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MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFDNYRHTTFTQRAKWANATADLLEAEANQSAALMT LEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLWQT VRFAAPALMAGNVGLLKHASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILRDPRVAAATLTGS EPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQSCIAAKRFIAHADIYDE FVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKRPDRPGWFYPPTVIT DITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAGQVFINGMT VSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_02573 | gabD1 | - | 100% (457) | succinic semialdehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02639 | - | 3e-33 | 29.97% (347) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0239c | gabD1 | 0.0 | 85.71% (455) | succinic semialdehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1858 | - | 8e-72 | 34.81% (451) | succinate-semialdehyde dehydrogenase (NAD(P)(+)) |
| M. tuberculosis H37Rv | Rv0234c | gabD1 | 0.0 | 85.71% (455) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3471 | gabD1 | 0.0 | 77.02% (457) | succinic semialdehyde dehydrogenase |
| M. marinum M | MMAR_0490 | gabD1 | 0.0 | 81.76% (455) | succinate-semialdehyde dehydrogenase |
| M. avium 104 | MAV_4936 | gabD1 | 0.0 | 80.00% (455) | succinic semialdehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6452 | - | 1e-100 | 44.03% (452) | [NADP+] succinate-semialdehyde dehydrogenase [Mycobacterium |
| M. thermoresistible (build 8) | TH_4137 | - | 1e-68 | 34.63% (462) | PUTATIVE putative [NADP+] succinate-semialdehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1153 | gabD1 | 0.0 | 81.54% (455) | succinic semialdehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1844 | - | 2e-89 | 40.71% (452) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0239c|M.bovis_AF2122/97 MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
Rv0234c|M.tuberculosis_H37Rv MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
MLBr_02573|M.leprae_Br4923 --------------------------------------------------
MMAR_0490|M.marinum_M --------------------------------------------------
MUL_1153|M.ulcerans_Agy99 --------------------------------------------------
MAV_4936|M.avium_104 --------------------------------------------------
MAB_3471|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_6452|M.smegmatis_MC2_155 -------------------------------------------------M
Mvan_1844|M.vanbaalenii_PYR-1 -------------------------------------------------M
Mflv_1858|M.gilvum_PYR-GCK -------------------------MDNSAVEALLASVPTGLWIGGEERE
TH_4137|M.thermoresistible__bu -----------------------------------------MYIDGEWQS
Mb0239c|M.bovis_AF2122/97 KDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQ-TSFA
Rv0234c|M.tuberculosis_H37Rv KDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQ-TSFA
MLBr_02573|M.leprae_Br4923 ----MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFDNYRH-TTFT
MMAR_0490|M.marinum_M ----MPIATTNPATGETVKTFTAASNDEVDAAIARAYARFQDYRRNTTLA
MUL_1153|M.ulcerans_Agy99 ----MPIATTNPATGETVKTFTAASNDEVDAAIARAYARFQDYRRNTTFA
MAV_4936|M.avium_104 ----MPIATINPATGETVKTFTPASDAEVDAAIARAYERFLDYRHSTTFA
MAB_3471|M.abscessus_ATCC_1997 ----MPIATINPATGETIKTFTAASDAEIDAAIGRAHDRFRQYRT-TSFS
MSMEG_6452|M.smegmatis_MC2_155 NMTQ--YAVTDPATAEVVATYPTATDAEVQAAIEAAHKTGRTWAKSTTVA
Mvan_1844|M.vanbaalenii_PYR-1 TATQPPYRTLNPATGEVLATFDTATDDLIATAITAADDAYRAWRE-QPLE
Mflv_1858|M.gilvum_PYR-GCK GTS--TFDVLDPSDDTVLTSVADATADDARAALDAACAVQAEWAG-TAPR
TH_4137|M.thermoresistible__bu AASGKTFASINPANGAVLDSVPDGEREDARRAIDAAAAALPDWRS-RTAY
:*: .: : *: * : .
