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GKRQDTRERIERDIVAIGRRHLVTEGAAGLSLRAIARDLGMVSSAVYRYVASRDELLTLLLVDAYTDLAD TVETARAASTGDWREQLRALGHAIRAWAVRQPASWALLYGSPVPGYHAPRDRTVTPGTRVVAALFDVVSA GIAAGDIASGEHPAPQPLSGDFDRLREQFGFAGDDVLLGKCLTLWAALIGAVGLEVFGQYGPDTFADPAL AFDTQIAALTEMLCQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3414 | - | - | 100% (226) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0973 | - | 3e-07 | 30.34% (178) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4816 | - | 1e-05 | 32.00% (75) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1846 | - | 4e-78 | 61.23% (227) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv1816 | - | 4e-78 | 61.23% (227) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4787c | - | 3e-24 | 35.07% (211) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0334 | - | 4e-06 | 32.00% (75) | TetR family transcriptional regulator |
| M. avium 104 | MAV_2899 | - | 2e-81 | 63.84% (224) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_3659 | - | 1e-82 | 67.84% (227) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_2336 | - | 2e-08 | 32.90% (155) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4787 | - | 2e-06 | 32.00% (75) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3167 | - | 7e-87 | 66.81% (226) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0334|M.marinum_M MNERTPSSRPHRSGRSRDSPSREERKEATRRAIIAAALKLVHDRSFSALS
MUL_4787|M.ulcerans_Agy99 MNERTPSSRPHRSSRSRDSPSREERKEATRRAIIAAALKLVHDRSFSALS
Mb1846|M.bovis_AF2122/97 ------------MCQTCRVGKRRDAREQIEAKIVELGRRQLLDHGAAGLS
Rv1816|M.tuberculosis_H37Rv ------------MCQTCRVGKRRDAREQIEAKIVELGRRQLLDHGAAGLS
MAV_2899|M.avium_104 ------------------MGKRQQSREQIEARIIELGRRQLVDRGAAGLS
Mflv_3414|M.gilvum_PYR-GCK ------------------MGKRQDTRERIERDIVAIGRRHLVTEGAAGLS
MSMEG_3659|M.smegmatis_MC2_155 ------------------MGKRQESRERIEAAIVEIGRQHLVTEGAAGLS
Mvan_3167|M.vanbaalenii_PYR-1 ------------MCDTGRVGKRQDTRDRIERQIVEIGRAHLVTHGAAALS
MAB_4787c|M.abscessus_ATCC_199 -------MPTRTNAADVPATRRARQRAQTTDEIKALARRQLADGGTGALS
TH_2336|M.thermoresistible__bu ---VSGVGKPISREAALLTSRASAGTGPTRQRLIEVAIELFKQHSVAGTS
: . . . .. *
MMAR_0334|M.marinum_M LREVTREAGIVPAAFYRHFESMEALGLVLIDESFRTLRDTLRGARAGRLD
MUL_4787|M.ulcerans_Agy99 LREVTREAGIVPAAFYRHFESMEALGLVLIDESFRTLRDTLRGARAGRLD
Mb1846|M.bovis_AF2122/97 LRAIARNLGMVSSAVYRYVSSRDELLTLLLVDAYSDLADTVDRARDDTVA
Rv1816|M.tuberculosis_H37Rv LRAIARNLGMVSSAVYRYVSSRDELLTLLLVDAYSDLADTVDRARDDTVA
MAV_2899|M.avium_104 VRAIARDLGMVSSAVYRYVSSRDELLTLLLVDAYSDLADTVDRAR-ETAG
Mflv_3414|M.gilvum_PYR-GCK LRAIARDLGMVSSAVYRYVASRDELLTLLLVDAYTDLADTVETARAASTG
MSMEG_3659|M.smegmatis_MC2_155 MRAVARDLGMVSSAVYRYVASRDELLTLLVVDAYTELADAVAAAVADVSA
Mvan_3167|M.vanbaalenii_PYR-1 LRAIARELGMVSSAVYRYVASRDELLTLLLVDAYGELADSVERARDAAAG
MAB_4787c|M.abscessus_ATCC_199 LRGIAREMGMAPAALFRYFETQAALITALCVDANGALAQAMSDGQKAAPE
TH_2336|M.thermoresistible__bu LQMISDALGLTKSAIYHHFRTRDELLTAVMEPLISEVAEIVSAAEARRGA
:: :: *:. :*.:::. : * : : : : .
