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MDGDPDLCIGGAWRHACDGGTRDIINPANGAVAAVVDEATPQDALDAVAAARAAFDQGGWRATAVAERSA LLQRIADLLQRDKEDLARLETVDTGKTLAESRIDIDDVTSVFRYYANLVASEAERVVDVGDPAVISRVIR EPIGVCVLIAPWNYPLLQMSWKVAPALAAGCTMVAKPSEVTPLSTIAFAKLLDEAGVPPGVVNLIQGSGA TLGPALTDNPQVDFISFTGGLATGRTIARTAAEHVTKVALELGGKNPHLVFADIRDAGRESGWDAAVDHV LTGVFLHSGQVCSAGTRLIIEESIADEFVAALAARAATIRMGDGLDPASETGPLVSAQHRDKVESYVRLG ISEGAQLIAGGCRPEDPVLAGGYFYRPTIFDRCDRSMRIVQEETFGPILTVERFTDEAEAVTLGNDTEYG LAAGVRTTDTARGERVVRALRHGTVWLNDFGYYTAAAEWGGFGRSGNGRELGPTGLAEYQEIKHIWHNTA PAAAGWFTG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3083 | - | - | 100% (499) | betaine-aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4860 | - | 2e-93 | 39.13% (483) | gamma-aminobutyraldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4952 | - | 1e-82 | 37.63% (497) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0467 | - | 1e-83 | 38.49% (491) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0458 | - | 1e-83 | 38.49% (491) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 5e-61 | 31.84% (468) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 5e-92 | 38.68% (486) | gamma-aminobutyraldehyde dehydrogenase |
| M. marinum M | MMAR_3556 | - | 6e-91 | 38.23% (497) | aldehyde dehydrogenase NAD dependent |
| M. avium 104 | MAV_1897 | - | 1e-104 | 43.61% (493) | betaine-aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6297 | - | 1e-103 | 40.89% (494) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3902 | - | 2e-93 | 40.98% (488) | PUTATIVE putative 5-carboxymethyl-2-hydroxymuconate |
| M. ulcerans Agy99 | MUL_2789 | - | 1e-90 | 38.03% (497) | gamma-aminobutyraldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0014 | - | 1e-102 | 42.62% (481) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0467|M.bovis_AF2122/97 MTVFSRPGSAG------ALMSYESRYQNFIGGQWVAPVHGRYFENPTPVT
Rv0458|M.tuberculosis_H37Rv MTVFSRPGSAG------ALMSYESRYQNFIGGQWVAPVHGRYFENPTPVT
MAV_1897|M.avium_104 MTDTTISNG---------VTEQLVHFDLVIGGESVAAESGRTYDSIDPYT
MSMEG_6297|M.smegmatis_MC2_155 MTVTTFRPSDVATLTNPDAASDVADLSMFIAGEAVSAADGATFDSYEPRS
Mflv_3083|M.gilvum_PYR-GCK ---------------------MDGDPDLCIGGAWRHACDGGTRDIINPAN
TH_3902|M.thermoresistible__bu LRANRFQPKDN---------TVTWKYDLYIDGKWDTGTSGRALTVVNPAT
Mvan_0014|M.vanbaalenii_PYR-1 ----------M---------SDIPHYRMYIDGAWRDAAD--TIEVRSPAT
MMAR_3556|M.marinum_M ------------------MTTTVSVAGSWINGA-AHSTGGRQHAVINPAT
MUL_2789|M.ulcerans_Agy99 ------------------MTTTVSVAGSWINGA-AHSTGGRQHAVINPAT
MAB_3328|M.abscessus_ATCC_1997 ----------------------MSVPSSWINGR-PVATHGDTHRVINPAT
MLBr_02573|M.leprae_Br4923 ----------------------------------------MSIATINPAT
* .