Mb0239c|M.bovis_AF2122/97 QRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYA
Rv0234c|M.tuberculosis_H37Rv QRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYA
MLBr_02573|M.leprae_Br4923 QRAKWANATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYA
MMAR_0490|M.marinum_M QRAEWAHATADLIEAEADQTAALMTLEMGKTIASAKAEVLKSAKGFRYYA
MUL_1153|M.ulcerans_Agy99 QRAEWAHATADLIEAEADQTAALMTLEMGKTIASAKAEVLKSAKGFRYYA
MAV_4936|M.avium_104 QRAQWANATADLLEAEADEVAAMMTLEMGKTLKSAKAEALKCAKGFRYYA
MAB_3471|M.abscessus_ATCC_1997 DRAAWALSTADLLEAEADDVAALMTLEMGKTLASAKAEVLKCAKGFRFYA
MSMEG_6452|M.smegmatis_MC2_155 ERAALIRKVAELHEQRREQLADVIVREMGKPRDQSLGEVDFCAAIYQYYA
Mvan_1844|M.vanbaalenii_PYR-1 ARVDVVRHVGRLLRERATELAELAKLEMGKKLDEGTGEVEFSASIFEFYA
Mflv_1858|M.gilvum_PYR-GCK KRGEILRSVFETITARADDIAALMTLEMGKVLAESKGEVTYGAEFFRWFA
TH_4137|M.thermoresistible__bu ERAEVLVEAHRIMLERRDDLAELMTREQGKPLRMARTEVGYAADFLLWFA
* . . : * : * ** . *. * ::*
Mb0239c|M.bovis_AF2122/97 ENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAA
Rv0234c|M.tuberculosis_H37Rv ENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAA
MLBr_02573|M.leprae_Br4923 EKAETLLADEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAA
MMAR_0490|M.marinum_M DNAAALLADEPADAGKVGASQAYTRYQPLGVVLAVMPWNFPLWQAVRFAA
MUL_1153|M.ulcerans_Agy99 DNAAALLADEPADAGKVGASQAYTRYQPLGVVLAVMPWNFPLWQAGRFAA
MAV_4936|M.avium_104 QNAEQLLADEPADAGKVGAARAYIRYQPLGVVLAVMPWNFPLWQAVRFAA
MAB_3471|M.abscessus_ATCC_1997 ENAEAMLAPEPADASAVNASQAYAQYQPLGVVLAVMPWNFPLWQAVRFAA
MSMEG_6452|M.smegmatis_MC2_155 DNAEKFLADEPIEL-LDGEGSAVIKRSPIGVLLGIMPWNYPYYQVARFAG
Mvan_1844|M.vanbaalenii_PYR-1 DHAAALLADQRIPS-FSG-GTAVVQRRPVGVLLGVMPWNFPVYQVARFAA
Mflv_1858|M.gilvum_PYR-GCK EEAVRIDG--RYTAAPAGTGRILVTKQAVGPCYAITPWNFPLAMGTRKMG
TH_4137|M.thermoresistible__bu EEAKRVYG--EVIPSARADQRFIVLAQPVGVCAAITPWNYPISMLTRKLA
:.* . . .:* .: ***:* * .
Mb0239c|M.bovis_AF2122/97 PALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLVSSG--AV
Rv0234c|M.tuberculosis_H37Rv PALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLVSSG--AV
MLBr_02573|M.leprae_Br4923 PALMAGNVGLLKHASNVPQCALYLADVIARGGFPEDCFQTLLISAN--GV
MMAR_0490|M.marinum_M PALMAGNVGLLKHASNVPQSALYLADVIARGGFPDGCFQTLLVSAS--AV
MUL_1153|M.ulcerans_Agy99 PALMAGNVGLLKHASNVPQSALYLADVIARAGFPDGCFQTLLVSAS--AV
MAV_4936|M.avium_104 PALMAGNVGILKHASNVPQSALYLADVITRGGFPEGCFQTLLVPSS--AV
MAB_3471|M.abscessus_ATCC_1997 PALMAGNVGLLKHASNVPQSALYLADVIARGGFPEGCFQTLLVPSS--AV
MSMEG_6452|M.smegmatis_MC2_155 PNLVVGNTILLKHAPQCPESAELLQLLFLEAGFPQGAYVDIRATNE--QV
Mvan_1844|M.vanbaalenii_PYR-1 PNLVLGNTILLKHAESVPQCALVIADVMRDAGVPEGVYTNLFASFD--QV
Mflv_1858|M.gilvum_PYR-GCK PAFAAGCTMIVKPAQETPLTMLLLAKLMADAGLPKGVLSVLPTTSPGPVT
TH_4137|M.thermoresistible__bu PALAAGCTSVLKPAEQTPLCAVETFKVFADAGVPAGVVNLVTCSDPEPVA
* : * . ::* * . * :: .*.* . : . .
