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MIEGLNYIGGAWVPAQSGRTFTRANPADPADVIGTFPASDADDVRNAVDALEKAAPEWAATAPERRASIL ESAAAQLESRSEALIAELVREEGKTVAEATMEVTRTPSNLRFYAAEATRAAGMTFPAAGDTMVYTVREPV GIVGAITPWNFPLNIPSRKLGPALAVGDPVLFKPSELTPLMGQRLVEALLAGGLPPGVLALVHGDGVAGA AVAADERVAAVTFTGSTAVGRSIHRAVGPHRRVQLEMGGKNPVVVADDADLDRAAALIVKGAFGLSGQAC TGTSRVIATDATHDGLVERVVARAEALRVGPGAQPGIDMGALASAAQAEKFAHYVGVGVDEGASLRCGGT RLDVPGHAGGFFVRPAVFTDTEPTMRIVSEEVFGPLLAFQRAGSLTEAIELANATEFGLSAAIVTGDLAT AAQFARESRTGLVKINQPTTGMAMNAPFGGYKASSTTTFKEQAGASMMEFYLTEKTVYLNPGF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1328 | - | - | 100% (483) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1856 | - | 9e-88 | 41.00% (478) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0352 | - | 2e-71 | 36.63% (486) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0467 | - | 1e-67 | 36.60% (459) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3083 | - | 2e-70 | 38.06% (444) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0458 | - | 1e-67 | 36.60% (459) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-54 | 34.17% (436) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0823 | - | 3e-84 | 40.59% (478) | aldehyde dehydrogenase |
| M. marinum M | MMAR_2875 | - | 8e-69 | 35.54% (484) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1897 | - | 2e-69 | 37.22% (446) | betaine-aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1461 | - | 0.0 | 77.50% (480) | 5-oxovalerate dehydrogenase |
| M. thermoresistible (build 8) | TH_3902 | - | 3e-71 | 38.74% (462) | PUTATIVE putative 5-carboxymethyl-2-hydroxymuconate |
| M. ulcerans Agy99 | MUL_2877 | - | 7e-69 | 35.54% (484) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2875|M.marinum_M ---MTTVAVP--------HHAMLIGGESVDSD--RRLSLVDPG-DESPVA
MUL_2877|M.ulcerans_Agy99 ---MTTVAVP--------HHAMLIGGESVDSD--RRLSLVDPG-DESPVA
MAV_1897|M.avium_104 ---MTDTTISNGVTEQLVHFDLVIGGESVAAESGRTYDSIDPY-TALPWA
Mflv_3083|M.gilvum_PYR-GCK ---------------MDGDPDLCIGGAWRHACDGGTRDIINPA-NGAVAA
TH_3902|M.thermoresistible__bu ---LRANRFQPKDNTVTWKYDLYIDGKWDTGTSGRALTVVNPA-TEETIG
Mb0467|M.bovis_AF2122/97 MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPV-TGQPFC
Rv0458|M.tuberculosis_H37Rv MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPV-TGQPFC
MLBr_02573|M.leprae_Br4923 ----------------------------------MSIATINPA-TGETVK
Mvan_1328|M.vanbaalenii_PYR-1 ----------------MIEGLNYIGGAWVPAQSGRTFTRANPADPADVIG
MSMEG_1461|M.smegmatis_MC2_155 ---------------MTVEGANFIDGQWIPAASGRTFARHNPADPDDLVG
MAB_0823|M.abscessus_ATCC_1997 --------------MHINEIQSFVGGRWISG-GGQAVISVCPAFPDRVIA
*
MMAR_2875|M.marinum_M TVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTD
MUL_2877|M.ulcerans_Agy99 TVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTD
MAV_1897|M.avium_104 RVPDCGPADVDRAVAAARAALR-GPWGQLTGTARGKLLWRLGELIAREAE
Mflv_3083|M.gilvum_PYR-GCK VVDEATPQDALDAVAAARAAFDQGGWRATAVAERSALLQRIADLLQRDKE
TH_3902|M.thermoresistible__bu TVPDASLDDIRRAIAAARTAFDEGPWPCMTPLERAAVIRRIAEVLQRRRS
Mb0467|M.bovis_AF2122/97 EVPRSDAADIDKALDAAHAAAP--GWGKTAPAERAAILNMIADRIDKNAA
Rv0458|M.tuberculosis_H37Rv EVPRSDAADIDKALDAAHAAAP--GWGKTAPAERAAILNMIADRIDKNAA
MLBr_02573|M.leprae_Br4923 TFTPTTQDEVEDAIARAYARFD--NYRHTTFTQRAKWANATADLLEAEAN
Mvan_1328|M.vanbaalenii_PYR-1 TFPASDADDVRNAVDALEKAAP--EWAATAPERRASILESAAAQLESRSE
MSMEG_1461|M.smegmatis_MC2_155 VFPASDGVDVRTAVDALDKAAP--EWAATPPERRAAILEAAAVQLESRAA
MAB_0823|M.abscessus_ATCC_1997 EGLAAGPAEFDEAAAAARAAQP--GWAAMSLHARGAMLSHAAAVVDRNAD
. * : . *.
MMAR_2875|M.marinum_M ELIELEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQR-PAPIET
MUL_2877|M.ulcerans_Agy99 ELIELEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQR-PAPIET
MAV_1897|M.avium_104 SLAELEVRDGGKLVREMIG-QMKALPDYYIYYAGLADKLQGEVVPVDKPN
Mflv_3083|M.gilvum_PYR-GCK DLARLETVDTGKTL-AESRIDIDDVTSVFRYYANLVAS--EAERVVDVGD
TH_3902|M.thermoresistible__bu ELVDLVRAETGS---PQWIVEMLQVGVPLRVCADVADRVLPQFRFVEPML
Mb0467|M.bovis_AF2122/97 ALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGALSQIDEDT
Rv0458|M.tuberculosis_H37Rv ALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGALSQIDEDT
MLBr_02573|M.leprae_Br4923 QSAALMTLEMGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEPAEAAAV
Mvan_1328|M.vanbaalenii_PYR-1 ALIAELVREEGK-TVAEATMEVTRTPSNLRFYAAEATRAAGMTFPAAGDT
MSMEG_1461|M.smegmatis_MC2_155 ELIAELIREEGK-TTAEATMEVSRTPANLRFYAGEALRSTGTTYPAPGEG
MAB_0823|M.abscessus_ATCC_1997 AWGLELAAEEGK-TKAEGIAEVRRAAQILRYYGNEGDRQTGEIFSSPRRG
* : .
MMAR_2875|M.marinum_M FPVLSQS---VVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVK
MUL_2877|M.ulcerans_Agy99 FPVLSQS---VVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVK
MAV_1897|M.avium_104 FFVYTR-------HEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVK
Mflv_3083|M.gilvum_PYR-GCK PAVISR-----VIREPIGVCVLIAPWNYPLLQMSWKVAPALAAGCTMVAK
TH_3902|M.thermoresistible__bu PSFDLRPGQGIISKEPIGVAALITPFNFPLFLNVMKLAPALAAGCTVVLK
Mb0467|M.bovis_AF2122/97 VAYHFH--------EPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVLK
Rv0458|M.tuberculosis_H37Rv VAYHFH--------EPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVLK
MLBr_02573|M.leprae_Br4923 GASKALAR-----YQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLK
Mvan_1328|M.vanbaalenii_PYR-1 -MVYTVR-------EPVGIVGAITPWNFPLNIPSRKLGPALAVGDPVLFK
MSMEG_1461|M.smegmatis_MC2_155 -LVYTLR-------EPVGIVGAITPWNFPFNIPSRKLGPALAAGNPVLYK
MAB_0823|M.abscessus_ATCC_1997 EHILVTR-------KPLGVVGVITPFNFPIAIPAWKIAPALVYGNAVLWK
:*:*: : *:* *: ...: * : *
MMAR_2875|M.marinum_M PDEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIA
MUL_2877|M.ulcerans_Agy99 PDEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIA
MAV_1897|M.avium_104 PSDHTPASTLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKIA
Mflv_3083|M.gilvum_PYR-GCK PSEVTPLSTIAFAKLLDEAGVPPGVVNLIQGSGATLGPALTDNPQVDFIS
TH_3902|M.thermoresistible__bu PSPLTPLEALVLGEVADEVGLPPGVLNIVTG-GAEESAELTTNPMVDLVS
Mb0467|M.bovis_AF2122/97 PAEQTPASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKVA
Rv0458|M.tuberculosis_H37Rv PAEQTPASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKVA
MLBr_02573|M.leprae_Br4923 HASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILRD-PRVAAAT
Mvan_1328|M.vanbaalenii_PYR-1 PSELTPLMGQRLVEALLAGGLPPGVLALVHG-DGVAGAAVAADERVAAVT
