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M. bovis AF2122 / 97 Mb1963c (-)

annotation: short chain dehydrogenase
coordinates: 2172085 - 2172852
length: 255

MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAIAARHLDALEKLADEIGTSGGKVVPVCCDVS
QHQQVTSMLDQVTAELGGIDIAVCNAGIITVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQG
GVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHKIRVNSVSPGYILTELVEPYTEYQPL
WEPKIPLGRLGRPEELAGLYLYLASEASSYMTGSDIVIDGGYTCP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1963c--100% (255)short chain dehydrogenase
M. bovis AF2122 / 97Mb0950c-2e-3533.98% (256) short chain dehydrogenase
M. bovis AF2122 / 97Mb1385fabG5e-3534.96% (246) 3-ketoacyl-(acyl-carrier-protein) reductase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_0305-1e-4038.10% (252) short-chain dehydrogenase/reductase SDR
M. tuberculosis H37RvRv1928c-1e-144100.00% (255) short chain dehydrogenase
M. leprae Br4923MLBr_01807fabG12e-3035.10% (245) 3-oxoacyl-
M. abscessus ATCC 19977MAB_4490c-8e-4036.29% (259) oxidoreductase
M. marinum MMMAR_2849-1e-11881.96% (255) short-chain type dehydrogenase/reductase
M. avium 104MAV_2775-1e-10875.98% (254) short chain dehydrogenase
M. smegmatis MC2 155MSMEG_0779-2e-4438.98% (254) short chain dehydrogenase
M. thermoresistible (build 8)TH_2623-3e-4338.82% (255) PUTATIVE short-chain dehydrogenase/reductase SDR
M. ulcerans Agy99MUL_3898fabG2e-3636.51% (241) 3-ketoacyl-(acyl-carrier-protein) reductase
M. vanbaalenii PYR-1Mvan_0441-9e-4338.00% (250) short-chain dehydrogenase/reductase SDR

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0305|M.gilvum_PYR-GCK          ------MTTTS--ANPFDLTGHVAVVTGGGSGIGLGMAGGLARAGATVAI
Mvan_0441|M.vanbaalenii_PYR-1       ------MTDAAPPANPFDLTGHVAVVTGGGSGIGLGMAEGLARAGATVAI
Mb1963c|M.bovis_AF2122/97           ----------MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAI
Rv1928c|M.tuberculosis_H37Rv        ----------MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAI
MMAR_2849|M.marinum_M               ----------MSVLDLFDLSGKRALITGASTGIGKKVALAYAEAGAQVAV
MAV_2775|M.avium_104                ------------MLDLFDLRGRRALVTGASTGIGKQVAQAYLQAGARVAI
MAB_4490c|M.abscessus_ATCC_199      --------MFDDPRALFDIAGKSAIVIGATGSLGQIASRALAGAGANVAI
TH_2623|M.thermoresistible__bu      ----------MGVLDKFRLDDKVVIVTGASSGLGVAFARACAEAGADVVL
MSMEG_0779|M.smegmatis_MC2_155      ---------------MFDLQGRSVVVTGGTKGIGRGIATVFARAGANVAV
MLBr_01807|M.leprae_Br4923          MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MUL_3898|M.ulcerans_Agy99           ------MCGAHRDRG-----YVYPVVTGGAQGLGLAIAERFVSEGARVVL
                                                            :: *.  .:*   :      *  *.:

