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CDTGRVGKRQDTRDRIERQIVEIGRAHLVTHGAAALSLRAIARELGMVSSAVYRYVASRDELLTLLLVDA YGELADSVERARDAAAGDWQDRLRAVAHATRAWAVHHPARWALLYGSPVPGYHAPREQTVGPGTRVVGLL FSAIAEGVAAGAVRTSKVTVPQSLSSDFDRLRAEFEFVADDDVVARCLVLWAALVGAISLEVFGQYGADT FADASVVFDAQMDLVIDLFCRQGAN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3167 | - | - | 100% (236) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4078 | - | 8e-09 | 32.08% (106) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2792 | - | 1e-07 | 29.85% (134) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1846 | - | 1e-81 | 64.91% (228) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_3414 | - | 6e-87 | 66.81% (226) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1816 | - | 1e-81 | 64.91% (228) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4787c | - | 1e-26 | 35.81% (229) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0992 | - | 2e-07 | 25.11% (227) | transcriptional regulatory protein |
| M. avium 104 | MAV_2899 | - | 1e-81 | 63.72% (226) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_3659 | - | 2e-79 | 66.52% (221) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_4347 | - | 8e-10 | 23.32% (223) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_0743 | - | 8e-08 | 25.55% (227) | transcriptional regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3414|M.gilvum_PYR-GCK -----------MGKRQDTRERIERDIVAIGRRHLVTEGAAGLSLRAIARD
MSMEG_3659|M.smegmatis_MC2_155 -----------MGKRQESRERIEAAIVEIGRQHLVTEGAAGLSMRAVARD
Mvan_3167|M.vanbaalenii_PYR-1 -----MCDTGRVGKRQDTRDRIERQIVEIGRAHLVTHGAAALSLRAIARE
Mb1846|M.bovis_AF2122/97 -----MCQTCRVGKRRDAREQIEAKIVELGRRQLLDHGAAGLSLRAIARN
Rv1816|M.tuberculosis_H37Rv -----MCQTCRVGKRRDAREQIEAKIVELGRRQLLDHGAAGLSLRAIARN
MAV_2899|M.avium_104 -----------MGKRQQSREQIEARIIELGRRQLVDRGAAGLSVRAIARD
MAB_4787c|M.abscessus_ATCC_199 MPTRTNAADVPATRRARQRAQTTDEIKALARRQLADGGTGALSLRGIARE
MMAR_0992|M.marinum_M --------MIGETTSPTQRSGVRDEMLHAAVALLDAHGPDALQTRKVAGA
MUL_0743|M.ulcerans_Agy99 --------MIGETTSPTQRSGVRDEMLHAAVALLDAHGPDALQTRKVAGA
TH_4347|M.thermoresistible__bu ----------------VTADDIREKLVDAGVRLLERDGVQALSARNLAAE
: . * * .*. * :*
Mflv_3414|M.gilvum_PYR-GCK LGMVSSAVYRYVASRDELLTLLLVDAYTDLADTVETARAASTGD---WRE
MSMEG_3659|M.smegmatis_MC2_155 LGMVSSAVYRYVASRDELLTLLVVDAYTELADAVAAAVADVSAAGARWRS
Mvan_3167|M.vanbaalenii_PYR-1 LGMVSSAVYRYVASRDELLTLLLVDAYGELADSVERARDAAAGD---WQD
Mb1846|M.bovis_AF2122/97 LGMVSSAVYRYVSSRDELLTLLLVDAYSDLADTVDRARDDTVADS--WSD
Rv1816|M.tuberculosis_H37Rv LGMVSSAVYRYVSSRDELLTLLLVDAYSDLADTVDRARDDTVADS--WSD
MAV_2899|M.avium_104 LGMVSSAVYRYVSSRDELLTLLLVDAYSDLADTVDRAR-ETAGEQ--WSD
MAB_4787c|M.abscessus_ATCC_199 MGMAPAALFRYFETQAALITALCVDANGALAQAMSDGQKAAPESD--SAA
MMAR_0992|M.marinum_M AGTSTMAVYTHFGGMPELIAEVAEEGLRQFDTALA-VPPSDDPVA-----
MUL_0743|M.ulcerans_Agy99 TGTSTMAVYTHFGGMPELIAEVADEGLRQFDTALA-VPPSDDPVA-----