MSMEG_1461|M.smegmatis_MC2_155 PSELTPLMGQRLVEALLDGGLPPSAVALVQG-DGVAGAAVAADPRVAAVT
MAB_0823|M.abscessus_ATCC_1997 PASTVPLLAMRLAQAFDAAGLPPGVLNLVVG-DTGVGDAMVNDSRVDALT
.* : .* . . : : : :
MMAR_2875|M.marinum_M FTGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDDA-------DLEMA
MUL_2877|M.ulcerans_Agy99 FTGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDDA-------DLEMA
MAV_1897|M.avium_104 FTGSTATGISVGKAAIDNMTRFTLELGGKSAQVVFDDA-------DLDAA
Mflv_3083|M.gilvum_PYR-GCK FTGGLATGRTIARTAAEHVTKVALELGGKNPHLVFADIRDAGRESGWDAA
TH_3902|M.thermoresistible__bu FTGSDTVGRQVMNQASATLKKVVLELGGKSANVIFADA-------DLDAA
Mb0467|M.bovis_AF2122/97 FTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAHD--DFCDK
Rv0458|M.tuberculosis_H37Rv FTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAHD--DFCDK
MLBr_02573|M.leprae_Br4923 LTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSA-------DLDAA
Mvan_1328|M.vanbaalenii_PYR-1 FTGSTAVGRSIHRAVGPH-RRVQLEMGGKNPVVVADDA-------DLDRA
MSMEG_1461|M.smegmatis_MC2_155 FTGSTAVGRAIHQQVGPQ-RRVQLEMGGKNPVVVAGDA-------DLDAA
MAB_0823|M.abscessus_ATCC_1997 FTGSTGVGRRIAAAGAARGIPVQAEMGGKNAAVVLDDA-------DVDLA
:** .* : *:**... :. . .
MMAR_2875|M.marinum_M VEGVLYGCFAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRD
MUL_2877|M.ulcerans_Agy99 VEGVLYGCFAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRD
MAV_1897|M.avium_104 ANGVIAGVFAATGQTCLAGSRLLVHESVADALVERIVARASTIKLGDPKD
Mflv_3083|M.gilvum_PYR-GCK VDHVLTGVFLHSGQVCSAGTRLIIEESIADEFVAALAARAATIRMGDGLD
TH_3902|M.thermoresistible__bu AAHVVGEFTLHAGQGCSLLTRTLVEESIHDELVDWVNKQLAALKVGDPAD
Mb0467|M.bovis_AF2122/97 ALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQGDPLD
Rv0458|M.tuberculosis_H37Rv ALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQGDPLD
MLBr_02573|M.leprae_Br4923 VATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTD
Mvan_1328|M.vanbaalenii_PYR-1 AALIVKGAFGLSGQACTGTSRVIATDATHDGLVERVVARAEALRVGPGAQ
MSMEG_1461|M.smegmatis_MC2_155 AALIVKGAFGLSGQACTGTSRVIAVDEVHDALLDRVVAKADALQVGPGNE
MAB_0823|M.abscessus_ATCC_1997 VEQVLLGAFRSTGQKCTATSRLVLTEGIADAFLSLLKDRADALVVGDPTA
. . *: * .* : : :: : :: *
MMAR_2875|M.marinum_M WDTDLGPVIDAAQRTRILNYIRGAQTDGATVALGGEALTG-GMFDKGFWV
MUL_2877|M.ulcerans_Agy99 WDTDLGPVIDAAQRTRILNYIRGAQTDGATVALGGEALTG-GMFDKGFWV
MAV_1897|M.avium_104 PATEMGPVSNQPQYEKVLSHFASAREQGATVAYGGE--PA-GELG-GFFV
Mflv_3083|M.gilvum_PYR-GCK PASETGPLVSAQHRDKVESYVRLGISEGAQLIAGGCRPED-PVLAGGYFY
TH_3902|M.thermoresistible__bu PSVMMGPLISEAQRNRVEGYIKAGVDEGAEIAFGGGRP---SHLERGYFV
Mb0467|M.bovis_AF2122/97 TETMLGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYM
Rv0458|M.tuberculosis_H37Rv TETMLGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYM
MLBr_02573|M.leprae_Br4923 PDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKRPDR-----PGWFY
Mvan_1328|M.vanbaalenii_PYR-1 PGIDMGALASAAQAEKFAHYVGVGVDEGASLRCGGTRL-DVPGHAGGFFV
