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VTRGAGPERSSAGDPVRTLKLLWRTPGEARTSRGPRQRTTVDAVVAAAIEIADADGLGAVTIRAVATRLG IATMATYTYVPGKAELLDLMLDTVYRQMPRRDLSGMAWRDRVSAIAGENRELLEQHPWVAQLATTRPPLG PGMIAKYEHELCAFDGLGLSDLDMDSALTYVLGFVMSVARIAIDTNAARADSGVTDDTWWEQAGPVLATV FDADEFPLAARVGEAAGRALGGAYNAEHAYRFGLARVLDGLAPVIGDRARGSGRSPAN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4078 | - | - | 100% (269) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1315 | - | 1e-21 | 32.20% (236) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3167 | - | 9e-09 | 32.08% (106) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1846 | - | 2e-05 | 29.90% (97) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_2560 | - | 1e-108 | 75.10% (257) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1816 | - | 2e-05 | 29.90% (97) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2957c | - | 5e-13 | 34.92% (126) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3679 | - | 2e-16 | 29.73% (222) | putative regulatory protein |
| M. avium 104 | MAV_5055 | - | 2e-13 | 39.00% (100) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_3332 | - | 1e-13 | 30.77% (156) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_3256 | - | 6e-09 | 32.99% (97) | PUTATIVE putative transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_3622 | - | 4e-16 | 29.73% (222) | putative regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4078|M.vanbaalenii_PYR-1 -----------MVTRGAGPERSSAGDPVRTLKLLWRTPGEARTSRGPRQR
Mflv_2560|M.gilvum_PYR-GCK MTSLPPATIGRMDNPGSGSARSSAGDPVRTLELLWRVPAEARSGRGPKQR
MMAR_3679|M.marinum_M ------------------------MFTLRTMYLSTVWEGDVR------AR
MUL_3622|M.ulcerans_Agy99 ----------------MISIRTSYVFTLRTMYLSTVWEGDVR------AR
Mb1846|M.bovis_AF2122/97 --------------------------MCQTCRVGKRRDAREQ--------
Rv1816|M.tuberculosis_H37Rv --------------------------MCQTCRVGKRRDAREQ--------
MSMEG_3332|M.smegmatis_MC2_155 ---------------MTQPPAGPSGPGDSAPSADATENGQNR-------P
MAV_5055|M.avium_104 ----------------------------------MRRAGLKR--------
MAB_2957c|M.abscessus_ATCC_199 -------------------------------------MTDPR--------
TH_3256|M.thermoresistible__bu --------------------------------------------------
Mvan_4078|M.vanbaalenii_PYR-1 TTVDAVVAAAIEIADADGLGAVTIRAVATRLGIATMATYTYVPGKAELLD
Mflv_2560|M.gilvum_PYR-GCK TSVDAVVAAAVGIADTQGLSAVTIRAVAGVLGLAPMAIYTYVPGKAELLD
MMAR_3679|M.marinum_M FTVSDIASAALAIVDQDGLSGLSMRSLAAALGTGPMTLYNYVRDRRELEA
MUL_3622|M.ulcerans_Agy99 FTVSDIASAALAIVDQDGLSGLSMRSLAAALGTGPMTLYNYVRDRRELEA
Mb1846|M.bovis_AF2122/97 -IEAKIVELGRRQLLDHGAAGLSLRAIARNLGMVSSAVYRYVSSRDELLT
Rv1816|M.tuberculosis_H37Rv -IEAKIVELGRRQLLDHGAAGLSLRAIARNLGMVSSAVYRYVSSRDELLT
MSMEG_3332|M.smegmatis_MC2_155 ITREAVLAGALDIIDRDGVDALSMRRLGEALGRDPMALYRHVPNKAAVLD
MAV_5055|M.avium_104 ---EAVVRAAVKIADAEGIEAISMRRVSQALGVTPMALYRYLPDKDALID
MAB_2957c|M.abscessus_ATCC_199 LTLESIVGKAIEIADSDGLSGVSMRKIADALGVGAMSLYRHVADKDALLV
TH_3256|M.thermoresistible__bu -------------------------MVAAAVG------------------
:. :*
Mvan_4078|M.vanbaalenii_PYR-1 LMLDTVYR------QMPRRDLSGMAWRDRVSAIAGENRELLEQHPWVAQL
