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KDFRAPVNGVDGDSASALVAVPKSQGAQTIRPDSVSRLVGALLDDHAAVVGRVRSVIRSRLPVYRSVADE ALEAELEWVLRSAVGGREALHEPQIAGLAAIGEARARDGVPVDDMLRAWRIGVEVVVECAREAARRLGVD DARVLELVQSALAWSDIAMATSAKAHRRTERALALEAEESDAEFVRGALMGSLPAAELRMHAELRGLDPG AEYVAVRARLGGDGPHLRLEQSLGFQDPAHSRRGLCALLDGDLAGFLIEPPRDVEGVVGFGPPRPLTRLS ESYRMAARALVTAEACGLRGAYDIAALGLRTAVAIDADVGELLRKRYLEPLSVGGSSRELIATVRTYLAC GMHVERTATRLFVHQNTVRYRLARFEELTGASLRDTEVVTEVWWVLELAAMRL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4933 | - | - | 100% (404) | hypothetical protein MAV_4933 |
| M. avium 104 | MAV_2195 | - | 3e-10 | 28.37% (356) | hypothetical protein MAV_2195 |
| M. avium 104 | MAV_1330 | - | 1e-07 | 31.17% (154) | hypothetical protein MAV_1330 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2266 | - | 7e-11 | 27.00% (400) | hypothetical protein Mb2266 |
| M. gilvum PYR-GCK | Mflv_0936 | - | 2e-12 | 25.00% (364) | hypothetical protein Mflv_0936 |
| M. tuberculosis H37Rv | Rv2242 | - | 7e-11 | 27.00% (400) | hypothetical protein Rv2242 |
| M. leprae Br4923 | MLBr_01652 | - | 1e-09 | 26.32% (285) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_0762 | - | 1e-13 | 25.00% (380) | hypothetical protein MAB_0762 |
| M. marinum M | MMAR_3335 | - | 8e-11 | 28.83% (281) | hypothetical protein MMAR_3335 |
| M. smegmatis MC2 155 | MSMEG_4044 | - | 2e-11 | 34.13% (126) | GAF domain-containing protein |
| M. thermoresistible (build 8) | TH_3478 | - | 6e-10 | 24.36% (390) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_1307 | - | 5e-11 | 28.83% (281) | hypothetical protein MUL_1307 |
| M. vanbaalenii PYR-1 | Mvan_3753 | - | 1e-10 | 29.27% (369) | hypothetical protein Mvan_3753 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2266|M.bovis_AF2122/97 --------------------------------------------------
Rv2242|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3335|M.marinum_M --------------------------------------------------
MUL_1307|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01652|M.leprae_Br4923 --------------------------------------------------
Mvan_3753|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4933|M.avium_104 --------------------------------------------MKDFRA
Mflv_0936|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0762|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3478|M.thermoresistible__bu --------------------------------------------------
MSMEG_4044|M.smegmatis_MC2_155 MSVRSDPLRAWMSAVTAISRTVNAAEPLETVLDDIAQMGCDLVGFDYCGV
Mb2266|M.bovis_AF2122/97 ----MNDNQLAPVAR---PRSPLELLDT------------VPDSLLRRLK
