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MTTVAVPHHAMLIGGESVDSDRRLSLVDPGDESPVATVACGDASHVDAAVAAAKASFEDGSWSRATPQER AAVMRRIVAAADQVTDELIELEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQRPAPIETFPVLS QSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEHTPLSILEFARIAERSGLPPGVINV VPGEGPEAGARLASHPDVGKIAFTGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVL YGCFAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPVIDAAQRTRILNYIRGAQ TDGATVALGGEALTGGMFDKGFWVAPTILTGVHNDMAIAREEVFGPVLVVIGYDGDEQAIAIANDSDYGL AASIWTSDNARGLAMAERIQSGSVWINDAHQINCRLPFGGYKQSGVGRELGPDALDAYTEVKTIHLDLSG GREAKPYDVLLGHPETG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2875 | - | - | 100% (507) | aldehyde dehydrogenase |
| M. marinum M | MMAR_3556 | - | 1e-98 | 39.68% (499) | aldehyde dehydrogenase NAD dependent |
| M. marinum M | MMAR_3965 | - | 1e-93 | 39.96% (478) | NAD-dependent aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 5e-93 | 40.56% (461) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4389 | - | 5e-97 | 39.75% (483) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 4e-93 | 39.39% (490) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-56 | 31.25% (464) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 2e-96 | 40.83% (480) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1897 | - | 1e-105 | 43.90% (492) | betaine-aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0327 | - | 1e-149 | 52.53% (495) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3080 | - | 1e-104 | 43.31% (478) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2877 | - | 0.0 | 99.01% (507) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0014 | - | 1e-151 | 52.99% (502) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2875|M.marinum_M --------MTTVAVPHHAMLIGGESVD--SDRRLSLVDPGDESPVATVAC
MUL_2877|M.ulcerans_Agy99 --------MTTVAVPHHAMLIGGESVD--SDRRLSLVDPGDESPVATVAC
MSMEG_0327|M.smegmatis_MC2_155 ----------MS--EHYSMYIDGKWID--TDEVYEIRSPATEELVATVAK
Mvan_0014|M.vanbaalenii_PYR-1 ----------MSDIPHYRMYIDGAWRD--AADTIEVRSPATGELVATVAY
Rv0223c|M.tuberculosis_H37Rv --------MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPM
MAB_4484|M.abscessus_ATCC_1997 ------------MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQCPL
TH_3080|M.thermoresistible__bu -------------VHPEELFIGGEWATPSSAQRIEVISPHTEEPVAAVAA
Mflv_4389|M.gilvum_PYR-GCK ---------MTQIVDTAGVFVGGEFRR--TDRTVPVFEAATGEILGEGPS
MAV_1897|M.avium_104 MTDTTISNGVTEQLVHFDLVIGGESVAAESGRTYDSIDPYTALPWARVPD
Mb2883c|M.bovis_AF2122/97 ------------------------------MSTTQLINPATEEVLASVDH
MLBr_02573|M.leprae_Br4923 -------------------------------MSIATINPATGETVKTFTP
.
MMAR_2875|M.marinum_M GDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIE
MUL_2877|M.ulcerans_Agy99 GDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIE
MSMEG_0327|M.smegmatis_MC2_155 GNTASVDAAVEAAKGAFAEGTWRRTPPAQRAAIINNVAERLGARADELAA
Mvan_0014|M.vanbaalenii_PYR-1 GGVTTVDDAVAAAKAADEAGVWRNTSAQQRADVLDAIADNLAARTDELTA
Rv0223c|M.tuberculosis_H37Rv AAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTK
MAB_4484|M.abscessus_ATCC_1997 ASPADVDAAVSAARRAFDNGPWPRLTPHERQAVLQKAVSLLESRKDEICK
TH_3080|M.thermoresistible__bu ACPDDVDRAVAAARAAFDTGPWPRMDPAERVAVIRGLAERYGERRSELAE
Mflv_4389|M.gilvum_PYR-GCK AAAADIDDAVAAARGE-GAAKWRAATVDERADGLKRFATALRGRAKHTST
MAV_1897|M.avium_104 CGPADVDRAVAAARAALR-GPWGQLTGTARGKLLWRLGELIAREAESLAE
Mb2883c|M.bovis_AF2122/97 TDANAVDDAVQRARAAQR--RWARLAPAQRAAGLRAFAAAVQAHLDELAA
MLBr_02573|M.leprae_Br4923 TTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAA
:: *: * : * .
