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GTYAITGSASGMGAAAVARLRADGHTVLTVDIKDADVVADLSTADGRADAAAQVLAACAGRLDGAVLAAG LGPSQGAERLRLIGAVNYLGVVDLLTRWRPALAVAQNAKVVVVGSNSTTTTPAVPGRAVRALLAGDVDRA IRAVRLYGPGKPAMMYAASKIAVTRWARRTAVLPEWAGAGIRLNVLAPGAVMTPLLQEQLDNKRQAKFVE KFPVPVGGYGEPDLLARWMCFMLSDAADFVCGSVIFVDGGTDALFRGDDWPRPVPVRRIARYVKRFLGRR *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1565 | - | - | 100% (281) | NAD-dependent epimerase/dehydratase |
| M. gilvum PYR-GCK | Mflv_4062 | - | 3e-16 | 29.18% (257) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4767 | - | 7e-16 | 26.89% (264) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 4e-19 | 29.21% (267) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2857c | - | 4e-19 | 29.21% (267) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 1e-09 | 27.48% (262) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0296 | - | 6e-12 | 28.85% (253) | putative 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase |
| M. marinum M | MMAR_0248 | - | 1e-106 | 67.51% (277) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5233 | - | 1e-111 | 70.04% (277) | 3-alpha-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3704 | - | 1e-102 | 65.34% (277) | 3-alpha-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_3227 | - | 3e-37 | 69.30% (114) | PUTATIVE 3-alpha-hydroxysteroid dehydrogenase |
| M. ulcerans Agy99 | MUL_4865 | - | 1e-105 | 67.51% (277) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_5193 | - | 1e-139 | 87.14% (280) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1565|M.gilvum_PYR-GCK -----------------MGTYAITGSASGMGAAAVARLRADGHTVLTVDI
Mvan_5193|M.vanbaalenii_PYR-1 -----------------MGTYAITGSASGMGAAAVARLRADGHTVITVDI
MMAR_0248|M.marinum_M -----------------MGTYAITGSASGMGNATASRLREAGHRVIGVDL
MUL_4865|M.ulcerans_Agy99 -----------------MGTYAITGSASGMGNATASRLWEAGHRVIGVDL
MAV_5233|M.avium_104 -----------------MGTYAITGSASGMGRETAQRLRDGGHTVIGVDI
MSMEG_3704|M.smegmatis_MC2_155 MPQFLSTFSVGGCPGGIIGTYAVTGAASGMGYQAAQKLREQGHTVIGVDL
TH_3227|M.thermoresistible__bu -----------------------------MGRAAAEKLRAAGHRVIGVDL
Mb2882c|M.bovis_AF2122/97 ----------------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEG
Rv2857c|M.tuberculosis_H37Rv ----------------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEG
MLBr_01807|M.leprae_Br4923 -------------MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAV
MAB_0296|M.abscessus_ATCC_1997 ----------------MVAVVTGAGGGVGSRVVT--TLARRHERVVAVDI
: :
Mflv_1565|M.gilvum_PYR-GCK KDADVVADLSTADGRADAAAQV--LAACAGRLDGAVLAAGLGPSQGAERL
Mvan_5193|M.vanbaalenii_PYR-1 KDADVVADLSTSDGRAAAAAQV--LTACDGRLDGAVLAAGLGPSQGAERL
MMAR_0248|M.marinum_M DGADVVADLSTQQGRLRAASDV--IAACDGRLDGAVLAAGLGPSPGPGRL
MUL_4865|M.ulcerans_Agy99 DGADVVADLSTQQGRLRAASDV--IAACDGRLDGAVLAAGLGPSPGPGRL
MAV_5233|M.avium_104 KDADVIADLSTPAGRADAAARV--LSQAGDRLDGAVLAAGLGPSPARDRV
MSMEG_3704|M.smegmatis_MC2_155 KEGEVVSDLSTPEGRRRAADEV--MRLSGGRLDGAVLAAGLGPGPGAERP
TH_3227|M.thermoresistible__bu KDAEVVADLSTPAGRAAAADQV--LAAAESRLDGAVLAAGLGPRPGRDSA
Mb2882c|M.bovis_AF2122/97 ATIVVGDVDVEAGGAAADELSG--LFVPTDVCDEDAVNGLFDGAAETYG-
Rv2857c|M.tuberculosis_H37Rv ATIVVGDVDVEAGGAAADELSG--LFVPTDVCDEDAVNGLFDGAAETYG-
MLBr_01807|M.leprae_Br4923 ARRLVADGHRVAVTHRASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQG-
MAB_0296|M.abscessus_ATCC_1997 DEVAIKQLVEYAADEGLDVI-----GQILDITDDTAVAVGVSDIESRVG-
: . * .: .
Mflv_1565|M.gilvum_PYR-GCK RLIGAVNYLGVVDLLTRWRPALAVAQNAKVVVVGSNSTTTTPAVPGRAVR
Mvan_5193|M.vanbaalenii_PYR-1 RMIATVNYLGVVELLERWRPALAAAANAKVVVIGSNSTTTTPAVPARAVR
MMAR_0248|M.marinum_M HRIAQVNYLGVVELLQAWRPALAAAERAKAVVIASNSTTTVPMVPRRSVR
MUL_4865|M.ulcerans_Agy99 HRIAQVNYLGVVELLQARRPALAAAERAKAVVIASNSTTTVPMVPRRSVR
MAV_5233|M.avium_104 RQIAAVNYFGVVELLQAWRPALAAAGNAKVVVVASNSATTMPTVPRRTVN
MSMEG_3704|M.smegmatis_MC2_155 RLIAEVNFLGVVELLEAWRPALAAADRAKVVVLSSNSTTTTPAVPARAIR
TH_3227|M.thermoresistible__bu RMIVQVNYFGVVELLQSWRPALAAAGNAKVVVIGSNSTTTIPLVPRX---
Mb2882c|M.bovis_AF2122/97 RIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMV
Rv2857c|M.tuberculosis_H37Rv RIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMV
MLBr_01807|M.leprae_Br4923 PVEVLVANAGITS--DMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMI
MAB_0296|M.abscessus_ATCC_1997 PITALVNGAGVLR--TGAAVEFSDADWARTFDVNVRAPFVLSREVARRMI
. *: :. : .
Mflv_1565|M.gilvum_PYR-GCK ALLAGDVDRAIRAVRLYGPGKPAMMYAASKIAVTRWARRTAVLPEWAGAG
Mvan_5193|M.vanbaalenii_PYR-1 ALLAGDVDKALRATRLYGPGRPAMVYAASKIAVTRWARRHAVRPEWAGAG
MMAR_0248|M.marinum_M ALLDHDADKAVRAVRLFGKAAPSLMYAASKIAVSHWVRRQAVLPEWAGSG
MUL_4865|M.ulcerans_Agy99 ALLDHDADKAVRAVRLFGRAAPSLMYGASKIAVSHWARRQAVLPEWAGSG
MAV_5233|M.avium_104 ALLAHDADKALRSVRLFGPAAPTMMYGASKLAVSRWVRRHAVLAEWAGSG
MSMEG_3704|M.smegmatis_MC2_155 ALLARDTDKAVRTVRVLGRAGTPIMYAASKIAVSRWVRRTAVSAAWAGAG
TH_3227|M.thermoresistible__bu ----------XRLLTISG------ALGTGNILPS------PVRPPVSG--
Mb2882c|M.bovis_AF2122/97 LAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSR--ELGVQFARQG
Rv2857c|M.tuberculosis_H37Rv LAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSR--ELGVQFARQG
MLBr_01807|M.leprae_Br4923 KQRFGRYIFMGSVVGLSGVPG-QANYAASKSGLIGMAR--SLARELGSRS
MAB_0296|M.abscessus_ATCC_1997 PRRAGSVVTVASNAALVARKG-MTAYAASKAAANAFTK--SLGLELAEYG
: . :.: : .