Rv2242|M.tuberculosis_H37Rv ----MNDNQLAPVAR---PRSPLELLDT------------VPDSLLRRLK
MMAR_3335|M.marinum_M ----MNDNQFSAIARLGSARSPLELLET------------VPDSLLRRLK
MUL_1307|M.ulcerans_Agy99 ----MNNNQFSAIARLGSARSPLELLET------------VPDSLLRRLK
MLBr_01652|M.leprae_Br4923 ----MNHNHFVPAP---PRRLPLELLDT------------VPDSLLRRLK
Mvan_3753|M.vanbaalenii_PYR-1 ----MTDNRFIPPR------STVEVLEN------------VPESTLRRLK
MAV_4933|M.avium_104 PVNGVDGDSASALVAVPKSQGAQTIRPD------------SVSRLVGALL
Mflv_0936|M.gilvum_PYR-GCK ----MPEPATGAPRIVDLPRETLEAMRA------------GLPALVDRMV
MAB_0762|M.abscessus_ATCC_1997 -------------------------MGE------------QLLARVDELC
TH_3478|M.thermoresistible__bu --------------------------------------------MLDELE
MSMEG_4044|M.smegmatis_MC2_155 MLDDVTHEVMQIAGSSGLRKRYLDLVRSEGWLEIHPADFSADLPATKAYR
Mb2266|M.bovis_AF2122/97 QYSGRLATEAVSAMQERLPFFADLE--ASQRASVALVVQTAVVNFVEWMH
Rv2242|M.tuberculosis_H37Rv QYSGRLATEAVSAMQERLPFFADLE--ASQRASVALVVQTAVVNFVEWMH
MMAR_3335|M.marinum_M QYSGRLATEAVSAMQERLPFFADLE--ASQRASVALVVQTAVVNFAEWMQ
MUL_1307|M.ulcerans_Agy99 QYSGRLATEAVSAMQERLPFFADLE--ASQRASVALVVQTAVVNFAEWMQ
MLBr_01652|M.leprae_Br4923 QYSGRLATEAVTAMQERLPFFADLE--ASQRASVTLVVQTAVVNFVQWMQ
Mvan_3753|M.vanbaalenii_PYR-1 QYSGRLATQAVHAMEERLPFFAELD--ASQRASVQLVVQTAVVNFAEWMR
MAV_4933|M.avium_104 DDHAAVVGRVRSVIRSRLPVYRSVA--DEALEAELEWVLRSAVGGREALH
Mflv_0936|M.gilvum_PYR-GCK EAVIAEVPLLAQAAQESWRPVIDTS--AQLLLGSLIDELGTSTGPPTAVP
MAB_0762|M.abscessus_ATCC_1997 AEQCRIIRERVAAYRDPVLVTDEDL--FAAGRDQMVYVLAAMGSG-----
TH_3478|M.thermoresistible__bu DIAAQVTAIIRAELPAYAAIPLDDH--RAAVQDQLSVILTGLREMRG--P
MSMEG_4044|M.smegmatis_MC2_155 ELTTIVVPDVYAENSERLHRFAAAQGYRSVLTAPLRVGKDNVGILAGYFR
Mb2266|M.bovis_AF2122/97 DPHSDVGYTAQAFELVPQDLTRRIALRQTVDMVRVTMEFFEEVVPLLARS
Rv2242|M.tuberculosis_H37Rv DPHSDVGYTAQAFELVPQDLTRRIALRQTVDMVRVTMEFFEEVVPLLARS
MMAR_3335|M.marinum_M NPRSDVSYTAQAFELVPQDLTRRIALRHTVDMVRVTMEFFEEVVPLLARS
MUL_1307|M.ulcerans_Agy99 NPRSDVSYTAQAFELVPQDLTRRIALRHTVDMVRVTMEFFEEVVPLLARS
MLBr_01652|M.leprae_Br4923 NPHSDVSYTAQAFELVPQDLARRIALRHTVDMVRVTMEFFEEVVPLLARS
Mvan_3753|M.vanbaalenii_PYR-1 DPRSNVSYTAQAFEVVPQDLRRRIALRQSVEMVRVTMEFFEEVVPLLARS
MAV_4933|M.avium_104 EP-QIAGLAAIGEARARDGVPVDDMLRAWRIGVEVVVECAREAARRLGVD
Mflv_0936|M.gilvum_PYR-GCK MQEVLDIAHRFGRREARNGRPAEVQLAAYRVGARELWRDWSALAAQGGVD
MAB_0762|M.abscessus_ATCC_1997 -APDTSAAARVGRLRAEQGVPLADVMSAYRAGGQFLWDALSQAIDAAGLS
TH_3478|M.thermoresistible__bu GPADLITAERLGRRRAEQGIDISALMRAYELPLQELWQRYAGLVCD-GKQ
MSMEG_4044|M.smegmatis_MC2_155 DPHDYEPEEIELAKLLAEQSANAIRTAQLRAAQQATINDLSAVNDELRRR
: .
