. leprae Br4923 | MLBr_01652 | - | 3e-05 | 32.56% (86) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_4202c | - | 2e-14 | 24.94% (429) | putative regulatory protein |
| M. marinum M | MMAR_4254 | - | 5e-06 | 39.66% (58) | hypothetical protein MMAR_4254 |
| M. avium 104 | MAV_1987 | - | 2e-12 | 26.40% (394) | putative DNA-binding protein |
| M. smegmatis MC2 155 | MSMEG_6492 | - | 2e-15 | 23.72% (565) | GAF domain-containing protein |
| M. thermoresistible (build 8) | TH_4203 | - | 3e-09 | 27.09% (299) | PUTATIVE sensor histidine kinase |
| M. ulcerans Agy99 | MUL_1307 | - | 3e-06 | 28.85% (156) | hypothetical protein MUL_1307 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5015|M.gilvum_PYR-GCK -----------------------MTRPLLTADRELALLRELIQAASSGPG
TH_4203|M.thermoresistible__bu -----------VTSGPHPDPVRDLSEQLLTADRELVLLRELIQAASRGPG
Mb1218c|M.bovis_AF2122/97 ----------------MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVA
Rv1186c|M.tuberculosis_H37Rv ----------------MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVA
MMAR_4254|M.marinum_M ----------------MGVAGVGLGQLLLALDATLVSLVEAPRGLDLPVA
MLBr_01652|M.leprae_Br4923 -----------------------MNHNHFVPAP---PRRLPLELLDTVP-
MUL_1307|M.ulcerans_Agy99 -----------------------MNNNQFSAIARLGSARSPLELLETVP-
MAV_1987|M.avium_104 --------------------MITLDRLVNVLGGYGVRLRWSSVPRSTELR
MSMEG_6492|M.smegmatis_MC2_155 MTWLGALRRLSASATAEEDLSHVLAEIAETARSLLGFDFCGVLLPDEQSR
Mvan_4407|M.vanbaalenii_PYR-1 -------------MSEPRSVIAAQTALIAALRDVVSARSVADVESATLAA
MAB_4202c|M.abscessus_ATCC_199 ------------------------MRWVLDQPELKLTLKSGAAGVGREIN
Mflv_5015|M.gilvum_PYR-GCK VEPLAAASAR---MITASTDSDVCFVHVLDDTERSLTLAGATPP--FDSE
TH_4203|M.thermoresistible__bu VEPLAAAAAR---MITAATASDVCFVHVLDDTERSLTLAGATPP--FDKE
Mb1218c|M.bovis_AF2122/97 STALIDSDDVRLGLAAAAGSADVFFLIGVTDDEAVRWVDDQARQ--RAPV
Rv1186c|M.tuberculosis_H37Rv STALIDSDDVRLGLAAAAGSADVFFLIGVTDDEAVRWVDDQARQ--RAPV
MMAR_4254|M.marinum_M SAALVDSDDVRLGLAAAAGSADIFFLLGVTDHEALRWIDGQAG----TPV
MLBr_01652|M.leprae_Br4923 DSLLRRLKQYSGRLATEAVTAMQERLPFFADLEASQRASVTLVV--QTAV
MUL_1307|M.ulcerans_Agy99 DSLLRRLKQYSGRLATEAVSAMQERLPFFADLEASQRASVALVV--QTAV
MAV_1987|M.avium_104 SVVIHETPED------RPVVGDVLLAVGAGSLDEAVRWAASAR-----AA
MSMEG_6492|M.smegmatis_MC2_155 HLRVRGASGLSSDYVDRVNSDRPLVLHGGSPSSRAFHTAEAVAIRDVTAE
Mvan_4407|M.vanbaalenii_PYR-1 VRSLLSADAAFWMDRVDDGFAMTALSGLIQPESHELSLVPPGAGLAAEIV
MAB_4202c|M.abscessus_ATCC_199 LALTTELADPAQWLSGGELVLTTGIGLPKSSRDRRRYLRSLDEN--NVAA
.
