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MTLNGKVALVTGAARGIGRGIALRLARDGADIALVDVLPEGLDGVADKIAGIGGKTTMFVADVSDREQVF AAVDHAAAALGGFDIMVNNAGIALVGPISDVTPEQIEKLWAINVNGVLWGTQAAVAKFKELKNKDKGRVS RIINASSIAGHDGFAMLGPYSATKFAVRALTQAAAKEHAADGITVNAYCPGVVGTDMWVEIDKRFAELTG AAEGETYDKFVGGIALGRAETPDDVAGFVSYLAGPDADYMTGQSGLIDGGLVYR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0789 | - | - | 100% (264) | acetoin reductases |
| M. vanbaalenii PYR-1 | Mvan_5843 | - | 3e-35 | 38.46% (260) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_5573 | - | 8e-32 | 34.73% (262) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 4e-35 | 38.55% (262) | 20-beta-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0124 | - | 1e-131 | 87.12% (264) | acetoin reductase |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 4e-35 | 38.55% (262) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 7e-24 | 31.25% (256) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0827 | - | 7e-36 | 39.08% (261) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_2981 | fabG3_1 | 3e-35 | 39.69% (262) | 20-beta-hydroxysteroid dehydrogenase FabG3_1 |
| M. avium 104 | MAV_2509 | - | 2e-34 | 38.08% (260) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5020 | - | 1e-114 | 76.89% (264) | acetoin(diacetyl) reductase |
| M. thermoresistible (build 8) | TH_4254 | - | 8e-31 | 32.70% (263) | PUTATIVE putative 2,5-dichloro-2,5-cyclohexadiene-1,4-diol |
| M. ulcerans Agy99 | MUL_1037 | fabG3 | 5e-30 | 35.25% (261) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2025|M.bovis_AF2122/97 --------------MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVF
Rv2002|M.tuberculosis_H37Rv --------------MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVF
MMAR_2981|M.marinum_M --------------MAGRLTGKVALVSGGARGMGASHVRALVAEGAHVVL
MAV_2509|M.avium_104 --------------MAERLAGKVALVSGGARGMGASHVRSLVAEGAKVVF
MUL_1037|M.ulcerans_Agy99 ---------------MGRVDGKVALISGGARGMGASHARLLVQEGAKVVI
TH_4254|M.thermoresistible__bu -----------MTAGSTRLAGKVVLVTGAGGGLGTAIARRLADEGARLVL
Mvan_0789|M.vanbaalenii_PYR-1 --------------MT--LNGKVALVTGAARGIGRGIALRLARDGADIAL
Mflv_0124|M.gilvum_PYR-GCK --------------MA--INGKVALVTGAARGIGRGIALRLARDGADVAL
MSMEG_5020|M.smegmatis_MC2_155 --------------MS--LQGKVALVTGAGRGIGRGIALRLAQDGADIAL
MAB_0827|M.abscessus_ATCC_1997 --------------MTSPLKSRRAFVTGGSRGIGAGIVRRLAEDGARVVF
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
. .: :::*. *:* . . :. :* :..
Mb2025|M.bovis_AF2122/97 GD-ILDEEGKAVAAELADAARYVH---LDVTQPAQWTAAVDTAVTAFGGL
Rv2002|M.tuberculosis_H37Rv GD-ILDEEGKAVAAELADAARYVH---LDVTQPAQWTAAVDTAVTAFGGL
MMAR_2981|M.marinum_M GD-ILDDEGRAVAAELGDAARYVH---LDVTQPEQWTAAVDTAVNEFGGL
MAV_2509|M.avium_104 GD-ILDDEGKAVAAEVGEATRYLH---LDVTKPEDWDAAVATALAEFGRI
MUL_1037|M.ulcerans_Agy99 GD-ILDEEGKALAEEIGDAARYVH---LDVTQPDQWEAAVATAVDEFGKL
TH_4254|M.thermoresistible__bu AD-LQESQCAALADELPAPAGAHHPLGFDVADETAWISAISTVSAQYGAL
Mvan_0789|M.vanbaalenii_PYR-1 VD-VLPEGLDGVADKIAGIGGKTTMFVADVSDREQVFAAVDHAAAALGGF
Mflv_0124|M.gilvum_PYR-GCK VD-VHQDGLDDVAAEIAEIGSKTTTFVADVSDRDQVFAAVRHASSALGGF
MSMEG_5020|M.smegmatis_MC2_155 VD-VTADGIDAVADEVAAIGSKATTFVADVSDRDAVFAAVEHAQSALGGF
MAB_0827|M.abscessus_ATCC_1997 TYSSSVQQAADVVDDINEDGGWARAVKADVADPDQLGAAIGQAAEELGGL
MLBr_01807|M.leprae_Br4923 TH------------RASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPV
**:. :*. . * .
Mb2025|M.bovis_AF2122/97 HVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEA--
Rv2002|M.tuberculosis_H37Rv HVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEA--
MMAR_2981|M.marinum_M HVLVNNAGILNIGTIEDYALSEWQRILDINVTGVFLGIRAAVKPMKEA--
MAV_2509|M.avium_104 DVLVNNAGIINIGTLEDYALSEWQRILDINLTGVFLGIRAVVKPMKKA--
MUL_1037|M.ulcerans_Agy99 DVLVNNVGIVALGQLKKFDLGKWQKVIDVNLTGTFLGMRAAVEPMTAA--
TH_4254|M.thermoresistible__bu HALVNNAAIGALGNVAEERLERWDRILDVGATGVWLGMKHAVPLIRRS--
Mvan_0789|M.vanbaalenii_PYR-1 DIMVNNAGIALVGPISDVTPEQIEKLWAINVNGVLWGTQAAVAKFKELKN
Mflv_0124|M.gilvum_PYR-GCK DIMVNNAGIALVGPISEVTPAEIQKLWSINVDGVLWGIQAAVAQFTTLHN
MSMEG_5020|M.smegmatis_MC2_155 DIMVNNAGVALVGPVAEVTPDDAARVWGVNVNGVLWGIQAAAAKFVEL--
MAB_0827|M.abscessus_ATCC_1997 DILVNNAGILSIGDVDTATLADFDEIVAVNVRAVFAGIKAASPHLTEG--
MLBr_01807|M.leprae_Br4923 EVLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQR-
. :* *..: : .: :. .. : . :
Mb2025|M.bovis_AF2122/97 ----GRGSIINISSIEG-LAGTVACHGYTATKFAVRGLTKSTALELGPSG
Rv2002|M.tuberculosis_H37Rv ----GRGSIINISSIEG-LAGTVACHGYTATKFAVRGLTKSTALELGPSG
MMAR_2981|M.marinum_M ----GRGSIINISSIEG-LAGTIASHGYTVSKFAVRGLTKSTALELGPSG
MAV_2509|M.avium_104 ----GRGSIINISSIEG-MAGTIACHGYTATKFAVRGLTKSAALELGPSG
MUL_1037|M.ulcerans_Agy99 ----GSGSIINVSSIEG-LRGAPAVHPYVASKWAVRGLTKSAALELAPLN
TH_4254|M.thermoresistible__bu ----GGGSVVNICSIFGTVGGFGDSAAYHAAKGAVRTLTKNAALHWAPDG
Mvan_0789|M.vanbaalenii_PYR-1 KDKGRVSRIINASSIAGHDG-FAMLGPYSATKFAVRALTQAAAKEHAADG
Mflv_0124|M.gilvum_PYR-GCK KEQGKISKIINASSIAGHDG-FAMLGPYSATKFAVRALTQAAAKEHAADG
MSMEG_5020|M.smegmatis_MC2_155 ---GVPGRIINASSIAGHDG-FAMLGVYSASKFAVRALTQAAAKEYASSG
MAB_0827|M.abscessus_ATCC_1997 ------GRIVTIGSINGDSSPTANLSLYSMTKAAVAGLTRGLAREFGPRG
MLBr_01807|M.leprae_Br4923 -----FGRYIFMGSVVG-LSGVPGQANYAASKSGLIGMARSLARELGSRS
. : *: * * :* .: ::: * . .. .
