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VTVEGANFIDGQWIPAASGRTFARHNPADPDDLVGVFPASDGVDVRTAVDALDKAAPEWAATPPERRAAI LEAAAVQLESRAAELIAELIREEGKTTAEATMEVSRTPANLRFYAGEALRSTGTTYPAPGEGLVYTLREP VGIVGAITPWNFPFNIPSRKLGPALAAGNPVLYKPSELTPLMGQRLVEALLDGGLPPSAVALVQGDGVAG AAVAADPRVAAVTFTGSTAVGRAIHQQVGPQRRVQLEMGGKNPVVVAGDADLDAAAALIVKGAFGLSGQA CTGTSRVIAVDEVHDALLDRVVAKADALQVGPGNEPGVQMGPLASAAQREKFLHYVHAGITEGATLRCGG TTVGDHGFFVRPAVFADALPTMRIVTEEVFGPLVAFQRAASLDEAVALANATEYGLAASIVTSDLAAATR FARQSKTGLVKINQPTTGMAMNAPFGGYKASSTQTFKEQAGPTLMEFYTLEKTVYLTPAL
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_1461 | - | - | 100% (480) | 5-oxovalerate dehydrogenase |
M. smegmatis MC2 155 | MSMEG_1158 | - | e-103 | 45.45% (473) | 5-oxovalerate dehydrogenase |
M. smegmatis MC2 155 | MSMEG_6687 | - | 1e-86 | 39.41% (477) | aldehyde dehydrogenase, thermostable |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2883c | aldC | 5e-66 | 35.75% (456) | aldehyde dehydrogenase |
M. gilvum PYR-GCK | Mflv_0428 | - | 2e-70 | 35.37% (475) | betaine-aldehyde dehydrogenase |
M. tuberculosis H37Rv | Rv0223c | - | 3e-71 | 35.37% (475) | aldehyde dehydrogenase |
M. leprae Br4923 | MLBr_02573 | gabD1 | 4e-56 | 32.68% (462) | succinic semialdehyde dehydrogenase |
M. abscessus ATCC 19977 | MAB_0823 | - | 1e-84 | 40.38% (478) | aldehyde dehydrogenase |
M. marinum M | MMAR_2875 | - | 1e-69 | 35.44% (474) | aldehyde dehydrogenase |
M. avium 104 | MAV_1897 | - | 2e-69 | 38.20% (445) | betaine-aldehyde dehydrogenase |
M. thermoresistible (build 8) | TH_3902 | - | 1e-72 | 38.04% (460) | PUTATIVE putative 5-carboxymethyl-2-hydroxymuconate |
M. ulcerans Agy99 | MUL_2877 | - | 2e-69 | 35.23% (474) | aldehyde dehydrogenase |
M. vanbaalenii PYR-1 | Mvan_1328 | - | 0.0 | 77.50% (480) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_1461|M.smegmatis_MC2_155 -----------------MTVEGANFIDGQWIPAASGRTFARHNPADPDDL Mvan_1328|M.vanbaalenii_PYR-1 ------------------MIEGLNYIGGAWVPAQSGRTFTRANPADPADV MAB_0823|M.abscessus_ATCC_1997 ----------------MHINEIQSFVGGRWISG-GGQAVISVCPAFPDRV MMAR_2875|M.marinum_M -----MTTVAVP--------HHAMLIGGESVDSD--RRLSLVDPG-DESP MUL_2877|M.ulcerans_Agy99 -----MTTVAVP--------HHAMLIGGESVDSD--RRLSLVDPG-DESP MAV_1897|M.avium_104 -----MTDTTISNGVTEQLVHFDLVIGGESVAAESGRTYDSIDPY-TALP Mb2883c|M.bovis_AF2122/97 -----MS------------------------------TTQLINPA-TEEV Mflv_0428|M.gilvum_PYR-GCK -----MTQSTAF-----RTEWDKLFIGGKWVEPASSEVIEVRSPA-TGDV Rv0223c|M.tuberculosis_H37Rv -----MSDS--------ATEYDKLFIGGKWTKPSTSDVIEVRCPA-TGEY TH_3902|M.thermoresistible__bu LRANRFQPKDNT-----VTWKYDLYIDGKWDTGTSGRALTVVNPA-TEET MLBr_02573|M.leprae_Br4923 ------------------------------------MSIATINPA-TGET * MSMEG_1461|M.smegmatis_MC2_155 VGVFPASDGVDVRTAVDALDKAAP--EWAATPPERRAAILEAAAVQLESR Mvan_1328|M.vanbaalenii_PYR-1 IGTFPASDADDVRNAVDALEKAAP--EWAATAPERRASILESAAAQLESR MAB_0823|M.abscessus_ATCC_1997 IAEGLAAGPAEFDEAAAAARAAQP--GWAAMSLHARGAMLSHAAAVVDRN MMAR_2875|M.marinum_M VATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQV MUL_2877|M.ulcerans_Agy99 VATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQV MAV_1897|M.avium_104 WARVPDCGPADVDRAVAAARAALR-GPWGQLTGTARGKLLWRLGELIARE Mb2883c|M.bovis_AF2122/97 LASVDHTDANAVDDAVQRARAAQR--RWARLAPAQRAAGLRAFAAAVQAH Mflv_0428|M.gilvum_PYR-GCK VGKVPLASAADVDAACAAAREAFDNGPWPQMSPTERAEVLGRAVKLMEER Rv0223c|M.tuberculosis_H37Rv VGKVPMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAER TH_3902|M.thermoresistible__bu IGTVPDASLDDIRRAIAAARTAFDEGPWPCMTPLERAAVIRRIAEVLQRR MLBr_02573|M.leprae_Br4923 VKTFTPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAE . * : . *. MSMEG_1461|M.smegmatis_MC2_155 AAELIAELIREEGKTT-AEATMEVSRTPANLRFYAGEALRSTGTTYPAPG Mvan_1328|M.vanbaalenii_PYR-1 SEALIAELVREEGKTV-AEATMEVTRTPSNLRFYAAEATRAAGMTFPAAG MAB_0823|M.abscessus_ATCC_1997 ADAWGLELAAEEGKTK-AEGIAEVRRAAQILRYYGNEGDRQTGEIFSSPR MMAR_2875|M.marinum_M TDELIELEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQR-PAPI MUL_2877|M.ulcerans_Agy99 TDELIELEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQR-PAPI MAV_1897|M.avium_104 AESLAELEVRDGGKLVREMIG-QMKALPDYYIYYAGLADKLQGEVVPVDK Mb2883c|M.bovis_AF2122/97 LDELAALEVANSGHPI-VSAEWEAGHVRDVLAFYAASPERLSGRQIPVAG Mflv_0428|M.gilvum_PYR-GCK ADELKFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQDIRDG Rv0223c|M.tuberculosis_H37Rv KDLFTKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTG TH_3902|M.thermoresistible__bu RSELVDLVRAETGSPQWIVEMLQVGVPLRVCADVADRVLPQFRFVEPMLP MLBr_02573|M.leprae_Br4923 ANQSAALMTLEMGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEPAEAA * . MSMEG_1461|M.smegmatis_MC2_155 EG-----LVYTLREPVGIVGAITPWNFPFNIPSRKLGPALAAGNPVLYKP Mvan_1328|M.vanbaalenii_PYR-1 DT-----MVYTVREPVGIVGAITPWNFPLNIPSRKLGPALAVGDPVLFKP MAB_0823|M.abscessus_ATCC_1997 RGE----HILVTRKPLGVVGVITPFNFPIAIPAWKIAPALVYGNAVLWKP MMAR_2875|M.marinum_M ETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKP MUL_2877|M.ulcerans_Agy99 ETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKP MAV_1897|M.avium_104 PNFFVYTR----HEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKP Mb2883c|M.bovis_AF2122/97 -GVDVTFN-----EPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKP Mflv_0428|M.gilvum_PYR-GCK VY----GQTLVVREPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKP Rv0223c|M.tuberculosis_H37Rv SY----GQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKP TH_3902|M.thermoresistible__bu SFDLRPGQGIISKEPIGVAALITPFNFPLFLNVMKLAPALAAGCTVVLKP MLBr_02573|M.leprae_Br4923 AVG--ASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKH :*:*:. : .:* *: ...: * : * MSMEG_1461|M.smegmatis_MC2_155 SELTPLMGQRLVEALLDGGLPPSAVALVQG-DGVAGAAVAADPRVAAVTF Mvan_1328|M.vanbaalenii_PYR-1 SELTPLMGQRLVEALLAGGLPPGVLALVHG-DGVAGAAVAADERVAAVTF MAB_0823|M.abscessus_ATCC_1997 ASTVPLLAMRLAQAFDAAGLPPGVLNLVVG-DTGVGDAMVNDSRVDALTF MMAR_2875|M.marinum_M DEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAF MUL_2877|M.ulcerans_Agy99 DEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAF MAV_1897|M.avium_104 SDHTPASTLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKIAF Mb2883c|M.bovis_AF2122/97 AELTPLTTMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVF Mflv_0428|M.gilvum_PYR-GCK AAETPLSVFAMAEMFVEAGLPEGVLSIVPG-GPETGQALTANPNLDKYTF Rv0223c|M.tuberculosis_H37Rv AAETPLTANALAEVFAEVGLPEGVLSVVPG-GIETGQALTSNPDIDMFTF TH_3902|M.thermoresistible__bu SPLTPLEALVLGEVADEVGLPPGVLNIVTG-GAEESAELTTNPMVDLVSF MLBr_02573|M.leprae_Br4923 ASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILR-DPRVAAATL .* : *: . . : . . : : MSMEG_1461|M.smegmatis_MC2_155 TGSTAVGRAIHQQVGPQ-RRVQLEMGGKNPVVVAGDADLDAAAALIVKGA Mvan_1328|M.vanbaalenii_PYR-1 TGSTAVGRSIHRAVGPH-RRVQLEMGGKNPVVVADDADLDRAAALIVKGA MAB_0823|M.abscessus_ATCC_1997 TGSTGVGRRIAAAGAARGIPVQAEMGGKNAAVVLDDADVDLAVEQVLLGA MMAR_2875|M.marinum_M TGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGC MUL_2877|M.ulcerans_Agy99 TGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGC MAV_1897|M.avium_104 TGSTATGISVGKAAIDNMTRFTLELGGKSAQVVFDDADLDAAANGVIAGV Mb2883c|M.bovis_AF2122/97 TGSTEVGKRVMAGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGV Mflv_0428|M.gilvum_PYR-GCK TGSSGVGKEIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSG Rv0223c|M.tuberculosis_H37Rv TGSSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSG TH_3902|M.thermoresistible__bu TGSDTVGRQVMNQASATLKKVVLELGGKSANVIFADADLDAAAAHVVGEF MLBr_02573|M.leprae_Br4923 TGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGR *** .* : *:**... :: . *: : MSMEG_1461|M.smegmatis_MC2_155 FGLSGQACTGTSRVIAVDEVHDALLDRVVAKADALQVGPGNEPGVQMGPL Mvan_1328|M.vanbaalenii_PYR-1 FGLSGQACTGTSRVIATDATHDGLVERVVARAEALRVGPGAQPGIDMGAL MAB_0823|M.abscessus_ATCC_1997 FRSTGQKCTATSRLVLTEGIADAFLSLLKDRADALVVGDPTADDTQMGPV MMAR_2875|M.marinum_M FAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPV MUL_2877|M.ulcerans_Agy99 FAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPV MAV_1897|M.avium_104 FAATGQTCLAGSRLLVHESVADALVERIVARASTIKLGDPKDPATEMGPV Mb2883c|M.bovis_AF2122/97 FDNAGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPL Mflv_0428|M.gilvum_PYR-GCK LMNSGQACVGQTRILAPRSRYDEVIEKLGEAVRNMAPGLPDNPAAMIGPL Rv0223c|M.tuberculosis_H37Rv VMNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPL TH_3902|M.thermoresistible__bu TLHAGQGCSLLTRTLVEESIHDELVDWVNKQLAALKVGDPADPSVMMGPL MLBr_02573|M.leprae_Br4923 VQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPL ** * .* : : .: . : * :*.: MSMEG_1461|M.smegmatis_MC2_155 ASAAQREKFLHYVHAGITEGATLRCGGT--TVGDHG--FFVRPAVFADAL Mvan_1328|M.vanbaalenii_PYR-1 ASAAQAEKFAHYVGVGVDEGASLRCGGTRLDVPGHAGGFFVRPAVFTDTE MAB_0823|M.abscessus_ATCC_1997 VSESAFGTITAGIGGAVAQGAVTLAGGHGYGDGPLAAGYFIAPTIMELGM MMAR_2875|M.marinum_M IDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVH MUL_2877|M.ulcerans_Agy99 IDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVH MAV_1897|M.avium_104 