Mflv_2560|M.gilvum_PYR-GCK LMLDSVYG------QMSRGDLSGLPWRHRVTAIADENRALLDEHPWVTQL
MMAR_3679|M.marinum_M LVADAVVA------DVKVP-APTDDWRADVHAIATAMWETMRQHPNAIPL
MUL_3622|M.ulcerans_Agy99 LVADAVVA------DVKVP-APIDDWRADVHAIATAMWETMRQHPNAIPL
Mb1846|M.bovis_AF2122/97 LLLVDAYSDLADTVDRARDDTVADSWSDDVIAIARAVRGWAVTNPARWAL
Rv1816|M.tuberculosis_H37Rv LLLVDAYSDLADTVDRARDDTVADSWSDDVIAIARAVRGWAVTNPARWAL
MSMEG_3332|M.smegmatis_MC2_155 GVVEMIFE-------QLSLDTTTPDWIAALRRLGHDFRNLARAHPNVVPL
MAV_5055|M.avium_104 VVVDESLA-------VVPVPDPSGSVTAELLRCFGGLYDLLLDHPGLARA
MAB_2957c|M.abscessus_ATCC_199 EMTAEVTR----RFAYPDEMMGVPDWRARVRVAVEHDFDLYSTHPWVLLA
TH_3256|M.thermoresistible__bu ----------------PPPQLDPTDWVAALRHWSTALWEVYHRHPWILQA
: :*
Mvan_4078|M.vanbaalenii_PYR-1 ATTRPPL------GPGMIAKYEHELCAFDGLGLSDLDMDSALTYVLGFVM
Mflv_2560|M.gilvum_PYR-GCK ATTRPPL------GPGTAAKYDHELRAFDGLGLSDLDMDSALTYVLGFVT
MMAR_3679|M.marinum_M VLTRRTV------SASSYMVADRLIAALGRSGVGDADLLASFRGVLGLVM
MUL_3622|M.ulcerans_Agy99 VLTRRTV------WASSYMVADRLIAALGRSGVGDADLLASFRGVLGLVM
Mb1846|M.bovis_AF2122/97 LYGSP--------VPGYHAPPDRTAGVATR-------VVGAFFDAIAAGI
Rv1816|M.tuberculosis_H37Rv LYGSP--------VPGYHAPPDRTAGVATR-------VVGAFFDAIAAGI
MSMEG_3332|M.smegmatis_MC2_155 LVTRPLATPLGMRPPGILRHLEQILALLTRCGFTGPDALHVYRTLFGFLY
MAV_5055|M.avium_104 AGERPLEG------PFATRLGNNVLTLLQHNKIDEADAANLLVSAFSLTL
MAB_2957c|M.abscessus_ATCC_199 YAVPRNG-----MQPETLVCFDWLLEAFSHLGVAAPEAAELTFQVWSYSQ
TH_3256|M.thermoresistible__bu AAAGPPAD------PQQLAWLDTALAALQGTGLAERDKLAAVTALMHLVR
. :
Mvan_4078|M.vanbaalenii_PYR-1 SVARIAIDTNAARADSGVTDDTWWEQAGPVLATVFDADEFPLAARVGEAA
Mflv_2560|M.gilvum_PYR-GCK SVARIADDAREARRDSGVSDQAWWDRAGPLLAEVFDDEKFPLAARIGAAA
MMAR_3679|M.marinum_M GSAQAELAGPLAGTGREKEQVAVAARIG-----GLAGAEHPHIAALAQAS
MUL_3622|M.ulcerans_Agy99 GSAQAELAGPLAGTGREKEQVAVAARIG-----GLAGAEHPHIAALAQAS
Mb1846|M.bovis_AF2122/97 ATGDIRLTDDVAPQPMSSDFEKIRQEFGFPGDDRVVTKCFLLWAGVVGAI
Rv1816|M.tuberculosis_H37Rv ATGDIRLTDDVAPQPMSSDFEKIRQEFGFPGDDRVVTKCFLLWAGVVGAI
MSMEG_3332|M.smegmatis_MC2_155 GHVLTELQEIVERP----EETDHVMRLG---LHRLPIGEFPHVRDLAPTW
MAV_5055|M.avium_104 GCALYRTSR------SGRTASSRLSQVG---------DEAPAVRRLRGRL
MAB_2957c|M.abscessus_ATCC_199 GVGLGAVGGQLVSPGARTDFSGLSELIAG----NAEVPESPRLAALLGLG
TH_3256|M.thermoresistible__bu GAAALHIDAG------RLDWPEYPVLLRR----LIDADRFPALTAALDAG
.
Mvan_4078|M.vanbaalenii_PYR-1 GRALGGAYNAEHAYRFGLARVLDGLAPVIGDRARGSGRSPAN-
Mflv_2560|M.gilvum_PYR-GCK GQAFGSAYDADHAYRFGLARVLDGLEPVINRTAR---------
MMAR_3679|M.marinum_M QRST-----PAADFERALDILLAGIESFERRRDRR--------
MUL_3622|M.ulcerans_Agy99 QRST-----PAADFERALDILLAGIESFERRRDRR--------
Mb1846|M.bovis_AF2122/97 SLEVFGQYGADMLTDPGVVFDAQTRLLVAVLAEH---------
Rv1816|M.tuberculosis_H37Rv SLEVFGQYGADMLTDPGVVFDAQTRLLVAVLAEH---------
MSMEG_3332|M.smegmatis_MC2_155 AAYDG-----LAELDRGLDILLTGLATRLDMPGGMPTRAPEPG
MAV_5055|M.avium_104 TVAS----ADDTVFRDALTRLIAGYVTTAAKTGGRRR------
MAB_2957c|M.abscessus_ATCC_199 DLPEVTN--PREVIAKGVEILCDGIARRYHKL-----------
TH_3256|M.thermoresistible__bu AFDPVDA-DPLTDLHSAVDYLLDGIAAKL--------------
.: