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TDTTISNGVTEQLVHFDLVIGGESVAAESGRTYDSIDPYTALPWARVPDCGPADVDRAVAAARAALRGPW GQLTGTARGKLLWRLGELIAREAESLAELEVRDGGKLVREMIGQMKALPDYYIYYAGLADKLQGEVVPVD KPNFFVYTRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKPSDHTPASTLAFAKLFAEAGFPPG VINVVTGWGPQTGAALAAHPDVDKIAFTGSTATGISVGKAAIDNMTRFTLELGGKSAQVVFDDADLDAAA NGVIAGVFAATGQTCLAGSRLLVHESVADALVERIVARASTIKLGDPKDPATEMGPVSNQPQYEKVLSHF ASAREQGATVAYGGEPAGELGGFFVKPTVLTGVDRSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEFG LAAGVWTKDVHRAHRVAARLNAGTVWVNAYRVVSPHVPFGGMGHSGIGRENGIDAVKDFTETKAVWVELS GATRDPFTLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1897 | - | - | 100% (501) | betaine-aldehyde dehydrogenase |
| M. avium 104 | MAV_2608 | - | 0.0 | 86.83% (501) | aldehyde dehydrogenase family protein |
| M. avium 104 | MAV_2765 | - | e-107 | 44.06% (463) | P-cumic aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0467 | - | 1e-92 | 40.54% (481) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3083 | - | 1e-104 | 43.61% (493) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0458 | - | 1e-92 | 40.54% (481) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 6e-59 | 32.13% (442) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 1e-93 | 42.02% (476) | gamma-aminobutyraldehyde dehydrogenase |
| M. marinum M | MMAR_2875 | - | 1e-105 | 43.90% (492) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6297 | - | 1e-130 | 46.94% (490) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3419 | - | 1e-100 | 44.65% (477) | PUTATIVE putative aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2877 | - | 1e-103 | 43.50% (492) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0014 | - | 1e-101 | 43.29% (492) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0467|M.bovis_AF2122/97 MTVFSRPGSAG------ALMSYESRYQNFIGGQWVAPVHGRYFENPTPVT
Rv0458|M.tuberculosis_H37Rv MTVFSRPGSAG------ALMSYESRYQNFIGGQWVAPVHGRYFENPTPVT
MAV_1897|M.avium_104 MTDTTISNG---------VTEQLVHFDLVIGGESVAAESGRTYDSIDPYT
MSMEG_6297|M.smegmatis_MC2_155 MTVTTFRPSDVATLTNPDAASDVADLSMFIAGEAVSAADGATFDSYEPRS
MMAR_2875|M.marinum_M -----------------MTTVAVPHHAMLIGGESVDSDR--RLSLVDPGD
MUL_2877|M.ulcerans_Agy99 -----------------MTTVAVPHHAMLIGGESVDSDR--RLSLVDPGD
Mvan_0014|M.vanbaalenii_PYR-1 -------------------MSDIPHYRMYIDGAWRDAAD--TIEVRSPAT
Mflv_3083|M.gilvum_PYR-GCK ---------------------MDGDPDLCIGGAWRHACDGGTRDIINPAN
TH_3419|M.thermoresistible__bu --------------VQRTLPDKLPAPRLVIGGGDVISTSGGVYEHHYAAT
MAB_3328|M.abscessus_ATCC_1997 ----------------------MSVPSSWINGR-PVATHGDTHRVINPAT
MLBr_02573|M.leprae_Br4923 ----------------------------------------MSIATINPAT
.
