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GTYAITGSASGMGRETAQRLRDGGHTVIGVDIKDADVIADLSTPAGRADAAARVLSQAGDRLDGAVLAAG LGPSPARDRVRQIAAVNYFGVVELLQAWRPALAAAGNAKVVVVASNSATTMPTVPRRTVNALLAHDADKA LRSVRLFGPAAPTMMYGASKLAVSRWVRRHAVLAEWAGSGVRLNALSPGAIMTPLLQEQLSTPRQARAVR SFPVPVGGFGDPGQLAEWMCFMLSDAADFLCGSVVFVDGGTDAYFRADDWPKVLPARRLPGYLRRFTRFR *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5233 | - | - | 100% (281) | 3-alpha-hydroxysteroid dehydrogenase |
| M. avium 104 | MAV_3714 | - | 6e-18 | 30.92% (262) | short chain dehydrogenase |
| M. avium 104 | MAV_3521 | - | 9e-16 | 31.58% (266) | NAD dependent epimerase/dehydratase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 5e-17 | 28.41% (271) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1565 | - | 1e-111 | 70.04% (277) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv2857c | - | 5e-17 | 28.41% (271) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 7e-05 | 26.01% (223) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0952 | - | 2e-11 | 27.98% (243) | short chain dehydrogenase |
| M. marinum M | MMAR_0248 | - | 1e-118 | 74.19% (279) | short-chain type dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_3704 | - | 1e-109 | 67.74% (279) | 3-alpha-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_3227 | - | 2e-43 | 73.91% (115) | PUTATIVE 3-alpha-hydroxysteroid dehydrogenase |
| M. ulcerans Agy99 | MUL_4865 | - | 1e-116 | 73.84% (279) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_5193 | - | 1e-113 | 71.84% (277) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0248|M.marinum_M --------------------------------------------------
MUL_4865|M.ulcerans_Agy99 --------------------------------------------------
MAV_5233|M.avium_104 --------------------------------------------------
Mflv_1565|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5193|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3704|M.smegmatis_MC2_155 --------------------------------------------------
TH_3227|M.thermoresistible__bu --------------------------------------------------
MAB_0952|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0248|M.marinum_M --------------------------------------------------
MUL_4865|M.ulcerans_Agy99 --------------------------------------------------
MAV_5233|M.avium_104 --------------------------------------------------
Mflv_1565|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5193|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3704|M.smegmatis_MC2_155 --------------------------------------------------
TH_3227|M.thermoresistible__bu --------------------------------------------------
MAB_0952|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0248|M.marinum_M --------------------------------------------------
MUL_4865|M.ulcerans_Agy99 --------------------------------------------------
MAV_5233|M.avium_104 --------------------------------------------------
Mflv_1565|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5193|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3704|M.smegmatis_MC2_155 --------------------------------------------------
TH_3227|M.thermoresistible__bu --------------------------------------------------
MAB_0952|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0248|M.marinum_M --------------------------------------------------
MUL_4865|M.ulcerans_Agy99 --------------------------------------------------
MAV_5233|M.avium_104 --------------------------------------------------
Mflv_1565|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5193|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3704|M.smegmatis_MC2_155 --------------------------------------------------
TH_3227|M.thermoresistible__bu --------------------------------------------------
