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VTDDVTPDAVIPYPGETQDMSDRPRDDMRDYVGRGLLDGKKALITGGDSGIGRAVAVAFAKEGADVAIAY LNETSDAAHTVSLIEAQGRPGLELPGDLAEPGHCRSIVEQTVKEFGGLDIVVNNVAFQSPADDLTEISDE QWRRTFAVNIDSFFHVTKAALSHLPDGSAIINTASINGLRGNKSLIDYSATKGAVIALTYSLAQSLAQRR IRVNCVAPGPVWTPLIPATMDADKVESFGGQVPMGRAAQPDEIAPSYVFFAASQMSSYYSGEVLAPIGGE TLPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1963 | - | - | 100% (284) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1263 | - | 1e-33 | 35.74% (249) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2415 | - | 8e-31 | 33.59% (262) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3589c | - | 2e-30 | 33.86% (254) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3559c | - | 1e-30 | 33.86% (254) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 8e-18 | 29.32% (249) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0827 | - | 2e-29 | 34.41% (247) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4765 | - | 1e-32 | 35.96% (267) | short chain dehydrogenase |
| M. avium 104 | MAV_1572 | - | 7e-32 | 34.14% (249) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1782 | - | 1e-124 | 78.55% (275) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3969 | - | 3e-72 | 49.28% (276) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0336 | - | 4e-33 | 35.96% (267) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4753 | - | 1e-139 | 84.45% (283) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1963|M.gilvum_PYR-GCK ----------MTDDVTPDA-VIPYPGETQDMSDRPRDDMRDYVGRGLLDG
Mvan_4753|M.vanbaalenii_PYR-1 ----------MSDDVTPEG-VIPYPGQTADMTPQPRDEMRDYTGTGLLSG
MSMEG_1782|M.smegmatis_MC2_155 MDSFESDKPGADQDLNDQHNVISYPGHTEDMADKPRDEMAQYVGRGLLEG
TH_3969|M.thermoresistible__bu ----------MGFPEQQQQ----VPGRQSAMDPVPDCGESSYRGSGKLTG
MMAR_4765|M.marinum_M -------------------------------------------MVDELAG
MUL_0336|M.ulcerans_Agy99 -------------------------------------------MVDELAG
MAV_1572|M.avium_104 --------------------------------------------MSLLSG
Mb3589c|M.bovis_AF2122/97 --------------------------------MNLSVAPKEIAGHGLLDG
Rv3559c|M.tuberculosis_H37Rv --------------------------------MNLSVAPKEIAGHGLLDG
MLBr_01807|M.leprae_Br4923 -----------------------------MTDAAAKVSAAPGRGKPAFVS
MAB_0827|M.abscessus_ATCC_1997 -----------------------------MTSPLK--------------S
.
Mflv_1963|M.gilvum_PYR-GCK KKALITGGD-SGIGRAVAVAFAKEGADVAIAYLNETSDAAHTVSLIEAQG
Mvan_4753|M.vanbaalenii_PYR-1 KRALITGGD-SGIGRAVAIAFAKEGADVAIAYLEEQADAAHTVSLIEAAG
MSMEG_1782|M.smegmatis_MC2_155 KRALISGGD-SGIGRAVAVAFAKEGADVAIAYLDEHDDATHTASLVERTG
TH_3969|M.thermoresistible__bu KRAVITGGD-SGIGRAVAIAYAREGADVLVSYLNEDDDAAEVAQLVTDAG
MMAR_4765|M.marinum_M KIAIVTGGA-SGIGRATVARFIAEGARVVIADVEEERGESLAAALGAD--
MUL_0336|M.ulcerans_Agy99 KIAIVTGGA-SGIGRATVARFIAEGARVVIADVEEERGESLAAALGAD--
MAV_1572|M.avium_104 QTAVITGGA-QGLGFAIAERFVAEGARVVLGDVNLEATQTAAKQLGGDQV
Mb3589c|M.bovis_AF2122/97 KVVVVTAAAGTGIGSATARRALAEGADVVISDHHERRLGETAAELSALGL
Rv3559c|M.tuberculosis_H37Rv KVVVVTAAAGTGIGSATARRALAEGADVVISDHHERRLGETAAELSALGL
MLBr_01807|M.leprae_Br4923 RSILVTGGN-RGIGLAVARRLVADGHRVAVTHRASVVP------------
MAB_0827|M.abscessus_ATCC_1997 RRAFVTGGS-RGIGAGIVRRLAEDGARVVFTYSSSVQQAADVVDDINEDG
: .::.. *:* . . :* * .