Mflv_5015|M.gilvum_PYR-GCK VGKIRLPLGQGISGWVASHRQPVVIR------------RDKESDPRYLPF
TH_4203|M.thermoresistible__bu VGKIRLPLGQGISGWVASHREPVVIT------------ENKEADPRYLPF
Mb1218c|M.bovis_AF2122/97 AIFVKHPSDSVVAGAVRAGSAVVAVE------------PRARWERLYHLV
Rv1186c|M.tuberculosis_H37Rv AIFVKHPSDSVVAGAVRAGSAVVAVE------------PRARWERLYHLV
MMAR_4254|M.marinum_M AIFVKQPSDAVVAKAVRSGAAVVAVE------------PQARWERLYRLV
MLBr_01652|M.leprae_Br4923 VNFVQWMQNPHSDVSYTAQAFELVPQ------------DLARRIALRHTV
MUL_1307|M.ulcerans_Agy99 VNFAEWMQNPRSDVSYTAQAFELVPQ------------DLTRRIALRHTV
MAV_1987|M.avium_104 VVVLRDDETPMTFDGVTDVGAVLVID------------PTVSWSAVAAVV
MSMEG_6492|M.smegmatis_MC2_155 PGFELWAGIANEQGYRSMIAVPLVARGEVLGTLNGYYGAVHTYTRFEVER
Mvan_4407|M.vanbaalenii_PYR-1 ANDAPASSSDYTVDPRAIPAFAAMFRRE------NIRSTAGAPMRSSEGV
MAB_4202c|M.abscessus_ATCC_199 LGFGTGLTFDEVPPELVSTADELGMP----------LLEIPLRTPFAAVV
Mflv_5015|M.gilvum_PYR-GCK QSLRGR---------DFTSMVSVPMETDPGGLVGVLNVHTVAERDFTD--
TH_4203|M.thermoresistible__bu QSLRGR---------DFTSMVSVPMETDPGGLVGVLNVHTVERREFTR--
Mb1218c|M.bovis_AF2122/97 NHVLEHHGDRADPTDDSGTDLFGLAQSLADRIHGMISIEDAQSHVLAYSA
Rv1186c|M.tuberculosis_H37Rv NHVLEHHGDRADPTDDSGTDLFGLAQSLADRIHGMISIEDAQSHVLAYSA
MMAR_4254|M.marinum_M NHVLEHHGDRT--TDDSGTDLFGLAQSLADRIHGMVSIEDAQSHVLAYSA
MLBr_01652|M.leprae_Br4923 DMVRVT------------MEFFEEVVPLLARSEEQLTALTVGILKYSR--
MUL_1307|M.ulcerans_Agy99 DMVRVT------------MEFFEEVVPLLARSEEQLTALTVGILKYSR--
MAV_1987|M.avium_104 YGLVLEGRETE--SGRGPTDLFALADSLADGIGNPVVIQDRHLGVLAYSR
MSMEG_6492|M.smegmatis_MC2_155 MTLLANHAAIAVSSARRLDELRALTASLRRQRDALTRSEQIHDRLLAVTL
Mvan_4407|M.vanbaalenii_PYR-1 VGVLFVFARRSREFTEDEMQLLMSIAGVARALRERLREGEFQRELLEQER
MAB_4202c|M.abscessus_ATCC_199 KAVSTR-----------IAELEYDAVLRASRAQPRITRAIVNGGVQAVTA
: .
