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MSTAPLAGKRALVTGGSRGIGAEIVRRLAADGAAVAFTYAASAAHAEKVVAEVAASGGEAVAIRADSADP TQVADAVEQTVAELGGLDILVNNSAVAHIAPIDDFPAEEFDRLVAINIGGVYWAVRSAIRYLSEGARIIN IGSINADRIPGPGLSVYGMTKGAVSSFTRGLARDLGPRGITVNNVQPGPIDTDANPDDGAFAESLKQVVA QGRYGHTSDVASLVSFLAGPESGYITGAHLNVDGGFTV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5843 | - | - | 100% (248) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4753 | - | 6e-36 | 39.13% (253) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0789 | - | 2e-35 | 38.46% (260) | acetoin reductases |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1963c | - | 6e-35 | 35.77% (246) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1963 | - | 7e-34 | 38.96% (249) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1928c | - | 6e-35 | 35.77% (246) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 7e-30 | 34.90% (255) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0827 | - | 2e-74 | 55.10% (245) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_2849 | - | 7e-35 | 36.84% (247) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_2509 | - | 2e-33 | 39.68% (247) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4351 | - | 5e-97 | 68.70% (246) | oxidoreductase YjgI |
| M. thermoresistible (build 8) | TH_3969 | - | 2e-35 | 35.80% (243) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1052 | - | 5e-32 | 39.83% (241) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5843|M.vanbaalenii_PYR-1 -------------------------------MSTAPLAGKRALVTGGSRG
MSMEG_4351|M.smegmatis_MC2_155 ---------------------------MTQAGSSTPLADRRVLVTGGSRG
MAB_0827|M.abscessus_ATCC_1997 --------------------------------MTSPLKSRRAFVTGGSRG
MLBr_01807|M.leprae_Br4923 ------------------MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRG
MAV_2509|M.avium_104 --------------------------------MAERLAGKVALVSGGARG
MUL_1052|M.ulcerans_Agy99 --------------------------------MTG--GGRVALVTGAAGG
Mb1963c|M.bovis_AF2122/97 ----------------------------MSVLDLFDLHGKRALITGASTG
Rv1928c|M.tuberculosis_H37Rv ----------------------------MSVLDLFDLHGKRALITGASTG
MMAR_2849|M.marinum_M ----------------------------MSVLDLFDLSGKRALITGASTG
Mflv_1963|M.gilvum_PYR-GCK MTDDVTPDAVIPYPGETQDMSDRPRDDMRDYVGRGLLDGKKALITGGDSG
TH_3969|M.thermoresistible__bu MG---FPEQQQQVPGRQSAMDPVPDCGESSYRGSGKLTGKRAVITGGDSG
.: .::*. *
Mvan_5843|M.vanbaalenii_PYR-1 IGAEIVRRLAADGAAVAFTYAASAAHAEKVVAEVAASGGEAVAIRADSAD
MSMEG_4351|M.smegmatis_MC2_155 IGAGIVRRLAADGAAVAFTYGASAAEAEKLVGDLTSEGAKVTAIQADSAD
MAB_0827|M.abscessus_ATCC_1997 IGAGIVRRLAEDGARVVFTYSSSVQQAADVVDDINEDGGWARAVKADVAD
MLBr_01807|M.leprae_Br4923 IGLAVARRLVADGHRVAVTHRASVVP------------DWFFGVECDVTD
MAV_2509|M.avium_104 MGASHVRSLVAEGAKVVFGDILDDEGKAVAAEVG----EATRYLHLDVTK
MUL_1052|M.ulcerans_Agy99 QGWAIVQRLRAEGHSVAACDLRADRLDALVAESGD---DAVISLALDVTD
Mb1963c|M.bovis_AF2122/97 IGKRVALAYVEAGAQVAIAAR-HLDALEKLADEIGTSGGKVVPVCCDVSQ
Rv1928c|M.tuberculosis_H37Rv IGKRVALAYVEAGAQVAIAAR-HLDALEKLADEIGTSGGKVVPVCCDVSQ
MMAR_2849|M.marinum_M IGKKVALAYAEAGAQVAVAAR-HSDALQVVADEIAGVGGKALPIRCDVTQ
Mflv_1963|M.gilvum_PYR-GCK IGRAVAVAFAKEGADVAIAYLNETSDAAHTVSLIEAQGRPGLELPGDLAE
TH_3969|M.thermoresistible__bu IGRAVAIAYAREGADVLVSYLNEDDDAAEVAQLVTDAGRRCVLVPGDLSD
* . * * : * :.