MMAR_2875|M.marinum_M LEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQRPAPIETFPVLS
MUL_2877|M.ulcerans_Agy99 LEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQRPAPIETFPVLS
MSMEG_0327|M.smegmatis_MC2_155 LQTRENGATIRITGALHVGLSVAQLQYLAAIAENYEWETPGPAIEP-VAA
Mvan_0014|M.vanbaalenii_PYR-1 LQVAENGATVRAAGAFLIGYAIAHLRYFAGLARTYAFQSSGPLMEAPTLA
Rv0223c|M.tuberculosis_H37Rv LLAAETGQPPTIIETMHWMGSMGAMNYFAGAADKVTWTETR---TGSYG-
MAB_4484|M.abscessus_ATCC_1997 AIADETGAPPMVIETLQWMGGFGAIQYYANAADAVKWKELR---NGAYG-
TH_3080|M.thermoresistible__bu LITAQIGAPISFAQRAQVGLPWTMMSAFCTLAENHPWQQTR---AGMYGA
Mflv_4389|M.gilvum_PYR-GCK LVSRENGMPITLSRAVNGAFPSVLVNYYAKLIRSWTAEEVR---PALIG-
MAV_1897|M.avium_104 LEVRDGGKLVREMIGQMKALP-DYYIYYAGLADKLQGEVVP---VDKPNF
Mb2883c|M.bovis_AF2122/97 LEVANSGHP-IVSAEWEAGHVRDVLAFYAASPERLSGRQIP-----VAGG
MLBr_02573|M.leprae_Br4923 LMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEA--AAVGAS
*
MMAR_2875|M.marinum_M QSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEHTPLS
MUL_2877|M.ulcerans_Agy99 QSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEHTPLS
MSMEG_0327|M.smegmatis_MC2_155 DGVVVREPLGVVAAIVPWNIPLLTTVWKIGPALVAGNSVVLKPDEHAPLL
Mvan_0014|M.vanbaalenii_PYR-1 AGMIVRDPVGVCAGMIPWNFPLLLAVWKLGPALAAGNTVVLKPDDQTPLT
Rv0223c|M.tuberculosis_H37Rv QSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLT
MAB_4484|M.abscessus_ATCC_1997 QTLVTREPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAETPLS
TH_3080|M.thermoresistible__bu DVHVRREPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPESPLD
Mflv_4389|M.gilvum_PYR-GCK HTVVRREPIGVVGAITPWNYPQALAVMKIAPALAAGCSVVLKASPETSLD
MAV_1897|M.avium_104 FVYTRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKPSDHTPAS
Mb2883c|M.bovis_AF2122/97 VDVTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLT
MLBr_02573|M.leprae_Br4923 KALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQC
:* ** : .** * ..: ** ::* .
MMAR_2875|M.marinum_M ILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAFTGSTAVG
MUL_2877|M.ulcerans_Agy99 ILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAFTGSTAVG
MSMEG_0327|M.smegmatis_MC2_155 ALELAREFDAAGLPPGVLNVVTGDGEPVGAHLSGHPDVRKVAFTGSTAVG
Mvan_0014|M.vanbaalenii_PYR-1 LLELARAADEVGLPAGVLNVVTGAGPTVGARLAEHPDVRKVAFTGSTEVG
Rv0223c|M.tuberculosis_H37Rv ANALAEVFAEVGLPEGVLSVVPG-GIETGQALTSNPDIDMFTFTGSSAVG
MAB_4484|M.abscessus_ATCC_1997 SFILAEVFAEAGVPEGVLSVVPG-GAETGRALTNNPDVDVFSFTGSTAVG
TH_3080|M.thermoresistible__bu ALLLAELIADSGIPSGVVNVLPG-PAGVGERLVRHPGVDKVSFTGSTAAG
Mflv_4389|M.gilvum_PYR-GCK ALVFAEAAAEAGLPPGVLNVVPG-DAAAGAHLVTHPGVDKVAFTGSTNAG
MAV_1897|M.avium_104 TLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKIAFTGSTATG
Mb2883c|M.bovis_AF2122/97 TMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVG
MLBr_02573|M.leprae_Br4923 ALYLADVIARGGFPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAG
:. *. . ...: . : .* : :*** .*