Mflv_1565|M.gilvum_PYR-GCK IRLNVLAPGAVMTPLLQEQLDNKRQAKFVE------KFPVPVGGYGEPDL
Mvan_5193|M.vanbaalenii_PYR-1 IRLNVLAPGAVMTPLLQEQLDNKRQARFVE------RFPVPVGGYGQPEQ
MMAR_0248|M.marinum_M VRLNALAPGAIMTPLLAEQLSDPTQAKAVR------SFPIPIGGFGEVTH
MUL_4865|M.ulcerans_Agy99 VRLNALAPGAIMTPLLAEQLSVPTQAKAVR------SFPIPVGGFGEVTH
MAV_5233|M.avium_104 VRLNALSPGAIMTPLLQEQLSTPRQARAVR------SFPVPVGGFGDPGQ
MSMEG_3704|M.smegmatis_MC2_155 IRLNALAPGAIMTPLLQSQLAEPLESKAVR------AFPVPIGGFGDAGQ
TH_3227|M.thermoresistible__bu ------------VPTVTWRIVGRRYAVHSR------VHPGKACG------
Mb2882c|M.bovis_AF2122/97 IRVNALCPGPVNTPLLQELFAKNPERAARR------MVHVPLGRFAEPDE
Rv2857c|M.tuberculosis_H37Rv IRVNALCPGPVNTPLLQELFAKNPERAARR------MVHVPLGRFAEPDE
MLBr_01807|M.leprae_Br4923 ITANVVAPGFIDTEMTRAMDSKYQEAALQA---------IPLGRIGAVEE
MAB_0296|M.abscessus_ATCC_1997 IRCNVVAPGSTDTPMLRAMLGDSSDAGLVAGSLGDYKPGIPLGRVAQPQH
.
Mflv_1565|M.gilvum_PYR-GCK LARWMCFMLSDAADFVCGSVIFVDGGTDALFRGDDWPRPVPVRRIARYVK
Mvan_5193|M.vanbaalenii_PYR-1 LAEWMRFMLSDAADFLCGSVIFVDGGTDSLFRRDDWPRPVPARRIIGYVQ
MMAR_0248|M.marinum_M MADWICFMLSDSADFLCGSVVFVDGGSDAYFRADDWPRSVPARRLPGYLL
MUL_4865|M.ulcerans_Agy99 MADWICFMLSDSADFLCGSVVFVDGGSDAYFRADDWPRPVPARRLPGYLL
MAV_5233|M.avium_104 LAEWMCFMLSDAADFLCGSVVFVDGGTDAYFRADDWPKVLPARRLPGYLR
MSMEG_3704|M.smegmatis_MC2_155 LADWICFMLSDSADFLCGSVVFVDGGSDAYFRATSWPRAVPVRGLAQYLW
TH_3227|M.thermoresistible__bu ---------------------------QFKMRSSPWHRTRSG-GLRGYRR
Mb2882c|M.bovis_AF2122/97 IAAAVAFLASDDASFITASTFLVDGGISSAYVTPL---------------
Rv2857c|M.tuberculosis_H37Rv IAAAVAFLASDDASFITASTFLVDGGISSAYVTPL---------------
MLBr_01807|M.leprae_Br4923 IAGAVSFLASEDAGYISGAVIPVDGGLGMGH-------------------
MAB_0296|M.abscessus_ATCC_1997 IADAVAFLLSDQAAHITMHTLVVDGGATLGV-------------------
Mflv_1565|M.gilvum_PYR-GCK RFLGRR-----
Mvan_5193|M.vanbaalenii_PYR-1 RFRGRG-----
MMAR_0248|M.marinum_M SFRRGSRSNIR
MUL_4865|M.ulcerans_Agy99 KFRRGTRTTVR
MAV_5233|M.avium_104 RFTR-----FR
MSMEG_3704|M.smegmatis_MC2_155 RFKRGAGR---
TH_3227|M.thermoresistible__bu SSR--------
Mb2882c|M.bovis_AF2122/97 -----------
Rv2857c|M.tuberculosis_H37Rv -----------
MLBr_01807|M.leprae_Br4923 -----------
MAB_0296|M.abscessus_ATCC_1997 -----------