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MTRTALVTGAGGGIGAATVARLAADGVHVIATDVAETIPALAADVDYVSFDLLTGDPQTLLSLIPGGALD YLVNAAGVALFDRDGSTLDVSESVWELTLGVNLHGMRRLTVAAVPYLRAGQGKSIVNVASIAGLRNMDSP LDAYQVSKAAVVSLTRSLALQLAPEGIRVNTVCPGAILTPMIEPLYLENPARRTNMEQRTPLGRMGFPVD IANAIRFLLSDEASFITATDLVVDGGWIAQTV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0614 | - | - | 100% (242) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_2281 | - | 3e-31 | 32.50% (240) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5918 | - | 6e-31 | 37.25% (247) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 3e-32 | 35.80% (243) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4062 | - | 1e-30 | 31.67% (240) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2857c | - | 3e-32 | 35.80% (243) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 1e-22 | 32.79% (244) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0072c | - | 2e-30 | 37.41% (270) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_3470 | - | 2e-30 | 36.03% (247) | short chain membrane-associated dehydrogenase |
| M. avium 104 | MAV_3714 | - | 3e-33 | 34.58% (240) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3830 | - | 2e-98 | 74.17% (240) | 3-oxoacyl- |
| M. thermoresistible (build 8) | TH_4254 | - | 6e-35 | 37.45% (251) | PUTATIVE putative 2,5-dichloro-2,5-cyclohexadiene-1,4-diol |
| M. ulcerans Agy99 | MUL_0336 | - | 4e-27 | 34.10% (261) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0614|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3830|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3714|M.avium_104 --------------------------------------------------
Mflv_4062|M.gilvum_PYR-GCK --------------------------------------------------
TH_4254|M.thermoresistible__bu --------------------------------------------------
MMAR_3470|M.marinum_M --------------------------------------------------
MUL_0336|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mvan_0614|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3830|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3714|M.avium_104 --------------------------------------------------
Mflv_4062|M.gilvum_PYR-GCK --------------------------------------------------
TH_4254|M.thermoresistible__bu --------------------------------------------------
MMAR_3470|M.marinum_M --------------------------------------------------
MUL_0336|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mvan_0614|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3830|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3714|M.avium_104 --------------------------------------------------
Mflv_4062|M.gilvum_PYR-GCK --------------------------------------------------
TH_4254|M.thermoresistible__bu --------------------------------------------------
MMAR_3470|M.marinum_M --------------------------------------------------
MUL_0336|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mvan_0614|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3830|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0072c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3714|M.avium_104 --------------------------------------------------
Mflv_4062|M.gilvum_PYR-GCK --------------------------------------------------
TH_4254|M.thermoresistible__bu --------------------------------------------------
MMAR_3470|M.marinum_M --------------------------------------------------
MUL_0336|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mvan_0614|M.vanbaalenii_PYR-1 ------MT-----RTALVTGAGGGIGAATVARLAADGVHVIATDVAE---
