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SNHYSLYIDGKWLDTDDNYEIRSPATEELVATVAKGDVSHVDAAVAAARGAFDEGTWRRTPPAERAALIN TVAERLAARTEELAALQSRENGATIRITGALHVGLSAAQLQYVAAIARDYEWETTGPAIEPVPAAGIVVR EPIGVVAAIVPWNIPLLTTVWKIGPALAAGNSVVLKPDEHAPLLPLELAREFDAAGLPPGILNVVTGDGE PVGAHLSGHPGVRKVAFTGSTAVGKSILRQSADSIRRVTLELGGKGANIILDDADIEMAVDGALFACMAN NGEACEAGTRLLIPRSRRDEILAKLLARASTLRLGDPLQPTTHVGPIISAHQRDRILDYFEIAKAEGATV ALGGGVPDGPGFDKGYWVEPTIFVDVTNNMRIAREEVFGPVLVVLTYDSTDEAIKIANDTNYGLSAGVWG SEENALQVARRLDSGMVWVNNWHVIHPAYPFGGYKESGLGREGGPHAIDEYVEEKFISIDRSGGIENKAF AIVIDPAV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0352 | - | - | 100% (499) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0014 | - | e-165 | 56.74% (497) | betaine-aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | e-105 | 43.16% (475) | betaine-aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 2e-92 | 39.87% (479) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_0428 | - | 1e-104 | 42.53% (475) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 1e-103 | 42.53% (475) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-62 | 33.77% (459) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 1e-105 | 43.38% (491) | aldehyde dehydrogenase |
| M. marinum M | MMAR_2875 | - | 1e-144 | 51.31% (495) | aldehyde dehydrogenase |
| M. avium 104 | MAV_3969 | - | 1e-106 | 44.78% (469) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0327 | - | 0.0 | 84.14% (498) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3080 | - | 1e-103 | 43.93% (478) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2877 | - | 1e-142 | 50.91% (495) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0352|M.vanbaalenii_PYR-1 -------MSNHYSLYIDGKWLD--TDDNYEIRSPATEELVATVAKGDVSH
MSMEG_0327|M.smegmatis_MC2_155 -------MSEHYSMYIDGKWID--TDEVYEIRSPATEELVATVAKGNTAS
MMAR_2875|M.marinum_M ---MTTVAVPHHAMLIGGESVD--SDRRLSLVDPGDESPVATVACGDASH
MUL_2877|M.ulcerans_Agy99 ---MTTVAVPHHAMLIGGESVD--SDRRLSLVDPGDESPVATVACGDASH
Rv0223c|M.tuberculosis_H37Rv ---MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAAD
MAB_4484|M.abscessus_ATCC_1997 -------MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQCPLASPAD
Mflv_0428|M.gilvum_PYR-GCK MTQSTAFRTEWDKLFIGGKWVEPASSEVIEVRSPATGDVVGKVPLASAAD
MAV_3969|M.avium_104 -------MDHDAAVRTDGHGRR---ADVIRVISPHTERPVAEVDAATPSD
TH_3080|M.thermoresistible__bu --------VHPEELFIGGEWATPSSAQRIEVISPHTEEPVAAVAAACPDD
Mb0791|M.bovis_AF2122/97 ---MALWGDGISALLIDGKLSD-GRAGTFPTVNPATEEVLGVAADADAED
MLBr_02573|M.leprae_Br4923 --------------------------MSIATINPATGETVKTFTPTTQDE
* :
Mvan_0352|M.vanbaalenii_PYR-1 VDAAVAAARGAFDEGTWRRTPPAERAALINTVAERLAARTEELAALQSRE
MSMEG_0327|M.smegmatis_MC2_155 VDAAVEAAKGAFAEGTWRRTPPAQRAAIINNVAERLGARADELAALQTRE
MMAR_2875|M.marinum_M VDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIELEMAC
MUL_2877|M.ulcerans_Agy99 VDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIELEMAC
Rv0223c|M.tuberculosis_H37Rv VDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAE
MAB_4484|M.abscessus_ATCC_1997 VDAAVSAARRAFDNGPWPRLTPHERQAVLQKAVSLLESRKDEICKAIADE
Mflv_0428|M.gilvum_PYR-GCK VDAACAAAREAFDNGPWPQMSPTERAEVLGRAVKLMEERADELKFLLAAE
MAV_3969|M.avium_104 VDAAVAAARAAFDAGTWSRGGPSHRIAAIRRLADIYDRRRAEMAETITAE
TH_3080|M.thermoresistible__bu VDRAVAAARAAFDTGPWPRMDPAERVAVIRGLAERYGERRSELAELITAQ
Mb0791|M.bovis_AF2122/97 MGRAIEAARRAFDSTDWSR-NTELRVRCVRQLRDAMQQHVEELRELTISE
MLBr_02573|M.leprae_Br4923 VEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAALMTLE
: * * * : *
Mvan_0352|M.vanbaalenii_PYR-1 NGATIRITGALHVGLSAAQLQYVAAIARDYEWETTGP-AIEPVPA-AGIV
MSMEG_0327|M.smegmatis_MC2_155 NGATIRITGALHVGLSVAQLQYLAAIAENYEWETPGP-AIEPVAA-DGVV
MMAR_2875|M.marinum_M NGATIRLATGFHIGYALSHFSYFADLAESYAYQRPAPIETFPVLS-QSVV
MUL_2877|M.ulcerans_Agy99 NGATIRLATGFHIGHALSHFSYFADLAESYAYQRPAPIETFPVLS-QSVV
Rv0223c|M.tuberculosis_H37Rv TGQPPTIIETMHWMGSMGAMNYFAGAADKVTWTETRTGSYG-----QSIV
MAB_4484|M.abscessus_ATCC_1997 TGAPPMVIETLQWMGGFGAIQYYANAADAVKWKELRNGAYG-----QTLV
Mflv_0428|M.gilvum_PYR-GCK TGQPPTIVDMMQYGAAMSSFQFYAGAADKFTWQDIRDGVYG-----QTLV
MAV_3969|M.avium_104 IGAPISFARRAQVGLPAFMIRAFCDLAERHPWQETRPGFFGS----DVYV
TH_3080|M.thermoresistible__bu IGAPISFAQRAQVGLPWTMMSAFCTLAENHPWQQTRAGMYGA----DVHV
Mb0791|M.bovis_AF2122/97 VGAPRMLTASAQLEGPVGDLSFAADTAESYPWKQDLGEASPLGIATRRTL
MLBr_02573|M.leprae_Br4923 MGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEPAEAAAVG--ASKALA
* . : . *
Mvan_0352|M.vanbaalenii_PYR-1 VREPIGVVAAIVPWNIPLLTTVWKIGPALAAGNSVVLKPDEHAPLLPLEL
MSMEG_0327|M.smegmatis_MC2_155 VREPLGVVAAIVPWNIPLLTTVWKIGPALVAGNSVVLKPDEHAPLLALEL
MMAR_2875|M.marinum_M HREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEHTPLSILEF
MUL_2877|M.ulcerans_Agy99 HREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEHTPLSILEF
Rv0223c|M.tuberculosis_H37Rv SREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTANAL
MAB_4484|M.abscessus_ATCC_1997 TREPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAETPLSSFIL
Mflv_0428|M.gilvum_PYR-GCK VREPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKPAAETPLSVFAM
MAV_3969|M.avium_104 RREPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPESPLDALLL
TH_3080|M.thermoresistible__bu RREPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPESPLDALLL
Mb0791|M.bovis_AF2122/97 AREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAAL
MLBr_02573|M.leprae_Br4923 RYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALYL
:. *** *: .**.* **: ** ::* . * :
Mvan_0352|M.vanbaalenii_PYR-1 AREFDAAG-LPPGILNVVTGDGEPVGAHLSGHPGVRKVAFTGSTAVGKSI
MSMEG_0327|M.smegmatis_MC2_155 AREFDAAG-LPPGVLNVVTGDGEPVGAHLSGHPDVRKVAFTGSTAVGKSI
MMAR_2875|M.marinum_M ARIAERSG-LPPGVINVVPGEGPEAGARLASHPDVGKIAFTGSTAVGREI
MUL_2877|M.ulcerans_Agy99 ARIAERSG-LPPGVINVVPGEGPEAGARLASHPDVGKIAFTGSTAVGREI
Rv0223c|M.tuberculosis_H37Rv AEVFAEVG-LPEGVLSVVPGG-IETGQALTSNPDIDMFTFTGSSAVGREV