Mflv_1963|M.gilvum_PYR-GCK RPGLELPGDLAEPGHCRSIVEQTVKEFGGLDIVVNNVAFQSPADDLTEIS
Mvan_4753|M.vanbaalenii_PYR-1 QRGIQLPGDLADPSHCRGVVAETVKQLGGLDIVVNNVAFQSPVSDLAEIS
MSMEG_1782|M.smegmatis_MC2_155 RRCLRLPGDLSEVEQCRAIVSRTAGALGGIDIVVNNVAYQRPTEKFTDIS
TH_3969|M.thermoresistible__bu RRCVLVPGDLSDPAHCRSVIDRAVSEFDGLDVLVVNHAHQMTHPTLEEIS
MMAR_4765|M.marinum_M --AMFCRTDVSQPEQVAAVVAAAVENFGGLHVMVNNAGVSG-VMHRRFLD
MUL_0336|M.ulcerans_Agy99 --AMFCRTDVSQPEQVAAVVAAAVDNFGGLHVMVNNAGVSG-AMHRRFLD
MAV_1572|M.avium_104 --ALAVRCDVTKSSEVETLIQTAVERFGGLDIMVNNAGITR-DATMRKMT
Mb3589c|M.bovis_AF2122/97 GRVEHVVCDVTSTAQVDALIDSTTARMGRLDVLVNNAGLGG-QTPVADMT
Rv3559c|M.tuberculosis_H37Rv GRVEHVVCDVTSTAQVDALIDSTTARMGRLDVLVNNAGLGG-QTPVADMT
MLBr_01807|M.leprae_Br4923 DWFFGVECDVTDNDAIGAAFKAVEEHQGPVEVLVANAGITS-DMLIMRMS
MAB_0827|M.abscessus_ATCC_1997 GWARAVKADVADPDQLGAAIGQAAEELGGLDILVNNAGILS-IGDVDTAT
*::. . . . :.::* * .
Mflv_1963|M.gilvum_PYR-GCK DEQ--WRRTFAVNIDSFFHVTKAALSHLPDG---SAIINTASINGLRGNK
Mvan_4753|M.vanbaalenii_PYR-1 DEQ--WRRTFAVNIDSFFHVTKAALQHLPDG---SAIINTGSINGLRGNK
MSMEG_1782|M.smegmatis_MC2_155 DEQ--WRHTFAVNIDSFFYVTKAALEYLPDG---GAIINTASINGLRGNK
TH_3969|M.thermoresistible__bu DEE--WDYTFRLNIGAYFHLVKAALPHLKPG---ASIIGSSSVNSDMPSP
MMAR_4765|M.marinum_M DDLADFHRVMAVNVLGVMAGTRDAARHMAAH-GGGSIVNLTSIGGIQAGG
MUL_0336|M.ulcerans_Agy99 DDLADFHRVMAVNVLGVMAGTRDAARHMAAH-GGGSIVNLTSIGGIQAGG
MAV_1572|M.avium_104 EEQ--FDQVIAVHLKGTWNGTRLAAAIMREN-KRGAIINMSSVSGKVGMV
Mb3589c|M.bovis_AF2122/97 DDE--WDRVLDVSLTSVFRATRAALRYFRDAPHGGVIVNNASVLGWRAQH
Rv3559c|M.tuberculosis_H37Rv DDE--WDRVLDVSLTSVFRATRAALRYFRDAPHGGVIVNNASVLGWRAQH
MLBr_01807|M.leprae_Br4923 EEQ--FQKVIDVNLTGVFRVAKLASRNMIKQRFGRYIFMGSVVG-LSGVP
MAB_0827|M.abscessus_ATCC_1997 LAD--FDEIVAVNVRAVFAGIKAASPHLTEG--GRIVTIGSINGDSSPTA
: . : : . : * : :
Mflv_1963|M.gilvum_PYR-GCK SLIDYSATKGAVIALTYSLAQSLAQRRIRVNCVAPGPVWTPLIPATMD--
Mvan_4753|M.vanbaalenii_PYR-1 TLIDYSATKGAVIALTYSLAQSLADRNIRVNCVAPGPVWTPLIPATMD--
MSMEG_1782|M.smegmatis_MC2_155 TLIDYSATKGAVIALTYALAQSLTERRIRVNCVAPGPVWTPLIPATMD--