MSMEG_3830|M.smegmatis_MC2_155 ------MS-----RTALVTGANGGIGSATVARLVKNGVEVIATDLGE---
MAB_0072c|M.abscessus_ATCC_199 ------MTGRLTGKVALVTGAARGIGRAQAVRFAQEGADIIALDICAPVH
Mb2882c|M.bovis_AF2122/97 ---MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAG
Rv2857c|M.tuberculosis_H37Rv ---MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAG
MAV_3714|M.avium_104 ---MMDLTQRLAGRVAVITGAGGGIGLAAARRMHAEGATIVVADIDADAG
Mflv_4062|M.gilvum_PYR-GCK ----MDLSQRLKDKVAVITGGASGIGLATAKRMRSEGAIVVIGDLDEKTG
TH_4254|M.thermoresistible__bu ---MTAGSTRLAGKVVLVTGAGGGLGTAIARRLADEGARLVLADLQESQC
MMAR_3470|M.marinum_M ------MLDHRASRTFVVTGASSGIGLATVGRLLEQGCAVVGADVVTP--
MUL_0336|M.ulcerans_Agy99 ------MVDELAGKIAIVTGGASGIGRATVARFIAEGARVVIADVEEERG
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
: ::**. *:* * . :* :: *:
Mvan_0614|M.vanbaalenii_PYR-1 ---TIPALAADVDYVSFDLLTGDPQTLLSLIPGGAL--------DYLVNA
MSMEG_3830|M.smegmatis_MC2_155 ---RSDTVPADADYVPFDLRSGDPHELFERLGGRGL--------DYLVNA
MAB_0072c|M.abscessus_ATCC_199 TTITPPATRADLDKTSELVESAGRRVIPGVVDVRNLRDVQTFTQDAVTEF
Mb2882c|M.bovis_AF2122/97 GAAADELSG-----LFVPTDVCDEDAVNGLFDGAAETYG---RIDIAFNN
Rv2857c|M.tuberculosis_H37Rv GAAADELSG-----LFVPTDVCDEDAVNGLFDGAAETYG---RIDIAFNN
MAV_3714|M.avium_104 AAAADELSG-----LFVPTDVADEDAVNALFDTAVRRYG---RIDIAFNN
Mflv_4062|M.gilvum_PYR-GCK KSVANDLNV-----TFVQVDVSDQVAVDNLFDTAFEVHG---GVDIAFNN
TH_4254|M.thermoresistible__bu AALADELPAPAGAHHPLGFDVADETAWISAISTVSAQYG---ALHALVNN
MMAR_3470|M.marinum_M ---PHDLGPR---FTFVTADVTDEDAVAGVFDAVPDR------LDGVVHS
MUL_0336|M.ulcerans_Agy99 ESLAAALGAD---AMFCRTDVSQPEQVAAVVAAAVDNFG---GLHVMVNN
MLBr_02565|M.leprae_Br4923 ALDETANRVG---GTTLSLDVTADDAVDKITEHLHDYQGG--HADILVNN
. .
Mvan_0614|M.vanbaalenii_PYR-1 AGVALFDRDG------STLDVSESVWELTLGVNLHGMRRLTVAAVPYLRA
MSMEG_3830|M.smegmatis_MC2_155 AGVALFDRDG------SMLDIDESIWDVTLGVNLHGLRKVTAAAVEHLRR
MAB_0072c|M.abscessus_ATCC_199 GGLDIVCATAGITSRRMLLDMPESDWQTMLDVNLTGVWHTTRAATPHLIA
Mb2882c|M.bovis_AF2122/97 AGISPPEDNL-------IENTELAAWQRVQDVNLKSVYLCCRAALRHMVL
Rv2857c|M.tuberculosis_H37Rv AGISPPEDNL-------IENTELAAWQRVQDVNLKSVYLCCRAALRHMVL
MAV_3714|M.avium_104 AGISPPDDDV-------IENTEPPAWQRVQDVNLKSVYLCCRAALRHMVS
Mflv_4062|M.gilvum_PYR-GCK AGISPPEDDL-------IENTGIDAWDRVQDINLKSVFFCCKAALRHMVP
TH_4254|M.thermoresistible__bu AAIGALGN---------VAEERLERWDRILDVGATGVWLGMKHAVPLIRR
MMAR_3470|M.marinum_M AGVAGGGP---------VHLLARAEWDRVIGVNLTGTFLVAKAALARMIE
MUL_0336|M.ulcerans_Agy99 AGVSGAMHRR-------FLDDDLADFHRVMAVNVLGVMAGTRDAARHMAA
MLBr_02565|M.leprae_Br4923 AGITRDKLLA---------NMDDCRWDAVLEVNLLAPQRLTEGLVGNGSI
..: :. :. .
Mvan_0614|M.vanbaalenii_PYR-1 -----GQGKSIVNVASIAGLRNMDSPLDAYQVSKAAVVSLTRSLALQLAP
MSMEG_3830|M.smegmatis_MC2_155 -----GSGKSIVNVASTAGLRGMDSPLDAYQVSKAAVVSLTRALALQLAP
MAB_0072c|M.abscessus_ATCC_199 -----RGGGAMVLVSSIAGLRGLVG-VSHYVAAKHGVVGLMRSLAIELAP
Mb2882c|M.bovis_AF2122/97 -----AGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFAR
Rv2857c|M.tuberculosis_H37Rv -----AGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFAR
MAV_3714|M.avium_104 -----ARRGSIINTASFVAVMGSATSQISYTAAKGGVLALSRELGVQFAR
Mflv_4062|M.gilvum_PYR-GCK -----AQKGSIVNTASFVAVNGSATSQISYTASKGGVLAMSRELGIQYAR
TH_4254|M.thermoresistible__bu -----SGGGSVVNICSIFGTVGGFGDSAAYHAAKGAVRTLTKNAALHWAP
MMAR_3470|M.marinum_M QPRVDGERGSIVTLASIEGLEGTAG-GSSYNAAKGGVVLLTKNIALDYGP
MUL_0336|M.ulcerans_Agy99 -----HGGGSIVNLTSIGGIQAGGG-VMTYRASKGAVIQFTKSAAIELAH
MLBr_02565|M.leprae_Br4923 S-----KGGRVIVLSSMAGIAGNRG-QTNYATAKAGVIGLTQALAPGLAE
:: * . * .:* .* : : . .