MAB_4484|M.abscessus_ATCC_1997 AEVFAEAG-VPEGVLSVVPGG-AETGRALTNNPDVDVFSFTGSTAVGKEI
Mflv_0428|M.gilvum_PYR-GCK AEMFVEAG-LPEGVLSIVPGG-PETGQALTANPNLDKYTFTGSSGVGKEI
MAV_3969|M.avium_104 AEMISEAD-LPPGAVSVLPGD-AALGAYLAGHRGVDKVSFTGSTAAGRAV
TH_3080|M.thermoresistible__bu AELIADSG-IPSGVVNVLPGP-AGVGERLVRHPGVDKVSFTGSTAAGRAV
Mb0791|M.bovis_AF2122/97 GEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTATGRAV
MLBr_02573|M.leprae_Br4923 ADVIARGG-FPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAGQAV
. .* . .. : * . : ::*** .*: :
Mvan_0352|M.vanbaalenii_PYR-1 LRQSADSIRRVTLELGGKGANIILDDADIEMAVDGALFACMANNGEACEA
MSMEG_0327|M.smegmatis_MC2_155 LRQSADTVRRVTLELGGKGANIILDDADIDMAVDGALFACMANNGEACEA
MMAR_2875|M.marinum_M MRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGCFAYSGQVCES
MUL_2877|M.ulcerans_Agy99 MRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGCFAYSGQVCES
Rv0223c|M.tuberculosis_H37Rv GRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVN
MAB_4484|M.abscessus_ATCC_1997 AEIAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSGLMNAGQGCVN
Mflv_0428|M.gilvum_PYR-GCK AKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSGLMNSGQACVG
MAV_3969|M.avium_104 AAACAANLTKVSLELGGKSAALVLDDAPPDKVAAGVRAASLSNSGQICNA
TH_3080|M.thermoresistible__bu AAAAAAGLKRVSLELGGKSAAVVLSDADPAAVATAVRSASLSNSGQICNA
Mb0791|M.bovis_AF2122/97 MADAAATIKKVFLELGGKSAFVVLDDADLAAASAVSAFSACMHAGQGCAI
MLBr_02573|M.leprae_Br4923 GAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQSCIA
.. : *****... ::: .. . . *: *
Mvan_0352|M.vanbaalenii_PYR-1 GTRLLIPRSRRDEILAKLLARASTLRLGDPLQPTTHVGPIISAHQRDRIL
MSMEG_0327|M.smegmatis_MC2_155 GTRLLIPASRRDEIVDKLLARASTLRVGDPLDPATHIGPVISQTQRDRIL
MMAR_2875|M.marinum_M GTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPVIDAAQRTRIL
MUL_2877|M.ulcerans_Agy99 GTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPVIDAAQRTRIL
Rv0223c|M.tuberculosis_H37Rv QTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVE
MAB_4484|M.abscessus_ATCC_1997 QTRVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLITEKQRTRVE
Mflv_0428|M.gilvum_PYR-GCK QTRILAPRSRYDEVIEKLGEAVRNMAPGLPDNPAAMIGPLISEKQRDRVE
MAV_3969|M.avium_104 LTRVLVPQARHDDYVDALAAHMGGLRVGDPADPDTDLGPLVSRRQQQRVR
TH_3080|M.thermoresistible__bu LTRILMPAGRAAEFTDALAAEMESLVIGDPTDAETQIGPLVARRQQERVR
Mb0791|M.bovis_AF2122/97 TTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQRDRVQ
MLBr_02573|M.leprae_Br4923 AKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVE
.* : : : * . : : **: : ::
Mvan_0352|M.vanbaalenii_PYR-1 DYFEIAKAEGATVALGGGVPDGPGFDKGYWVEPTIFVDVTNNMRIAREEV
MSMEG_0327|M.smegmatis_MC2_155 NYFRIAAEEGAIAALGGKARSGPEFDKGYWIEPTIYLDVTNDMRVAREEV
MMAR_2875|M.marinum_M NYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVHNDMAIAREEV
MUL_2877|M.ulcerans_Agy99 NYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVHNDMAIAREEV
Rv0223c|M.tuberculosis_H37Rv GYIAKGIEEGARLVCGG-GRPEG-LDNGFFIQPTVFADVDNKMTIAQEEI