Mb2266|M.bovis_AF2122/97 EE-----------------------QLTALTVGILKYSRDLAFTAATAYA
Rv2242|M.tuberculosis_H37Rv EE-----------------------QLTALTVGILKYSRDLAFTAATAYA
MMAR_3335|M.marinum_M EE-----------------------QLTALTVGILKYSRDLAFTAASAYA
MUL_1307|M.ulcerans_Agy99 EE-----------------------QLTALTVGILKYSRDLAFTAASAYA
MLBr_01652|M.leprae_Br4923 EE-----------------------QLTALTVGILKYSRDLAFTAATAYA
Mvan_3753|M.vanbaalenii_PYR-1 ED-----------------------QLAAMTAGILRYSRDLAFAAATAYA
MAV_4933|M.avium_104 DA-----------------------RVLELVQSALAWSDIAMATSAKAHR
Mflv_0936|M.gilvum_PYR-GCK RD-----------------------QVSAFAEMFFAYLDLISAAGVAGHA
MAB_0762|M.abscessus_ATCC_1997 RQ-----------------------ELRAAASQAWQNHDRYTDAMAEGYR
TH_3478|M.thermoresistible__bu AQ-----------------------ELIALAPSLLRWLHQLGGAAATGHQ
MSMEG_4044|M.smegmatis_MC2_155 RASLDWADQQHRRLMRLVLNDIGMDGLVAALADMLQASATVLDSAERVLA
: :
Mb2266|M.bovis_AF2122/97 DAAE------------------------ARGTWDSRMEASVVDAVVRGDT
Rv2242|M.tuberculosis_H37Rv DAAE------------------------ARGTWDSRMEASVVDAVVRGDT
MMAR_3335|M.marinum_M DAAE------------------------ARGTWDSRMEASVVDAVVRGDT
MUL_1307|M.ulcerans_Agy99 DAAE------------------------ARGTWDSRMEASVVDAVVRGDT
MLBr_01652|M.leprae_Br4923 DAAE------------------------ARGTWDSRMEASVVDAVVRGDT
Mvan_3753|M.vanbaalenii_PYR-1 DQAE------------------------ARGAWDTRMEANLVDAVVRGGT
MAV_4933|M.avium_104 RTER------------------------ALALEAEESDAEFVRGALMGSL
Mflv_0936|M.gilvum_PYR-GCK QEQS------------------------RSGLDRERRRERLVRMLLS-DT
MAB_0762|M.abscessus_ATCC_1997 DVVV------------------------EQLIQRDQERAALVSGLIDGRF
TH_3478|M.thermoresistible__bu IVTT------------------------SQLANEVRLQAQLLDLITADPA
MSMEG_4044|M.smegmatis_MC2_155 EASAGEYIDPPKLDRKTRSKWEDTGRYEALLIDRQAAETWLIPIVLSGEV
.:
Mb2266|M.bovis_AF2122/97 GPELLSRAAALN--------------------------------------
Rv2242|M.tuberculosis_H37Rv GPELLSRAAALN--------------------------------------
MMAR_3335|M.marinum_M GPELLSRAAALN--------------------------------------
MUL_1307|M.ulcerans_Agy99 GPELLSRAAALN--------------------------------------
MLBr_01652|M.leprae_Br4923 GPELLSRAAALN--------------------------------------
Mvan_3753|M.vanbaalenii_PYR-1 RPELQSQAAALN--------------------------------------
MAV_4933|M.avium_104 PAAELRMHAELR--------------------------------------
Mflv_0936|M.gilvum_PYR-GCK ASDELDLAAEYA--------------------------------------
MAB_0762|M.abscessus_ATCC_1997 PAGITAWNAAHQ--------------------------------------
TH_3478|M.thermoresistible__bu GAQTLVLAGRLG--------------------------------------
MSMEG_4044|M.smegmatis_MC2_155 AGWLWVITEPSEPDAGRQRLIEHFALVVGLEILKQRHIVEVQERLCGDLM