Mb0239c|M.bovis_AF2122/97 EAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPS
Rv0234c|M.tuberculosis_H37Rv EAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPS
MLBr_02573|M.leprae_Br4923 EAILRDPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS
MMAR_0490|M.marinum_M EGILRDPRVAAATLTGSEPAGQSVGAIAGDEIKPTVLELGGSDPFIVMPS
MUL_1153|M.ulcerans_Agy99 EGILRDPRVAAATLTGSEPAGQSVGAIAGDEIKPTVLELGGSDPFIVMPS
MAV_4936|M.avium_104 ERILRDPRVAAATLTGSEPAGQSVAAIAGDEIKPTVLELGGSDPFIVMPS
MAB_3471|M.abscessus_ATCC_1997 ERILRDPRVAAATLTGSEPAGRSVAAIAGDEVKPTVLELGGSDPFIVMPS
MSMEG_6452|M.smegmatis_MC2_155 ANIIADPRVAAVSLTGSERAGAAVAEIAGRNLKKCVLELGGSDPFIVLST
Mvan_1844|M.vanbaalenii_PYR-1 ETIIGDPRVQGVSVTGSERAGAAVAATAGRSLKKCLLELGGSDPFIVLD-
Mflv_1858|M.gilvum_PYR-GCK ETLIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGNAPFVVFDD
TH_4137|M.thermoresistible__bu DELLGDPRVRKISFTGSTEVGRMIASRAGATMKRVSMELGGHAPFLVFPD
:: * *: :.*** .* : :. : :**** **:*:
Mb0239c|M.bovis_AF2122/97 ADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAALR
Rv0234c|M.tuberculosis_H37Rv ADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAALR
MLBr_02573|M.leprae_Br4923 ADLDAAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLR
MMAR_0490|M.marinum_M ADLDKAVSTAVTGRVQNNGQSCIAAKRFIAHADIYDAFVDKFVEQMSALT
MUL_1153|M.ulcerans_Agy99 ADLDKAVSTAVTGRVQNNGQSCIAAKRFIAHADIYDAFVDKFVEQMSALT
MAV_4936|M.avium_104 ADLDEAVKTAVTARVQNNGQSCIAAKRFIVHTDIYDTFVDKFVEQMKALK
MAB_3471|M.abscessus_ATCC_1997 ADLEQAVSTAVTARVQNNGQSCIAAKRFIAHRDIYDDFLSRFVEKMAALR
MSMEG_6452|M.smegmatis_MC2_155 DDLDATVQAAVDGRMENTGQACNAAKRFIVNESIYDDFLAKFTEKLLAAG
Mvan_1844|M.vanbaalenii_PYR-1 GDSKQLARTAWEFRVYNMGQACNSNKRMIVTDDLYDDFVAELVTLAGDLA
Mflv_1858|M.gilvum_PYR-GCK ADVDAAVDGAILAKMRNGGEACTAANRIHVANAVREEFTDKFVKRMSEFT
TH_4137|M.thermoresistible__bu ADPEHAAKGGAAVKFLNTGQACICPNRFIVHRSIAEPFIATLRARIEKLV
* . . . :. * *::* . :*: . : : * :
Mb0239c|M.bovis_AF2122/97 VGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRLDRP---
Rv0234c|M.tuberculosis_H37Rv VGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRLDRP---
MLBr_02573|M.leprae_Br4923 VGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKRPDRP---
MMAR_0490|M.marinum_M VGDPTDPQTQVGPLATEQSRDEIAQQVDDAAAAGAVIRCGGKPLAGP---
MUL_1153|M.ulcerans_Agy99 VGDPTDPQTQVGPLATEQSRDEIAQQVDDAAAAGAVIRCGGKPLAGP---
MAV_4936|M.avium_104 VGDPTDPATDVGPLATESGRDEIAKQVDDAVAAGATLRCGGKPLDGP---
MAB_3471|M.abscessus_ATCC_1997 VGDPTDPATDVGPLATEQGRDEVDKQVQQAVAAGASIRCGGTRPDGP---
MSMEG_6452|M.smegmatis_MC2_155 --------EGIAPLSSEQAAVRLEDQVKSAVEAGAKLTAAGERKG-----
Mvan_1844|M.vanbaalenii_PYR-1 P-------AEIAPMSSRKAAETLAAQVADAVDKGATLHVGGELAEGP---
Mflv_1858|M.gilvum_PYR-GCK LGKGLDEKSTLGPLINAKQVATVTELVSDAVSRGATVAVGGVAPGGP---