MSMEG_1461|M.smegmatis_MC2_155 PGVQMGPLASAAQREKFLHYVHAGITEGATLRCGGT---TVGDHG--FFV
MAB_0823|M.abscessus_ATCC_1997 DDTQMGPVVSESAFGTITAGIGGAVAQGAVTLAGGHGY-GDGPLAAGYFI
*. . . . ** ** ::
MMAR_2875|M.marinum_M APTILTGVHNDMAIAREEVFGPVLVVIGYDGDEQAIAIANDSDYGLAASI
MUL_2877|M.ulcerans_Agy99 APTILTGVHNDMAIAREEVFGPVLVVSGYDGDEQAIAIANDSDYGLAASI
MAV_1897|M.avium_104 KPTVLTGVDRSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEFGLAAGV
Mflv_3083|M.gilvum_PYR-GCK RPTIFDRCDRSMRIVQEETFGPILTVERFTDEAEAVTLGNDTEYGLAAGV
TH_3902|M.thermoresistible__bu EPTLFTGVRNEMKIAQEEIFGPVGVVIPFTSEHEAVRLANDSDFGLGGGV
Mb0467|M.bovis_AF2122/97 QPTIFTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGV
Rv0458|M.tuberculosis_H37Rv QPTIFTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGV
MLBr_02573|M.leprae_Br4923 PPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNA
Mvan_1328|M.vanbaalenii_PYR-1 RPAVFTDTEPTMRIVSEEVFGPLLAFQRAGSLTEAIELANATEFGLSAAI
MSMEG_1461|M.smegmatis_MC2_155 RPAVFADALPTMRIVTEEVFGPLVAFQRAASLDEAVALANATEYGLAASI
MAB_0823|M.abscessus_ATCC_1997 APTIMELGMGAVDLWTEELFGPVLAVRRAADTEEAFRLANDSEYGLSAAI
*::: : :* ***: . . :*. .* : :**..
MMAR_2875|M.marinum_M WTSDNARGLAMAERIQSGSVWINDAH-QINCRLPFGGYKQSGVG---REL
MUL_2877|M.ulcerans_Agy99 WTSDNARGLAMAERIRSGSVWINDAH-QINCRLLFGGYKQSGVG---REL
MAV_1897|M.avium_104 WTKDVHRAHRVAARLNAGTVWVNAYR-VVSPHVPFGGMGHSGIG---REN
Mflv_3083|M.gilvum_PYR-GCK RTTDTARGERVVRALRHGTVWLNDFG-YYTAAAEWGGFGRSGNG---REL
TH_3902|M.thermoresistible__bu WSTDVERALRVAQRIRTGMVAINGGGGSMGKTGPFGGFKASGLG---REW
Mb0467|M.bovis_AF2122/97 WSRDGNTAYRAGRDIQAGRVWVNCYH-LYPAHAAFGGYKQSGIG---REG
Rv0458|M.tuberculosis_H37Rv WSRDGNTAYRAGRDIQAGRVWVNCYH-LYPAHAAFGGYKQSGIG---REG
MLBr_02573|M.leprae_Br4923 WTQNESEQRHFIDNIVAGQVFINGMT-VSYPELPFGGIKRSGYG---REL
Mvan_1328|M.vanbaalenii_PYR-1 VTGDLATAAQFARESRTGLVKINQPTTGMAMNAPFGGYKASSTTTFKEQA
MSMEG_1461|M.smegmatis_MC2_155 VTSDLAAATRFARQSKTGLVKINQPTTGMAMNAPFGGYKASSTQTFKEQA
MAB_0823|M.abscessus_ATCC_1997 FTKDLTRALSAVDHVDVGILHVNSESAGADPHVPFGGAKKSGLG--PKEQ
: : * : :* :** *. .:
MMAR_2875|M.marinum_M GPDALDAYTEVKTIHLDLSGGREAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 GPDTLDAYTEVKTIHLDLSGGREAKPYDVLLGHPETG
MAV_1897|M.avium_104 GIDAVKDFTETKAVWVELSG---ATRDPFTLG-----
Mflv_3083|M.gilvum_PYR-GCK GPTGLAEYQEIKHIWHNTAPAAAGWFTG---------
TH_3902|M.thermoresistible__bu GEWGLDEFLEMKQIIW---PIAGG-------------
Mb0467|M.bovis_AF2122/97 HQMMLQHYQHTKNLLVSYSDKALGFF-----------
Rv0458|M.tuberculosis_H37Rv HQMMLQHYQHTKNLLVSYSDKALGFF-----------
MLBr_02573|M.leprae_Br4923 STHGIREFCNIKTVWIA--------------------
Mvan_1328|M.vanbaalenii_PYR-1 GASMMEFYLTEKTVYLN--PGF---------------
MSMEG_1461|M.smegmatis_MC2_155 GPTLMEFYTLEKTVYLT--PAL---------------
MAB_0823|M.abscessus_ATCC_1997 GRAAREFFTHTTTVYLRGEEAM---------------
: . :