Mb0467|M.bovis_AF2122/97 GQPFCEVPRSDAADIDKALDAAHAAAPG--WGKTAPAERAAILNMIADRI
Rv0458|M.tuberculosis_H37Rv GQPFCEVPRSDAADIDKALDAAHAAAPG--WGKTAPAERAAILNMIADRI
MAV_1897|M.avium_104 ALPWARVPDCGPADVDRAVAAARAALRGP-WGQLTGTARGKLLWRLGELI
MSMEG_6297|M.smegmatis_MC2_155 GRVWARLPRANSTDIDRAVRAARAAFEGP-WGAVSPADRGRFLMKIAAVV
Mflv_3083|M.gilvum_PYR-GCK GAVAAVVDEATPQDALDAVAAARAAFDQGGWRATAVAERSALLQRIADLL
TH_3902|M.thermoresistible__bu EETIGTVPDASLDDIRRAIAAARTAFDEGPWPCMTPLERAAVIRRIAEVL
Mvan_0014|M.vanbaalenii_PYR-1 GELVATVAYGGVTTVDDAVAAAKAADEAGVWRNTSAQQRADVLDAIADNL
MMAR_3556|M.marinum_M QETIAELALATPADVDRAVVAARRALPQ--WAGVTPAERSAVLAKLADLL
MUL_2789|M.ulcerans_Agy99 QETIAELALATPADVDHAVVAARRALPQ--WAGVTTAERSAVLAELADLL
MAB_3328|M.abscessus_ATCC_1997 GEAVADLKLATTADVDAAVAAARAAGPA--WASSTPVDRSSVLAKLAAVL
MLBr_02573|M.leprae_Br4923 GETVKTFTPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLL
. *: * : : *. . :
Mb0467|M.bovis_AF2122/97 DKNAAALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIR-------A
Rv0458|M.tuberculosis_H37Rv DKNAAALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIR-------A
MAV_1897|M.avium_104 AREAESLAELEVRDGGKLVREMIG-QMKALPDYYIYYAGLAD-------K
MSMEG_6297|M.smegmatis_MC2_155 DRHRDQLTVIESRDNGKPVREVRA-EIDAVVRYFEYFAGVCQ-------T
Mflv_3083|M.gilvum_PYR-GCK QRDKEDLARLETVDTGKTLAESRI-DIDDVTSVFRYYANLVA-------S
TH_3902|M.thermoresistible__bu QRRRSELVDLVRAETGSPQWIVEMLQVG---VPLRVCADVADRVLPQFRF
Mvan_0014|M.vanbaalenii_PYR-1 AARTDELTALQVAENGATVRAAGAFLIGYAIAHLRYFAGLAR--TYAFQS
MMAR_3556|M.marinum_M EQRAPELIAEEVCQTGKPLRLAEEFDVPGSVDNIRFFAGAAR-------R
MUL_2789|M.ulcerans_Agy99 EQRAPELIAEEVCQTGKPLRLAEEFDVPGSVDNIRFFAGAAR-------R
MAB_3328|M.abscessus_ATCC_1997 SANADTLVADEVAQTGKPVRLASEFDVPGSIDNVEFFAGAAR-------H
MLBr_02573|M.leprae_Br4923 EAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAET------LL
: * :
Mb0467|M.bovis_AF2122/97 QEGALSQIDEDT-VAYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGN
Rv0458|M.tuberculosis_H37Rv QEGALSQIDEDT-VAYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGN
MAV_1897|M.avium_104 LQGEVVPVDKPNFFVYTRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGC
MSMEG_6297|M.smegmatis_MC2_155 TVGETHP-QAATAFSYTRREPVGVVGAIVPWNSPLLMLAWKLSPALAGGN
Mflv_3083|M.gilvum_PYR-GCK EAERVVDVGDPAVISRVIREPIGVCVLIAPWNYPLLQMSWKVAPALAAGC
TH_3902|M.thermoresistible__bu VEPMLPSFDLRPGQGIISKEPIGVAALITPFNFPLFLNVMKLAPALAAGC
Mvan_0014|M.vanbaalenii_PYR-1 SGPLMEAPTLAAG--MIVRDPVGVCAGMIPWNFPLLLAVWKLGPALAAGN
MMAR_3556|M.marinum_M LPGQATAEYSADHTSSIRREAIGVVATITPWNYPLQMAVWKVMPALAAGC
MUL_2789|M.ulcerans_Agy99 LPGQATAEYSADHTSSIRREAIGVVATITPWNYPLQMAVWKVMPALAAGC
MAB_3328|M.abscessus_ATCC_1997 LEGKATAEYSADHTSSIRREAAGVVATITPWNYPLQMAVWKVLPALAAGC
MLBr_02573|M.leprae_Br4923 ADEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGN
:. ** : *:* *: ..* .*
Mb0467|M.bovis_AF2122/97 TAVLKPAEQTPASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDR
Rv0458|M.tuberculosis_H37Rv TAVLKPAEQTPASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDR
MAV_1897|M.avium_104 TFVVKPSDHTPASTLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPD
MSMEG_6297|M.smegmatis_MC2_155 TIILKPAEETSVSAVVFAQLIAEVGLPDGVFNVVTGIGEEAGAALVAHPD
Mflv_3083|M.gilvum_PYR-GCK TMVAKPSEVTPLSTIAFAKLLDEAGVPPGVVNLIQGSGATLGPALTDNPQ
TH_3902|M.thermoresistible__bu TVVLKPSPLTPLEALVLGEVADEVGLPPGVLNIVTG-GAEESAELTTNPM
Mvan_0014|M.vanbaalenii_PYR-1 TVVLKPDDQTPLTLLELARAADEVGLPAGVLNVVTGAGPTVGARLAEHPD
MMAR_3556|M.marinum_M TVVIKPSELTPLTTLTLARLAAEAGLPDGVLNVVTGLGADVGAALAAHPG
MUL_2789|M.ulcerans_Agy99 TVVIKPSELTPLTTLTLARLAAEAGLPDGVLNVVTGLGADVGAALAAHPG
MAB_3328|M.abscessus_ATCC_1997 TVVIKPSELTPLTTLTLARLAAEAGLPEGVLNVVTGRGDDVGYALASHPD
MLBr_02573|M.leprae_Br4923 VGLLKHASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILRD-PR
. : * .. : : .* . .: : . *
Mb0467|M.bovis_AF2122/97 IAKVAFTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADV-----LA
Rv0458|M.tuberculosis_H37Rv IAKVAFTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADV-----LA
MAV_1897|M.avium_104 VDKIAFTGSTATGISVGKAAIDNMTRFTLELGGKSAQVVFDD-------A
MSMEG_6297|M.smegmatis_MC2_155 VDKIAFTGSTEVGKQIAATAASDLKLVTFELGGKSPTVIFDD-------A
Mflv_3083|M.gilvum_PYR-GCK VDFISFTGGLATGRTIARTAAEHVTKVALELGGKNPHLVFADIRDAGRES
TH_3902|M.thermoresistible__bu VDLVSFTGSDTVGRQVMNQASATLKKVVLELGGKSANVIFAD-------A
Mvan_0014|M.vanbaalenii_PYR-1 VRKVAFTGSTEVGKSVMRAAADTVKKVTLELGGKGASIVLDD-------A
MMAR_3556|M.marinum_M VDLVTFTGSTAVGRKVMAAAATHGRRTQLELGGKAPFVVFDD-------A