Mflv_0305|M.gilvum_PYR-GCK          LGRNAQRLDDAAATLRTHG-NPVLPLVCDVTDEEAVTETMARIRDEFGWL
Mvan_0441|M.vanbaalenii_PYR-1       LGRSAQRLDSAAATLRSHG-NPVLPVVCDVTDEQAVTDAMARIRSEFGWL
Mb1963c|M.bovis_AF2122/97           AARHLDALEKLADEIGTSG-GKVVPVCCDVSQHQQVTSMLDQVTAELGGI
Rv1928c|M.tuberculosis_H37Rv        AARHLDALEKLADEIGTSG-GKVVPVCCDVSQHQQVTSMLDQVTAELGGI
MMAR_2849|M.marinum_M               AARHSDALQVVADEIAGVG-GKALPIRCDVTQPDQVRGMLDQMTGELGGI
MAV_2775|M.avium_104                AARDFEALQRTADELTAGGTGGVVAIRCDVTQPDEVSGMVDRMIAELGGI
MAB_4490c|M.abscessus_ATCC_199      CGSREDALSDLRDELAAAP-GCIVPIARRPDSESASDAIVKETIEAFGGV
TH_2623|M.thermoresistible__bu      AARRVERLQQTAEQVRATG-RRALTVATDVVDPQQCQEMVDAAMTEFGRV
MSMEG_0779|M.smegmatis_MC2_155      AGRSTADIDACVADLDQLGSGKVIGVQTDVSDRAQCDALAGRAVEEFGGI
MLBr_01807|M.leprae_Br4923          THR---ASVVPDWFFG---------VECDVTDNDAIGAAFKAVEEHQGPV
MUL_3898|M.ulcerans_Agy99           GDVNLEATEAAAKQLGGGE--VAVAVRCDVTKADEVETLLQAALERFGGL
                                                  .          :     .               * :

Mflv_0305|M.gilvum_PYR-GCK          DSCFANAGVRGRFTPVLETSLAEFRSVTSVDLDGVFLTLREAARQMVAAG
Mvan_0441|M.vanbaalenii_PYR-1       DSCFANAGVRGTFTPTLDTSLAEFREVTRVDLDGVFVTLREAARQMIGAG
Mb1963c|M.bovis_AF2122/97           DIAVCNAGII-TVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQG
Rv1928c|M.tuberculosis_H37Rv        DIAVCNAGII-TVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQG
MMAR_2849|M.marinum_M               DIAVCNAGIV-SVQAMLDMPLEEFQRIQDTNVTGVFLTAQAAARAMVDQG
MAV_2775|M.avium_104                DIAVCNAGII-SVSPMLEMPAAEFQRIQDTNVTGVFLTAQAAARAMVRQG
MAB_4490c|M.abscessus_ATCC_199      DILVVASGVN-EVAPAVDMQPARFEAVLDANVTSTWLAVRSAGRAMIERG
TH_2623|M.thermoresistible__bu      DVLVNNAGVG-TAVPATRETPEEFRTVIDINLNGSYWAAQACGRVMRP--
MSMEG_0779|M.smegmatis_MC2_155      DVVCANAGVF-PDAPLATMTPEQLNGIFAVNVNGTFYAVQACLDALIASG
MLBr_01807|M.leprae_Br4923          EVLVANAGIT-SDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQR
MUL_3898|M.ulcerans_Agy99           DIMVNNAGIT-RDATMRKMTEEQFDQVIDVHLKGTWNGIRLAAAIMRENK
                                    :     :*:             .:  :   .: . :   : .   :    

Mflv_0305|M.gilvum_PYR-GCK          RGGSLVGVSSLGAFQG--MPRQPAYAASKAGVTSMMDSFAVELAR-HGIR
Mvan_0441|M.vanbaalenii_PYR-1       RGGSLVGVSSLGAVQG--MPRQPAYAASKAGVTSLMDSLAVEFAR-YGIR
Mb1963c|M.bovis_AF2122/97           QGGVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAP-HKIR
Rv1928c|M.tuberculosis_H37Rv        QGGVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAP-HKIR
MMAR_2849|M.marinum_M               LGGTIITTASMSGHIINIPQQVSHYCTSKAAVVHLTKAMAVELAP-HQIR
MAV_2775|M.avium_104                RGGAIITTASMSGHIINVPQQVGHYCASKAAVIQLTKAMAVEFAP-HDIR
MAB_4490c|M.abscessus_ATCC_199      RGGKIILTSSARGKLG-HPAGYTAYCASKAAVDGLVRSFGCEWGR-YGIT
TH_2623|M.thermoresistible__bu      -GSSIVNISSILGITT-ASLPQAAYSASKAGVIGLTRDLAQQWTPRKGIR
MSMEG_0779|M.smegmatis_MC2_155      -SGRVVLTSSITGPITGYPGWS-HYGATKAAQLGFMRTAAIELAP-HKIT
MLBr_01807|M.leprae_Br4923          -FGRYIFMGSVVGLSG--VPGQANYAASKSGLIGMARSLARELGS-RSIT
MUL_3898|M.ulcerans_Agy99           -RGAIVNMSSVSGKVG--MVGQTNYSAAKAGIVGMTKAAAKELAH-VGVR
                                      .  :  .*  .           * ::*:.   :    . :      : 