MMAR_2875|M.marinum_M REIMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGCFAYSGQV
MUL_2877|M.ulcerans_Agy99 REIMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGCFAYSGQV
MSMEG_0327|M.smegmatis_MC2_155 KSILRQSADTVRRVTLELGGKGANIILDDADIDMAVDGALFACMANNGEA
Mvan_0014|M.vanbaalenii_PYR-1 KSVMRAAADTVKKVTLELGGKGASIVLDDADLDLAVDGSLFAFLLMSGQA
Rv0223c|M.tuberculosis_H37Rv REVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQG
MAB_4484|M.abscessus_ATCC_1997 KEIAEIAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSGLMNAGQG
TH_3080|M.thermoresistible__bu RAVAAAAAAGLKRVSLELGGKSAAVVLSDADPAAVATAVRSASLSNSGQI
Mflv_4389|M.gilvum_PYR-GCK RVIGAECGRLIRPVTLELGGKSAAVILDDADLDTTVNGLRTASFVNNGQT
MAV_1897|M.avium_104 ISVGKAAIDNMTRFTLELGGKSAQVVFDDADLDAAANGVIAGVFAATGQT
Mb2883c|M.bovis_AF2122/97 KRVMAGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGVFDNAGQD
MLBr_02573|M.leprae_Br4923 QAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQS
: . : *****... ::: . * . . . *:
MMAR_2875|M.marinum_M CESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPVIDAAQRT
MUL_2877|M.ulcerans_Agy99 CESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPVIDAAQRT
MSMEG_0327|M.smegmatis_MC2_155 CEAGTRLLIPASRRDEIVDKLLARASTLRVGDPLDPATHIGPVISQTQRD
Mvan_0014|M.vanbaalenii_PYR-1 CESGTRLLVHESIHDEFVRRMVARAETLVMGDPMSLASDLGPLVSAKQKA
Rv0223c|M.tuberculosis_H37Rv CVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRT
MAB_4484|M.abscessus_ATCC_1997 CVNQTRVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLITEKQRT
TH_3080|M.thermoresistible__bu CNALTRILMPAGRAAEFTDALAAEMESLVIGDPTDAETQIGPLVARRQQE
Mflv_4389|M.gilvum_PYR-GCK CHLSSRILVPAKRYAEFVSAIAELADSLTVGDPLDEKTEIGPLVSERQRE
MAV_1897|M.avium_104 CLAGSRLLVHESVADALVERIVARASTIKLGDPKDPATEMGPVSNQPQYE
Mb2883c|M.bovis_AF2122/97 CCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPLVSRAHRD
MLBr_02573|M.leprae_Br4923 CIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRA
* .* : . . : :* . . :.:**:
MMAR_2875|M.marinum_M RILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVHNDMAIAR
MUL_2877|M.ulcerans_Agy99 RILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVHNDMAIAR
MSMEG_0327|M.smegmatis_MC2_155 RILNYFRIAAEEGAIAALGGKARSGPEFDKGYWIEPTIYLDVTNDMRVAR
Mvan_0014|M.vanbaalenii_PYR-1 RVEKYIALGQEEGCKLAYQGTVPTDPALAQGHWVPPTILTGATNDMRIAR
Rv0223c|M.tuberculosis_H37Rv RVEGYIAKGIEEGARLVCGG-GRPEG-LDNGFFIQPTVFADVDNKMTIAQ
MAB_4484|M.abscessus_ATCC_1997 RVEGYIAKGIAEGARLAYGG-KRPEG-LDGGYFVQPTIFADVDNSMTIAQ
TH_3080|M.thermoresistible__bu RVRGYIEAGCAEGARLVTGGPGLPAG-VDRGWYVQPTLFADADNSMRIAR
Mflv_4389|M.gilvum_PYR-GCK RVLDYVQVGRDSGARLVAGG-SVPTG-LERGWYVAPTVFADVDNSDRLAQ
MAV_1897|M.avium_104 KVLSHFASAREQGATVAYGG--EPAG-ELGGFFVKPTVLTGVDRSMRAVA
Mb2883c|M.bovis_AF2122/97 KVAGYVP----DDAPVAFRG-TAPAG---RGFWFPPTVLTPKRGD-RTVT
MLBr_02573|M.leprae_Br4923 QVEQQVDAAAAAGAVIRCGGKRPDRP----GWFYPPTVITDITKDMALYT
:: . .. * * : **: .