Mb0467|M.bovis_AF2122/97 GQPFCEVPRSDAADIDKALDAAHAAAP--GWGKTAPAERAAILNMIADRI
Rv0458|M.tuberculosis_H37Rv GQPFCEVPRSDAADIDKALDAAHAAAP--GWGKTAPAERAAILNMIADRI
MAV_1897|M.avium_104 ALPWARVPDCGPADVDRAVAAARAALR-GPWGQLTGTARGKLLWRLGELI
MSMEG_6297|M.smegmatis_MC2_155 GRVWARLPRANSTDIDRAVRAARAAFE-GPWGAVSPADRGRFLMKIAAVV
MMAR_2875|M.marinum_M ESPVATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAA
MUL_2877|M.ulcerans_Agy99 ESPVATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAA
Mvan_0014|M.vanbaalenii_PYR-1 GELVATVAYGGVTTVDDAVAAAKAADEAGVWRNTSAQQRADVLDAIADNL
Mflv_3083|M.gilvum_PYR-GCK GAVAAVVDEATPQDALDAVAAARAAFDQGGWRATAVAERSALLQRIADLL
TH_3419|M.thermoresistible__bu GGVQAEVPLAGPAEVDAAVAAARAAFP--AWRDLDLNRRRDILQELARRL
MAB_3328|M.abscessus_ATCC_1997 GEAVADLKLATTADVDAAVAAARAAGP--AWASSTPVDRSSVLAKLAAVL
MLBr_02573|M.leprae_Br4923 GETVKTFTPTTQDEVEDAIARAYARFD--NYRHTTFTQRAKWANATADLL
. *: * * : *
Mb0467|M.bovis_AF2122/97 DKNAAALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEG-ALS
Rv0458|M.tuberculosis_H37Rv DKNAAALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEG-ALS
MAV_1897|M.avium_104 AREAESLAELEVRDGGKLVREMIG-QMKALPDYYIYYAGLADKLQG-EVV
MSMEG_6297|M.smegmatis_MC2_155 DRHRDQLTVIESRDNGKPVREVRA-EIDAVVRYFEYFAGVCQTTVG-ETH
MMAR_2875|M.marinum_M DQVTDELIELEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQRPA
MUL_2877|M.ulcerans_Agy99 DQVTDELIELEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQRPA
Mvan_0014|M.vanbaalenii_PYR-1 AARTDELTALQVAENGATVRAAGAFLIGYAIAHLRYFAGLARTYAFQSSG
Mflv_3083|M.gilvum_PYR-GCK QRDKEDLARLETVDTGKTLAESRI-DIDDVTSVFRYYANLVASEAE-RVV
TH_3419|M.thermoresistible__bu VADGERLGAIATLEVGTPNLLASS-SSAMAADWFTYYAGWIGRSAG-EVV
MAB_3328|M.abscessus_ATCC_1997 SANADTLVADEVAQTGKPVRLASEFDVPGSIDNVEFFAGAARHLEGKATA
MLBr_02573|M.leprae_Br4923 EAEANQSAALMTLEMGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEPA
* ::*
Mb0467|M.bovis_AF2122/97 QIDEDTVAYH---FHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVL
Rv0458|M.tuberculosis_H37Rv QIDEDTVAYH---FHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVL
MAV_1897|M.avium_104 PVDKPNFFVY--TRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVV
MSMEG_6297|M.smegmatis_MC2_155 P-QAATAFSY--TRREPVGVVGAIVPWNSPLLMLAWKLSPALAGGNTIIL
MMAR_2875|M.marinum_M PIETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVV
MUL_2877|M.ulcerans_Agy99 PIETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVV
Mvan_0014|M.vanbaalenii_PYR-1 PLMEAPTLAAGMIVRDPVGVCAGMIPWNFPLLLAVWKLGPALAAGNTVVL
Mflv_3083|M.gilvum_PYR-GCK DVGDPAVISR--VIREPIGVCVLIAPWNYPLLQMSWKVAPALAAGCTMVA
TH_3419|M.thermoresistible__bu PVPAGGALDY--VLDEPLGVIAAIIPWNGPLISIGMKVAPALAAGNCVVL
MAB_3328|M.abscessus_ATCC_1997 EYSADHTSSIR---REAAGVVATITPWNYPLQMAVWKVLPALAAGCTVVI
MLBr_02573|M.leprae_Br4923 EAAAVGASKAL-ARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLL
:. ** : *** *: ..: .* :
Mb0467|M.bovis_AF2122/97 KPAEQTPASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKV
Rv0458|M.tuberculosis_H37Rv KPAEQTPASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKV
MAV_1897|M.avium_104 KPSDHTPASTLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKI
MSMEG_6297|M.smegmatis_MC2_155 KPAEETSVSAVVFAQLIAEVGLPDGVFNVVTGIGEEAGAALVAHPDVDKI
MMAR_2875|M.marinum_M KPDEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKI
MUL_2877|M.ulcerans_Agy99 KPDEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKI
Mvan_0014|M.vanbaalenii_PYR-1 KPDDQTPLTLLELARAADEVGLPAGVLNVVTGAGPTVGARLAEHPDVRKV
Mflv_3083|M.gilvum_PYR-GCK KPSEVTPLSTIAFAKLLDEAGVPPGVVNLIQGSGATLGPALTDNPQVDFI
TH_3419|M.thermoresistible__bu KPPENAPFSALRFAELAAEAGLPPGVLNVIPG-GAEAGSALCSHPGVDKI
MAB_3328|M.abscessus_ATCC_1997 KPSELTPLTTLTLARLAAEAGLPEGVLNVVTGRGDDVGYALASHPDVDLV
MLBr_02573|M.leprae_Br4923 KHASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILRD-PRVAAA
* . .. : : .* . .: : . * :
Mb0467|M.bovis_AF2122/97 AFTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADV-----LAAHDD
Rv0458|M.tuberculosis_H37Rv AFTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADV-----LAAHDD
MAV_1897|M.avium_104 AFTGSTATGISVGKAAIDNMTRFTLELGGKSAQVVFDD-------ADLDA
MSMEG_6297|M.smegmatis_MC2_155 AFTGSTEVGKQIAATAASDLKLVTFELGGKSPTVIFDD-------ADLDA
MMAR_2875|M.marinum_M AFTGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDD-------ADLEM
MUL_2877|M.ulcerans_Agy99 AFTGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDD-------ADLEM
Mvan_0014|M.vanbaalenii_PYR-1 AFTGSTEVGKSVMRAAADTVKKVTLELGGKGASIVLDD-------ADLDL
Mflv_3083|M.gilvum_PYR-GCK SFTGGLATGRTIARTAAEHVTKVALELGGKNPHLVFADIRDAGRESGWDA
TH_3419|M.thermoresistible__bu TFTGGGETARKVFAAAAQALTPVVLELGGKSANIVFPD-------ADLDA
MAB_3328|M.abscessus_ATCC_1997 TFTGSTAVGRKVMAAAAVHGHRTQLELGGKAPFVVFDD-------ADMDA
MLBr_02573|M.leprae_Br4923 TLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS-------ADLDA
::** .. : * :****. . :.: . : :
Mb0467|M.bovis_AF2122/97 FCDKALEG-FTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQ
Rv0458|M.tuberculosis_H37Rv FCDKALEG-FTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQ
MAV_1897|M.avium_104 AANGVIAG-VFAAT---GQTCLAGSRLLVHESVADALVERIVARASTIKL
MSMEG_6297|M.smegmatis_MC2_155 AVHRTAYG-IFSAA---GQTCQAASRIFVQDTIHDEFLDRFAALARRIRV
MMAR_2875|M.marinum_M AVEGVLYG-CFAYS---GQVCESGTRALVPTTLYQEFVDRLVKRAATIVV
MUL_2877|M.ulcerans_Agy99 AVEGVLYG-CFAYS---GQVCESGTRALVPTTLYQEFVDRLVKRAATIVV
Mvan_0014|M.vanbaalenii_PYR-1 AVDGSLFA-FLLMS---GQACESGTRLLVHESIHDEFVRRMVARAETLVM
Mflv_3083|M.gilvum_PYR-GCK AVDHVLTG-VFLHS---GQVCSAGTRLIIEESIADEFVAALAARAATIRM
TH_3419|M.thermoresistible__bu AATMAVSAGLMMLS---GQGCILPTRLLVHDDVYDEMVTRVVAGADALTV
MAB_3328|M.abscessus_ATCC_1997 AIAGAVAG-AIINS---GQDCTAATRALVARDLYDDFVAGVGEVMSKVVV
MLBr_02573|M.leprae_Br4923 AVATAVTG-RVQNN---GQSCIAAKRFIAHADIYDEFVEKFVARMETLRV
. *: * .* : : : :: :
Mb0467|M.bovis_AF2122/97 GDPLDTETMLGSQASNDQLEKVLSYIEIGKQEGA-VIIAGGERAELGGDL
Rv0458|M.tuberculosis_H37Rv GDPLDTETMLGSQASNDQLEKVLSYIEIGKQEGA-VIIAGGERAELGGDL
MAV_1897|M.avium_104 GDPKDPATEMGPVSNQPQYEKVLSHFASAREQGA-TVAYGGEP----AGE
MSMEG_6297|M.smegmatis_MC2_155 GDPLSERTQMGAQISAQHRERIAGYVASGIQEGA-NLVCGGTQPTE-APL
MMAR_2875|M.marinum_M GPTRDWDTDLGPVIDAAQRTRILNYIRGAQTDGA-TVALGGEALTG-GMF
MUL_2877|M.ulcerans_Agy99 GPTRDWDTDLGPVIDAAQRTRILNYIRGAQTDGA-TVALGGEALTG-GMF
Mvan_0014|M.vanbaalenii_PYR-1 GDPMSLASDLGPLVSAKQKARVEKYIALGQEEGC-KLAYQGTVPTD-PAL
Mflv_3083|M.gilvum_PYR-GCK GDGLDPASETGPLVSAQHRDKVESYVRLGISEGA-QLIAGGCRPED-PVL
TH_3419|M.thermoresistible__bu GDPWQPTTMMGPLATAAQLERVTRAVDSALSDKAGKLLAGGRRPDG---L
MAB_3328|M.abscessus_ATCC_1997 GDPLDPDTDIGPLISAAHRAKVSSIVDRAPAQGG-RIVTGATAPDL----
MLBr_02573|M.leprae_Br4923 GDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGA-VIRCGGKRPDR----
* . : *. :: . . : .
