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VTVEGANFIDGQWIPAASGRTFARHNPADPDDLVGVFPASDGVDVRTAVDALDKAAPEWAATPPERRAAI LEAAAVQLESRAAELIAELIREEGKTTAEATMEVSRTPANLRFYAGEALRSTGTTYPAPGEGLVYTLREP VGIVGAITPWNFPFNIPSRKLGPALAAGNPVLYKPSELTPLMGQRLVEALLDGGLPPSAVALVQGDGVAG AAVAADPRVAAVTFTGSTAVGRAIHQQVGPQRRVQLEMGGKNPVVVAGDADLDAAAALIVKGAFGLSGQA CTGTSRVIAVDEVHDALLDRVVAKADALQVGPGNEPGVQMGPLASAAQREKFLHYVHAGITEGATLRCGG TTVGDHGFFVRPAVFADALPTMRIVTEEVFGPLVAFQRAASLDEAVALANATEYGLAASIVTSDLAAATR FARQSKTGLVKINQPTTGMAMNAPFGGYKASSTQTFKEQAGPTLMEFYTLEKTVYLTPAL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1461 | - | - | 100% (480) | 5-oxovalerate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1158 | - | e-103 | 45.45% (473) | 5-oxovalerate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6687 | - | 1e-86 | 39.41% (477) | aldehyde dehydrogenase, thermostable |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 5e-66 | 35.75% (456) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0428 | - | 2e-70 | 35.37% (475) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 3e-71 | 35.37% (475) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 4e-56 | 32.68% (462) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0823 | - | 1e-84 | 40.38% (478) | aldehyde dehydrogenase |
| M. marinum M | MMAR_2875 | - | 1e-69 | 35.44% (474) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1897 | - | 2e-69 | 38.20% (445) | betaine-aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3902 | - | 1e-72 | 38.04% (460) | PUTATIVE putative 5-carboxymethyl-2-hydroxymuconate |
| M. ulcerans Agy99 | MUL_2877 | - | 2e-69 | 35.23% (474) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1328 | - | 0.0 | 77.50% (480) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1461|M.smegmatis_MC2_155 -----------------MTVEGANFIDGQWIPAASGRTFARHNPADPDDL
Mvan_1328|M.vanbaalenii_PYR-1 ------------------MIEGLNYIGGAWVPAQSGRTFTRANPADPADV
MAB_0823|M.abscessus_ATCC_1997 ----------------MHINEIQSFVGGRWISG-GGQAVISVCPAFPDRV
MMAR_2875|M.marinum_M -----MTTVAVP--------HHAMLIGGESVDSD--RRLSLVDPG-DESP
MUL_2877|M.ulcerans_Agy99 -----MTTVAVP--------HHAMLIGGESVDSD--RRLSLVDPG-DESP
MAV_1897|M.avium_104 -----MTDTTISNGVTEQLVHFDLVIGGESVAAESGRTYDSIDPY-TALP
Mb2883c|M.bovis_AF2122/97 -----MS------------------------------TTQLINPA-TEEV
Mflv_0428|M.gilvum_PYR-GCK -----MTQSTAF-----RTEWDKLFIGGKWVEPASSEVIEVRSPA-TGDV
Rv0223c|M.tuberculosis_H37Rv -----MSDS--------ATEYDKLFIGGKWTKPSTSDVIEVRCPA-TGEY
TH_3902|M.thermoresistible__bu LRANRFQPKDNT-----VTWKYDLYIDGKWDTGTSGRALTVVNPA-TEET
MLBr_02573|M.leprae_Br4923 ------------------------------------MSIATINPA-TGET
*
MSMEG_1461|M.smegmatis_MC2_155 VGVFPASDGVDVRTAVDALDKAAP--EWAATPPERRAAILEAAAVQLESR
Mvan_1328|M.vanbaalenii_PYR-1 IGTFPASDADDVRNAVDALEKAAP--EWAATAPERRASILESAAAQLESR
MAB_0823|M.abscessus_ATCC_1997 IAEGLAAGPAEFDEAAAAARAAQP--GWAAMSLHARGAMLSHAAAVVDRN
MMAR_2875|M.marinum_M VATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQV
MUL_2877|M.ulcerans_Agy99 VATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQV
MAV_1897|M.avium_104 WARVPDCGPADVDRAVAAARAALR-GPWGQLTGTARGKLLWRLGELIARE
Mb2883c|M.bovis_AF2122/97 LASVDHTDANAVDDAVQRARAAQR--RWARLAPAQRAAGLRAFAAAVQAH
Mflv_0428|M.gilvum_PYR-GCK VGKVPLASAADVDAACAAAREAFDNGPWPQMSPTERAEVLGRAVKLMEER
Rv0223c|M.tuberculosis_H37Rv VGKVPMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAER
TH_3902|M.thermoresistible__bu IGTVPDASLDDIRRAIAAARTAFDEGPWPCMTPLERAAVIRRIAEVLQRR
MLBr_02573|M.leprae_Br4923 VKTFTPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAE
. * : . *.