Mflv_0305|M.gilvum_PYR-GCK          ANTVAPGWFETEMT----SEGMADERFTSRVLPRVPVRRWGAAEDVAGVG
Mvan_0441|M.vanbaalenii_PYR-1       ANTIQPGWFATEMT----ADGMADERFRARVLPRVPVRRWGAAEDVG--G
Mb1963c|M.bovis_AF2122/97           VNSVSPGYILTELV------EPYTEYQPL-WEPKIPLGRLGRPEELA--G
Rv1928c|M.tuberculosis_H37Rv        VNSVSPGYILTELV------EPYTEYQPL-WEPKIPLGRLGRPEELA--G
MMAR_2849|M.marinum_M               VNSVSPGYIRTELV------EPLADYHAL-WEPKIPLGRMGRPEELT--G
MAV_2775|M.avium_104                VNSVSPGYIRTELV------EPLHEYHRQ-WQPKIPLGRMGRPDELA--G
MAB_4490c|M.abscessus_ATCC_199      VNGLAPTVFRSPLTSWMFTDEPAAQATRENFLSRIPLGRLGEPEDLA--G
TH_2623|M.thermoresistible__bu      VNAIAPGFFKSEMT------DQYKPGYLDSQMPRVLMGRTGDPEELA--A
MSMEG_0779|M.smegmatis_MC2_155      VNAIMPGNIMTEGL------LENGEEYIASMARSIPAGALGTPEDIG--H
MLBr_01807|M.leprae_Br4923          ANVVAPGFIDTEMT------RAMDSKYQEAALQAIPLGRIGAVEEIA--G
MUL_3898|M.ulcerans_Agy99           VNAIAPGLIRSAMT------EAMPQRIWDQKLAEVPMGRAGEPSEVA--S
                                    .* : *  : :                       :     *  .::    

Mflv_0305|M.gilvum_PYR-GCK          VAVYLAGPASAYHTGDVLRLDGGYLKF--------
Mvan_0441|M.vanbaalenii_PYR-1       IAVYLASPASAYHTGDVLRLDGGYLKF--------
Mb1963c|M.bovis_AF2122/97           LYLYLASEASSYMTGSDIVIDGGYTCP--------
Rv1928c|M.tuberculosis_H37Rv        LYLYLASEASSYMTGSDIVIDGGYTCP--------
MMAR_2849|M.marinum_M               LYLYLASAASSYMTGSDIVIDGGYTCP--------
MAV_2775|M.avium_104                IYLYLASAASSYMTGSDIVIDGGYSCP--------
MAB_4490c|M.abscessus_ATCC_199      PILFLSAPASDFLTGHVVYPDGGYTAG--------
TH_2623|M.thermoresistible__bu      TLVWLVSDAGGYVTGQTIVVDGGITIT--------
MSMEG_0779|M.smegmatis_MC2_155      LAAFLATKEAGYITGQAIAVDGGQVLPESLDAIAT
MLBr_01807|M.leprae_Br4923          AVSFLASEDAGYISGAVIPVDGGLGMGH-------
MUL_3898|M.ulcerans_Agy99           VALFLACDLSSYMTGTVLDVTGGRFI---------
                                       :*    . : :*  :   **