Mb2266|M.bovis_AF2122/97 ------WDTTAPATVLVGTPAPGPNGSN--------SDGDSERASQDVRD
Rv2242|M.tuberculosis_H37Rv ------WDTTAPATVLVGTPAPGPNGSN--------SDGDSERASQDVRD
MMAR_3335|M.marinum_M ------WDTTAPATVVVGTPASARDGSD--------G---SERAIQDVRD
MUL_1307|M.ulcerans_Agy99 ------WDTTAPATVVVGTPASARDGSD--------G---SERAIQDVRD
MLBr_01652|M.leprae_Br4923 ------WDTTAPATVVVGTPTPNHDGPN--------GQVSSERASQEVRE
Mvan_3753|M.vanbaalenii_PYR-1 ------WDATAPATVIVGMPRPDR----------------AEFAGDDVHE
MAV_4933|M.avium_104 ------GLDPGAEYVAVRARLGGDGP--------------HLRLEQSLGF
Mflv_0936|M.gilvum_PYR-GCK ------TWATPRTLTAVAMP--------------------TRQERGATAI
MAB_0762|M.abscessus_ATCC_1997 ------LGLPESGAFVVVAIESGP------------------LDYRTLRS
TH_3478|M.thermoresistible__bu ------LDTGGTFQAVGFTPS---------------------VDPHRLER
MSMEG_4044|M.smegmatis_MC2_155 VDLLRTSDVPPSTMLIQRAEALGHDLTTPHWLAVFAGEFGPKLDQVALTV
Mb2266|M.bovis_AF2122/97 TAARHGRAALTDVHGTWLVAIVSGQLSPTEKFLKDLLAAFADAP------
Rv2242|M.tuberculosis_H37Rv TAARHGRAALTDVHGTWLVAIVSGQLSPTEKFLKDLLAAFADAP------
MMAR_3335|M.marinum_M AAAQHGRAALTDVHGTWLVAIVSGHLSPTDKVFKDLLEAFSDGP------
MUL_1307|M.ulcerans_Agy99 AAAQHGRAALTDVHGTWLVAIVSGHLSPTDKVFKDLLEAFSDGP------
MLBr_01652|M.leprae_Br4923 IAARHGRAALTDVHGTWLVAIISGQLAPTDKFFSDLLHAFSDGP------
Mvan_3753|M.vanbaalenii_PYR-1 VADRNGRTALSDVHGTWLVAIISGGLSPTDRFLSELMTVFADGP------
MAV_4933|M.avium_104 QDPAHSRRGLCALLDGDLAGFLIE--PPRD----------VEGV------
Mflv_0936|M.gilvum_PYR-GCK TSDPRTLRVPDDAVDSRIGMHVVLVCDVGGSARASFVASLAGTG------
MAB_0762|M.abscessus_ATCC_1997 AEKALRDQGFASAWRVDPDMQVGIVALPTPSRLEELGETLRNLG------
TH_3478|M.thermoresistible__bu VIVRLRIHAGPVVAGVHDGMFVVLQQHDRTGVVTQLCRPHAAGG------
MSMEG_4044|M.smegmatis_MC2_155 REAAPRQETLVGVYASSVVMLIPCDRDPLRIVQRTLTRITESSGGGRLAV
:
Mb2266|M.bovis_AF2122/97 VVIGPTAPMLTAAHRSASEAISGMNAVAGWRGAPRPVLARELLPERALMG
Rv2242|M.tuberculosis_H37Rv VVIGPTAPMLTAAHRSASEAISGMNAVAGWRGAPRPVLARELLPERALMG
MMAR_3335|M.marinum_M VVIGPTAPMLTAAYHSASEAISGMNAVAGWRGAPRPVLARELLPERALMG
MUL_1307|M.ulcerans_Agy99 VVIGPTAPMLTAAYHSASEAISGMNAVAGWRGASRPVLARELLPERALMG
MLBr_01652|M.leprae_Br4923 VVIGPTAPMLTAAYHSASEAVSGMNAVAGWSGAPRPVQARELLPERALMG
Mvan_3753|M.vanbaalenii_PYR-1 VVIGPTAPTLGAAHRSATEAIAGMNAVAGWAGAPRPVSARELLPERALLG
MAV_4933|M.avium_104 VGFGPPRPLTRLSESYRMAARALVTAEACGLRGAYDIAALGLRTAVAIDA
Mflv_0936|M.gilvum_PYR-GCK AVVGPARSWTDAQSSVRRVLRAMRLRRP---DGGDVLDTEEILPELVVGA
MAB_0762|M.abscessus_ATCC_1997 VRRIGVSPVYDGYPPPGPPLNYAKAALLAATEDDPVVAFDANPYAVAAIT
TH_3478|M.thermoresistible__bu VFGIGEPRYGLQGAALSIGDARRAAGLAAVLGHDVVFSRHWLLASVLASA
MSMEG_4044|M.smegmatis_MC2_155 ALSPPVERLADYPVNYQTGVRTTQLRLAAGAGGLVDLRRVPLTSLLLLNS
. .