MAB_0952|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0248|M.marinum_M --------------------------------------------------
MUL_4865|M.ulcerans_Agy99 --------------------------------------------------
MAV_5233|M.avium_104 --------------------------------------------------
Mflv_1565|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5193|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3704|M.smegmatis_MC2_155 --------------------------------------------------
TH_3227|M.thermoresistible__bu --------------------------------------------------
MAB_0952|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0248|M.marinum_M --------------------------------------------------
MUL_4865|M.ulcerans_Agy99 --------------------------------------------------
MAV_5233|M.avium_104 --------------------------------------------------
Mflv_1565|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5193|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3704|M.smegmatis_MC2_155 --------------------------------------------------
TH_3227|M.thermoresistible__bu --------------------------------------------------
MAB_0952|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mb2882c|M.bovis_AF2122/97 ------------------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRA
Rv2857c|M.tuberculosis_H37Rv ------------------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRA
MMAR_0248|M.marinum_M ---------------------------MGTYAITGSASGMGNATASRLRE
MUL_4865|M.ulcerans_Agy99 ---------------------------MGTYAITGSASGMGNATASRLWE
MAV_5233|M.avium_104 ---------------------------MGTYAITGSASGMGRETAQRLRD
Mflv_1565|M.gilvum_PYR-GCK ---------------------------MGTYAITGSASGMGAAAVARLRA
Mvan_5193|M.vanbaalenii_PYR-1 ---------------------------MGTYAITGSASGMGAAAVARLRA
MSMEG_3704|M.smegmatis_MC2_155 ----------MPQFLSTFSVGGCPGGIIGTYAVTGAASGMGYQAAQKLRE
TH_3227|M.thermoresistible__bu ---------------------------------------MGRAAAEKLRA
MAB_0952|M.abscessus_ATCC_1997 ---------MVVESAEPAERKVMFDLSARSVLVTGGTKGIGRGIATVFAR
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
:* :
Mb2882c|M.bovis_AF2122/97 EGATIV---------VGDVDVEAGGAAADELSGLFVPTDVCDEDAVNGLF
Rv2857c|M.tuberculosis_H37Rv EGATIV---------VGDVDVEAGGAAADELSGLFVPTDVCDEDAVNGLF
MMAR_0248|M.marinum_M AGHRVIGVDLDGADVVADLSTQQGRLRAASDVIAACDGRLDGAVLAAGLG
MUL_4865|M.ulcerans_Agy99 AGHRVIGVDLDGADVVADLSTQQGRLRAASDVIAACDGRLDGAVLAAGLG
MAV_5233|M.avium_104 GGHTVIGVDIKDADVIADLSTPAGRADAAARVLSQAGDRLDGAVLAAGLG
Mflv_1565|M.gilvum_PYR-GCK DGHTVLTVDIKDADVVADLSTADGRADAAAQVLAACAGRLDGAVLAAGLG
Mvan_5193|M.vanbaalenii_PYR-1 DGHTVITVDIKDADVVADLSTSDGRAAAAAQVLTACDGRLDGAVLAAGLG
MSMEG_3704|M.smegmatis_MC2_155 QGHTVIGVDLKEGEVVSDLSTPEGRRRAADEVMRLSGGRLDGAVLAAGLG
TH_3227|M.thermoresistible__bu AGHRVIGVDLKDAEVVADLSTPAGRAAAADQVLAAAESRLDGAVLAAGLG
MAB_0952|M.abscessus_ATCC_1997 AGANVAVAARSPRE-LSSVTAELGELGAGNVIGVRLD--VSDPGSCADAA
MLBr_00862|M.leprae_Br4923 RGAEVVVSDID----EAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFA
* : . . * : .
Mb2882c|M.bovis_AF2122/97 DGAAETYGRIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCC
Rv2857c|M.tuberculosis_H37Rv DGAAETYGRIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCC
MMAR_0248|M.marinum_M PSPGPGRLHRIAQVNYLGVVELLQAWRPALAAAERAKAVVIASNSTTTVP
MUL_4865|M.ulcerans_Agy99 PSPGPGRLHRIAQVNYLGVVELLQARRPALAAAERAKAVVIASNSTTTVP
MAV_5233|M.avium_104 PSPARDRVRQIAAVNYFGVVELLQAWRPALAAAGNAKVVVVASNSATTMP
Mflv_1565|M.gilvum_PYR-GCK PSQGAERLRLIGAVNYLGVVDLLTRWRPALAVAQNAKVVVVGSNSTTTTP
Mvan_5193|M.vanbaalenii_PYR-1 PSQGAERLRMIATVNYLGVVELLERWRPALAAAANAKVVVIGSNSTTTTP
MSMEG_3704|M.smegmatis_MC2_155 PGPGAERPRLIAEVNFLGVVELLEAWRPALAAADRAKVVVLSSNSTTTTP
TH_3227|M.thermoresistible__bu PRPGRDSARMIVQVNYFGVVELLQSWRPALAAAGNAKVVVIGSNSTTTIP
MAB_0952|M.abscessus_ATCC_1997 RTVVDAFGALDVVCANAGIFP--EARLDTMTPEQLSEVLDVNVKGTVYTV
MLBr_00862|M.leprae_Br4923 EQVSAKHGVPDIVVNNAGIGQ--AGRFLDTPPEEFDRVLAVNLGGVVNCC
*: .. : ..
