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GTYAITGSASGMGNATASRLWEAGHRVIGVDLDGADVVADLSTQQGRLRAASDVIAACDGRLDGAVLAAG LGPSPGPGRLHRIAQVNYLGVVELLQARRPALAAAERAKAVVIASNSTTTVPMVPRRSVRALLDHDADKA VRAVRLFGRAAPSLMYGASKIAVSHWARRQAVLPEWAGSGVRLNALAPGAIMTPLLAEQLSVPTQAKAVR SFPIPVGGFGEVTHMADWICFMLSDSADFLCGSVVFVDGGSDAYFRADDWPRPVPARRLPGYLLKFRRGT RTTVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4865 | - | - | 100% (286) | short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_4361 | - | 6e-14 | 29.43% (265) | short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_1052 | - | 3e-13 | 31.11% (270) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 8e-16 | 29.43% (265) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1565 | - | 1e-105 | 67.51% (277) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv2857c | - | 8e-16 | 29.43% (265) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 3e-06 | 25.58% (258) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0164 | - | 1e-11 | 26.98% (252) | short chain dehydrogenase/reductase |
| M. marinum M | MMAR_0248 | - | 1e-155 | 95.45% (286) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5233 | - | 1e-116 | 73.84% (279) | 3-alpha-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3704 | - | 1e-107 | 68.21% (280) | 3-alpha-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_3227 | - | 6e-37 | 68.70% (115) | PUTATIVE 3-alpha-hydroxysteroid dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5193 | - | 1e-106 | 68.35% (278) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4865|M.ulcerans_Agy99 ----------------------------MGTYAITGSASGMGNATASRLW
MMAR_0248|M.marinum_M ----------------------------MGTYAITGSASGMGNATASRLR
MAV_5233|M.avium_104 ----------------------------MGTYAITGSASGMGRETAQRLR
Mflv_1565|M.gilvum_PYR-GCK ----------------------------MGTYAITGSASGMGAAAVARLR
Mvan_5193|M.vanbaalenii_PYR-1 ----------------------------MGTYAITGSASGMGAAAVARLR
MSMEG_3704|M.smegmatis_MC2_155 -----------MPQFLSTFSVGGCPGGIIGTYAVTGAASGMGYQAAQKLR
TH_3227|M.thermoresistible__bu ----------------------------------------MGRAAAEKLR
Mb2882c|M.bovis_AF2122/97 --------MMDLSQRLAG-----------RVAVITGGGSGIGLAAGRRMR
Rv2857c|M.tuberculosis_H37Rv --------MMDLSQRLAG-----------RVAVITGGGSGIGLAAGRRMR
MLBr_01807|M.leprae_Br4923 --------MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLV
MAB_0164|M.abscessus_ATCC_1997 MNLTDFQSLYDLSG---------------RTAIVTGGTRGIGYAIAEALG
:* :
MUL_4865|M.ulcerans_Agy99 EAGHRVIGVDLDGADVVADLSTQQGRLRAASDVIAACDGRLDGAVLAAGL
MMAR_0248|M.marinum_M EAGHRVIGVDLDGADVVADLSTQQGRLRAASDVIAACDGRLDGAVLAAGL
MAV_5233|M.avium_104 DGGHTVIGVDIKDADVIADLSTPAGRADAAARVLSQAGDRLDGAVLAAGL
Mflv_1565|M.gilvum_PYR-GCK ADGHTVLTVDIKDADVVADLSTADGRADAAAQVLAACAGRLDGAVLAAGL
Mvan_5193|M.vanbaalenii_PYR-1 ADGHTVITVDIKDADVVADLSTSDGRAAAAAQVLTACDGRLDGAVLAAGL
MSMEG_3704|M.smegmatis_MC2_155 EQGHTVIGVDLKEGEVVSDLSTPEGRRRAADEVMRLSGGRLDGAVLAAGL
TH_3227|M.thermoresistible__bu AAGHRVIGVDLKDAEVVADLSTPAGRAAAADQVLAAAESRLDGAVLAAGL
Mb2882c|M.bovis_AF2122/97 AEGATIVVGDVDVEAGGAAADELSGL-----FVPTDVCDEDAVNGLFDGA
Rv2857c|M.tuberculosis_H37Rv AEGATIVVGDVDVEAGGAAADELSGL-----FVPTDVCDEDAVNGLFDGA
MLBr_01807|M.leprae_Br4923 ADGHRVAV----THRASVVPDWFFG-------VECDVTDNDAIGAAFKAV
MAB_0164|M.abscessus_ATCC_1997 ACGASVVVSSRKSDACTAAAKELHDKGYRALGVPAHMGELGDIDALVTAT
* : . . * .
