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M. vanbaalenii PYR-1 Mvan_2897 (-)

annotation: NAD-dependent epimerase/dehydratase
coordinates: 3070036 - 3070908
length: 290

MGTYVVSGSASGMGHAAAERLRAAGHSVIGVDITATPRPLDVAADLSTAEGRRSAAEEVLAACGGALDGA
ILAAGVGPVAGRDRLIAQVNYFGVVELLTALRPAFARTAAAKVVVVSSNSTTTTPLVPQRAVRALLAGDV
ENALRAVRWFGKRSAPMTYAASKIAVSRWVRRHAVTQQWAGAGIRLNALAPGAIMTPLLAEQLADPTESK
AIKAFPVPIGGYGDAGHLADWMVFMLSEAADFLCGSVIFVDGGSDAYFRSESWPAPVPARMLPRYAQRFL
GYRRATRPVA
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_2897--100% (290)NAD-dependent epimerase/dehydratase
M. vanbaalenii PYR-1Mvan_5193-e-10065.37% (283) NAD-dependent epimerase/dehydratase
M. vanbaalenii PYR-1Mvan_2281-9e-1829.17% (264) short chain dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2882c-9e-1729.50% (261) short chain dehydrogenase
M. gilvum PYR-GCKMflv_1565-1e-10065.26% (285) NAD-dependent epimerase/dehydratase
M. tuberculosis H37RvRv2857c-9e-1729.50% (261) short chain dehydrogenase
M. leprae Br4923MLBr_01807fabG16e-0724.62% (264) 3-oxoacyl-
M. abscessus ATCC 19977MAB_4490c-4e-1226.32% (266) oxidoreductase
M. marinum MMMAR_0248-1e-10465.05% (289) short-chain type dehydrogenase/reductase
M. avium 104MAV_5233-1e-10063.51% (285) 3-alpha-hydroxysteroid dehydrogenase
M. smegmatis MC2 155MSMEG_3704-1e-10367.26% (281) 3-alpha-hydroxysteroid dehydrogenase
M. thermoresistible (build 8)TH_3227-6e-3460.16% (128) PUTATIVE 3-alpha-hydroxysteroid dehydrogenase
M. ulcerans Agy99MUL_4865-1e-10263.67% (289) short-chain type dehydrogenase/reductase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_0248|M.marinum_M               --------------------MGTYAITGSASGMGNATASRLREAGHRVIG
MUL_4865|M.ulcerans_Agy99           --------------------MGTYAITGSASGMGNATASRLWEAGHRVIG
MAV_5233|M.avium_104                --------------------MGTYAITGSASGMGRETAQRLRDGGHTVIG
Mflv_1565|M.gilvum_PYR-GCK          --------------------MGTYAITGSASGMGAAAVARLRADGHTVLT
Mvan_2897|M.vanbaalenii_PYR-1       --------------------MGTYVVSGSASGMGHAAAERLRAAGHSVIG
MSMEG_3704|M.smegmatis_MC2_155      ---MPQFLSTFSVGGCPGGIIGTYAVTGAASGMGYQAAQKLREQGHTVIG
TH_3227|M.thermoresistible__bu      --------------------------------MGRAAAEKLRAAGHRVIG
Mb2882c|M.bovis_AF2122/97           MMDLSQRLAG-----------RVAVITGGGSGIGLAAGRRMRAEGAT---
Rv2857c|M.tuberculosis_H37Rv        MMDLSQRLAG-----------RVAVITGGGSGIGLAAGRRMRAEGAT---
MLBr_01807|M.leprae_Br4923          MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHR---
MAB_4490c|M.abscessus_ATCC_199      MFDDPRALFDIAG--------KSAIVIGATGSLGQIASRALAGAGANVAI
                                                                    :*  .   :   *     