Mb2882c|M.bovis_AF2122/97 RAALRHMVLAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGV
Rv2857c|M.tuberculosis_H37Rv RAALRHMVLAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGV
MMAR_0248|M.marinum_M MVPRRSVRALLDHDADKAVRAVRLFGKAAPSLMYAASKIAVSHWVRRQAV
MUL_4865|M.ulcerans_Agy99 MVPRRSVRALLDHDADKAVRAVRLFGRAAPSLMYGASKIAVSHWARRQAV
MAV_5233|M.avium_104 TVPRRTVNALLAHDADKALRSVRLFGPAAPTMMYGASKLAVSRWVRRHAV
Mflv_1565|M.gilvum_PYR-GCK AVPGRAVRALLAGDVDRAIRAVRLYGPGKPAMMYAASKIAVTRWARRTAV
Mvan_5193|M.vanbaalenii_PYR-1 AVPARAVRALLAGDVDKALRATRLYGPGRPAMVYAASKIAVTRWARRHAV
MSMEG_3704|M.smegmatis_MC2_155 AVPARAIRALLARDTDKAVRTVRVLGRAGTPIMYAASKIAVSRWVRRTAV
TH_3227|M.thermoresistible__bu LVPRX---------------------------------------XRLLTI
MAB_0952|M.abscessus_ATCC_1997 QACLAPLTASGRGRVILTSSITGPVTGYPGWSHYGASKAAQLGFMRTAAI
MLBr_00862|M.leprae_Br4923 RAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAAT--YMFSDCL
. :
Mb2882c|M.bovis_AF2122/97 Q--FARQGIRVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEP
Rv2857c|M.tuberculosis_H37Rv Q--FARQGIRVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEP
MMAR_0248|M.marinum_M LPEWAGSGVRLNALAPGAIMTPLLAEQLSDPTQAKAVRSFPIPIGGFGEV
MUL_4865|M.ulcerans_Agy99 LPEWAGSGVRLNALAPGAIMTPLLAEQLSVPTQAKAVRSFPIPVGGFGEV
MAV_5233|M.avium_104 LAEWAGSGVRLNALSPGAIMTPLLQEQLSTPRQARAVRSFPVPVGGFGDP
Mflv_1565|M.gilvum_PYR-GCK LPEWAGAGIRLNVLAPGAVMTPLLQEQLDNKRQAKFVEKFPVPVGGYGEP
Mvan_5193|M.vanbaalenii_PYR-1 RPEWAGAGIRLNVLAPGAVMTPLLQEQLDNKRQARFVERFPVPVGGYGQP
MSMEG_3704|M.smegmatis_MC2_155 SAAWAGAGIRLNALAPGAIMTPLLQSQLAEPLESKAVRAFPVPIGGFGDA
TH_3227|M.thermoresistible__bu SGALGTGNILPSPVRPPVSGVPTVTWRIVGRRYAVHSRVHPGKACG----
MAB_0952|M.abscessus_ATCC_1997 E--LAPRGVTVNAILPGNILTEGLVDMGEEYISGMAR---SIPMGMLGSP
MLBr_00862|M.leprae_Br4923 RAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQER-VRDRRGQLDMM
.: . : * . :
Mb2882c|M.bovis_AF2122/97 DEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL-------------
Rv2857c|M.tuberculosis_H37Rv DEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL-------------
MMAR_0248|M.marinum_M THMADWICFMLSDSADFLCGSVVFVDGGSDAYFRADDWPRSVPARRLPGY
MUL_4865|M.ulcerans_Agy99 THMADWICFMLSDSADFLCGSVVFVDGGSDAYFRADDWPRPVPARRLPGY
MAV_5233|M.avium_104 GQLAEWMCFMLSDAADFLCGSVVFVDGGTDAYFRADDWPKVLPARRLPGY
Mflv_1565|M.gilvum_PYR-GCK DLLARWMCFMLSDAADFVCGSVIFVDGGTDALFRGDDWPRPVPVRRIARY
Mvan_5193|M.vanbaalenii_PYR-1 EQLAEWMRFMLSDAADFLCGSVIFVDGGTDSLFRRDDWPRPVPARRIIGY
MSMEG_3704|M.smegmatis_MC2_155 GQLADWICFMLSDSADFLCGSVVFVDGGSDAYFRATSWPRAVPVRGLAQY
TH_3227|M.thermoresistible__bu -----------------------------QFKMRSSPWHRTR-SGGLRGY
MAB_0952|M.abscessus_ATCC_1997 VDIGHLAAFLATDEAGYITGQAIVVDGGQVLPESPDAVNP----------
MLBr_00862|M.leprae_Br4923 FRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTA
Mb2882c|M.bovis_AF2122/97 -------------
Rv2857c|M.tuberculosis_H37Rv -------------
MMAR_0248|M.marinum_M LLSFRRGSRSNIR
MUL_4865|M.ulcerans_Agy99 LLKFRRGTRTTVR
MAV_5233|M.avium_104 LRRFTR-----FR
Mflv_1565|M.gilvum_PYR-GCK VKRFLGRR-----
Mvan_5193|M.vanbaalenii_PYR-1 VQRFRGRG-----
MSMEG_3704|M.smegmatis_MC2_155 LWRFKRGAGR---
TH_3227|M.thermoresistible__bu RRSSR--------
MAB_0952|M.abscessus_ATCC_1997 -------------
MLBr_00862|M.leprae_Br4923 RIRVI--------