MUL_4865|M.ulcerans_Agy99 GPSPGPGRLHRIAQVNYLGVVELLQARRPALAAAERAKAVVIASNSTTTV
MMAR_0248|M.marinum_M GPSPGPGRLHRIAQVNYLGVVELLQAWRPALAAAERAKAVVIASNSTTTV
MAV_5233|M.avium_104 GPSPARDRVRQIAAVNYFGVVELLQAWRPALAAAGNAKVVVVASNSATTM
Mflv_1565|M.gilvum_PYR-GCK GPSQGAERLRLIGAVNYLGVVDLLTRWRPALAVAQNAKVVVVGSNSTTTT
Mvan_5193|M.vanbaalenii_PYR-1 GPSQGAERLRMIATVNYLGVVELLERWRPALAAAANAKVVVIGSNSTTTT
MSMEG_3704|M.smegmatis_MC2_155 GPGPGAERPRLIAEVNFLGVVELLEAWRPALAAADRAKVVVLSSNSTTTT
TH_3227|M.thermoresistible__bu GPRPGRDSARMIVQVNYFGVVELLQSWRPALAAAGNAKVVVIGSNSTTTI
Mb2882c|M.bovis_AF2122/97 AETYG----RIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLC
Rv2857c|M.tuberculosis_H37Rv AETYG----RIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLC
MLBr_01807|M.leprae_Br4923 EEHQG----PVEVLVANAGITS--DMLIMRMSEEQFQKVIDVNLTGVFRV
MAB_0164|M.abscessus_ATCC_1997 VDEYG----GVDIVVN--AAANPVAQPMGSYTPEALGKSFDVNVRGPVFL
. . . : : .
MUL_4865|M.ulcerans_Agy99 PMVPRRSVRALLDHDADKAVRAVRLFGRAAPSLMYGASKIAVSHWARRQA
MMAR_0248|M.marinum_M PMVPRRSVRALLDHDADKAVRAVRLFGKAAPSLMYAASKIAVSHWVRRQA
MAV_5233|M.avium_104 PTVPRRTVNALLAHDADKALRSVRLFGPAAPTMMYGASKLAVSRWVRRHA
Mflv_1565|M.gilvum_PYR-GCK PAVPGRAVRALLAGDVDRAIRAVRLYGPGKPAMMYAASKIAVTRWARRTA
Mvan_5193|M.vanbaalenii_PYR-1 PAVPARAVRALLAGDVDKALRATRLYGPGRPAMVYAASKIAVTRWARRHA
MSMEG_3704|M.smegmatis_MC2_155 PAVPARAIRALLARDTDKAVRTVRVLGRAGTPIMYAASKIAVSRWVRRTA
TH_3227|M.thermoresistible__bu PLVPRX-------------XRLLTISG------ALGTGNILPS------P
Mb2882c|M.bovis_AF2122/97 CRAALRHMVLAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSR--E
Rv2857c|M.tuberculosis_H37Rv CRAALRHMVLAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSR--E
MLBr_01807|M.leprae_Br4923 AKLASRNMIKQRFGRYIFMGSVVGLSG-VPGQANYAASKSGLIGMAR--S
MAB_0164|M.abscessus_ATCC_1997 VQAALPHLTASEHASVLNVVSVAAFQY-VPMLSMYAAMKATLMSFTR--S
. . : :
MUL_4865|M.ulcerans_Agy99 VLPEWAGSGVRLNALAPGAIMTPLLAEQLSVPTQAKAVRSFPIPVGGFGE
MMAR_0248|M.marinum_M VLPEWAGSGVRLNALAPGAIMTPLLAEQLSDPTQAKAVRSFPIPIGGFGE
MAV_5233|M.avium_104 VLAEWAGSGVRLNALSPGAIMTPLLQEQLSTPRQARAVRSFPVPVGGFGD