MMAR_0248|M.marinum_M               VDLDGA----DVVADLSTQQGRLRAASDVIAACDGRLDGAVLAAGLGPSP
MUL_4865|M.ulcerans_Agy99           VDLDGA----DVVADLSTQQGRLRAASDVIAACDGRLDGAVLAAGLGPSP
MAV_5233|M.avium_104                VDIKDA----DVIADLSTPAGRADAAARVLSQAGDRLDGAVLAAGLGPSP
Mflv_1565|M.gilvum_PYR-GCK          VDIKDA----DVVADLSTADGRADAAAQVLAACAGRLDGAVLAAGLGPSQ
Mvan_2897|M.vanbaalenii_PYR-1       VDITATPRPLDVAADLSTAEGRRSAAEEVLAACGGALDGAILAAGVGPVA
MSMEG_3704|M.smegmatis_MC2_155      VDLKEG----EVVSDLSTPEGRRRAADEVMRLSGGRLDGAVLAAGLGPGP
TH_3227|M.thermoresistible__bu      VDLKDA----EVVADLSTPAGRAAAADQVLAAAESRLDGAVLAAGLGPRP
Mb2882c|M.bovis_AF2122/97           ----------IVVGDVDVEAGGAAADELSGLFVPTDVCDEDAVNGLFDGA
Rv2857c|M.tuberculosis_H37Rv        ----------IVVGDVDVEAGGAAADELSGLFVPTDVCDEDAVNGLFDGA
MLBr_01807|M.leprae_Br4923          ----------VAV----THRASVVPDWFFG--VECDVTDNDAIGAAFKAV
MAB_4490c|M.abscessus_ATCC_199      CG--------SREDALSDLRDELAAAPGCIVPIARRPDSESASDAIVKET
                                                            .             .     .     

MMAR_0248|M.marinum_M               GPGRLHRIAQVNYLGVVELLQAWRPALAAAERAKAVVIASNSTTTVPMVP
MUL_4865|M.ulcerans_Agy99           GPGRLHRIAQVNYLGVVELLQARRPALAAAERAKAVVIASNSTTTVPMVP
MAV_5233|M.avium_104                ARDRVRQIAAVNYFGVVELLQAWRPALAAAGNAKVVVVASNSATTMPTVP
Mflv_1565|M.gilvum_PYR-GCK          GAERLRLIGAVNYLGVVDLLTRWRPALAVAQNAKVVVVGSNSTTTTPAVP
Mvan_2897|M.vanbaalenii_PYR-1       GRDRL--IAQVNYFGVVELLTALRPAFARTAAAKVVVVSSNSTTTTPLVP
MSMEG_3704|M.smegmatis_MC2_155      GAERPRLIAEVNFLGVVELLEAWRPALAAADRAKVVVLSSNSTTTTPAVP
TH_3227|M.thermoresistible__bu      GRDSARMIVQVNYFGVVELLQSWRPALAAAGNAKVVVIGSNSTTTIPLVP
Mb2882c|M.bovis_AF2122/97           AETYGRIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAA
Rv2857c|M.tuberculosis_H37Rv        AETYGRIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAA
MLBr_01807|M.leprae_Br4923          EEHQGPVEVLVANAGITS--DMLIMRMSEEQFQKVIDVNLTGVFRVAKLA
MAB_4490c|M.abscessus_ATCC_199      IEAFGGVDILVVASGVNEVAPAVD--MQPARFEAVLDANVTSTWLAVRSA
                                              .   *:                  .     ...      .

MMAR_0248|M.marinum_M               RRSVRALLDHDADKAVRAVR-LFGKAAPSLMYAASKIAVSHWVRRQAVLP
MUL_4865|M.ulcerans_Agy99           RRSVRALLDHDADKAVRAVR-LFGRAAPSLMYGASKIAVSHWARRQAVLP
MAV_5233|M.avium_104                RRTVNALLAHDADKALRSVR-LFGPAAPTMMYGASKLAVSRWVRRHAVLA
Mflv_1565|M.gilvum_PYR-GCK          GRAVRALLAGDVDRAIRAVR-LYGPGKPAMMYAASKIAVTRWARRTAVLP
Mvan_2897|M.vanbaalenii_PYR-1       QRAVRALLAGDVENALRAVR-WFGKRSAPMTYAASKIAVSRWVRRHAVTQ
MSMEG_3704|M.smegmatis_MC2_155      ARAIRALLARDTDKAVRTVR-VLGRAGTPIMYAASKIAVSRWVRRTAVSA
TH_3227|M.thermoresistible__bu      RX-------------XRLLT-ISG--------------------------
Mb2882c|M.bovis_AF2122/97           LRHMVLAGKGSIVNTASFVA-VMGSATSQISYTASKGGVLAMSR--ELGV
Rv2857c|M.tuberculosis_H37Rv        LRHMVLAGKGSIVNTASFVA-VMGSATSQISYTASKGGVLAMSR--ELGV
MLBr_01807|M.leprae_Br4923          SRNMIKQRFGRYIFMGSVVG-LSG-VPGQANYAASKSGLIGMAR--SLAR
MAB_4490c|M.abscessus_ATCC_199      GRAMIERGRGGKIILTSSARGKLGHPAGYTAYCASKAAVDGLVR--SFGC
                                                           *                          