MUL_2789|M.ulcerans_Agy99 VDLVTFTGSTAVGRKVMAAAATHGRRTQLELGGKAPFVVFDD-------A
MAB_3328|M.abscessus_ATCC_1997 VDLVTFTGSTAVGRKVMAAAAVHGHRTQLELGGKAPFVVFDD-------A
MLBr_02573|M.leprae_Br4923 VAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS-------A
: ::** .* : * :****. . :.: . :
Mb0467|M.bovis_AF2122/97 AHDDFCDKALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKA
Rv0458|M.tuberculosis_H37Rv AHDDFCDKALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKA
MAV_1897|M.avium_104 DLDAAANGVIAG--VFAAT-GQTCLAGSRLLVHESVADALVERIVARAST
MSMEG_6297|M.smegmatis_MC2_155 DLDAAVHRTAYG--IFSAA-GQTCQAASRIFVQDTIHDEFLDRFAALARR
Mflv_3083|M.gilvum_PYR-GCK GWDAAVDHVLTG--VFLHS-GQVCSAGTRLIIEESIADEFVAALAARAAT
TH_3902|M.thermoresistible__bu DLDAAAAHVVGE---FTLHAGQGCSLLTRTLVEESIHDELVDWVNKQLAA
Mvan_0014|M.vanbaalenii_PYR-1 DLDLAVDGSLFA---FLLMSGQACESGTRLLVHESIHDEFVRRMVARAET
MMAR_3556|M.marinum_M DLDAAIQGAVAG---ALINSGQDCTAATRAIVARELYHDFVAGVADVMST
MUL_2789|M.ulcerans_Agy99 DLDAAIQGAVAG---AVINSGQDCTAATRAIVARELCHDFVAGVADVMST
MAB_3328|M.abscessus_ATCC_1997 DMDAAIAGAVAG---AIINSGQDCTAATRALVARDLYDDFVAGVGEVMSK
MLBr_02573|M.leprae_Br4923 DLDAAVATAVTG---RVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMET
* *: * .* : : . ::
Mb0467|M.bovis_AF2122/97 VRQGDPLDTETMLGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGG
Rv0458|M.tuberculosis_H37Rv VRQGDPLDTETMLGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGG
MAV_1897|M.avium_104 IKLGDPKDPATEMGPVSNQPQYEKVLSHFASAREQGATVAYGGEP---AG
MSMEG_6297|M.smegmatis_MC2_155 IRVGDPLSERTQMGAQISAQHRERIAGYVASGIQEGANLVCGGTQPTEAP
Mflv_3083|M.gilvum_PYR-GCK IRMGDGLDPASETGPLVSAQHRDKVESYVRLGISEGAQLIAGGCRPE-DP
TH_3902|M.thermoresistible__bu LKVGDPADPSVMMGPLISEAQRNRVEGYIKAGVDEGAEIAFGGGRPSH--
Mvan_0014|M.vanbaalenii_PYR-1 LVMGDPMSLASDLGPLVSAKQKARVEKYIALGQEEGCKLAYQGTVPTDPA
MMAR_3556|M.marinum_M VVIGDPMDPDTDIGPLISLAHRDRVADIVAKAPAQGARIVVGGRIP----
MUL_2789|M.ulcerans_Agy99 VVIGDPMDPDTDIGPLISLAHRDRVADILAKAPAQGARIVVGGRIP----
MAB_3328|M.abscessus_ATCC_1997 VVVGDPLDPDTDIGPLISAAHRAKVSSIVDRAPAQGGRIVTGATAP----
MLBr_02573|M.leprae_Br4923 LRVGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKRP----
: ** . *. . :: . . * : .