Mb2266|M.bovis_AF2122/97 DASAIVA-LHTDVMRPLADAGPT----LIETLDAYLDCGGAIEACARKLF
Rv2242|M.tuberculosis_H37Rv DASAIVA-LHTDVMRPLADAGPT----LIETLDAYLDCGGAIEACARKLF
MMAR_3335|M.marinum_M DASAIVA-LHTDVMRPLADAGPT----LIETLDAYLDCGGAIEACARKLF
MUL_1307|M.ulcerans_Agy99 DASAIVA-LHTDVMRPLADAGPT----LIETLDAYLDCGGAIEACARKLF
MLBr_01652|M.leprae_Br4923 DASAIVA-LHTDVMLPLADAGPT----LIETLDAYLDCGGAIEACARKLF
Mvan_3753|M.vanbaalenii_PYR-1 DATAGAA-LEAEVMRPLSDAGPA----LMETLDAYLDSGGAIEACARKLF
MAV_4933|M.avium_104 DVGELLR-KRYLEPLSVGGSSRE----LIATVRTYLACGMHVERTATRLF
Mflv_0936|M.gilvum_PYR-GCK DADALAD-LRARALAPLADFPEASRDRLTETLRSWLLHQGRRDDIAADLF
MAB_0762|M.abscessus_ATCC_1997 DPQTMAR-YRDLVLGSLTEIGVVDRQLLVDTFRQWVDCDGSIPATARVLF
TH_3478|M.thermoresistible__bu DHLDHLG-RGAEIASEHPH--------LSEAVVAFAHNGFSTAAAARVLH
MSMEG_4044|M.smegmatis_MC2_155 TVPDQLRRFAENLIEPLESHDEQRETDLVATLRTWLVEGFSAAATGNRLT
* :. : . *
Mb2266|M.bovis_AF2122/97 VHPNTVRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPH-----
Rv2242|M.tuberculosis_H37Rv VHPNTVRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPH-----
MMAR_3335|M.marinum_M VHPNTIRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPPSGA-A
MUL_1307|M.ulcerans_Agy99 VHPNTIRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPPSGA-A
MLBr_01652|M.leprae_Br4923 VHPNTVRYRLKRITDFTGHDPTLPRDAYVLRVAATVGKLNYPTHH-----
Mvan_3753|M.vanbaalenii_PYR-1 VHPNTVRYRLKRIADFTGRDPTVPRDAYVLRVASSVGRLARQAHLSAAPA
MAV_4933|M.avium_104 VHQNTVRYRLARFEELTG---ASLRDTEVVTEVWWVLELAAMRL------
Mflv_0936|M.gilvum_PYR-GCK VSPSTIRYRLRQLRDAYGDRLRDPRTIAELTVALAMDVATLGGQTRPAIV
MAB_0762|M.abscessus_ATCC_1997 CHPNTVRYRLRRLKQLTGRDVARPRDIAELHLAVEADRRLSWA-------
TH_3478|M.thermoresistible__bu LHPNTVSYRLDRWTQLTGWELNDFEGLARSVVCIALSARRASGPSATASG
MSMEG_4044|M.smegmatis_MC2_155 VHVNTVGYRLAKIQSLLGLDLRKADVRLELQLAVIVWDIMRGEQA-----
.*: *** : . *
Mb2266|M.bovis_AF2122/97 --------------------
Rv2242|M.tuberculosis_H37Rv --------------------
MMAR_3335|M.marinum_M NNTITPVPLPVRRGTEGP--
MUL_1307|M.ulcerans_Agy99 NNTITPVPLPVRRGTEGP--
MLBr_01652|M.leprae_Br4923 --------------------
Mvan_3753|M.vanbaalenii_PYR-1 AASAQAIGVASVTSPENLGT
MAV_4933|M.avium_104 --------------------
Mflv_0936|M.gilvum_PYR-GCK GG------------------
MAB_0762|M.abscessus_ATCC_1997 --------------------
TH_3478|M.thermoresistible__bu --------------------
MSMEG_4044|M.smegmatis_MC2_155 --------------------