Mflv_5015|M.gilvum_PYR-GCK -----R--DVELLLVIGRLIAGAMHQARLHRQLVARERAHENFVEQVIEA
TH_4203|M.thermoresistible__bu -----R--DVDLLLVIGRLIAGGLHQARLHRQLVARERAHEIFVEQVIEA
Mb1218c|M.bovis_AF2122/97 SNDEAD--ELRRLSILGRAGPPEHLQWIGQWGIFDALRAGREVVRVAERP
Rv1186c|M.tuberculosis_H37Rv SNDEAD--ELRRLSILGRAGPPEHLQWIGQWGIFDALRPGREVVRVAERP
MMAR_4254|M.marinum_M SSDEAD--ELRRLSILGRAGPPEHLKWIGQWGIFDALRSGSEVVRVAERP
MLBr_01652|M.leprae_Br4923 -----------DLAFTAATAYADAAEARGTWDSRMEASVVDAVVRGDTGP
MUL_1307|M.ulcerans_Agy99 -----------DLAFTAASAYADAAEARGTWDSRMEASVVDAVVRGDTGP
MAV_1987|M.avium_104 -LAQAD--PALVETVLQRQTPEPLRALLEARGVFAHLQVADEPLFVAEDA
MSMEG_6492|M.smegmatis_MC2_155 RSGGLDGIAAVLQGLIGRPILIDDIQHEVLACSVVTTDFPDTTWRAAAEA
Mvan_4407|M.vanbaalenii_PYR-1 SRAAAG---DRLLRAAETFSSSMLRGQPLAAGLEAASDELGVRLHVRGLP
MAB_4202c|M.abscessus_ATCC_199 ELGRSLRASVVVLDPGGTVVASHPRNLDVATVNLVRGALSPGASAGVQQL
Mflv_5015|M.gilvum_PYR-GCK QELERRRLAGDIHDG--------ISQRLVTLSYRLDAAAQAAKSPADHAA
TH_4203|M.thermoresistible__bu QELERRRLAADIHDG--------ISQRLVTLSYRLDAAIRAVDDP---AT
Mb1218c|M.bovis_AF2122/97 ELGLRPRLAIGIHQPGVGA----LRPPVFAGTIWVQQGSQPLADDAEEML
Rv1186c|M.tuberculosis_H37Rv ELGLRPRLAIGIHQPGVGA----LRPPVFAGTIWVQQGSQPLADDAEEML
MMAR_4254|M.marinum_M ELGLRPRLAIGIHQPPVAA----RRPPVFAGSIWVQQGSQPLAEDADEVL
MLBr_01652|M.leprae_Br4923 ELLSR---AAALN-----------WDTTAPATVVVGTPTPNHDGPNGQVS
MUL_1307|M.ulcerans_Agy99 ELLSR---AAALN-----------WDTTAPATVVVGTPASARDGSDG---
MAV_1987|M.avium_104 ERGLSGRMVVAVRAG-----------AELIGSVWVACEAPLQPAALRALA
MSMEG_6492|M.smegmatis_MC2_155 GTGSSPVPVGQFDGTTYLASAVHLGDEVAARIWFPETSIDLDPIMVRAVE
Mvan_4407|M.vanbaalenii_PYR-1 APGSPTSHMLPIEDAPTVS----SGPEARIPGADLAVLSADGALPEMQLA
MAB_4202c|M.abscessus_ATCC_199 DPGITVSQQAIGVGG------------TSYGVLAVVSKTPLTFVDQVLLG
Mflv_5015|M.gilvum_PYR-GCK LTEQLDRARELADLTLQEARAAISGLRPPVLDDLGLAGGLASLARSIPQI
TH_4203|M.thermoresistible__bu VTEQLSKARELADLTLEETRAAISGLRPPVLDDLGLSGGLASLAQSVGQL
Mb1218c|M.bovis_AF2122/97 RGAAVLAARIMSRLATQPNTHALRVQQLLGLAELNATTAPVDVSTIAREL
Rv1186c|M.tuberculosis_H37Rv RGAAVLAARIMSRLATQPNTHALRVQQLLGLAELNATTAPVDVSTIAREL
MMAR_4254|M.marinum_M RGAAVLGARIMTRLASRPSTHARRVQQLLGLADPDPTAAPADVTAIAREL
MLBr_01652|M.leprae_Br4923 SERASQEVREIAARHGRAALTDVHGTWLVAIIS----GQLAPTDKFFSDL
MUL_1307|M.ulcerans_Agy99 SERAIQDVRDAAAQHGRAALTDVHGTWLVAIVS----GHLSPTDKVFKDL
MAV_1987|M.avium_104 DGARTVALHLLRSRASADLERQVESELVIRLLEGTADAATVASRLDLAHN
MSMEG_6492|M.smegmatis_MC2_155 HASIVTALELLRCQTAAEVEQRLRGELLSDVLSSGAALSDRLLDRAHRLG
Mvan_4407|M.vanbaalenii_PYR-1 LLAQLIGIDFRRQRVELETELALTDQMVHSLLTGDFQELERLWSRTALLG
