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MPQFLSTFSVGGCPGGIIGTYAVTGAASGMGYQAAQKLREQGHTVIGVDLKEGEVVSDLSTPEGRRRAAD EVMRLSGGRLDGAVLAAGLGPGPGAERPRLIAEVNFLGVVELLEAWRPALAAADRAKVVVLSSNSTTTTP AVPARAIRALLARDTDKAVRTVRVLGRAGTPIMYAASKIAVSRWVRRTAVSAAWAGAGIRLNALAPGAIM TPLLQSQLAEPLESKAVRAFPVPIGGFGDAGQLADWICFMLSDSADFLCGSVVFVDGGSDAYFRATSWPR AVPVRGLAQYLWRFKRGAGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3704 | - | - | 100% (300) | 3-alpha-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2598 | - | 4e-20 | 31.70% (265) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4862 | - | 3e-13 | 26.80% (250) | 3-alpha-hydroxysteroid dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 8e-19 | 32.08% (265) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1565 | - | 1e-102 | 65.34% (277) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv2857c | - | 8e-19 | 32.08% (265) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 1e-06 | 30.84% (107) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4490c | - | 5e-12 | 32.57% (175) | oxidoreductase |
| M. marinum M | MMAR_0248 | - | 1e-111 | 69.40% (281) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5233 | - | 1e-109 | 67.74% (279) | 3-alpha-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_3227 | - | 2e-38 | 67.54% (114) | PUTATIVE 3-alpha-hydroxysteroid dehydrogenase |
| M. ulcerans Agy99 | MUL_4865 | - | 1e-107 | 68.21% (280) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_2897 | - | 1e-103 | 67.26% (281) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0248|M.marinum_M --------------------MGTYAITGSASGMGNATASRLREAGHRVIG
MUL_4865|M.ulcerans_Agy99 --------------------MGTYAITGSASGMGNATASRLWEAGHRVIG
MAV_5233|M.avium_104 --------------------MGTYAITGSASGMGRETAQRLRDGGHTVIG
Mflv_1565|M.gilvum_PYR-GCK --------------------MGTYAITGSASGMGAAAVARLRADGHTVLT
Mvan_2897|M.vanbaalenii_PYR-1 --------------------MGTYVVSGSASGMGHAAAERLRAAGHSVIG
MSMEG_3704|M.smegmatis_MC2_155 ---MPQFLSTFSVGGCPGGIIGTYAVTGAASGMGYQAAQKLREQGHTVIG
TH_3227|M.thermoresistible__bu --------------------------------MGRAAAEKLRAAGHRVIG
Mb2882c|M.bovis_AF2122/97 MMDLSQRLAG-----------RVAVITGGGSGIGLAAGRRMRAEGAT---
Rv2857c|M.tuberculosis_H37Rv MMDLSQRLAG-----------RVAVITGGGSGIGLAAGRRMRAEGAT---
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHR---
MAB_4490c|M.abscessus_ATCC_199 MFDDPRALFDIAG--------KSAIVIGATGSLGQIASRALAGAGANVAI
:* . : *
MMAR_0248|M.marinum_M VDLDGA----DVVADLSTQQGRLRAASDVIAACDGRLDGAVLAAGLGPSP
MUL_4865|M.ulcerans_Agy99 VDLDGA----DVVADLSTQQGRLRAASDVIAACDGRLDGAVLAAGLGPSP
MAV_5233|M.avium_104 VDIKDA----DVIADLSTPAGRADAAARVLSQAGDRLDGAVLAAGLGPSP
Mflv_1565|M.gilvum_PYR-GCK VDIKDA----DVVADLSTADGRADAAAQVLAACAGRLDGAVLAAGLGPSQ
Mvan_2897|M.vanbaalenii_PYR-1 VDITATPRPLDVAADLSTAEGRRSAAEEVLAACGGALDGAILAAGVGPVA
MSMEG_3704|M.smegmatis_MC2_155 VDLKEG----EVVSDLSTPEGRRRAADEVMRLSGGRLDGAVLAAGLGPGP
TH_3227|M.thermoresistible__bu VDLKDA----EVVADLSTPAGRAAAADQVLAAAESRLDGAVLAAGLGPRP
Mb2882c|M.bovis_AF2122/97 ----------IVVGDVDVEAGGAAADELSGLFVPTDVCDEDAVNGLFDGA
Rv2857c|M.tuberculosis_H37Rv ----------IVVGDVDVEAGGAAADELSGLFVPTDVCDEDAVNGLFDGA
MLBr_01807|M.leprae_Br4923 ----------VAV----THRASVVPDWFFG--VECDVTDNDAIGAAFKAV
MAB_4490c|M.abscessus_ATCC_199 CG--------SREDALSDLRDELAAAPGCIVPIARRPDSESASDAIVKET
. . .
MMAR_0248|M.marinum_M GPGRLHRIAQVNYLGVVELLQAWRPALAAAERAKAVVIASNSTTTVPMVP
MUL_4865|M.ulcerans_Agy99 GPGRLHRIAQVNYLGVVELLQARRPALAAAERAKAVVIASNSTTTVPMVP
MAV_5233|M.avium_104 ARDRVRQIAAVNYFGVVELLQAWRPALAAAGNAKVVVVASNSATTMPTVP
Mflv_1565|M.gilvum_PYR-GCK GAERLRLIGAVNYLGVVDLLTRWRPALAVAQNAKVVVVGSNSTTTTPAVP
Mvan_2897|M.vanbaalenii_PYR-1 GRDRL--IAQVNYFGVVELLTALRPAFARTAAAKVVVVSSNSTTTTPLVP
MSMEG_3704|M.smegmatis_MC2_155 GAERPRLIAEVNFLGVVELLEAWRPALAAADRAKVVVLSSNSTTTTPAVP
TH_3227|M.thermoresistible__bu GRDSARMIVQVNYFGVVELLQSWRPALAAAGNAKVVVIGSNSTTTIPLVP
Mb2882c|M.bovis_AF2122/97 AETYGRIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAA
Rv2857c|M.tuberculosis_H37Rv AETYGRIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAA
MLBr_01807|M.leprae_Br4923 EEHQGPVEVLVANAGITS--DMLIMRMSEEQFQKVIDVNLTGVFRVAKLA
MAB_4490c|M.abscessus_ATCC_199 IEAFGGVDILVVASGVNEVAPAVD--MQPARFEAVLDANVTSTWLAVRSA
. *: . ... .
MMAR_0248|M.marinum_M RRSVRALLDHDADKAVRAVR-LFGKAAPSLMYAASKIAVSHWVRRQAVLP
MUL_4865|M.ulcerans_Agy99 RRSVRALLDHDADKAVRAVR-LFGRAAPSLMYGASKIAVSHWARRQAVLP
MAV_5233|M.avium_104 RRTVNALLAHDADKALRSVR-LFGPAAPTMMYGASKLAVSRWVRRHAVLA
Mflv_1565|M.gilvum_PYR-GCK GRAVRALLAGDVDRAIRAVR-LYGPGKPAMMYAASKIAVTRWARRTAVLP
Mvan_2897|M.vanbaalenii_PYR-1 QRAVRALLAGDVENALRAVR-WFGKRSAPMTYAASKIAVSRWVRRHAVTQ
MSMEG_3704|M.smegmatis_MC2_155 ARAIRALLARDTDKAVRTVR-VLGRAGTPIMYAASKIAVSRWVRRTAVSA
TH_3227|M.thermoresistible__bu RX-------------XRLLT-ISG--------------------------
Mb2882c|M.bovis_AF2122/97 LRHMVLAGKGSIVNTASFVA-VMGSATSQISYTASKGGVLAMSR--ELGV
Rv2857c|M.tuberculosis_H37Rv LRHMVLAGKGSIVNTASFVA-VMGSATSQISYTASKGGVLAMSR--ELGV
MLBr_01807|M.leprae_Br4923 SRNMIKQRFGRYIFMGSVVG-LSG-VPGQANYAASKSGLIGMAR--SLAR
MAB_4490c|M.abscessus_ATCC_199 GRAMIERGRGGKIILTSSARGKLGHPAGYTAYCASKAAVDGLVR--SFGC
*
MMAR_0248|M.marinum_M EWAGSGVRLNALAPGAIMTPLLAEQLSDPTQAKAVRS---FPIPIGGFGE
MUL_4865|M.ulcerans_Agy99 EWAGSGVRLNALAPGAIMTPLLAEQLSVPTQAKAVRS---FPIPVGGFGE
MAV_5233|M.avium_104 EWAGSGVRLNALSPGAIMTPLLQEQLSTPRQARAVRS---FPVPVGGFGD
Mflv_1565|M.gilvum_PYR-GCK EWAGAGIRLNVLAPGAVMTPLLQEQLDNKRQAKFVEK---FPVPVGGYGE