Mflv_1565|M.gilvum_PYR-GCK VLPEWAGAGIRLNVLAPGAVMTPLLQEQLDNKRQAKFVEKFPVPVGGYGE
Mvan_5193|M.vanbaalenii_PYR-1 VRPEWAGAGIRLNVLAPGAVMTPLLQEQLDNKRQARFVERFPVPVGGYGQ
MSMEG_3704|M.smegmatis_MC2_155 VSAAWAGAGIRLNALAPGAIMTPLLQSQLAEPLESKAVRAFPVPIGGFGD
TH_3227|M.thermoresistible__bu VRPPVSG--------------VPTVTWRIVGRRYAVHSRVHPGKACG---
Mb2882c|M.bovis_AF2122/97 LGVQFARQGIRVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAE
Rv2857c|M.tuberculosis_H37Rv LGVQFARQGIRVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAE
MLBr_01807|M.leprae_Br4923 LARELGSRSITANVVAPGFIDTEMTRAMDSKYQEAALQ---AIPLGRIGA
MAB_0164|M.abscessus_ATCC_1997 MAAEYTARGIRVNALAPGTVDTYMLQQNPQEIIDAMAA---QSFMGRVAH
: .
MUL_4865|M.ulcerans_Agy99 VTHMADWICFMLSDSADFLCGSVVFVDGGSDAYFRADDWPRPVPARRLPG
MMAR_0248|M.marinum_M VTHMADWICFMLSDSADFLCGSVVFVDGGSDAYFRADDWPRSVPARRLPG
MAV_5233|M.avium_104 PGQLAEWMCFMLSDAADFLCGSVVFVDGGTDAYFRADDWPKVLPARRLPG
Mflv_1565|M.gilvum_PYR-GCK PDLLARWMCFMLSDAADFVCGSVIFVDGGTDALFRGDDWPRPVPVRRIAR
Mvan_5193|M.vanbaalenii_PYR-1 PEQLAEWMRFMLSDAADFLCGSVIFVDGGTDSLFRRDDWPRPVPARRIIG
MSMEG_3704|M.smegmatis_MC2_155 AGQLADWICFMLSDSADFLCGSVVFVDGGSDAYFRATSWPRAVPVRGLAQ
TH_3227|M.thermoresistible__bu ------------------------------QFKMRSSPWHRTRSG-GLRG
Mb2882c|M.bovis_AF2122/97 PDEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL------------
Rv2857c|M.tuberculosis_H37Rv PDEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL------------
MLBr_01807|M.leprae_Br4923 VEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH----------------
MAB_0164|M.abscessus_ATCC_1997 TDEMIGPALLLLSDAGSFITGQVIVADGGGGVQR----------------
MUL_4865|M.ulcerans_Agy99 YLLKFRRGTRTTVR
MMAR_0248|M.marinum_M YLLSFRRGSRSNIR
MAV_5233|M.avium_104 YLRRFTR-----FR
Mflv_1565|M.gilvum_PYR-GCK YVKRFLGRR-----
Mvan_5193|M.vanbaalenii_PYR-1 YVQRFRGRG-----
MSMEG_3704|M.smegmatis_MC2_155 YLWRFKRGAGR---
TH_3227|M.thermoresistible__bu YRRSSR--------
Mb2882c|M.bovis_AF2122/97 --------------
Rv2857c|M.tuberculosis_H37Rv --------------
MLBr_01807|M.leprae_Br4923 --------------
MAB_0164|M.abscessus_ATCC_1997 --------------