MAB_4202c|M.abscessus_ATCC_199 HTNSLLALDFDKPSRLQEAQRRLNGQALGLLLGDERNLGPVWAQLGQAAD
:
Mflv_5015|M.gilvum_PYR-GCK GI----ETDLD-------------DTRLADHIELALYRIAQECLQN----
TH_4203|M.thermoresistible__bu DIGVDIEVDLA-------------ETRLPDHIELALYRIAQECLQN----
Mb1218c|M.bovis_AF2122/97 GVAAEGNATLIGFDTAENRDTAVRHVRLVDVMALSASAFRHDAQVAANGS
Rv1186c|M.tuberculosis_H37Rv GVAAEGNATLIGFDTAENRDTAVRHVRLVDVMALSASAFRHDAQVAANGS
MMAR_4254|M.marinum_M GLSADGNAALIGFDTIEADD---KQSRLADVLALSASAFRRDAQVGTNGS
MLBr_01652|M.leprae_Br4923 LHAFSDGPVVIG---------------PTAPMLTAAYHSASEAVSG----
MUL_1307|M.ulcerans_Agy99 LEAFSDGPVVIG---------------PTAPMLTAAYHSASEAISG----
MAV_1987|M.avium_104 GLRVVAVQAFVGADR-------DAPLLLAFERATTGFGWSRPGRSALAGN
MSMEG_6492|M.smegmatis_MC2_155 HDLTVPHIAIVGAFTG----LDPVAERRAYERSLVLLAKESAAHRPKPVV
Mvan_4407|M.vanbaalenii_PYR-1 MNPAVPRVLVSIG-----------RDRPVDRMLLDRIRREMRSRISGGYS
MAB_4202c|M.abscessus_ATCC_199 ARGRIRVLVVDAES-----------QTALVRVLPAVTRDMESAGYPVFAH
.
Mflv_5015|M.gilvum_PYR-GCK -----------------------------------------------VVK
TH_4203|M.thermoresistible__bu -----------------------------------------------VVK
Mb1218c|M.bovis_AF2122/97 RIYVLLPQTTTGRAVTSWVRGTISALRAELGVALRAAIAG-PVAGLAEVN
Rv1186c|M.tuberculosis_H37Rv RIYVLLPQTTTGRAVTSWVRGTISALRAELGVALRAAIAG-PVAGLAEVN
MMAR_4254|M.marinum_M RIYVVLPQTATARSLTSWVRGTISALRSELGVELRATIAA-PVAGLDGLA
MLBr_01652|M.leprae_Br4923 ----------------------------------------------MNAV
MUL_1307|M.ulcerans_Agy99 ----------------------------------------------MNAV
MAV_1987|M.avium_104 SVYAVLPADEASTARRWVGALRAALPERLTMIAGISG-----VAEVGDLA
MSMEG_6492|M.smegmatis_MC2_155 AMHAGTIVMLWPAQDAADAAGAGEVVRQAMRAASADRQAT-VAVGPGDVA
Mvan_4407|M.vanbaalenii_PYR-1 TTYGGDVVLLCPVPEVEQEAKLVGQVESIVTACRPERLTAGIGPVCRKAD
MAB_4202c|M.abscessus_ATCC_199 TGERQLTVVLPGAETADFARRLFGDVDARIKKGLRAGLSG-----AHPVG
Mflv_5015|M.gilvum_PYR-GCK HARASAARLTFAVDDN------TARLEIADDGVG-FDTFEHPLGSDE---
TH_4203|M.thermoresistible__bu HARARTARLTYAVDRGEH--GEVARLEIVDDGVG-FDTFEHPLGGDD---
Mb1218c|M.bovis_AF2122/97 PARVEVDRVLESAERHPI-LGQVTSLAEARTTVL-LDEIVTLVGTDQRLV
Rv1186c|M.tuberculosis_H37Rv PARVEVDRVLESAERHPI-LGQVTSLAEARTTVL-LDEIVTLVGTDQRLV
MMAR_4254|M.marinum_M SARVEVDRVLDSAERHPISIGRVTSLAEARTTVL-LDEIVTLVGNDARLI
MLBr_01652|M.leprae_Br4923 AGWSGAPRPVQARELLP----ERALMGDASAIVA-LHTDVMLPLADAG--
MUL_1307|M.ulcerans_Agy99 AGWRGASRPVLARELLP----ERALMGDASAIVA-LHTDVMRPLADAG--
MAV_1987|M.avium_104 AARQEADECLALHEMSPA--APPPAYDESWDDIL-LQRLRAAARSGRAPT