MMAR_0334|M.marinum_M PN----RVIESSVEILIGSVAERREHWRFIVRERSTGLSVLR--------
MUL_4787|M.ulcerans_Agy99 PN----RVIESSVEILIGSVAERREHWRFIVRERSTGLSVLR--------
Mb1846|M.bovis_AF2122/97 DS--WSDDVIAIARAVRGWAVTNPARWALLYGSPVPGYHAPPDRTAGVAT
Rv1816|M.tuberculosis_H37Rv DS--WSDDVIAIARAVRGWAVTNPARWALLYGSPVPGYHAPPDRTAGVAT
MAV_2899|M.avium_104 EQ--WSDDVIAIARATRRWAVEHPACWALLYGSPVPGYHAPPERTVAAGT
Mflv_3414|M.gilvum_PYR-GCK D---WREQLRALGHAIRAWAVRQPASWALLYGSPVPGYHAPRDRTVTPGT
MSMEG_3659|M.smegmatis_MC2_155 AGARWRSQIRAIAHATRNWALDQPARWALLYGSPVPGYHAPAERTVVPGT
Mvan_3167|M.vanbaalenii_PYR-1 D---WQDRLRAVAHATRAWAVHHPARWALLYGSPVPGYHAPREQTVGPGT
MAB_4787c|M.abscessus_ATCC_199 SD--SAARLRAAFVAARRWALAHPGDFALLSGTPIPGYAAQPAETGPAAM
TH_2336|M.thermoresistible__bu RT-----RADHFLRGYAALAAAHREVISLLTGDP----------GVVALL
. . ::
MMAR_0334|M.marinum_M YAIRTEIRLITSELAT------------------DLARFPGLNEWSTEDL
MUL_4787|M.ulcerans_Agy99 YAIRTDIRLITSELAT------------------DLARFPGLNEWSTEDL
Mb1846|M.bovis_AF2122/97 RVVGAFFDAIAAGIATGDIRLTDDVAPQPMSS--DFEKIRQEFGFPGDDR
Rv1816|M.tuberculosis_H37Rv RVVGAFFDAIAAGIATGDIRLTDDVAPQPMSS--DFEKIRQEFGFPGDDR
MAV_2899|M.avium_104 RVVAALFDAVAAGITTGDIRLTNDPAPQPMSS--DFERIRHEFGFPGDDL
Mflv_3414|M.gilvum_PYR-GCK RVVAALFDVVSAGIAAGDIASGEHPAPQPLSG--DFDRLREQFGFAGDDV
MSMEG_3659|M.smegmatis_MC2_155 RVVVALFAAVARGIAEGDIPATEETVAQPLSG--DFARLRAEFGLHVDDA
Mvan_3167|M.vanbaalenii_PYR-1 RVVGLLFSAIAEGVAAGAVRTSKVTVPQSLSS--DFDRLRAEFEFVADDD
MAB_4787c|M.abscessus_ATCC_199 RVIASFMDAYLRAVAAGEAVPRRTRFRPSAPGPLLVAMFGEDTAPPIDPA
TH_2336|M.thermoresistible__bu RTRPDWAEVVQRQMAL-------------------LGDVQPGPGGRVKAA
. :: . . .
MMAR_0334|M.marinum_M NILATLFVNAMIVTAEAIEDA--QSSEALEEIRRIAVKQLRMVAIGVAGW
MUL_4787|M.ulcerans_Agy99 NILATMFVNAMIVTAEAIEDA--QSSEALEEIRRIAVKQLRMVAIGVAGW
Mb1846|M.bovis_AF2122/97 VVTKCFLLWAGVVGAISLEVFGQYGADMLTDPGVVFDAQTRLLVAVLAEH
Rv1816|M.tuberculosis_H37Rv VVTKCFLLWAGVVGAISLEVFGQYGADMLTDPGVVFDAQTRLLVAVLAEH
MAV_2899|M.avium_104 VIAKCFLLWAGVLGAISLEVFGQYGADTLTDVEAVFDAQLRLLVDVLTRH
Mflv_3414|M.gilvum_PYR-GCK LLGKCLTLWAALIGAVGLEVFGQYGPDTFADPALAFDTQIAALTEMLCQ-
MSMEG_3659|M.smegmatis_MC2_155 TMARCFALWAGLIGAVSLEVFGQYGADTLTDPRQLFDLQIDSLTGALTN-
Mvan_3167|M.vanbaalenii_PYR-1 VVARCLVLWAALVGAISLEVFGQYGADTFADASVVFDAQMDLVIDLFCRQ
MAB_4787c|M.abscessus_ATCC_199 IIGIGIFAWASITGYLAGEVFGSLG-DLVADSDALYHDHVDTVLCGMGFA
TH_2336|M.thermoresistible__bu VVMAGIAAAAGVD-------YGDLDEAALRDELLAAGRRTLGLRAPHARG
: : * : . . : : :
MMAR_0334|M.marinum_M KSRP
MUL_4787|M.ulcerans_Agy99 KSRP
Mb1846|M.bovis_AF2122/97 ----
Rv1816|M.tuberculosis_H37Rv ----
MAV_2899|M.avium_104 ----
Mflv_3414|M.gilvum_PYR-GCK ----
MSMEG_3659|M.smegmatis_MC2_155 ----
Mvan_3167|M.vanbaalenii_PYR-1 GAN-
MAB_4787c|M.abscessus_ATCC_199 GV--
TH_2336|M.thermoresistible__bu ----