Mvan_5843|M.vanbaalenii_PYR-1 PTQVADAVEQTVAELGGLDILVNN-SAVAHIAPIDDFPAEEFDRLVAINI
MSMEG_4351|M.smegmatis_MC2_155 PDQVAAAVSQAVADLGGLDVLVNN-AGVAHVAPAEEFTREQFDRLVNVNI
MAB_0827|M.abscessus_ATCC_1997 PDQLGAAIGQAAEELGGLDILVNN-AGILSIGDVDTATLADFDEIVAVNV
MLBr_01807|M.leprae_Br4923 NDAIGAAFKAVEEHQGPVEVLVAN-AGITSDMLIMRMSEEQFQKVIDVNL
MAV_2509|M.avium_104 PEDWDAAVATALAEFGRIDVLVNN-AGIINIGTLEDYALSEWQRILDINL
MUL_1052|M.ulcerans_Agy99 EAQWQEAVERAVTRFGALTALINN-AGVLHRAALVDETAAGFESAWRVNC
Mb1963c|M.bovis_AF2122/97 HQQVTSMLDQVTAELGGIDIAVCN-AGIITVTPMLDMPLEEFQRLQNTNV
Rv1928c|M.tuberculosis_H37Rv HQQVTSMLDQVTAELGGIDIAVCN-AGIITVTPMLDMPLEEFQRLQNTNV
MMAR_2849|M.marinum_M PDQVRGMLDQMTGELGGIDIAVCN-AGIVSVQAMLDMPLEEFQRIQDTNV
Mflv_1963|M.gilvum_PYR-GCK PGHCRSIVEQTVKEFGGLDIVVNNVAFQSPADDLTEISDEQWRRTFAVNI
TH_3969|M.thermoresistible__bu PAHCRSVIDRAVSEFDGLDVLVVNHAHQMTHPTLEEISDEEWDYTFRLNI
. . : : * : . : *
Mvan_5843|M.vanbaalenii_PYR-1 GGVYWAVRSAIRYLSEG---ARIINIGSINADRIPGPGLS-VYGMTKGAV
MSMEG_4351|M.smegmatis_MC2_155 GGVFWAIHAAIPHFGEG---SRIINIGSINADRVPAPNLG-VYAMTKGAV
MAB_0827|M.abscessus_ATCC_1997 RAVFAGIKAASPHLTEG---GRIVTIGSINGDSSPTANLS-LYSMTKAAV
MLBr_01807|M.leprae_Br4923 TGVFRVAKLASRNMIKQR-FGRYIFMGSVVG-LSGVPGQA-NYAASKSGL
MAV_2509|M.avium_104 TGVFLGIRAVVKPMKKAG-RGSIINISSIEG-MAGTIACH-GYTATKFAV
MUL_1052|M.ulcerans_Agy99 LGAFLGMRAALGALSAAE-GPVIVNICSTGA-IRPFPHHC-AYGAAKWAL
Mb1963c|M.bovis_AF2122/97 TGVFLTAQAAAKAMVKQGQGGVIINTASMSGHIINVPQQVSHYCASKAAV
Rv1928c|M.tuberculosis_H37Rv TGVFLTAQAAAKAMVKQGQGGVIINTASMSGHIINVPQQVSHYCASKAAV
MMAR_2849|M.marinum_M TGVFLTAQAAARAMVDQGLGGTIITTASMSGHIINIPQQVSHYCTSKAAV
Mflv_1963|M.gilvum_PYR-GCK DSFFHVTKAALSHLPD---GSAIINTASINGLRG--NKSLIDYSATKGAV
TH_3969|M.thermoresistible__bu GAYFHLVKAALPHLKP---GASIIGSSSVNSDMP--SPTLAPYAATKAAI
. : : . : : * . * :* .:
Mvan_5843|M.vanbaalenii_PYR-1 SSFTRGLARDLGPRGITVNNVQPGPIDTDAN-P-DDGAFAESLKQVVAQG
MSMEG_4351|M.smegmatis_MC2_155 QALTIGLARELGPRGITITNVQPGPIDTDMN-P-ADGGLAEVMTSVTALG