Mvan_2897|M.vanbaalenii_PYR-1 QWAGAGIRLNALAPGAIMTPLLAEQLADPTESKAIKA---FPVPIGGYGD
MSMEG_3704|M.smegmatis_MC2_155 AWAGAGIRLNALAPGAIMTPLLQSQLAEPLESKAVRA---FPVPIGGFGD
TH_3227|M.thermoresistible__bu ----------ALGTGNILPSPVRPPVSG--------------VPTVTWRI
Mb2882c|M.bovis_AF2122/97 QFARQGIRVNALCPGPVNTPLLQELFAKNPERAARRM---VHVPLGRFAE
Rv2857c|M.tuberculosis_H37Rv QFARQGIRVNALCPGPVNTPLLQELFAKNPERAARRM---VHVPLGRFAE
MLBr_01807|M.leprae_Br4923 ELGSRSITANVVAPGFIDTEMTRAMDSKYQEAALQ------AIPLGRIGA
MAB_4490c|M.abscessus_ATCC_199 EWGRYGITVNGLAPTVFRSPLTSWMFTDEPAAQATRENFLSRIPLGRLGE
: . . . :*
MMAR_0248|M.marinum_M VTHMADWICFMLSDSADFLCGSVVFVDGGSDAYFRADDWPRSVPARRLPG
MUL_4865|M.ulcerans_Agy99 VTHMADWICFMLSDSADFLCGSVVFVDGGSDAYFRADDWPRPVPARRLPG
MAV_5233|M.avium_104 PGQLAEWMCFMLSDAADFLCGSVVFVDGGTDAYFRADDWPKVLPARRLPG
Mflv_1565|M.gilvum_PYR-GCK PDLLARWMCFMLSDAADFVCGSVIFVDGGTDALFRGDDWPRPVPVRRIAR
Mvan_2897|M.vanbaalenii_PYR-1 AGHLADWMVFMLSEAADFLCGSVIFVDGGSDAYFRSESWPAPVPARMLPR
MSMEG_3704|M.smegmatis_MC2_155 AGQLADWICFMLSDSADFLCGSVVFVDGGSDAYFRATSWPRAVPVRGLAQ
TH_3227|M.thermoresistible__bu VG---RRYAVHSRVHPGKACG---------QFKMRSSPWHRTRSG-GLRG
Mb2882c|M.bovis_AF2122/97 PDEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL------------
Rv2857c|M.tuberculosis_H37Rv PDEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL------------
MLBr_01807|M.leprae_Br4923 VEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH----------------
MAB_4490c|M.abscessus_ATCC_199 PEDLAGPILFLSAPASDFLTGHVVYPDGGYTAG-----------------
. .. .
MMAR_0248|M.marinum_M YLLSFRRGSRSNIR--
MUL_4865|M.ulcerans_Agy99 YLLKFRRGTRTTVR--
MAV_5233|M.avium_104 YLRRFTR-----FR--
Mflv_1565|M.gilvum_PYR-GCK YVKRFLG-----RR--
Mvan_2897|M.vanbaalenii_PYR-1 YAQRFLGYRRATRPVA
MSMEG_3704|M.smegmatis_MC2_155 YLWRFKRG---AGR--
TH_3227|M.thermoresistible__bu YRRSSR----------
Mb2882c|M.bovis_AF2122/97 ----------------
Rv2857c|M.tuberculosis_H37Rv ----------------
MLBr_01807|M.leprae_Br4923 ----------------
MAB_4490c|M.abscessus_ATCC_199 ----------------