MSMEG_6492|M.smegmatis_MC2_155 SHRESYQTAKGALQVAIMSGRTAAVVGLDDLGIAGLLLRINDPAALSTFA
Mvan_4407|M.vanbaalenii_PYR-1 DYPLGVREALFARQVAAQSRTGKAVVSSAELGMYRLFAHVGGTDALLGAV
MAB_4202c|M.abscessus_ATCC_199 RLADAVQNARLAASVAER---GGTPLEFTSLAGSALLSFGASREVLVAVA
. . :
Mflv_5015|M.gilvum_PYR-GCK -------------------------MGGYGLLSMAERAEIVGG---RLNI
TH_4203|M.thermoresistible__bu -------------------------MSGYGLLSMAERAEIVGG---RLNI
Mb1218c|M.bovis_AF2122/97 DPRIRDL----GAQDPVLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRI
Rv1186c|M.tuberculosis_H37Rv DPRIRDL----GAQDPVLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRI
MMAR_4254|M.marinum_M DPRIPDL----RAKDPVLADTLRVYLDSFGDIGLAAQSLQVHPNTVRYRI
MLBr_01652|M.leprae_Br4923 ---------------PTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRL
MUL_1307|M.ulcerans_Agy99 ---------------PTLIETLDAYLDCGGAIEACARKLFVHPNTIRYRL
MAV_1987|M.avium_104 RGPVADLGRHDRANGTDYLATLRAWLQAQGDPAEAGRQLGVHENTVRYRL
MSMEG_6492|M.smegmatis_MC2_155 RRTLAPILDYDHAHRTELLVTLRAYLECRQERSATATRLVIHPNTVAQRL
Mvan_4407|M.vanbaalenii_PYR-1 LETLGPLLDADGRDGSDLLNTLHAFLEHDRRIAETARALHLHVNTLRYRV
MAB_4202c|M.abscessus_ATCC_199 NATLEPIVEHDAVHGSELMTSLRAYLEANGHWESAATVVGVHRHTLRKRI
: : .:
Mflv_5015|M.gilvum_PYR-GCK R--------SRPGSGTTVTATIPLHQGGA---------------------
TH_4203|M.thermoresistible__bu R--------SRPGAGTAVIATIPLPPATR---------------------
Mb1218c|M.bovis_AF2122/97 RRIEQLLSTSLGDPDVRLLFSLGLRAMERTA-------------------
Rv1186c|M.tuberculosis_H37Rv RRIEQLLSTSLGDPDVRLLFSLGLRAMERTA-------------------
MMAR_4254|M.marinum_M RRVEKLLSTSFADPDVRLVFSLGLRATDRSS-------------------
MLBr_01652|M.leprae_Br4923 KRITDFTGHDPTLPRDAYVLRVAATVGKLNYPTHH---------------
MUL_1307|M.ulcerans_Agy99 KRITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPPSGAANNTITPVPLPV
MAV_1987|M.avium_104 RKMAEITNLSLDDSKKRLAMMIELAAIHTD--------------------
MSMEG_6492|M.smegmatis_MC2_155 RRIESLCSVTLTDPAVILQFSAALTVYDIAALD-----------------
Mvan_4407|M.vanbaalenii_PYR-1 DRIARLLKTDLDDPEKRFFILLALRLRGVVGLGPNDSRQAPSSAGENVQ-
MAB_4202c|M.abscessus_ATCC_199 ETVQSLLACDLDIARVRAELLLAMLTGTPGTGN-----------------
.
Mflv_5015|M.gilvum_PYR-GCK -------
TH_4203|M.thermoresistible__bu -------
Mb1218c|M.bovis_AF2122/97 -------
Rv1186c|M.tuberculosis_H37Rv -------
MMAR_4254|M.marinum_M -------
MLBr_01652|M.leprae_Br4923 -------
MUL_1307|M.ulcerans_Agy99 RRGTEGP
MAV_1987|M.avium_104 -------
MSMEG_6492|M.smegmatis_MC2_155 -------
Mvan_4407|M.vanbaalenii_PYR-1 -------
MAB_4202c|M.abscessus_ATCC_199 -------