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MTQAGSSTPLADRRVLVTGGSRGIGAGIVRRLAADGAAVAFTYGASAAEAEKLVGDLTSEGAKVTAIQAD SADPDQVAAAVSQAVADLGGLDVLVNNAGVAHVAPAEEFTREQFDRLVNVNIGGVFWAIHAAIPHFGEGS RIINIGSINADRVPAPNLGVYAMTKGAVQALTIGLARELGPRGITITNVQPGPIDTDMNPADGGLAEVMT SVTALGRYGHAGDIAAVVSFLAGPESGYVTGASWNVDGGYTA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4351 | - | - | 100% (252) | oxidoreductase YjgI |
| M. smegmatis MC2 155 | MSMEG_5596 | - | 4e-40 | 38.71% (248) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_5020 | - | 2e-39 | 40.78% (255) | acetoin(diacetyl) reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 1e-33 | 38.71% (248) | 20-beta-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0124 | - | 3e-40 | 40.55% (254) | acetoin reductase |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 1e-33 | 38.71% (248) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 5e-31 | 37.50% (240) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0827 | - | 8e-77 | 56.50% (246) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_2981 | fabG3_1 | 1e-33 | 38.13% (257) | 20-beta-hydroxysteroid dehydrogenase FabG3_1 |
| M. avium 104 | MAV_2509 | - | 3e-33 | 37.50% (248) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_3969 | - | 2e-34 | 34.55% (246) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 8e-30 | 38.02% (242) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_5843 | - | 5e-97 | 68.70% (246) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4351|M.smegmatis_MC2_155 ------------------------MTQAGSSTPLADRRVLVTGGSRGIGA
Mvan_5843|M.vanbaalenii_PYR-1 ----------------------------MSTAPLAGKRALVTGGSRGIGA
MAB_0827|M.abscessus_ATCC_1997 -----------------------------MTSPLKSRRAFVTGGSRGIGA
Mb2025|M.bovis_AF2122/97 -----------------------------MSGRLIGKVALVSGGARGMGA
Rv2002|M.tuberculosis_H37Rv -----------------------------MSGRLIGKVALVSGGARGMGA
MMAR_2981|M.marinum_M -----------------------------MAGRLTGKVALVSGGARGMGA
MAV_2509|M.avium_104 -----------------------------MAERLAGKVALVSGGARGMGA
Mflv_0124|M.gilvum_PYR-GCK -----------------------------MA--INGKVALVTGAARGIGR
MLBr_01807|M.leprae_Br4923 ---------------MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGL
MUL_0315|M.ulcerans_Agy99 ------------------------MRPD-SSPSWCTITSVVTGGASGIGL
TH_3969|M.thermoresistible__bu MGFPEQQQQVPGRQSAMDPVPDCGESSYRGSGKLTGKRAVITGGDSGIGR
.::*. *:*
MSMEG_4351|M.smegmatis_MC2_155 GIVRRLAADGAAVAFTYGASAAEAEKLVGDLTSEGAKVTAIQADSADPDQ
Mvan_5843|M.vanbaalenii_PYR-1 EIVRRLAADGAAVAFTYAASAAHAEKVVAEVAASGGEAVAIRADSADPTQ
MAB_0827|M.abscessus_ATCC_1997 GIVRRLAEDGARVVFTYSSSVQQAADVVDDINEDGGWARAVKADVADPDQ
Mb2025|M.bovis_AF2122/97 SHVRAMVAEGAKVVFG-DILDEEGKAVAAELADA---ARYVHLDVTQPAQ
Rv2002|M.tuberculosis_H37Rv SHVRAMVAEGAKVVFG-DILDEEGKAVAAELADA---ARYVHLDVTQPAQ
MMAR_2981|M.marinum_M SHVRALVAEGAHVVLG-DILDDEGRAVAAELGDA---ARYVHLDVTQPEQ
MAV_2509|M.avium_104 SHVRSLVAEGAKVVFG-DILDDEGKAVAAEVGEA---TRYLHLDVTKPED
Mflv_0124|M.gilvum_PYR-GCK GIALRLARDGADVALV-DVHQDGLDDVAAEIAEIGSKTTTFVADVSDRDQ
MLBr_01807|M.leprae_Br4923 AVARRLVADGHRVAVT------HRASVVPDWFFG------VECDVTDNDA
MUL_0315|M.ulcerans_Agy99 AIARRLSADGTDVATL------DLK--TPDGGLA------FSADVTNRSQ
TH_3969|M.thermoresistible__bu AVAIAYAREGADVLVSYLNEDDDAAEVAQLVTDAGRRCVLVPGDLSDPAH
. :* * . . * :.