Mb0467|M.bovis_AF2122/97 SGGYYMQPTIFTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLY
Rv0458|M.tuberculosis_H37Rv SGGYYMQPTIFTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLY
MAV_1897|M.avium_104 LGGFFVKPTVLTGVDRSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEF
MSMEG_6297|M.smegmatis_MC2_155 AQGYYYSPTILDGVNRDMRMIREEIFGPVTGVMSFTDEADAVAKANDTEY
MMAR_2875|M.marinum_M DKGFWVAPTILTGVHNDMAIAREEVFGPVLVVIGYDGDEQAIAIANDSDY
MUL_2877|M.ulcerans_Agy99 DKGFWVAPTILTGVHNDMAIAREEVFGPVLVVSGYDGDEQAIAIANDSDY
Mvan_0014|M.vanbaalenii_PYR-1 AQGHWVPPTILTGATNDMRIAREEIFGPVLVVLTYGDDDEAVAIANDSEY
Mflv_3083|M.gilvum_PYR-GCK AGGYFYRPTIFDRCDRSMRIVQEETFGPILTVERFTDEAEAVTLGNDTEY
TH_3419|M.thermoresistible__bu DAGYFYRPTVFGDVDPASDLAQTEIFGPVLAILRFRSEEEAVELANNTQY
MAB_3328|M.abscessus_ATCC_1997 -PGSFYRPTLIADVAETSEVYRDEIFGPVLTVRPFTDDDDALRQANDTAY
MLBr_02573|M.leprae_Br4923 -PGWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPF
* : **:: * ***: : . :*: .* : :
Mb0467|M.bovis_AF2122/97 GLGAGVWSRDGNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGR
Rv0458|M.tuberculosis_H37Rv GLGAGVWSRDGNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGR
MAV_1897|M.avium_104 GLAAGVWTKDVHRAHRVAARLNAGTVWVNAYRVVSPHVPFGGMGHSGIGR
MSMEG_6297|M.smegmatis_MC2_155 GLAGSVWTRDVSRAHRVAASIAAGLIWVNTTRTINHLVPFGGYKQSGYGR
MMAR_2875|M.marinum_M GLAASIWTSDNARGLAMAERIQSGSVWINDAHQINCRLPFGGYKQSGVGR
MUL_2877|M.ulcerans_Agy99 GLAASIWTSDNARGLAMAERIRSGSVWINDAHQINCRLLFGGYKQSGVGR
Mvan_0014|M.vanbaalenii_PYR-1 GLSAGVWSADRERALGIARRLQSGTVWVNDWHMINAMYPFGGVKQSGLGR
Mflv_3083|M.gilvum_PYR-GCK GLAAGVRTTDTARGERVVRALRHGTVWLNDFGYYTAAAEWGGFGRSGNGR
TH_3419|M.thermoresistible__bu GLAAYIHTRDLRRAHVMAAALDAGGVAVNGFPIVPSAAPFGGVKQSGFGR
MAB_3328|M.abscessus_ATCC_1997 GLAASAWTRDVYRAQRASREIRAGCVWINDHIPIISEMPHGGFGASGFGK
MLBr_02573|M.leprae_Br4923 GLGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGR
**.. : : : * : :* ** ** *:
Mb0467|M.bovis_AF2122/97 EGHQMMLQHYQHTKNLLVSYSDKALGFF-----------
Rv0458|M.tuberculosis_H37Rv EGHQMMLQHYQHTKNLLVSYSDKALGFF-----------
MAV_1897|M.avium_104 ENGIDAVKDFTETKAVWVELSGATRDPFTLG--------
MSMEG_6297|M.smegmatis_MC2_155 EGGQAVMEHYTRIKSVWVDMQDDLPNWYAD---------
MMAR_2875|M.marinum_M ELGPDALDAYTEVKTIHLDLSGGREAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 ELGPDTLDAYTEVKTIHLDLSGGREAKPYDVLLGHPETG
Mvan_0014|M.vanbaalenii_PYR-1 ELGPDALDEYTEPKFIHVDMTDDRRKHVYPVVISAAAQG
Mflv_3083|M.gilvum_PYR-GCK ELGPTGLAEYQEIKHIWHNTAPAAAGWFTG---------
TH_3419|M.thermoresistible__bu EGGIWGLREFQRTKNVYIGLQ------------------
MAB_3328|M.abscessus_ATCC_1997 DMSDYSLEEYLTVKHVMSDITGTADKDWHRTIFAKR---
MLBr_02573|M.leprae_Br4923 ELSTHGIREFCNIKTVWIA--------------------
: : : * :