TH_4137|M.thermoresistible__bu PGDGLAAGTTVGPLIDEVALKKMQRQVDDAVDKGAKLELGGSRLQGPAFD
:.*: : * *. ** : .*
Mb0239c|M.bovis_AF2122/97 -GWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFG
Rv0234c|M.tuberculosis_H37Rv -GWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFG
MLBr_02573|M.leprae_Br4923 -GWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFG
MMAR_0490|M.marinum_M -GWYYPPTVITDITKDMNLYTEEVFGPVASVYRAADIDEAIEIANATTFG
MUL_1153|M.ulcerans_Agy99 -GWYYPPTVITDITKDMNLYTEEVFGPVASVYRAADIDEAIEIANATTFG
MAV_4936|M.avium_104 -GWFYPPTVVTDITKDMALYTEEVFGPVASMYRAADIDEAIEIANATTFG
MAB_3471|M.abscessus_ATCC_1997 -GWYYPPTVITDITKNMPIFGEEVFGPVASVYRATDIEEAIEVANATSFG
MSMEG_6452|M.smegmatis_MC2_155 --AFFPPAVLTGVTEDNPVYRQELFGPVAVVYKAGSEEEAVQIANDTPFG
Mvan_1844|M.vanbaalenii_PYR-1 -AAFYTPAVLTGVTPDMRAYSEELFGPVAVVYRVRDEEEAVALANASAYG
Mflv_1858|M.gilvum_PYR-GCK -GNFYPATVLTDVPADARILKEEVFGPVAPIAGFDTEEEGIAAANDTEYG
TH_4137|M.thermoresistible__bu NGHFYAPTILTGVTPDMLICSEETFGPIAPVMVFDDEDEAIAMANSTEYG
::..:::*.:. : :* ***:* : ::.: ** : :*
Mb0239c|M.bovis_AF2122/97 LGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRE
Rv0234c|M.tuberculosis_H37Rv LGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRE
MLBr_02573|M.leprae_Br4923 LGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRE
MMAR_0490|M.marinum_M LGSNAWTQDEAEQRRFINDIEAGQVFINGMTVSYPELPFGGIKRSGYGRE
MUL_1153|M.ulcerans_Agy99 LGSNAWTQDEAEQRRFINDIEAGQVFINGMTVSYPELPFGGIKRSGYGRE
MAV_4936|M.avium_104 LGSNAWTNDAAEQQRFIDDIEAGQVFINGMTVSYPELGFGGVKRSGYGRE
MAB_3471|M.abscessus_ATCC_1997 LGANAWTRETAEQQRFINELDAGQVFINGMTVSYPEVPFGGIKRSGYGRE
MSMEG_6452|M.smegmatis_MC2_155 LGSYVFTTDSEQAARVADKIEAGMVFVNAVGAEGAELPFGGVKRSGFGRE
Mvan_1844|M.vanbaalenii_PYR-1 LGASVFSTDTARAEKVAQRLEAGMVNVNTPAGEGPDIPFGGVKRSGFGRE
Mflv_1858|M.gilvum_PYR-GCK LAAYVYTQSLDRALRVAEGIESGMVGVNRGVISDPAAPFGGIKESGFGRE
TH_4137|M.thermoresistible__bu LAGYIYTRDISRAIRVGEALDFGMIGINDINPTSAAVPFGGIKQSGLGRE
*.. :: . . :. : : * : :* . ***:*.** ***
Mb0239c|M.bovis_AF2122/97 LSAHGIREFCNIKTVWIA--------------
Rv0234c|M.tuberculosis_H37Rv LSAHGIREFCNIKTVWIA--------------
MLBr_02573|M.leprae_Br4923 LSTHGIREFCNIKTVWIA--------------
MMAR_0490|M.marinum_M LAGHGIREFCNIKTVWVG--------------
MUL_1153|M.ulcerans_Agy99 LAGHGIREFCNIKTVWVG--------------
MAV_4936|M.avium_104 LAGLGIRAFCNAKTVWIGSSKSGDAGGGSKVE
MAB_3471|M.abscessus_ATCC_1997 LSAHGIREFCNIKTVWIA--------------
MSMEG_6452|M.smegmatis_MC2_155 LGRYGIDEFVNKKLIRVVD-------------
Mvan_1844|M.vanbaalenii_PYR-1 LGALGIDEFVNKQVYVVAD-------------
Mflv_1858|M.gilvum_PYR-GCK GGTEGIEEYLDTKYIALTK-------------
TH_4137|M.thermoresistible__bu GARAGIEEYLDTKVLGIAL-------------
. ** : : : :