MAB_4484|M.abscessus_ATCC_1997 GYIAKGIAEGARLAYGG-KRPEG-LDGGYFVQPTIFADVDNSMTIAQEEI
Mflv_0428|M.gilvum_PYR-GCK GYIKKGIEEGARVITGG-GRPEG-LDSGWFVEPTVFADVDNSMTIAQEEI
MAV_3969|M.avium_104 DYIRIGQQEGARLVVGGADMPDG-LDRGWYVRPTLFAAAGNAMRIAREEI
TH_3080|M.thermoresistible__bu GYIEAGCAEGARLVTGGPGLPAG-VDRGWYVQPTLFADADNSMRIAREEI
Mb0791|M.bovis_AF2122/97 GYLDLAVAEGGRFACGG-ARPAD-REVGFYIEPTVIAGLTNDARVAREEI
MLBr_02573|M.leprae_Br4923 QQVDAAAAAGAVIRCGGKRPDRP----GWFYPPTVITDITKDMALYTDEV
. . *. ** *:: **: : : :*:
Mvan_0352|M.vanbaalenii_PYR-1 FGPVLVVLTYDSTDEAIKIANDTNYGLSAGVWGSE-ENALQVARRLDSGM
MSMEG_0327|M.smegmatis_MC2_155 FGPVLVVMTYDTDEDALAVANDTNYGLSAGVWGSE-ERATALARRLEAGM
MMAR_2875|M.marinum_M FGPVLVVIGYDGDEQAIAIANDSDYGLAASIWTSDNARGLAMAERIQSGS
MUL_2877|M.ulcerans_Agy99 FGPVLVVSGYDGDEQAIAIANDSDYGLAASIWTSDNARGLAMAERIRSGS
Rv0223c|M.tuberculosis_H37Rv FGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQIRTGT
MAB_4484|M.abscessus_ATCC_1997 FGPVLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGLEVAAQIRTGT
Mflv_0428|M.gilvum_PYR-GCK FGPVLSVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRALKIARRIRTGT
MAV_3969|M.avium_104 FGPVITVIPYRDDDEAVAIANDSDYGLAGSVWSDDTDRALALATRIHTGT
TH_3080|M.thermoresistible__bu FGPVLTVIPYPDEDAAVAIANDSDYGLAGSVFTADTERGLAIAARIRTGT
Mb0791|M.bovis_AF2122/97 FGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRVGT
MLBr_02573|M.leprae_Br4923 FGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAGQ
**** : : *: :** : :**.. : : . . .: *
Mvan_0352|M.vanbaalenii_PYR-1 VWVNNWHVIHPAYPFGGYKESGLGREGGPHAIDEYVEEKFISIDRSGGIE
MSMEG_0327|M.smegmatis_MC2_155 VWVNNWHIIHPAYPFGGYKESGLGREGGPNAIDEYVEEKFIAVDRSGGIE
MMAR_2875|M.marinum_M VWINDAHQINCRLPFGGYKQSGVGRELGPDALDAYTEVKTIHLDLSGGRE
MUL_2877|M.ulcerans_Agy99 VWINDAHQINCRLLFGGYKQSGVGRELGPDTLDAYTEVKTIHLDLSGGRE
Rv0223c|M.tuberculosis_H37Rv YGINW-YAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMGYTVA
MAB_4484|M.abscessus_ATCC_1997 YGINW-YAFDPSCPFGGYKQSGIGRENGPEGIEEYCELKSVLLPMGYTLE
Mflv_0428|M.gilvum_PYR-GCK YAVNM-YAFDPCAPFGGYKNSGIGRENGWEGIEAYCEQKSILLPFGYTPP
MAV_3969|M.avium_104 VGVNQGYTMDPFAPFGGVKASGYGRELGPEGLDGYLDTKSIAVAPSG---
TH_3080|M.thermoresistible__bu FGVNQGYTMDPFAPFGGVKGSGYGRELGPEGIDAYTDVKSISVAPASTT-
Mb0791|M.bovis_AF2122/97 VNVNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIATAAN----
MLBr_02573|M.leprae_Br4923 VFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA------
:* *** * ** *** . . : : * :
Mvan_0352|M.vanbaalenii_PYR-1 NKAFAIVIDPAV--
MSMEG_0327|M.smegmatis_MC2_155 NKAFAIVIDPAGD-
MMAR_2875|M.marinum_M AKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 AKPYDVLLGHPETG
Rv0223c|M.tuberculosis_H37Rv --------------
MAB_4484|M.abscessus_ATCC_1997 SI------------
Mflv_0428|M.gilvum_PYR-GCK AS------------
MAV_3969|M.avium_104 --------------
TH_3080|M.thermoresistible__bu --------------
Mb0791|M.bovis_AF2122/97 --------------
MLBr_02573|M.leprae_Br4923 --------------