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M. smegmatis MC2 155 MSMEG_1461 (-)

annotation: 5-oxovalerate dehydrogenase
coordinates: 1557700 - 1559142
length: 480

VTVEGANFIDGQWIPAASGRTFARHNPADPDDLVGVFPASDGVDVRTAVDALDKAAPEWAATPPERRAAI
LEAAAVQLESRAAELIAELIREEGKTTAEATMEVSRTPANLRFYAGEALRSTGTTYPAPGEGLVYTLREP
VGIVGAITPWNFPFNIPSRKLGPALAAGNPVLYKPSELTPLMGQRLVEALLDGGLPPSAVALVQGDGVAG
AAVAADPRVAAVTFTGSTAVGRAIHQQVGPQRRVQLEMGGKNPVVVAGDADLDAAAALIVKGAFGLSGQA
CTGTSRVIAVDEVHDALLDRVVAKADALQVGPGNEPGVQMGPLASAAQREKFLHYVHAGITEGATLRCGG
TTVGDHGFFVRPAVFADALPTMRIVTEEVFGPLVAFQRAASLDEAVALANATEYGLAASIVTSDLAAATR
FARQSKTGLVKINQPTTGMAMNAPFGGYKASSTQTFKEQAGPTLMEFYTLEKTVYLTPAL
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_1461--100% (480)5-oxovalerate dehydrogenase
M. smegmatis MC2 155MSMEG_1158-e-10345.45% (473) 5-oxovalerate dehydrogenase
M. smegmatis MC2 155MSMEG_6687-1e-8639.41% (477) aldehyde dehydrogenase, thermostable

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2883caldC5e-6635.75% (456) aldehyde dehydrogenase
M. gilvum PYR-GCKMflv_0428-2e-7035.37% (475) betaine-aldehyde dehydrogenase
M. tuberculosis H37RvRv0223c-3e-7135.37% (475) aldehyde dehydrogenase
M. leprae Br4923MLBr_02573gabD14e-5632.68% (462) succinic semialdehyde dehydrogenase
M. abscessus ATCC 19977MAB_0823-1e-8440.38% (478) aldehyde dehydrogenase
M. marinum MMMAR_2875-1e-6935.44% (474) aldehyde dehydrogenase
M. avium 104MAV_1897-2e-6938.20% (445) betaine-aldehyde dehydrogenase
M. thermoresistible (build 8)TH_3902-1e-7238.04% (460) PUTATIVE putative 5-carboxymethyl-2-hydroxymuconate
M. ulcerans Agy99MUL_2877-2e-6935.23% (474) aldehyde dehydrogenase
M. vanbaalenii PYR-1Mvan_1328-0.077.50% (480) aldehyde dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_1461|M.smegmatis_MC2_155      -----------------MTVEGANFIDGQWIPAASGRTFARHNPADPDDL
Mvan_1328|M.vanbaalenii_PYR-1       ------------------MIEGLNYIGGAWVPAQSGRTFTRANPADPADV
MAB_0823|M.abscessus_ATCC_1997      ----------------MHINEIQSFVGGRWISG-GGQAVISVCPAFPDRV
MMAR_2875|M.marinum_M               -----MTTVAVP--------HHAMLIGGESVDSD--RRLSLVDPG-DESP
MUL_2877|M.ulcerans_Agy99           -----MTTVAVP--------HHAMLIGGESVDSD--RRLSLVDPG-DESP
MAV_1897|M.avium_104                -----MTDTTISNGVTEQLVHFDLVIGGESVAAESGRTYDSIDPY-TALP
Mb2883c|M.bovis_AF2122/97           -----MS------------------------------TTQLINPA-TEEV
Mflv_0428|M.gilvum_PYR-GCK          -----MTQSTAF-----RTEWDKLFIGGKWVEPASSEVIEVRSPA-TGDV
Rv0223c|M.tuberculosis_H37Rv        -----MSDS--------ATEYDKLFIGGKWTKPSTSDVIEVRCPA-TGEY
TH_3902|M.thermoresistible__bu      LRANRFQPKDNT-----VTWKYDLYIDGKWDTGTSGRALTVVNPA-TEET
MLBr_02573|M.leprae_Br4923          ------------------------------------MSIATINPA-TGET
                                                                               *      

MSMEG_1461|M.smegmatis_MC2_155      VGVFPASDGVDVRTAVDALDKAAP--EWAATPPERRAAILEAAAVQLESR
Mvan_1328|M.vanbaalenii_PYR-1       IGTFPASDADDVRNAVDALEKAAP--EWAATAPERRASILESAAAQLESR
MAB_0823|M.abscessus_ATCC_1997      IAEGLAAGPAEFDEAAAAARAAQP--GWAAMSLHARGAMLSHAAAVVDRN
MMAR_2875|M.marinum_M               VATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQV
MUL_2877|M.ulcerans_Agy99           VATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQV
MAV_1897|M.avium_104                WARVPDCGPADVDRAVAAARAALR-GPWGQLTGTARGKLLWRLGELIARE
Mb2883c|M.bovis_AF2122/97           LASVDHTDANAVDDAVQRARAAQR--RWARLAPAQRAAGLRAFAAAVQAH
Mflv_0428|M.gilvum_PYR-GCK          VGKVPLASAADVDAACAAAREAFDNGPWPQMSPTERAEVLGRAVKLMEER
Rv0223c|M.tuberculosis_H37Rv        VGKVPMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAER
TH_3902|M.thermoresistible__bu      IGTVPDASLDDIRRAIAAARTAFDEGPWPCMTPLERAAVIRRIAEVLQRR
MLBr_02573|M.leprae_Br4923          VKTFTPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAE
                                               .  *            :   .   *.             

MSMEG_1461|M.smegmatis_MC2_155      AAELIAELIREEGKTT-AEATMEVSRTPANLRFYAGEALRSTGTTYPAPG
Mvan_1328|M.vanbaalenii_PYR-1       SEALIAELVREEGKTV-AEATMEVTRTPSNLRFYAAEATRAAGMTFPAAG
MAB_0823|M.abscessus_ATCC_1997      ADAWGLELAAEEGKTK-AEGIAEVRRAAQILRYYGNEGDRQTGEIFSSPR
MMAR_2875|M.marinum_M               TDELIELEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQR-PAPI
MUL_2877|M.ulcerans_Agy99           TDELIELEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQR-PAPI
MAV_1897|M.avium_104                AESLAELEVRDGGKLVREMIG-QMKALPDYYIYYAGLADKLQGEVVPVDK
Mb2883c|M.bovis_AF2122/97           LDELAALEVANSGHPI-VSAEWEAGHVRDVLAFYAASPERLSGRQIPVAG
Mflv_0428|M.gilvum_PYR-GCK          ADELKFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQDIRDG
Rv0223c|M.tuberculosis_H37Rv        KDLFTKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTG
TH_3902|M.thermoresistible__bu      RSELVDLVRAETGSPQWIVEMLQVGVPLRVCADVADRVLPQFRFVEPMLP
MLBr_02573|M.leprae_Br4923          ANQSAALMTLEMGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEPAEAA
                                                *                     .               

MSMEG_1461|M.smegmatis_MC2_155      EG-----LVYTLREPVGIVGAITPWNFPFNIPSRKLGPALAAGNPVLYKP
Mvan_1328|M.vanbaalenii_PYR-1       DT-----MVYTVREPVGIVGAITPWNFPLNIPSRKLGPALAVGDPVLFKP
MAB_0823|M.abscessus_ATCC_1997      RGE----HILVTRKPLGVVGVITPFNFPIAIPAWKIAPALVYGNAVLWKP
MMAR_2875|M.marinum_M               ETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKP
MUL_2877|M.ulcerans_Agy99           ETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKP
MAV_1897|M.avium_104                PNFFVYTR----HEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKP
Mb2883c|M.bovis_AF2122/97           -GVDVTFN-----EPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKP
Mflv_0428|M.gilvum_PYR-GCK          VY----GQTLVVREPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKP
Rv0223c|M.tuberculosis_H37Rv        SY----GQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKP
TH_3902|M.thermoresistible__bu      SFDLRPGQGIISKEPIGVAALITPFNFPLFLNVMKLAPALAAGCTVVLKP
MLBr_02573|M.leprae_Br4923          AVG--ASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKH
                                                 :*:*:.  : .:* *:       ...:  *   : * 

MSMEG_1461|M.smegmatis_MC2_155      SELTPLMGQRLVEALLDGGLPPSAVALVQG-DGVAGAAVAADPRVAAVTF
Mvan_1328|M.vanbaalenii_PYR-1       SELTPLMGQRLVEALLAGGLPPGVLALVHG-DGVAGAAVAADERVAAVTF
MAB_0823|M.abscessus_ATCC_1997      ASTVPLLAMRLAQAFDAAGLPPGVLNLVVG-DTGVGDAMVNDSRVDALTF
MMAR_2875|M.marinum_M               DEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAF
MUL_2877|M.ulcerans_Agy99           DEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAF
MAV_1897|M.avium_104                SDHTPASTLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKIAF
Mb2883c|M.bovis_AF2122/97           AELTPLTTMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVF
Mflv_0428|M.gilvum_PYR-GCK          AAETPLSVFAMAEMFVEAGLPEGVLSIVPG-GPETGQALTANPNLDKYTF
Rv0223c|M.tuberculosis_H37Rv        AAETPLTANALAEVFAEVGLPEGVLSVVPG-GIETGQALTSNPDIDMFTF
TH_3902|M.thermoresistible__bu      SPLTPLEALVLGEVADEVGLPPGVLNIVTG-GAEESAELTTNPMVDLVSF
MLBr_02573|M.leprae_Br4923          ASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILR-DPRVAAATL
                                       .*     :       *:  . .  :          .  .  :    :

MSMEG_1461|M.smegmatis_MC2_155      TGSTAVGRAIHQQVGPQ-RRVQLEMGGKNPVVVAGDADLDAAAALIVKGA
Mvan_1328|M.vanbaalenii_PYR-1       TGSTAVGRSIHRAVGPH-RRVQLEMGGKNPVVVADDADLDRAAALIVKGA
MAB_0823|M.abscessus_ATCC_1997      TGSTGVGRRIAAAGAARGIPVQAEMGGKNAAVVLDDADVDLAVEQVLLGA
MMAR_2875|M.marinum_M               TGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGC
MUL_2877|M.ulcerans_Agy99           TGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGC
MAV_1897|M.avium_104                TGSTATGISVGKAAIDNMTRFTLELGGKSAQVVFDDADLDAAANGVIAGV
Mb2883c|M.bovis_AF2122/97           TGSTEVGKRVMAGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGV
Mflv_0428|M.gilvum_PYR-GCK          TGSSGVGKEIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSG
Rv0223c|M.tuberculosis_H37Rv        TGSSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSG
TH_3902|M.thermoresistible__bu      TGSDTVGRQVMNQASATLKKVVLELGGKSANVIFADADLDAAAAHVVGEF
MLBr_02573|M.leprae_Br4923          TGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGR
                                    ***  .*  :             *:**... ::  . *:  :        

MSMEG_1461|M.smegmatis_MC2_155      FGLSGQACTGTSRVIAVDEVHDALLDRVVAKADALQVGPGNEPGVQMGPL
Mvan_1328|M.vanbaalenii_PYR-1       FGLSGQACTGTSRVIATDATHDGLVERVVARAEALRVGPGAQPGIDMGAL
MAB_0823|M.abscessus_ATCC_1997      FRSTGQKCTATSRLVLTEGIADAFLSLLKDRADALVVGDPTADDTQMGPV
MMAR_2875|M.marinum_M               FAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPV
MUL_2877|M.ulcerans_Agy99           FAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPV
MAV_1897|M.avium_104                FAATGQTCLAGSRLLVHESVADALVERIVARASTIKLGDPKDPATEMGPV
Mb2883c|M.bovis_AF2122/97           FDNAGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPL
Mflv_0428|M.gilvum_PYR-GCK          LMNSGQACVGQTRILAPRSRYDEVIEKLGEAVRNMAPGLPDNPAAMIGPL
Rv0223c|M.tuberculosis_H37Rv        VMNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPL
TH_3902|M.thermoresistible__bu      TLHAGQGCSLLTRTLVEESIHDELVDWVNKQLAALKVGDPADPSVMMGPL
MLBr_02573|M.leprae_Br4923          VQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPL
                                        ** *   .* :      : .:  .      :  *        :*.:

MSMEG_1461|M.smegmatis_MC2_155      ASAAQREKFLHYVHAGITEGATLRCGGT--TVGDHG--FFVRPAVFADAL
Mvan_1328|M.vanbaalenii_PYR-1       ASAAQAEKFAHYVGVGVDEGASLRCGGTRLDVPGHAGGFFVRPAVFTDTE
MAB_0823|M.abscessus_ATCC_1997      VSESAFGTITAGIGGAVAQGAVTLAGGHGYGDGPLAAGYFIAPTIMELGM
MMAR_2875|M.marinum_M               IDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVH
MUL_2877|M.ulcerans_Agy99           IDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVH
MAV_1897|M.avium_104                SNQPQYEKVLSHFASAREQGATVAYGGE--PAGELG-GFFVKPTVLTGVD
Mb2883c|M.bovis_AF2122/97           VSRAHRDKVAGYVP----DDAPVAFRGT----APAGRGFWFPPTVLT-PK
Mflv_0428|M.gilvum_PYR-GCK          ISEKQRDRVEGYIKKGIEEGARVITGGG--RPEGLDSGWFVEPTVFADVD
Rv0223c|M.tuberculosis_H37Rv        ISEKQRTRVEGYIAKGIEEGARLVCGGG--RPEGLDNGFFIQPTVFADVD
TH_3902|M.thermoresistible__bu      ISEAQRNRVEGYIKAGVDEGAEIAFGGG--RPSHLERGYFVEPTLFTGVR
MLBr_02573|M.leprae_Br4923          ATESGRAQVEQQVDAAAAAGAVIRCGGK----RPDRPGWFYPPTVITDIT
                                            .   .      .*     *           ::  *:::    

MSMEG_1461|M.smegmatis_MC2_155      PTMRIVTEEVFGPLVAFQRAASLDEAVALANATEYGLAASIVTSDLAAAT
Mvan_1328|M.vanbaalenii_PYR-1       PTMRIVSEEVFGPLLAFQRAGSLTEAIELANATEFGLSAAIVTGDLATAA
MAB_0823|M.abscessus_ATCC_1997      GAVDLWTEELFGPVLAVRRAADTEEAFRLANDSEYGLSAAIFTKDLTRAL
MMAR_2875|M.marinum_M               NDMAIAREEVFGPVLVVIGYDGDEQAIAIANDSDYGLAASIWTSDNARGL
MUL_2877|M.ulcerans_Agy99           NDMAIAREEVFGPVLVVSGYDGDEQAIAIANDSDYGLAASIWTSDNARGL
MAV_1897|M.avium_104                RSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEFGLAAGVWTKDVHRAH
Mb2883c|M.bovis_AF2122/97           RGDRTVTDEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRAL
Mflv_0428|M.gilvum_PYR-GCK          NSMTIAQEEIFGPVLSVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRAL
Rv0223c|M.tuberculosis_H37Rv        NKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGI
TH_3902|M.thermoresistible__bu      NEMKIAQEEIFGPVGVVIPFTSEHEAVRLANDSDFGLGGGVWSTDVERAL
MLBr_02573|M.leprae_Br4923          KDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQR
                                           :*:***:  .       :*.  ** : :**..   : :     

MSMEG_1461|M.smegmatis_MC2_155      RFARQSKTGLVKINQPTTGMAMNAPFGGYKASSTQTFKEQAGPTLMEFYT
Mvan_1328|M.vanbaalenii_PYR-1       QFARESRTGLVKINQPTTGMAMNAPFGGYKASSTTTFKEQAGASMMEFYL
MAB_0823|M.abscessus_ATCC_1997      SAVDHVDVGILHVNSESAGADPHVPFGGAKKSGLG--PKEQGRAAREFFT
MMAR_2875|M.marinum_M               AMAERIQSGSVWIN-DAHQINCRLPFGGYKQSGVG---RELGPDALDAYT
MUL_2877|M.ulcerans_Agy99           AMAERIRSGSVWIN-DAHQINCRLLFGGYKQSGVG---RELGPDTLDAYT
MAV_1897|M.avium_104                RVAARLNAGTVWVN-AYRVVSPHVPFGGMGHSGIG---RENGIDAVKDFT
Mb2883c|M.bovis_AF2122/97           RVARAVESGNLSVN-SHSSVRFNTPFGGFKQSGVG---RELGPDAPLQFT
Mflv_0428|M.gilvum_PYR-GCK          KIARRIRTGTYAVN--MYAFDPCAPFGGYKNSGIG---RENGWEGIEAYC
Rv0223c|M.tuberculosis_H37Rv        KISQQIRTGTYGIN--WYAFDPGSPFGGYKNSGIG---RENGPEGVEHFT
TH_3902|M.thermoresistible__bu      RVAQRIRTGMVAINGGGGSMGKTGPFGGFKASGLG---REWGEWGLDEFL
MLBr_02573|M.leprae_Br4923          HFIDNIVAGQVFIN-GMTVSYPELPFGGIKRSGYG---RELSTHGIREFC
                                            *   :*           ***   *.     .: .      : 

MSMEG_1461|M.smegmatis_MC2_155      LEKTVYLT--PAL---------------
Mvan_1328|M.vanbaalenii_PYR-1       TEKTVYLN--PGF---------------
MAB_0823|M.abscessus_ATCC_1997      HTTTVYLRGEEAM---------------
MMAR_2875|M.marinum_M               EVKTIHLDLSGGREAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99           EVKTIHLDLSGGREAKPYDVLLGHPETG
MAV_1897|M.avium_104                ETKAVWVELSG---ATRDPFTLG-----
Mb2883c|M.bovis_AF2122/97           ETKNVFIAVGEEM---------------
Mflv_0428|M.gilvum_PYR-GCK          EQKSILLPFGYTPPAS------------
Rv0223c|M.tuberculosis_H37Rv        QQKSVLLPMGYTVA--------------
TH_3902|M.thermoresistible__bu      EMKQIIWPIAGG----------------
MLBr_02573|M.leprae_Br4923          NIKTVWIA--------------------
                                      . :