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SDDVTPEGVIPYPGQTADMTPQPRDEMRDYTGTGLLSGKRALITGGDSGIGRAVAIAFAKEGADVAIAYL EEQADAAHTVSLIEAAGQRGIQLPGDLADPSHCRGVVAETVKQLGGLDIVVNNVAFQSPVSDLAEISDEQ WRRTFAVNIDSFFHVTKAALQHLPDGSAIINTGSINGLRGNKTLIDYSATKGAVIALTYSLAQSLADRNI RVNCVAPGPVWTPLIPATMDAEKTASFGEHVPMGRAAQPDEIAPSYVFFAASRMSSYYSGEVLAPIGGET LPV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4753 | - | - | 100% (284) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_5843 | - | 7e-36 | 39.13% (253) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4209 | - | 6e-30 | 37.65% (247) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 8e-31 | 34.94% (249) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1963 | - | 1e-139 | 84.45% (283) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2857c | - | 8e-31 | 34.94% (249) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 7e-19 | 30.13% (239) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0827 | - | 2e-30 | 34.54% (249) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4765 | - | 9e-32 | 36.78% (261) | short chain dehydrogenase |
| M. avium 104 | MAV_0886 | - | 3e-32 | 34.77% (256) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_1782 | - | 1e-119 | 75.55% (274) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3969 | - | 2e-75 | 51.45% (276) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0336 | - | 5e-32 | 36.23% (265) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4765|M.marinum_M -----------------------------MVDELAG--------------
MUL_0336|M.ulcerans_Agy99 -----------------------------MVDELAG--------------
MAV_0886|M.avium_104 -----------------------------MVNELAG--------------
Mb2882c|M.bovis_AF2122/97 --------------------------MMDLSQRLAG--------------
Rv2857c|M.tuberculosis_H37Rv --------------------------MMDLSQRLAG--------------
MLBr_01807|M.leprae_Br4923 -----------------------------MTDAAAKVSAAPGRGKPAFVS
MAB_0827|M.abscessus_ATCC_1997 -----------------------------MTSPLK--------------S
Mvan_4753|M.vanbaalenii_PYR-1 ----------MSDDVTPEG-VIPYPGQTADMTPQPRDEMRDYTGTGLLSG
Mflv_1963|M.gilvum_PYR-GCK ----------MTDDVTPDA-VIPYPGETQDMSDRPRDDMRDYVGRGLLDG
MSMEG_1782|M.smegmatis_MC2_155 MDSFESDKPGADQDLNDQHNVISYPGHTEDMADKPRDEMAQYVGRGLLEG
TH_3969|M.thermoresistible__bu ----------MGFPEQQQQ----VPGRQSAMDPVPDCGESSYRGSGKLTG
MMAR_4765|M.marinum_M KIAIVTGGASGIGRATVARFIAEGARVVIADVEEERGES----LAAALGA
MUL_0336|M.ulcerans_Agy99 KIAIVTGGASGIGRATVARFIAEGARVVIADVEEERGES----LAAALGA
MAV_0886|M.avium_104 KVAIVTGGASGIGRGIVERFVAEGARVVIADIETERGER----LAAELGG
Mb2882c|M.bovis_AF2122/97 RVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAGGA----AADELSG
Rv2857c|M.tuberculosis_H37Rv RVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAGGA----AADELSG
MLBr_01807|M.leprae_Br4923 RSILVTGGNRGIGLAVARRLVADGHRVAVTHRASVVP------------D
MAB_0827|M.abscessus_ATCC_1997 RRAFVTGGSRGIGAGIVRRLAEDGARVVFTYSSSVQQAADVVDDINEDGG
Mvan_4753|M.vanbaalenii_PYR-1 KRALITGGDSGIGRAVAIAFAKEGADVAIAYLEEQADAAHTVSLIEAAGQ
Mflv_1963|M.gilvum_PYR-GCK KKALITGGDSGIGRAVAVAFAKEGADVAIAYLNETSDAAHTVSLIEAQGR
MSMEG_1782|M.smegmatis_MC2_155 KRALISGGDSGIGRAVAVAFAKEGADVAIAYLDEHDDATHTASLVERTGR
TH_3969|M.thermoresistible__bu KRAVITGGDSGIGRAVAIAYAREGADVLVSYLNEDDDAAEVAQLVTDAGR
: .::** *** . :* : .