SNQPQYEKVLSHFASAREQGATVAYGGE--PAGELG-GFFVKPTVLTGVD Mb2883c|M.bovis_AF2122/97 VSRAHRDKVAGYVP----DDAPVAFRGT----APAGRGFWFPPTVLT-PK Mflv_0428|M.gilvum_PYR-GCK ISEKQRDRVEGYIKKGIEEGARVITGGG--RPEGLDSGWFVEPTVFADVD Rv0223c|M.tuberculosis_H37Rv ISEKQRTRVEGYIAKGIEEGARLVCGGG--RPEGLDNGFFIQPTVFADVD TH_3902|M.thermoresistible__bu ISEAQRNRVEGYIKAGVDEGAEIAFGGG--RPSHLERGYFVEPTLFTGVR MLBr_02573|M.leprae_Br4923 ATESGRAQVEQQVDAAAAAGAVIRCGGK----RPDRPGWFYPPTVITDIT . . .* * :: *::: MSMEG_1461|M.smegmatis_MC2_155 PTMRIVTEEVFGPLVAFQRAASLDEAVALANATEYGLAASIVTSDLAAAT Mvan_1328|M.vanbaalenii_PYR-1 PTMRIVSEEVFGPLLAFQRAGSLTEAIELANATEFGLSAAIVTGDLATAA MAB_0823|M.abscessus_ATCC_1997 GAVDLWTEELFGPVLAVRRAADTEEAFRLANDSEYGLSAAIFTKDLTRAL MMAR_2875|M.marinum_M NDMAIAREEVFGPVLVVIGYDGDEQAIAIANDSDYGLAASIWTSDNARGL MUL_2877|M.ulcerans_Agy99 NDMAIAREEVFGPVLVVSGYDGDEQAIAIANDSDYGLAASIWTSDNARGL MAV_1897|M.avium_104 RSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEFGLAAGVWTKDVHRAH Mb2883c|M.bovis_AF2122/97 RGDRTVTDEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRAL Mflv_0428|M.gilvum_PYR-GCK NSMTIAQEEIFGPVLSVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRAL Rv0223c|M.tuberculosis_H37Rv NKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGI TH_3902|M.thermoresistible__bu NEMKIAQEEIFGPVGVVIPFTSEHEAVRLANDSDFGLGGGVWSTDVERAL MLBr_02573|M.leprae_Br4923 KDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQR :*:***: . :*. ** : :**.. : : MSMEG_1461|M.smegmatis_MC2_155 RFARQSKTGLVKINQPTTGMAMNAPFGGYKASSTQTFKEQAGPTLMEFYT Mvan_1328|M.vanbaalenii_PYR-1 QFARESRTGLVKINQPTTGMAMNAPFGGYKASSTTTFKEQAGASMMEFYL MAB_0823|M.abscessus_ATCC_1997 SAVDHVDVGILHVNSESAGADPHVPFGGAKKSGLG--PKEQGRAAREFFT MMAR_2875|M.marinum_M AMAERIQSGSVWIN-DAHQINCRLPFGGYKQSGVG---RELGPDALDAYT MUL_2877|M.ulcerans_Agy99 AMAERIRSGSVWIN-DAHQINCRLLFGGYKQSGVG---RELGPDTLDAYT MAV_1897|M.avium_104 RVAARLNAGTVWVN-AYRVVSPHVPFGGMGHSGIG---RENGIDAVKDFT Mb2883c|M.bovis_AF2122/97 RVARAVESGNLSVN-SHSSVRFNTPFGGFKQSGVG---RELGPDAPLQFT Mflv_0428|M.gilvum_PYR-GCK KIARRIRTGTYAVN--MYAFDPCAPFGGYKNSGIG---RENGWEGIEAYC Rv0223c|M.tuberculosis_H37Rv KISQQIRTGTYGIN--WYAFDPGSPFGGYKNSGIG---RENGPEGVEHFT TH_3902|M.thermoresistible__bu RVAQRIRTGMVAINGGGGSMGKTGPFGGFKASGLG---REWGEWGLDEFL MLBr_02573|M.leprae_Br4923 HFIDNIVAGQVFIN-GMTVSYPELPFGGIKRSGYG---RELSTHGIREFC * :* *** *. .: . : MSMEG_1461|M.smegmatis_MC2_155 LEKTVYLT--PAL--------------- Mvan_1328|M.vanbaalenii_PYR-1 TEKTVYLN--PGF--------------- MAB_0823|M.abscessus_ATCC_1997 HTTTVYLRGEEAM--------------- MMAR_2875|M.marinum_M EVKTIHLDLSGGREAKPYDVLLGHPETG MUL_2877|M.ulcerans_Agy99 EVKTIHLDLSGGREAKPYDVLLGHPETG MAV_1897|M.avium_104 ETKAVWVELSG---ATRDPFTLG----- Mb2883c|M.bovis_AF2122/97 ETKNVFIAVGEEM--------------- Mflv_0428|M.gilvum_PYR-GCK EQKSILLPFGYTPPAS------------ Rv0223c|M.tuberculosis_H37Rv QQKSVLLPMGYTVA-------------- TH_3902|M.thermoresistible__bu EMKQIIWPIAGG---------------- MLBr_02573|M.leprae_Br4923 NIKTVWIA-------------------- . :