MSMEG_1461|M.smegmatis_MC2_155 AAELIAELIREEGKTT-AEATMEVSRTPANLRFYAGEALRSTGTTYPAPG
Mvan_1328|M.vanbaalenii_PYR-1 SEALIAELVREEGKTV-AEATMEVTRTPSNLRFYAAEATRAAGMTFPAAG
MAB_0823|M.abscessus_ATCC_1997 ADAWGLELAAEEGKTK-AEGIAEVRRAAQILRYYGNEGDRQTGEIFSSPR
MMAR_2875|M.marinum_M TDELIELEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQR-PAPI
MUL_2877|M.ulcerans_Agy99 TDELIELEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQR-PAPI
MAV_1897|M.avium_104 AESLAELEVRDGGKLVREMIG-QMKALPDYYIYYAGLADKLQGEVVPVDK
Mb2883c|M.bovis_AF2122/97 LDELAALEVANSGHPI-VSAEWEAGHVRDVLAFYAASPERLSGRQIPVAG
Mflv_0428|M.gilvum_PYR-GCK ADELKFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQDIRDG
Rv0223c|M.tuberculosis_H37Rv KDLFTKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTG
TH_3902|M.thermoresistible__bu RSELVDLVRAETGSPQWIVEMLQVGVPLRVCADVADRVLPQFRFVEPMLP
MLBr_02573|M.leprae_Br4923 ANQSAALMTLEMGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEPAEAA
* .
MSMEG_1461|M.smegmatis_MC2_155 EG-----LVYTLREPVGIVGAITPWNFPFNIPSRKLGPALAAGNPVLYKP
Mvan_1328|M.vanbaalenii_PYR-1 DT-----MVYTVREPVGIVGAITPWNFPLNIPSRKLGPALAVGDPVLFKP
MAB_0823|M.abscessus_ATCC_1997 RGE----HILVTRKPLGVVGVITPFNFPIAIPAWKIAPALVYGNAVLWKP
MMAR_2875|M.marinum_M ETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKP
MUL_2877|M.ulcerans_Agy99 ETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKP
MAV_1897|M.avium_104 PNFFVYTR----HEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKP
Mb2883c|M.bovis_AF2122/97 -GVDVTFN-----EPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKP
Mflv_0428|M.gilvum_PYR-GCK VY----GQTLVVREPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKP
Rv0223c|M.tuberculosis_H37Rv SY----GQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKP
TH_3902|M.thermoresistible__bu SFDLRPGQGIISKEPIGVAALITPFNFPLFLNVMKLAPALAAGCTVVLKP
MLBr_02573|M.leprae_Br4923 AVG--ASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKH
:*:*:. : .:* *: ...: * : *
MSMEG_1461|M.smegmatis_MC2_155 SELTPLMGQRLVEALLDGGLPPSAVALVQG-DGVAGAAVAADPRVAAVTF
Mvan_1328|M.vanbaalenii_PYR-1 SELTPLMGQRLVEALLAGGLPPGVLALVHG-DGVAGAAVAADERVAAVTF
MAB_0823|M.abscessus_ATCC_1997 ASTVPLLAMRLAQAFDAAGLPPGVLNLVVG-DTGVGDAMVNDSRVDALTF
MMAR_2875|M.marinum_M DEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAF
MUL_2877|M.ulcerans_Agy99 DEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAF
MAV_1897|M.avium_104 SDHTPASTLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKIAF
Mb2883c|M.bovis_AF2122/97 AELTPLTTMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVF
Mflv_0428|M.gilvum_PYR-GCK AAETPLSVFAMAEMFVEAGLPEGVLSIVPG-GPETGQALTANPNLDKYTF
Rv0223c|M.tuberculosis_H37Rv AAETPLTANALAEVFAEVGLPEGVLSVVPG-GIETGQALTSNPDIDMFTF