Mb0467|M.bovis_AF2122/97 DLSGGYYMQPTIFTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDT
Rv0458|M.tuberculosis_H37Rv DLSGGYYMQPTIFTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDT
MAV_1897|M.avium_104 ELGG-FFVKPTVLTGVDRSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDT
MSMEG_6297|M.smegmatis_MC2_155 LAQG-YYYSPTILDGVNRDMRMIREEIFGPVTGVMSFTDEADAVAKANDT
Mflv_3083|M.gilvum_PYR-GCK VLAGGYFYRPTIFDRCDRSMRIVQEETFGPILTVERFTDEAEAVTLGNDT
TH_3902|M.thermoresistible__bu LERG-YFVEPTLFTGVRNEMKIAQEEIFGPVGVVIPFTSEHEAVRLANDS
Mvan_0014|M.vanbaalenii_PYR-1 LAQG-HWVPPTILTGATNDMRIAREEIFGPVLVVLTYGDDDEAVAIANDS
MMAR_3556|M.marinum_M DLAG-AFYLPTLLADVGEQSQAYREEIFGPVLTVRAHDGDDDALRQANDT
MUL_2789|M.ulcerans_Agy99 DLAG-AFYLPTLLADVGEQSQAYREEIFGPVLTVRAHDGDDDALRQANDT
MAB_3328|M.abscessus_ATCC_1997 DLPG-SFYRPTLIADVAETSEVYRDEIFGPVLTVRPFTDDDDALRQANDT
MLBr_02573|M.leprae_Br4923 DRPG-WFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANAT
* : **:: :* ***: * . :*: .* :
Mb0467|M.bovis_AF2122/97 LYGLGAGVWSRDGNTAYRAGRDIQAGRVWVN-CYHLYPAHAAFGGYKQSG
Rv0458|M.tuberculosis_H37Rv LYGLGAGVWSRDGNTAYRAGRDIQAGRVWVN-CYHLYPAHAAFGGYKQSG
MAV_1897|M.avium_104 EFGLAAGVWTKDVHRAHRVAARLNAGTVWVN-AYRVVSPHVPFGGMGHSG
MSMEG_6297|M.smegmatis_MC2_155 EYGLAGSVWTRDVSRAHRVAASIAAGLIWVN-TTRTINHLVPFGGYKQSG
Mflv_3083|M.gilvum_PYR-GCK EYGLAAGVRTTDTARGERVVRALRHGTVWLN-DFGYYTAAAEWGGFGRSG
TH_3902|M.thermoresistible__bu DFGLGGGVWSTDVERALRVAQRIRTGMVAINGGGGSMGKTGPFGGFKASG
Mvan_0014|M.vanbaalenii_PYR-1 EYGLSAGVWSADRERALGIARRLQSGTVWVN-DWHMINAMYPFGGVKQSG
MMAR_3556|M.marinum_M DYGLAASAWTRDVYRAQRASREISAGCVWIN-DHIPIVSEMPHGGVAASG
MUL_2789|M.ulcerans_Agy99 DYGLAASAWTRDVYRAQRASREISAGCVWIN-DHIPIVSEMPHGGVAASG
MAB_3328|M.abscessus_ATCC_1997 AYGLAASAWTRDVYRAQRASREIRAGCVWIN-DHIPIISEMPHGGFGASG
MLBr_02573|M.leprae_Br4923 PFGLGSNAWTQNESEQRHFIDNIVAGQVFIN-GMTVSYPELPFGGIKRSG
:**.... : : : * : :* ** **
Mb0467|M.bovis_AF2122/97 IGREGHQMMLQHYQHTKNLLVSYSDKALGFF-----------
Rv0458|M.tuberculosis_H37Rv IGREGHQMMLQHYQHTKNLLVSYSDKALGFF-----------
MAV_1897|M.avium_104 IGRENGIDAVKDFTETKAVWVELSGATRDPFTLG--------
MSMEG_6297|M.smegmatis_MC2_155 YGREGGQAVMEHYTRIKSVWVDMQDDLPNWYAD---------
Mflv_3083|M.gilvum_PYR-GCK NGRELGPTGLAEYQEIKHIWHNTAPAAAGWFTG---------
TH_3902|M.thermoresistible__bu LGREWGEWGLDEFLEMKQIIWPIAGG----------------
Mvan_0014|M.vanbaalenii_PYR-1 LGRELGPDALDEYTEPKFIHVDMTDDRRKHVYPVVISAAAQG
MMAR_3556|M.marinum_M FGKDMSEYSFEEYLTIKHVMSDITGVAEKPWHRTIFSTRI--
MUL_2789|M.ulcerans_Agy99 FGNDMSEYSFDEYLTIKHVMSDITGVAEKPWHRTIFSTRI--
MAB_3328|M.abscessus_ATCC_1997 FGKDMSDYSLEEYLTVKHVMSDITGTADKDWHRTIFAKR---
MLBr_02573|M.leprae_Br4923 YGRELSTHGIREFCNIKTVWIA--------------------
*.: . .: * :