Mb2025|M.bovis_AF2122/97 IRVNSIHPGLVKTP----------------MTDWVPEDIFQTALGRAAEP
Rv2002|M.tuberculosis_H37Rv IRVNSIHPGLVKTP----------------MTDWVPEDIFQTALGRAAEP
MMAR_2981|M.marinum_M IRVNSIHPGLVKTP----------------MTEWVPEDLFQTALGRAAEP
MAV_2509|M.avium_104 IRVNSIHPGLIKTP----------------MTEWVPEDIFQSALGRAAEP
MUL_1037|M.ulcerans_Agy99 IRVNSIHPGFIRTP----------------MTANLPDDMVTIPLGRPAES
TH_4254|M.thermoresistible__bu VRVNSLHPGFIETPQLRELYK---------GTERYERMLAGTPLGRLGRP
Mvan_0789|M.vanbaalenii_PYR-1 ITVNAYCPGVVGTDMWVEIDKRFAELTGAAEGETYDKFVGGIALGRAETP
Mflv_0124|M.gilvum_PYR-GCK ITVNAYCPGVVGTDMWVEIDKRFAELTGAAEGETYDKFVGGIALGRAETP
MSMEG_5020|M.smegmatis_MC2_155 ITVNAYCPGVVGTDMWVEIDQRFADLTGAEVGATFDQFVGGIALGRAETP
MAB_0827|M.abscessus_ATCC_1997 ITINNVQPGPIGTDMNPE------------DGQLADILRPNIAVGRYGQP
MLBr_01807|M.leprae_Br4923 ITANVVAPGFIDTEMTR-----------AMDSKYQEAALQAIPLGRIGAV
: * ** : * .:**
Mb2025|M.bovis_AF2122/97 VEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEWV
Rv2002|M.tuberculosis_H37Rv VEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEWV
MMAR_2981|M.marinum_M MEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHKDFSAVDVAAQPEWV
MAV_2509|M.avium_104 KEVSNLVVYLASDESSYSTGSEFVVDGGTTAGLGHKDFSNVETDAQPDWV
MUL_1037|M.ulcerans_Agy99 REVSTFVVFLASDDASYATGSEFVMDGGLVTDVPHKQF------------
TH_4254|M.thermoresistible__bu DEIAAVVAFLVSDDASFITGSEVYADGGWTAR------------------
Mvan_0789|M.vanbaalenii_PYR-1 DDVAGFVSYLAGPDADYMTGQSGLIDGGLVYR------------------
Mflv_0124|M.gilvum_PYR-GCK DDVAGFVSYLAGPDSDYMTGQAGLIDGGLVYR------------------
MSMEG_5020|M.smegmatis_MC2_155 EDVAAFVSYLAGPDAAYMTGQAPIIDGGLVYR------------------
MAB_0827|M.abscessus_ATCC_1997 RDIASLVSYLVSDEAWYITGTAINIDGGFTA-------------------
MLBr_01807|M.leprae_Br4923 EEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH-----------------
::: * :*.. :: : :* ***
Mb2025|M.bovis_AF2122/97 T
Rv2002|M.tuberculosis_H37Rv T
MMAR_2981|M.marinum_M T
MAV_2509|M.avium_104 T
MUL_1037|M.ulcerans_Agy99 -
TH_4254|M.thermoresistible__bu -
Mvan_0789|M.vanbaalenii_PYR-1 -
Mflv_0124|M.gilvum_PYR-GCK -
MSMEG_5020|M.smegmatis_MC2_155 -
MAB_0827|M.abscessus_ATCC_1997 -
MLBr_01807|M.leprae_Br4923 -