TH_3902|M.thermoresistible__bu SPLTPLEALVLGEVADEVGLPPGVLNIVTG-GAEESAELTTNPMVDLVSF
MLBr_02573|M.leprae_Br4923 ASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILR-DPRVAAATL
.* : *: . . : . . : :
MSMEG_1461|M.smegmatis_MC2_155 TGSTAVGRAIHQQVGPQ-RRVQLEMGGKNPVVVAGDADLDAAAALIVKGA
Mvan_1328|M.vanbaalenii_PYR-1 TGSTAVGRSIHRAVGPH-RRVQLEMGGKNPVVVADDADLDRAAALIVKGA
MAB_0823|M.abscessus_ATCC_1997 TGSTGVGRRIAAAGAARGIPVQAEMGGKNAAVVLDDADVDLAVEQVLLGA
MMAR_2875|M.marinum_M TGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGC
MUL_2877|M.ulcerans_Agy99 TGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGC
MAV_1897|M.avium_104 TGSTATGISVGKAAIDNMTRFTLELGGKSAQVVFDDADLDAAANGVIAGV
Mb2883c|M.bovis_AF2122/97 TGSTEVGKRVMAGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGV
Mflv_0428|M.gilvum_PYR-GCK TGSSGVGKEIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSG
Rv0223c|M.tuberculosis_H37Rv TGSSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSG
TH_3902|M.thermoresistible__bu TGSDTVGRQVMNQASATLKKVVLELGGKSANVIFADADLDAAAAHVVGEF
MLBr_02573|M.leprae_Br4923 TGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGR
*** .* : *:**... :: . *: :
MSMEG_1461|M.smegmatis_MC2_155 FGLSGQACTGTSRVIAVDEVHDALLDRVVAKADALQVGPGNEPGVQMGPL
Mvan_1328|M.vanbaalenii_PYR-1 FGLSGQACTGTSRVIATDATHDGLVERVVARAEALRVGPGAQPGIDMGAL
MAB_0823|M.abscessus_ATCC_1997 FRSTGQKCTATSRLVLTEGIADAFLSLLKDRADALVVGDPTADDTQMGPV
MMAR_2875|M.marinum_M FAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPV
MUL_2877|M.ulcerans_Agy99 FAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPV
MAV_1897|M.avium_104 FAATGQTCLAGSRLLVHESVADALVERIVARASTIKLGDPKDPATEMGPV
Mb2883c|M.bovis_AF2122/97 FDNAGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPL
Mflv_0428|M.gilvum_PYR-GCK LMNSGQACVGQTRILAPRSRYDEVIEKLGEAVRNMAPGLPDNPAAMIGPL
Rv0223c|M.tuberculosis_H37Rv VMNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPL
TH_3902|M.thermoresistible__bu TLHAGQGCSLLTRTLVEESIHDELVDWVNKQLAALKVGDPADPSVMMGPL
MLBr_02573|M.leprae_Br4923 VQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPL
** * .* : : .: . : * :*.:
MSMEG_1461|M.smegmatis_MC2_155 ASAAQREKFLHYVHAGITEGATLRCGGT--TVGDHG--FFVRPAVFADAL
Mvan_1328|M.vanbaalenii_PYR-1 ASAAQAEKFAHYVGVGVDEGASLRCGGTRLDVPGHAGGFFVRPAVFTDTE
MAB_0823|M.abscessus_ATCC_1997 VSESAFGTITAGIGGAVAQGAVTLAGGHGYGDGPLAAGYFIAPTIMELGM
MMAR_2875|M.marinum_M IDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVH
MUL_2877|M.ulcerans_Agy99 IDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVH
MAV_1897|M.avium_104 SNQPQYEKVLSHFASAREQGATVAYGGE--PAGELG-GFFVKPTVLTGVD
Mb2883c|M.bovis_AF2122/97 VSRAHRDKVAGYVP----DDAPVAFRGT----APAGRGFWFPPTVLT-PK
Mflv_0428|M.gilvum_PYR-GCK ISEKQRDRVEGYIKKGIEEGARVITGGG--RPEGLDSGWFVEPTVFADVD
Rv0223c|M.tuberculosis_H37Rv ISEKQRTRVEGYIAKGIEEGARLVCGGG--RPEGLDNGFFIQPTVFADVD
TH_3902|M.thermoresistible__bu ISEAQRNRVEGYIKAGVDEGAEIAFGGG--RPSHLERGYFVEPTLFTGVR
MLBr_02573|M.leprae_Br4923 ATESGRAQVEQQVDAAAAAGAVIRCGGK----RPDRPGWFYPPTVITDIT
. . .* * :: *:::
MSMEG_1461|M.smegmatis_MC2_155 PTMRIVTEEVFGPLVAFQRAASLDEAVALANATEYGLAASIVTSDLAAAT
Mvan_1328|M.vanbaalenii_PYR-1 PTMRIVSEEVFGPLLAFQRAGSLTEAIELANATEFGLSAAIVTGDLATAA
MAB_0823|M.abscessus_ATCC_1997 GAVDLWTEELFGPVLAVRRAADTEEAFRLANDSEYGLSAAIFTKDLTRAL
MMAR_2875|M.marinum_M NDMAIAREEVFGPVLVVIGYDGDEQAIAIANDSDYGLAASIWTSDNARGL
MUL_2877|M.ulcerans_Agy99 NDMAIAREEVFGPVLVVSGYDGDEQAIAIANDSDYGLAASIWTSDNARGL
MAV_1897|M.avium_104 RSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEFGLAAGVWTKDVHRAH
Mb2883c|M.bovis_AF2122/97 RGDRTVTDEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRAL
Mflv_0428|M.gilvum_PYR-GCK NSMTIAQEEIFGPVLSVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRAL
Rv0223c|M.tuberculosis_H37Rv NKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGI
TH_3902|M.thermoresistible__bu NEMKIAQEEIFGPVGVVIPFTSEHEAVRLANDSDFGLGGGVWSTDVERAL
MLBr_02573|M.leprae_Br4923 KDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQR
:*:***: . :*. ** : :**.. : :
MSMEG_1461|M.smegmatis_MC2_155 RFARQSKTGLVKINQPTTGMAMNAPFGGYKASSTQTFKEQAGPTLMEFYT
Mvan_1328|M.vanbaalenii_PYR-1 QFARESRTGLVKINQPTTGMAMNAPFGGYKASSTTTFKEQAGASMMEFYL
MAB_0823|M.abscessus_ATCC_1997 SAVDHVDVGILHVNSESAGADPHVPFGGAKKSGLG--PKEQGRAAREFFT
MMAR_2875|M.marinum_M AMAERIQSGSVWIN-DAHQINCRLPFGGYKQSGVG---RELGPDALDAYT
MUL_2877|M.ulcerans_Agy99 AMAERIRSGSVWIN-DAHQINCRLLFGGYKQSGVG---RELGPDTLDAYT
MAV_1897|M.avium_104 RVAARLNAGTVWVN-AYRVVSPHVPFGGMGHSGIG---RENGIDAVKDFT
Mb2883c|M.bovis_AF2122/97 RVARAVESGNLSVN-SHSSVRFNTPFGGFKQSGVG---RELGPDAPLQFT
Mflv_0428|M.gilvum_PYR-GCK KIARRIRTGTYAVN--MYAFDPCAPFGGYKNSGIG---RENGWEGIEAYC
Rv0223c|M.tuberculosis_H37Rv KISQQIRTGTYGIN--WYAFDPGSPFGGYKNSGIG---RENGPEGVEHFT
TH_3902|M.thermoresistible__bu RVAQRIRTGMVAINGGGGSMGKTGPFGGFKASGLG---REWGEWGLDEFL
MLBr_02573|M.leprae_Br4923 HFIDNIVAGQVFIN-GMTVSYPELPFGGIKRSGYG---RELSTHGIREFC
* :* *** *. .: . :
MSMEG_1461|M.smegmatis_MC2_155 LEKTVYLT--PAL---------------
Mvan_1328|M.vanbaalenii_PYR-1 TEKTVYLN--PGF---------------
MAB_0823|M.abscessus_ATCC_1997 HTTTVYLRGEEAM---------------
MMAR_2875|M.marinum_M EVKTIHLDLSGGREAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 EVKTIHLDLSGGREAKPYDVLLGHPETG
MAV_1897|M.avium_104 ETKAVWVELSG---ATRDPFTLG-----
Mb2883c|M.bovis_AF2122/97 ETKNVFIAVGEEM---------------
Mflv_0428|M.gilvum_PYR-GCK EQKSILLPFGYTPPAS------------
Rv0223c|M.tuberculosis_H37Rv QQKSVLLPMGYTVA--------------
TH_3902|M.thermoresistible__bu EMKQIIWPIAGG----------------
MLBr_02573|M.leprae_Br4923 NIKTVWIA--------------------
. :