MMAR_2875|M.marinum_M EEVFGPVLVVIGYDGDEQAIAIANDSDYGLAASIWTSDNARGLAMAERIQ
MUL_2877|M.ulcerans_Agy99 EEVFGPVLVVSGYDGDEQAIAIANDSDYGLAASIWTSDNARGLAMAERIR
MSMEG_0327|M.smegmatis_MC2_155 EEVFGPVLVVMTYDTDEDALAVANDTNYGLSAGVWGSE-ERATALARRLE
Mvan_0014|M.vanbaalenii_PYR-1 EEIFGPVLVVLTYGDDDEAVAIANDSEYGLSAGVWSADRERALGIARRLQ
Rv0223c|M.tuberculosis_H37Rv EEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQIR
MAB_4484|M.abscessus_ATCC_1997 EEIFGPVLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGLEVAAQIR
TH_3080|M.thermoresistible__bu EEIFGPVLTVIPYPDEDAAVAIANDSDYGLAGSVFTADTERGLAIAARIR
Mflv_4389|M.gilvum_PYR-GCK EEIFGPVITITAYADDADAVRLANDTEFGLAGTVWSQDSARATEIARAMH
MAV_1897|M.avium_104 EEVFGPVLAVMTFTDEDEAIAAANDTEFGLAAGVWTKDVHRAHRVAARLN
Mb2883c|M.bovis_AF2122/97 DEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVARAVE
MLBr_02573|M.leprae_Br4923 DEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIV
:*:**** : *: ** : :**.. : : . . :
MMAR_2875|M.marinum_M SGSVWINDAHQINCRLPFGGYKQSGVGRELGPDALDAYTEVKTIHLDLSG
MUL_2877|M.ulcerans_Agy99 SGSVWINDAHQINCRLLFGGYKQSGVGRELGPDTLDAYTEVKTIHLDLSG
MSMEG_0327|M.smegmatis_MC2_155 AGMVWVNNWHIIHPAYPFGGYKESGLGREGGPNAIDEYVEEKFIAVDRSG
Mvan_0014|M.vanbaalenii_PYR-1 SGTVWVNDWHMINAMYPFGGVKQSGLGRELGPDALDEYTEPKFIHVDMTD
Rv0223c|M.tuberculosis_H37Rv TGTYGIN-WYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMGY
MAB_4484|M.abscessus_ATCC_1997 TGTYGIN-WYAFDPSCPFGGYKQSGIGRENGPEGIEEYCELKSVLLPMGY
TH_3080|M.thermoresistible__bu TGTFGVNQGYTMDPFAPFGGVKGSGYGRELGPEGIDAYTDVKSISVAPAS
Mflv_4389|M.gilvum_PYR-GCK TGSVGVN-HYQLDIQSPFGGIKSSGLGRELGPEGLDAYLVTKSIYQADPF
MAV_1897|M.avium_104 AGTVWVNAYRVVSPHVPFGGMGHSGIGRENGIDAVKDFTETKAVWVELSG
Mb2883c|M.bovis_AF2122/97 SGNLSVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKNVFIAVGE
MLBr_02573|M.leprae_Br4923 AGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA---
:* :* *** ** *** . . : * :
MMAR_2875|M.marinum_M GREAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 GREAKPYDVLLGHPETG
MSMEG_0327|M.smegmatis_MC2_155 GIENKAFAIVIDPAGD-
Mvan_0014|M.vanbaalenii_PYR-1 DRRKHVYPVVISAAAQG
Rv0223c|M.tuberculosis_H37Rv TVA--------------
MAB_4484|M.abscessus_ATCC_1997 TLESI------------
TH_3080|M.thermoresistible__bu TT---------------
Mflv_4389|M.gilvum_PYR-GCK PE---------------
MAV_1897|M.avium_104 ATRDPFTLG--------
Mb2883c|M.bovis_AF2122/97 EM---------------
MLBr_02573|M.leprae_Br4923 -----------------