TH_4347|M.thermoresistible__bu AGTSTMAVYTRFGGMPGVLEAVAGEIFARFADALTQIPQTGDPVA-----
* . *:: . :: : : : ::
Mflv_3414|M.gilvum_PYR-GCK QLRALGHAIRAWAVRQPASWALLYGSPVPGYHAPRDRTVTPGTRVVAALF
MSMEG_3659|M.smegmatis_MC2_155 QIRAIAHATRNWALDQPARWALLYGSPVPGYHAPAERTVVPGTRVVVALF
Mvan_3167|M.vanbaalenii_PYR-1 RLRAVAHATRAWAVHHPARWALLYGSPVPGYHAPREQTVGPGTRVVGLLF
Mb1846|M.bovis_AF2122/97 DVIAIARAVRGWAVTNPARWALLYGSPVPGYHAPPDRTAGVATRVVGAFF
Rv1816|M.tuberculosis_H37Rv DVIAIARAVRGWAVTNPARWALLYGSPVPGYHAPPDRTAGVATRVVGAFF
MAV_2899|M.avium_104 DVIAIARATRRWAVEHPACWALLYGSPVPGYHAPPERTVAAGTRVVAALF
MAB_4787c|M.abscessus_ATCC_199 RLRAAFVAARRWALAHPGDFALLSGTPIPGYAAQPAETGPAAMRVIASFM
MMAR_0992|M.marinum_M DLVATGAAYRRYAIERPHMYRLMFGSTSAHGIN-APTQNVLTLTISQIEQ
MUL_0743|M.ulcerans_Agy99 DLVATGAAYRRYAIERPHMYRLMFGSTSAHGIN-APAQNVLTLTISQIEQ
TH_4347|M.thermoresistible__bu DFLLMGAAYREYALTHPQRYLLMFGTATPASIAGSRADLTATGEVSDRTE
. * * :*: .* : *: *:. . :
Mflv_3414|M.gilvum_PYR-GCK DVVSAGIAAGDIASGEHPAPQPLSG--DFDRLREQFGFAGD---DVLLGK
MSMEG_3659|M.smegmatis_MC2_155 AAVARGIAEGDIPATEETVAQPLSG--DFARLRAEFGLHVD---DATMAR
Mvan_3167|M.vanbaalenii_PYR-1 SAIAEGVAAGAVRTSKVTVPQSLSS--DFDRLRAEFEFVAD---DDVVAR
Mb1846|M.bovis_AF2122/97 DAIAAGIATGDIRLTDDVAPQPMSS--DFEKIRQEFGFPGD---DRVVTK
Rv1816|M.tuberculosis_H37Rv DAIAAGIATGDIRLTDDVAPQPMSS--DFEKIRQEFGFPGD---DRVVTK
MAV_2899|M.avium_104 DAVAAGITTGDIRLTNDPAPQPMSS--DFERIRHEFGFPGD---DLVIAK
MAB_4787c|M.abscessus_ATCC_199 DAYLRAVAAGEAVPRRTRFRPSAPGPLLVAMFGEDTAPPID---PAIIGI
MMAR_0992|M.marinum_M RHPSFAHVVRGVRRSMLAGRITVNGGADRNRASAPDGLATDVPDAEIVAT
MUL_0743|M.ulcerans_Agy99 RHPSFAHVVRGVRRSMLAGRITVNGGDDRNRAAAPDGLATDVLDAEIVAT
TH_4347|M.thermoresistible__bu WAASFEALRTMVRRMIAAGRIRDDGE---------------------AAI
.
Mflv_3414|M.gilvum_PYR-GCK CLTLWAALIGAVGLEVFGQYGPDTFADPALAFDTQIAALTEMLCQ-----
MSMEG_3659|M.smegmatis_MC2_155 CFALWAGLIGAVSLEVFGQYGADTLTDPRQLFDLQIDSLTGALTN-----
Mvan_3167|M.vanbaalenii_PYR-1 CLVLWAALVGAISLEVFGQYGADTFADASVVFDAQMDLVIDLFCRQGAN-
Mb1846|M.bovis_AF2122/97 CFLLWAGVVGAISLEVFGQYGADMLTDPGVVFDAQTRLLVAVLAEH----
Rv1816|M.tuberculosis_H37Rv CFLLWAGVVGAISLEVFGQYGADMLTDPGVVFDAQTRLLVAVLAEH----
MAV_2899|M.avium_104 CFLLWAGVLGAISLEVFGQYGADTLTDVEAVFDAQLRLLVDVLTRH----
MAB_4787c|M.abscessus_ATCC_199 GIFAWASITGYLAGEVFGSLG-DLVADSDALYHDHVDTVLCGMGFAGV--
MMAR_0992|M.marinum_M AAQFWALIHGFVMLELAGFFGDEGAAIEPVLASMTTNLLVALGDSPELAK
MUL_0743|M.ulcerans_Agy99 AAQFWALIHGFVMLELAGFFGDEGAAIEPVLASMTTNLLVALGDSPELAK
TH_4347|M.thermoresistible__bu AGRLWSLIHGEVMLELAGFFGAEGHGLTKILTPMTVDMLVGLGDDRARVE
*: : * : *: * * : :
Mflv_3414|M.gilvum_PYR-GCK ------------
MSMEG_3659|M.smegmatis_MC2_155 ------------
Mvan_3167|M.vanbaalenii_PYR-1 ------------
Mb1846|M.bovis_AF2122/97 ------------
Rv1816|M.tuberculosis_H37Rv ------------
MAV_2899|M.avium_104 ------------
MAB_4787c|M.abscessus_ATCC_199 ------------
MMAR_0992|M.marinum_M RSQRLATGAG--
MUL_0743|M.ulcerans_Agy99 RSQRLTTGAG--
TH_4347|M.thermoresistible__bu ASLTTAAEAHGR