MMAR_0248|M.marinum_M               EWAGSGVRLNALAPGAIMTPLLAEQLSDPTQAKAVRS---FPIPIGGFGE
MUL_4865|M.ulcerans_Agy99           EWAGSGVRLNALAPGAIMTPLLAEQLSVPTQAKAVRS---FPIPVGGFGE
MAV_5233|M.avium_104                EWAGSGVRLNALSPGAIMTPLLQEQLSTPRQARAVRS---FPVPVGGFGD
Mflv_1565|M.gilvum_PYR-GCK          EWAGAGIRLNVLAPGAVMTPLLQEQLDNKRQAKFVEK---FPVPVGGYGE
Mvan_2897|M.vanbaalenii_PYR-1       QWAGAGIRLNALAPGAIMTPLLAEQLADPTESKAIKA---FPVPIGGYGD
MSMEG_3704|M.smegmatis_MC2_155      AWAGAGIRLNALAPGAIMTPLLQSQLAEPLESKAVRA---FPVPIGGFGD
TH_3227|M.thermoresistible__bu      ----------ALGTGNILPSPVRPPVSG--------------VPTVTWRI
Mb2882c|M.bovis_AF2122/97           QFARQGIRVNALCPGPVNTPLLQELFAKNPERAARRM---VHVPLGRFAE
Rv2857c|M.tuberculosis_H37Rv        QFARQGIRVNALCPGPVNTPLLQELFAKNPERAARRM---VHVPLGRFAE
MLBr_01807|M.leprae_Br4923          ELGSRSITANVVAPGFIDTEMTRAMDSKYQEAALQ------AIPLGRIGA
MAB_4490c|M.abscessus_ATCC_199      EWGRYGITVNGLAPTVFRSPLTSWMFTDEPAAQATRENFLSRIPLGRLGE
                                               : .  . .                       :*      

MMAR_0248|M.marinum_M               VTHMADWICFMLSDSADFLCGSVVFVDGGSDAYFRADDWPRSVPARRLPG
MUL_4865|M.ulcerans_Agy99           VTHMADWICFMLSDSADFLCGSVVFVDGGSDAYFRADDWPRPVPARRLPG
MAV_5233|M.avium_104                PGQLAEWMCFMLSDAADFLCGSVVFVDGGTDAYFRADDWPKVLPARRLPG
Mflv_1565|M.gilvum_PYR-GCK          PDLLARWMCFMLSDAADFVCGSVIFVDGGTDALFRGDDWPRPVPVRRIAR
Mvan_2897|M.vanbaalenii_PYR-1       AGHLADWMVFMLSEAADFLCGSVIFVDGGSDAYFRSESWPAPVPARMLPR
MSMEG_3704|M.smegmatis_MC2_155      AGQLADWICFMLSDSADFLCGSVVFVDGGSDAYFRATSWPRAVPVRGLAQ
TH_3227|M.thermoresistible__bu      VG---RRYAVHSRVHPGKACG---------QFKMRSSPWHRTRSG-GLRG
Mb2882c|M.bovis_AF2122/97           PDEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL------------
Rv2857c|M.tuberculosis_H37Rv        PDEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL------------
MLBr_01807|M.leprae_Br4923          VEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH----------------
MAB_4490c|M.abscessus_ATCC_199      PEDLAGPILFLSAPASDFLTGHVVYPDGGYTAG-----------------
                                             .     ..   .                             

MMAR_0248|M.marinum_M               YLLSFRRGSRSNIR--
MUL_4865|M.ulcerans_Agy99           YLLKFRRGTRTTVR--
MAV_5233|M.avium_104                YLRRFTR-----FR--
Mflv_1565|M.gilvum_PYR-GCK          YVKRFLG-----RR--
Mvan_2897|M.vanbaalenii_PYR-1       YAQRFLGYRRATRPVA
MSMEG_3704|M.smegmatis_MC2_155      YLWRFKRG---AGR--
TH_3227|M.thermoresistible__bu      YRRSSR----------
Mb2882c|M.bovis_AF2122/97           ----------------
Rv2857c|M.tuberculosis_H37Rv        ----------------
MLBr_01807|M.leprae_Br4923          ----------------
MAB_4490c|M.abscessus_ATCC_199      ----------------