MAB_0827|M.abscessus_ATCC_1997 AGLTRGLAREFGPRGITINNVQPGPIGTDMN-P-EDGQLADILRPNIAVG
MLBr_01807|M.leprae_Br4923 IGMARSLARELGSRSITANVVAPGFIDTEMTRA-MDSKYQEAALQAIPLG
MAV_2509|M.avium_104 RGLTKSAALELGPSGIRVNSIHPGLIKTPMT----EWVPED--IFQSALG
MUL_1052|M.ulcerans_Agy99 RGLTQTAAAELAPAGFRVNAVFPGPIATSML----DEPTQARLAAVSMFG
Mb1963c|M.bovis_AF2122/97 IHLTKAMAVELAPHKIRVNSVSPGYILTELVEP--YTEYQPLWEPKIPLG
Rv1928c|M.tuberculosis_H37Rv IHLTKAMAVELAPHKIRVNSVSPGYILTELVEP--YTEYQPLWEPKIPLG
MMAR_2849|M.marinum_M VHLTKAMAVELAPHQIRVNSVSPGYIRTELVEP--LADYHALWEPKIPLG
Mflv_1963|M.gilvum_PYR-GCK IALTYSLAQSLAQRRIRVNCVAPGPVWTPLIPATMDADKVESFGGQVPMG
TH_3969|M.thermoresistible__bu ANFSASLAQMLGDKGIRVNSVAPGPIWTPLIPSTMPPEKVARFGDDTPLG
:: * :. : . : ** : * *
Mvan_5843|M.vanbaalenii_PYR-1 RYGHTSDVASLVSFLAG-PESGYITGAHLNVDGGFTV-------------
MSMEG_4351|M.smegmatis_MC2_155 RYGHAGDIAAVVSFLAG-PESGYVTGASWNVDGGYTA-------------
MAB_0827|M.abscessus_ATCC_1997 RYGQPRDIASLVSYLVS-DEAWYITGTAINIDGGFTA-------------
MLBr_01807|M.leprae_Br4923 RIGAVEEIAGAVSFLAS-EDAGYISGAVIPVDGGLGMGH-----------
MAV_2509|M.avium_104 RAAEPKEVSNLVVYLAS-DESSYSTGSEFVVDGGTTAGLGHKDFSNVETD
MUL_1052|M.ulcerans_Agy99 RLGRHAEVADAVAFLVS-ENSSFITGSELVVDGGQCLQVP----------
Mb1963c|M.bovis_AF2122/97 RLGRPEELAGLYLYLAS-EASSYMTGSDIVIDGGYTCP------------
Rv1928c|M.tuberculosis_H37Rv RLGRPEELAGLYLYLAS-EASSYMTGSDIVIDGGYTCP------------
MMAR_2849|M.marinum_M RMGRPEELTGLYLYLAS-AASSYMTGSDIVIDGGYTCP------------
Mflv_1963|M.gilvum_PYR-GCK RAAQPDEIAPSYVFFAASQMSSYYSGEVLAPIGGETLPG-----------
TH_3969|M.thermoresistible__bu RAGQPAELAGAYVLLAADEGS-YISGARIAVTGGRPIL------------
* . ::: :.. : : :* **
Mvan_5843|M.vanbaalenii_PYR-1 -------
MSMEG_4351|M.smegmatis_MC2_155 -------
MAB_0827|M.abscessus_ATCC_1997 -------
MLBr_01807|M.leprae_Br4923 -------
MAV_2509|M.avium_104 AQPDWVT
MUL_1052|M.ulcerans_Agy99 -------
Mb1963c|M.bovis_AF2122/97 -------
Rv1928c|M.tuberculosis_H37Rv -------
MMAR_2849|M.marinum_M -------
Mflv_1963|M.gilvum_PYR-GCK -------
TH_3969|M.thermoresistible__bu -------