MSMEG_4351|M.smegmatis_MC2_155 VAAAVSQAVADLGGLDVLVN-NAGVAHVAPAEEFTREQFDRLVNVNIGGV
Mvan_5843|M.vanbaalenii_PYR-1 VADAVEQTVAELGGLDILVN-NSAVAHIAPIDDFPAEEFDRLVAINIGGV
MAB_0827|M.abscessus_ATCC_1997 LGAAIGQAAEELGGLDILVN-NAGILSIGDVDTATLADFDEIVAVNVRAV
Mb2025|M.bovis_AF2122/97 WTAAVDTAVTAFGGLHVLVN-NAGILNIGTIEDYALTEWQRILDVNLTGV
Rv2002|M.tuberculosis_H37Rv WTAAVDTAVTAFGGLHVLVN-NAGILNIGTIEDYALTEWQRILDVNLTGV
MMAR_2981|M.marinum_M WTAAVDTAVNEFGGLHVLVN-NAGILNIGTIEDYALSEWQRILDINVTGV
MAV_2509|M.avium_104 WDAAVATALAEFGRIDVLVN-NAGIINIGTLEDYALSEWQRILDINLTGV
Mflv_0124|M.gilvum_PYR-GCK VFAAVRHASSALGGFDIMVN-NAGIALVGPISEVTPAEIQKLWSINVDGV
MLBr_01807|M.leprae_Br4923 IGAAFKAVEEHQGPVEVLVA-NAGITSDMLIMRMSEEQFQKVIDVNLTGV
MUL_0315|M.ulcerans_Agy99 VDAALAAIRQRLGPVTILVN-AAGLDGFKRFSNITFEDWQRVIDVNLNGV
TH_3969|M.thermoresistible__bu CRSVIDRAVSEFDGLDVLVVNHAHQMTHPTLEEISDEEWDYTFRLNIGAY
.. . . ::* : . : : :*: .
MSMEG_4351|M.smegmatis_MC2_155 FWAIHAAIPHF--------GEGSRIINIGSINADRVPAPNLGVYAMTKGA
Mvan_5843|M.vanbaalenii_PYR-1 YWAVRSAIRYL--------SEGARIINIGSINADRIPGPGLSVYGMTKGA
MAB_0827|M.abscessus_ATCC_1997 FAGIKAASPHL--------TEGGRIVTIGSINGDSSPTANLSLYSMTKAA
Mb2025|M.bovis_AF2122/97 FLGIRAVVKPM-----KEAGRGS-IINISSIEG-LAGTVACHGYTATKFA
Rv2002|M.tuberculosis_H37Rv FLGIRAVVKPM-----KEAGRGS-IINISSIEG-LAGTVACHGYTATKFA
MMAR_2981|M.marinum_M FLGIRAAVKPM-----KEAGRGS-IINISSIEG-LAGTIASHGYTVSKFA
MAV_2509|M.avium_104 FLGIRAVVKPM-----KKAGRGS-IINISSIEG-MAGTIACHGYTATKFA
Mflv_0124|M.gilvum_PYR-GCK LWGIQAAVAQFTTLHNKEQGKISKIINASSIAG-HDGFAMLGPYSATKFA
MLBr_01807|M.leprae_Br4923 FRVAKLASRNMIK------QRFGRYIFMGSVVG-LSGVPGQANYAASKSG
MUL_0315|M.ulcerans_Agy99 FHTIQAVLPDMVA------AGWGRIVNISSSST-HSGTPYMTHYVAAKSA
TH_3969|M.thermoresistible__bu FHLVKAALPHLKP--------GASIIGSSSVNS-DMPSPTLAPYAATKAA
: . : . : .* * :* .
MSMEG_4351|M.smegmatis_MC2_155 VQALTIGLARELGPRGITITNVQPGPIDTDMN------------PADGGL
Mvan_5843|M.vanbaalenii_PYR-1 VSSFTRGLARDLGPRGITVNNVQPGPIDTDAN------------PDDGAF
MAB_0827|M.abscessus_ATCC_1997 VAGLTRGLAREFGPRGITINNVQPGPIGTDMN------------PEDGQL
Mb2025|M.bovis_AF2122/97 VRGLTKSTALELGPSGIRVNSIHPGLVKTPM--------------TDWVP
Rv2002|M.tuberculosis_H37Rv VRGLTKSTALELGPSGIRVNSIHPGLVKTPM--------------TDWVP
MMAR_2981|M.marinum_M VRGLTKSTALELGPSGIRVNSIHPGLVKTPM--------------TEWVP
MAV_2509|M.avium_104 VRGLTKSAALELGPSGIRVNSIHPGLIKTPM--------------TEWVP
Mflv_0124|M.gilvum_PYR-GCK VRALTQAAAKEHAADGITVNAYCPGVVGTDMWVEIDKRFAELTGAAEGET
MLBr_01807|M.leprae_Br4923 LIGMARSLARELGSRSITANVVAPGFIDTEMTR-------AMDSK----Y
MUL_0315|M.ulcerans_Agy99 VNGLTKALALEYGPSGITVNAVPPGFIDTPMLR-------NAAAQGHLGD
TH_3969|M.thermoresistible__bu IANFSASLAQMLGDKGIRVNSVAPGPIWTPLIP----------STMPPEK
: :: . * . .* . ** : *
MSMEG_4351|M.smegmatis_MC2_155 AEVMTSVTALGRYGHAGDIAAVVSFLAGPESGYVTGASWNVDG----GYT
Mvan_5843|M.vanbaalenii_PYR-1 AESLKQVVAQGRYGHTSDVASLVSFLAGPESGYITGAHLNVDG----GFT
MAB_0827|M.abscessus_ATCC_1997 ADILRPNIAVGRYGQPRDIASLVSYLVSDEAWYITGTAINIDG----GFT
Mb2025|M.bovis_AF2122/97 EDIFQT--ALGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLA
Rv2002|M.tuberculosis_H37Rv EDIFQT--ALGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLA
MMAR_2981|M.marinum_M EDLFQT--ALGRAAEPMEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLA
MAV_2509|M.avium_104 EDIFQS--ALGRAAEPKEVSNLVVYLASDESSYSTGSEFVVDGGTTAGLG
Mflv_0124|M.gilvum_PYR-GCK YDKFVGGIALGRAETPDDVAGFVSYLAGPDSDYMTGQAGLIDG----GLV
MLBr_01807|M.leprae_Br4923 QEAALQAIPLGRIGAVEEIAGAVSFLASEDAGYISGAVIPVDG----GLG
MUL_0315|M.ulcerans_Agy99 IEQNIARTPVRRIGKPEDIAAACAFLVSEEAGYITGQILGVNG----GRN
TH_3969|M.thermoresistible__bu VARFGDDTPLGRAGQPAELAGAYVLLAADEGSYISGARIAVTG----GRP
. * ::: *.. :. * :* : * *
MSMEG_4351|M.smegmatis_MC2_155 A----------------
Mvan_5843|M.vanbaalenii_PYR-1 V----------------
MAB_0827|M.abscessus_ATCC_1997 A----------------
Mb2025|M.bovis_AF2122/97 HNDFGAVEVSSQPEWVT
Rv2002|M.tuberculosis_H37Rv HNDFGAVEVSSQPEWVT
MMAR_2981|M.marinum_M HKDFSAVDVAAQPEWVT
MAV_2509|M.avium_104 HKDFSNVETDAQPDWVT
Mflv_0124|M.gilvum_PYR-GCK YR---------------
MLBr_01807|M.leprae_Br4923 MGH--------------
MUL_0315|M.ulcerans_Agy99 T----------------
TH_3969|M.thermoresistible__bu IL---------------