Mvan_0614|M.vanbaalenii_PYR-1 EGIRVNTVCPGAILTPMIEPLYL---------ENPARRTNMEQRTPLGRM
MSMEG_3830|M.smegmatis_MC2_155 EGIRANTVCPGAILTPMIDHLYV---------ENPARRVDMENRTPMRRL
MAB_0072c|M.abscessus_ATCC_199 HKIRVNTVHPTNVDTPMIQNEFVRT-LFRPDLEQPTREDFAAAAKTMNLL
Mb2882c|M.bovis_AF2122/97 QGIRVNALCPGPVNTPLLQELFA---------KNPERAARRMVHVPLGRF
Rv2857c|M.tuberculosis_H37Rv QGIRVNALCPGPVNTPLLQELFA---------KNPERAARRMVHVPLGRF
MAV_3714|M.avium_104 QGIRVNALCPGPVNTPLLQELFA---------KDPQRAARRLVHVPVGRF
Mflv_4062|M.gilvum_PYR-GCK QGIRVNALCPGPVNTPLLQELFA---------KDPERAARRLVHVPMGRF
TH_4254|M.thermoresistible__bu DGVRVNSLHPGFIETPQLRELY----------KGTERYERMLAGTPLGRL
MMAR_3470|M.marinum_M SGIRANAICPGFIATPLAEGVFG-------MPGMEGPRASITNEHALQRL
MUL_0336|M.ulcerans_Agy99 YEIRVNAIAPGNIPTPLLASSAAGLDQEQVERFTAQIRQTMREDRPLKRE
MLBr_02565|M.leprae_Br4923 KGITINAVAPGFIETQMTAAIPL------------ATREVGRRLNSLLQG
: *:: * : * .:
Mvan_0614|M.vanbaalenii_PYR-1 GFP----VDIANAIRFLLSDEASFITATDLVVDGGWIAQTV---------
MSMEG_3830|M.smegmatis_MC2_155 GMP----DEIASAIAFLLSDEASFVTATDLVVDGGWTAQIK---------
MAB_0072c|M.abscessus_ATCC_199 DLPWVEPLDIANASLFLASDEARYITSVSLPVDAGSTQR-----------
Mb2882c|M.bovis_AF2122/97 AEP----DEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL------
Rv2857c|M.tuberculosis_H37Rv AEP----DEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL------
MAV_3714|M.avium_104 AEP----GEIAAAAAFLASDDASFITASTFLVDGGISAAYVTPL------
Mflv_4062|M.gilvum_PYR-GCK AEP----EELAAAVAFLASDDASFITGSSFLVDGGITGHYVTPL------
TH_4254|M.thermoresistible__bu GRP----DEIAAVVAFLVSDDASFITGSEVYADGGWTAR-----------
MMAR_3470|M.marinum_M GKP----EEIAAMAAFLLSPDASFVTGQAIAVDGGYTAGRDHGVVRLFGL
MUL_0336|M.ulcerans_Agy99 GTP----EDIAEAALYFAGERSRYVTGTVLPVDGGTVAGKVIRRSR----
MLBr_02565|M.leprae_Br4923 GLP----VDVAETIAYFAIPASNAVTGNVIRVCGQAMLGA----------
* ::* :: : :*. . . .
Mvan_0614|M.vanbaalenii_PYR-1 --
MSMEG_3830|M.smegmatis_MC2_155 --
MAB_0072c|M.abscessus_ATCC_199 --
Mb2882c|M.bovis_AF2122/97 --
Rv2857c|M.tuberculosis_H37Rv --
MAV_3714|M.avium_104 --
Mflv_4062|M.gilvum_PYR-GCK --
TH_4254|M.thermoresistible__bu --
MMAR_3470|M.marinum_M PQ
MUL_0336|M.ulcerans_Agy99 --
MLBr_02565|M.leprae_Br4923 --