MMAR_4765|M.marinum_M DAMFCRTDVSQPEQVAAVVAAAVENFGGLHVMVNNAGVSGVMHRRFLDDD
MUL_0336|M.ulcerans_Agy99 DAMFCRTDVSQPEQVAAVVAAAVDNFGGLHVMVNNAGVSGAMHRRFLDDD
MAV_0886|M.avium_104 EAVFRRTDVSDIEQVGALVAAAVEKFGGLHVMVNNAGISSPLRR-LLDDD
Mb2882c|M.bovis_AF2122/97 --LFVPTDVCDEDAVNGLFDGAAETYGRIDIAFNNAGISPPEDNLIENTE
Rv2857c|M.tuberculosis_H37Rv --LFVPTDVCDEDAVNGLFDGAAETYGRIDIAFNNAGISPPEDNLIENTE
MLBr_01807|M.leprae_Br4923 WFFGVECDVTDNDAIGAAFKAVEEHQGPVEVLVANAGITS--DMLIMRMS
MAB_0827|M.abscessus_ATCC_1997 WARAVKADVADPDQLGAAIGQAAEELGGLDILVNNAGILS--IGDVDTAT
Mvan_4753|M.vanbaalenii_PYR-1 RGIQLPGDLADPSHCRGVVAETVKQLGGLDIVVNNVAFQSPVSDLAEISD
Mflv_1963|M.gilvum_PYR-GCK PGLELPGDLAEPGHCRSIVEQTVKEFGGLDIVVNNVAFQSPADDLTEISD
MSMEG_1782|M.smegmatis_MC2_155 RCLRLPGDLSEVEQCRAIVSRTAGALGGIDIVVNNVAYQRPTEKFTDISD
TH_3969|M.thermoresistible__bu RCVLVPGDLSDPAHCRSVIDRAVSEFDGLDVLVVNHAHQMTHPTLEEISD
*: : . . . . :.: . * .
MMAR_4765|M.marinum_M LADFHRVMAVNVLGVMAGTRDAARHMAAHGGGSIVNLTSIGGIQAGG-GV
MUL_0336|M.ulcerans_Agy99 LADFHRVMAVNVLGVMAGTRDAARHMAAHGGGSIVNLTSIGGIQAGG-GV
MAV_0886|M.avium_104 LADFHRVMGVNVLGVMAGTRDAARHMADNGGGAIINLTSIGGIQAGG-GV
Mb2882c|M.bovis_AF2122/97 LAAWQRVQDVNLKSVYLCCRAALRHMVLAGKGSIVNTASFVAVMGSATSQ
Rv2857c|M.tuberculosis_H37Rv LAAWQRVQDVNLKSVYLCCRAALRHMVLAGKGSIVNTASFVAVMGSATSQ
MLBr_01807|M.leprae_Br4923 EEQFQKVIDVNLTGVFRVAKLASRNMIKQRFGRYIFMGSVVG-LSGVPGQ
MAB_0827|M.abscessus_ATCC_1997 LADFDEIVAVNVRAVFAGIKAASPHLTEG--GRIVTIGSINGDSSPTANL
Mvan_4753|M.vanbaalenii_PYR-1 -EQWRRTFAVNIDSFFHVTKAALQHLPDG--SAIINTGSINGLRGNK-TL
Mflv_1963|M.gilvum_PYR-GCK -EQWRRTFAVNIDSFFHVTKAALSHLPDG--SAIINTASINGLRGNK-SL
MSMEG_1782|M.smegmatis_MC2_155 -EQWRHTFAVNIDSFFYVTKAALEYLPDG--GAIINTASINGLRGNK-TL
TH_3969|M.thermoresistible__bu -EEWDYTFRLNIGAYFHLVKAALPHLKPG--ASIIGSSSVNSDMPSP-TL
: :*: . : * : . : *. .