TH_3969|M.thermoresistible__bu TLAPYAATKAAIANFSASLAQMLGDKGIRVNSVAPGPIWTPLIPSTMP--
MMAR_4765|M.marinum_M GVMTYRASKAAVIQFTKSAAIELAHYEIRVNAIAPGNIPTPLLASSAAGM
MUL_0336|M.ulcerans_Agy99 GVMTYRASKGAVIQFTKSAAIELAHYEIRVNAIAPGNIPTPLLASSAAGL
MAV_1572|M.avium_104 GQTNYSAAKAGIVGMTKAAAKELAYLGVRVNAIAPG-----LIRSAMT--
Mb3589c|M.bovis_AF2122/97 SQSHYAAAKAGVMALTRCSAIEAAEYGVRINAVSPSIARHKFLDKTAS--
Rv3559c|M.tuberculosis_H37Rv SQSHYAAAKAGVMALTRCSAIEAAEYGVRINAVSPSIARHKFLDKTAS--
MLBr_01807|M.leprae_Br4923 GQANYAASKSGLIGMARSLARELGSRSITANVVAPGFIDTEMTRAMDSK-
MAB_0827|M.abscessus_ATCC_1997 NLSLYSMTKAAVAGLTRGLAREFGPRGITINNVQPGPIGTDMN-PEDGQ-
* :*..: :: * : * : *. :
Mflv_1963|M.gilvum_PYR-GCK ---------ADKVESFGGQVPMGRAAQPDEIAPSYVFFAASQMSSYYSGE
Mvan_4753|M.vanbaalenii_PYR-1 ---------AEKTASFGEHVPMGRAAQPDEIAPSYVFFAASRMSSYYSGE
MSMEG_1782|M.smegmatis_MC2_155 ---------AERVESFGEQAPYNRAAQPDEIAPSYVFFAADQLSSYYTGE
TH_3969|M.thermoresistible__bu ---------PEKVARFGDDTPLGRAGQPAELAGAYVLLAADEGS-YISGA
MMAR_4765|M.marinum_M DQEQVERFTAQIRQTMREDRPLKREGTPEDIAEAALYFAG-ERSRYVTGT
MUL_0336|M.ulcerans_Agy99 DQEQVERFTAQIRQTMREDRPLKREGTPEDIAEAALYFAG-ERSRYVTGT
MAV_1572|M.avium_104 -----EAMPQRIWDSKVAEVPMGRAGEPSEVASVALFLAS-DMSSYMTGT
Mb3589c|M.bovis_AF2122/97 ---------AELLDRLVAGEAFGRAAEPWEVAATIAFLAS-DYSSYLTGE
Rv3559c|M.tuberculosis_H37Rv ---------AELLDRLAAGEAFGRAAEPWEVAATIAFLAS-DYSSYLTGE
MLBr_01807|M.leprae_Br4923 -----------YQEAALQAIPLGRIGAVEEIAGAVSFLAS-EDAGYISGA
MAB_0827|M.abscessus_ATCC_1997 -----------LADILRPNIAVGRYGQPRDIASLVSYLVS-DEAWYITGT
. * . ::* :.. : * :*
Mflv_1963|M.gilvum_PYR-GCK VLAPIGGETLPG------
Mvan_4753|M.vanbaalenii_PYR-1 VLAPIGGETLPV------
MSMEG_1782|M.smegmatis_MC2_155 VLAPIGGETLPG------
TH_3969|M.thermoresistible__bu RIAVTGGRPIL-------
MMAR_4765|M.marinum_M VLPVDGGTVAGKVIRRSR
MUL_0336|M.ulcerans_Agy99 VLPVDGGTVAGKVIRRSR
MAV_1572|M.avium_104 VMEITGGRHL--------
Mb3589c|M.bovis_AF2122/97 VISVSCQHP---------
Rv3559c|M.tuberculosis_H37Rv VISVSCQHP---------
MLBr_01807|M.leprae_Br4923 VIPVDGGLGMGH------
MAB_0827|M.abscessus_ATCC_1997 AINIDGGFTA--------
: