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MGTYAITGSASGMGAAAVARLRADGHTVITVDIKDADVVADLSTSDGRAAAAAQVLTACDGRLDGAVLAA GLGPSQGAERLRMIATVNYLGVVELLERWRPALAAAANAKVVVIGSNSTTTTPAVPARAVRALLAGDVDK ALRATRLYGPGRPAMVYAASKIAVTRWARRHAVRPEWAGAGIRLNVLAPGAVMTPLLQEQLDNKRQARFV ERFPVPVGGYGQPEQLAEWMRFMLSDAADFLCGSVIFVDGGTDSLFRRDDWPRPVPARRIIGYVQRFRGR G
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5193 | - | - | 100% (281) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_2897 | - | e-100 | 65.37% (283) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_0614 | - | 8e-17 | 30.80% (263) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 1e-17 | 28.52% (256) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1565 | - | 1e-139 | 87.14% (280) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv2857c | - | 1e-17 | 28.52% (256) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-10 | 28.19% (259) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0827 | - | 8e-12 | 26.95% (256) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0248 | - | 1e-108 | 68.35% (278) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5233 | - | 1e-113 | 71.84% (277) | 3-alpha-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3704 | - | 1e-101 | 65.25% (282) | 3-alpha-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_3227 | - | 2e-40 | 57.93% (164) | PUTATIVE 3-alpha-hydroxysteroid dehydrogenase |
| M. ulcerans Agy99 | MUL_4865 | - | 1e-106 | 68.35% (278) | short-chain type dehydrogenase/reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5193|M.vanbaalenii_PYR-1 --------------------MGTYAITGSASGMGAAAVARLRADGHTVIT
Mflv_1565|M.gilvum_PYR-GCK --------------------MGTYAITGSASGMGAAAVARLRADGHTVLT
MMAR_0248|M.marinum_M --------------------MGTYAITGSASGMGNATASRLREAGHRVIG
MUL_4865|M.ulcerans_Agy99 --------------------MGTYAITGSASGMGNATASRLWEAGHRVIG
MAV_5233|M.avium_104 --------------------MGTYAITGSASGMGRETAQRLRDGGHTVIG
MSMEG_3704|M.smegmatis_MC2_155 ---MPQFLSTFSVGGCPGGIIGTYAVTGAASGMGYQAAQKLREQGHTVIG
TH_3227|M.thermoresistible__bu --------------------------------MGRAAAEKLRAAGHRVIG
Mb2882c|M.bovis_AF2122/97 MMDLSQR-----------LAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
Rv2857c|M.tuberculosis_H37Rv MMDLSQR-----------LAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MAB_0827|M.abscessus_ATCC_1997 MTSPLK--------------SRRAFVTGGSRGIGAGIVRRLAEDGARVVF
:* :: * :
Mvan_5193|M.vanbaalenii_PYR-1 VDIKDADVVADLSTSDGRAAAAAQVLTACDGRLDGAVLAAGLGPSQGAER
Mflv_1565|M.gilvum_PYR-GCK VDIKDADVVADLSTADGRADAAAQVLAACAGRLDGAVLAAGLGPSQGAER
MMAR_0248|M.marinum_M VDLDGADVVADLSTQQGRLRAASDVIAACDGRLDGAVLAAGLGPSPGPGR
MUL_4865|M.ulcerans_Agy99 VDLDGADVVADLSTQQGRLRAASDVIAACDGRLDGAVLAAGLGPSPGPGR
MAV_5233|M.avium_104 VDIKDADVIADLSTPAGRADAAARVLSQAGDRLDGAVLAAGLGPSPARDR
MSMEG_3704|M.smegmatis_MC2_155 VDLKEGEVVSDLSTPEGRRRAADEVMRLSGGRLDGAVLAAGLGPGPGAER
TH_3227|M.thermoresistible__bu VDLKDAEVVADLSTPAGRAAAADQVLAAAESRLDGAVLAAGLGPRPGRDS
Mb2882c|M.bovis_AF2122/97 GDVDVEAGG--------AAADELSGLFVPTDVCDEDAVNGLFDGAAETYG
Rv2857c|M.tuberculosis_H37Rv GDVDVEAGG--------AAADELSGLFVPTDVCDEDAVNGLFDGAAETYG
MLBr_01807|M.leprae_Br4923 THRASVVP--------------DWFFGVECDVTDNDAIGAAFKAVEEHQG
MAB_0827|M.abscessus_ATCC_1997 TYSSSVQQAADVVD--DINEDGGWARAVKADVADPDQLGAAIGQAAEELG
. * : . :
Mvan_5193|M.vanbaalenii_PYR-1 LRMIATVNYLGVVELLERWRPALAAAANAKVVVIGSNSTTTTPAVPARAV
Mflv_1565|M.gilvum_PYR-GCK LRLIGAVNYLGVVDLLTRWRPALAVAQNAKVVVVGSNSTTTTPAVPGRAV
MMAR_0248|M.marinum_M LHRIAQVNYLGVVELLQAWRPALAAAERAKAVVIASNSTTTVPMVPRRSV
MUL_4865|M.ulcerans_Agy99 LHRIAQVNYLGVVELLQARRPALAAAERAKAVVIASNSTTTVPMVPRRSV
MAV_5233|M.avium_104 VRQIAAVNYFGVVELLQAWRPALAAAGNAKVVVVASNSATTMPTVPRRTV
MSMEG_3704|M.smegmatis_MC2_155 PRLIAEVNFLGVVELLEAWRPALAAADRAKVVVLSSNSTTTTPAVPARAI
TH_3227|M.thermoresistible__bu ARMIVQVNYFGVVELLQSWRPALAAAGNAKVVVIGSNSTTTIPLVPRX--
Mb2882c|M.bovis_AF2122/97 -RIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHM
Rv2857c|M.tuberculosis_H37Rv -RIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHM
MLBr_01807|M.leprae_Br4923 -PVEVLVANAGITS--DMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNM
MAB_0827|M.abscessus_ATCC_1997 -GLDILVNNAGILS--IGDVDTATLADFDEIVAVNVRAVFAGIKAASPHL
. *: . : .. .
Mvan_5193|M.vanbaalenii_PYR-1 RALLAGDVDKALRATRLYGPGRPAMVYAASKIAVTRWARRHAVRPEWAGA
Mflv_1565|M.gilvum_PYR-GCK RALLAGDVDRAIRAVRLYGPGKPAMMYAASKIAVTRWARRTAVLPEWAGA
MMAR_0248|M.marinum_M RALLDHDADKAVRAVRLFGKAAPSLMYAASKIAVSHWVRRQAVLPEWAGS
MUL_4865|M.ulcerans_Agy99 RALLDHDADKAVRAVRLFGRAAPSLMYGASKIAVSHWARRQAVLPEWAGS
MAV_5233|M.avium_104 NALLAHDADKALRSVRLFGPAAPTMMYGASKLAVSRWVRRHAVLAEWAGS
MSMEG_3704|M.smegmatis_MC2_155 RALLARDTDKAVRTVRVLGRAGTPIMYAASKIAVSRWVRRTAVSAAWAGA
TH_3227|M.thermoresistible__bu -------------------------------------XRLLTISGALGTG
Mb2882c|M.bovis_AF2122/97 VLAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGV--QFARQ
Rv2857c|M.tuberculosis_H37Rv VLAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGV--QFARQ
MLBr_01807|M.leprae_Br4923 IKQRFGRYIFMGSVVG-LSGVPGQANYAASKSGLIGMARSLAR--ELGSR
MAB_0827|M.abscessus_ATCC_1997 TEG--GRIVTIGSINGDSSPTANLSLYSMTKAAVAGLTRGLAR--EFGPR
* .
Mvan_5193|M.vanbaalenii_PYR-1 GIRLNVLAPGAVMTPLLQEQLDNKRQARFVERFPVPVGGYGQPEQLAEWM
Mflv_1565|M.gilvum_PYR-GCK GIRLNVLAPGAVMTPLLQEQLDNKRQAKFVEKFPVPVGGYGEPDLLARWM
MMAR_0248|M.marinum_M GVRLNALAPGAIMTPLLAEQLSDPTQAKAVRSFPIPIGGFGEVTHMADWI
MUL_4865|M.ulcerans_Agy99 GVRLNALAPGAIMTPLLAEQLSVPTQAKAVRSFPIPVGGFGEVTHMADWI
MAV_5233|M.avium_104 GVRLNALSPGAIMTPLLQEQLSTPRQARAVRSFPVPVGGFGDPGQLAEWM
MSMEG_3704|M.smegmatis_MC2_155 GIRLNALAPGAIMTPLLQSQLAEPLESKAVRAFPVPIGGFGDAGQLADWI
TH_3227|M.thermoresistible__bu NILPSPVRPPVSGVPTVTWRIVGRRYAVHSRVHPGKACG-----------
Mb2882c|M.bovis_AF2122/97 GIRVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAAAV
Rv2857c|M.tuberculosis_H37Rv GIRVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAAAV
MLBr_01807|M.leprae_Br4923 SITANVVAPGFIDTEMTRAMDSKYQEAALQ---AIPLGRIGAVEEIAGAV
MAB_0827|M.abscessus_ATCC_1997 GITINNVQPGPIGTDMN-PEDGQLADILRP---NIAVGRYGQPRDIASLV
.: . : * .
Mvan_5193|M.vanbaalenii_PYR-1 RFMLSDAADFLCGSVIFVDGGTDSLFRRDDWPRPVPARRIIGYVQRFRGR
Mflv_1565|M.gilvum_PYR-GCK CFMLSDAADFVCGSVIFVDGGTDALFRGDDWPRPVPVRRIARYVKRFLGR
MMAR_0248|M.marinum_M CFMLSDSADFLCGSVVFVDGGSDAYFRADDWPRSVPARRLPGYLLSFRRG
MUL_4865|M.ulcerans_Agy99 CFMLSDSADFLCGSVVFVDGGSDAYFRADDWPRPVPARRLPGYLLKFRRG
MAV_5233|M.avium_104 CFMLSDAADFLCGSVVFVDGGTDAYFRADDWPKVLPARRLPGYLRRFTR-
MSMEG_3704|M.smegmatis_MC2_155 CFMLSDSADFLCGSVVFVDGGSDAYFRATSWPRAVPVRGLAQYLWRFKRG
TH_3227|M.thermoresistible__bu ----------------------QFKMRSSPWHRTR-SGGLRGYRRSSR--
Mb2882c|M.bovis_AF2122/97 AFLASDDASFITASTFLVDGGISSAYVTPL--------------------
Rv2857c|M.tuberculosis_H37Rv AFLASDDASFITASTFLVDGGISSAYVTPL--------------------
MLBr_01807|M.leprae_Br4923 SFLASEDAGYISGAVIPVDGGLGMGH------------------------
MAB_0827|M.abscessus_ATCC_1997 SYLVSDEAWYITGTAINIDGGFTA--------------------------
Mvan_5193|M.vanbaalenii_PYR-1 G-----
Mflv_1565|M.gilvum_PYR-GCK R-----
MMAR_0248|M.marinum_M SRSNIR
MUL_4865|M.ulcerans_Agy99 TRTTVR
MAV_5233|M.avium_104 ----FR
MSMEG_3704|M.smegmatis_MC2_155 AG---R
TH_3227|M.thermoresistible__bu ------
Mb2882c|M.bovis_AF2122/97 ------
Rv2857c|M.tuberculosis_H37Rv ------
MLBr_01807|M.leprae_Br4923 ------
MAB_0827|M.abscessus_ATCC_1997 ------