MMAR_4765|M.marinum_M MTYRASKAAVIQFTKSAAIELAHYEIRVNAIAPGNIPTPLLASSAAGMDQ
MUL_0336|M.ulcerans_Agy99 MTYRASKGAVIQFTKSAAIELAHYEIRVNAIAPGNIPTPLLASSAAGLDQ
MAV_0886|M.avium_104 MTYRASKAAVIQFTKAAAIELARYDIRVNAIAPGNIPTPILGKSAGDMDP
Mb2882c|M.bovis_AF2122/97 ISYTASKGGVLAMSRELGVQFARQGIRVNALCPGPVNTPLLQELFA-KNP
Rv2857c|M.tuberculosis_H37Rv ISYTASKGGVLAMSRELGVQFARQGIRVNALCPGPVNTPLLQELFA-KNP
MLBr_01807|M.leprae_Br4923 ANYAASKSGLIGMARSLARELGSRSITANVVAPGFIDTEMTRAMDSKYQE
MAB_0827|M.abscessus_ATCC_1997 SLYSMTKAAVAGLTRGLAREFGPRGITINNVQPGPIGTDMN-PEDGQLAD
Mvan_4753|M.vanbaalenii_PYR-1 IDYSATKGAVIALTYSLAQSLADRNIRVNCVAPGPVWTPLIPATMDAEKT
Mflv_1963|M.gilvum_PYR-GCK IDYSATKGAVIALTYSLAQSLAQRRIRVNCVAPGPVWTPLIPATMDADKV
MSMEG_1782|M.smegmatis_MC2_155 IDYSATKGAVIALTYALAQSLTERRIRVNCVAPGPVWTPLIPATMDAERV
TH_3969|M.thermoresistible__bu APYAATKAAIANFSASLAQMLGDKGIRVNSVAPGPIWTPLIPSTMPPEKV
* :*..: :: . : * * : ** : * :
MMAR_4765|M.marinum_M EQVERFTAQIRQTMREDRPLKREGTPEDIAEAALYFAG-ERSRYVTGTVL
MUL_0336|M.ulcerans_Agy99 EQVERFTAQIRQTMREDRPLKREGTPEDIAEAALYFAG-ERSRYVTGTVL
MAV_0886|M.avium_104 EQRERFEARIREGMREDRPLKREGTPDDVAEAALYFAT-ERSRYVTGTVL
Mb2882c|M.bovis_AF2122/97 ERAARRMVHV--------PLGRFAEPDEIAAAVAFLAS-DDASFITASTF
Rv2857c|M.tuberculosis_H37Rv ERAARRMVHV--------PLGRFAEPDEIAAAVAFLAS-DDASFITASTF
MLBr_01807|M.leprae_Br4923 AALQ------------AIPLGRIGAVEEIAGAVSFLAS-EDAGYISGAVI
MAB_0827|M.abscessus_ATCC_1997 ILRP------------NIAVGRYGQPRDIASLVSYLVS-DEAWYITGTAI
Mvan_4753|M.vanbaalenii_PYR-1 ASFG-----------EHVPMGRAAQPDEIAPSYVFFAASRMSSYYSGEVL
Mflv_1963|M.gilvum_PYR-GCK ESFG-----------GQVPMGRAAQPDEIAPSYVFFAASQMSSYYSGEVL
MSMEG_1782|M.smegmatis_MC2_155 ESFG-----------EQAPYNRAAQPDEIAPSYVFFAADQLSSYYTGEVL
TH_3969|M.thermoresistible__bu ARFG-----------DDTPLGRAGQPAELAGAYVLLAADEGS-YISGARI
. * . ::* :. : : :. :
MMAR_4765|M.marinum_M PVDGGTVAGKVIRRSR--
MUL_0336|M.ulcerans_Agy99 PVDGGTVAGKVIRRSR--
MAV_0886|M.avium_104 PVDGGTSAGKAMRSKRQG
Mb2882c|M.bovis_AF2122/97 LVDGGISSAYVTPL----
Rv2857c|M.tuberculosis_H37Rv LVDGGISSAYVTPL----
MLBr_01807|M.leprae_Br4923 PVDGGLGMGH--------
MAB_0827|M.abscessus_ATCC_1997 NIDGGFTA----------
Mvan_4753|M.vanbaalenii_PYR-1 APIGGETLPV--------
Mflv_1963|M.gilvum_PYR-GCK APIGGETLPG--------
MSMEG_1782|M.smegmatis_MC2_155 APIGGETLPG--------
TH_3969|M.thermoresistible__bu AVTGGRPIL---------
**