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ELGLEGKRFAVTGGTRGIGRAVVEGLLAEGASVAYCARTYEPVPGAVGTAVDVGDGAALATWVDATADAF SGLDGVVANVSALAIPETHENWHTSFDVDLMGTVNLVDAALPYLLEADSGSIVTISSVSGREIDFAAGPY GTMKAAIIHYTQGLAFKLAAQGVRANTVSPGNTYFPGGVWPSIEQSDPELFATALALNPTGRMATPQEVA NAVVFLSSAAASFITGTNLLVDGALTRGVQL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1185 | - | - | 100% (242) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_3395 | - | 3e-28 | 36.40% (261) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0614 | - | 2e-24 | 34.45% (238) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 2e-25 | 34.80% (250) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_5148 | - | 1e-111 | 80.16% (252) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1941 | - | 3e-25 | 34.80% (250) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 1e-18 | 29.31% (232) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0833 | - | 2e-30 | 34.27% (248) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0587 | - | 1e-25 | 36.21% (243) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_3551 | - | 1e-27 | 34.48% (261) | carveol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4382 | - | 1e-107 | 77.78% (252) | dehydrogenase/reductase SDR family protein member 10 |
| M. thermoresistible (build 8) | TH_2589 | - | 2e-27 | 33.33% (249) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4041 | - | 6e-24 | 33.33% (258) | short-chain type dehydrogenase/reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1976|M.bovis_AF2122/97 -------------MNHPDLAGKVAIVTGAGAGIGLAVARRLADEG-----
Rv1941|M.tuberculosis_H37Rv -------------MNHPDLAGKVAIVTGAGAGIGLAVARRLADEG-----
Mvan_1185|M.vanbaalenii_PYR-1 --------------MELGLEGKRFAVTGGTRGIGRAVVEGLLAEG-----
Mflv_5148|M.gilvum_PYR-GCK --------------MDLGLSGKRFVVSGGTRGIGRAVVEGLLAEG-----
MSMEG_4382|M.smegmatis_MC2_155 --------------MDLGLTGKRFVVTGGTRGIGRAVVEGLLAEG-----
MAV_3551|M.avium_104 ---------MATDDATGRVAGKRVLITGAARGMGRSHAVRLAEQGADCIL
MUL_4041|M.ulcerans_Agy99 ---------------MTRLVGQRILVTGAGSGIGQATVLRLLDEG-----
MAB_0833|M.abscessus_ATCC_1997 -------MNRETFSRLFDLTGRTAIVTGGTRGIGRALAEGYACAG-----
TH_2589|M.thermoresistible__bu -------VDRQTFDKLFDMTGRTVVVTGGTRGIGLALAEGYVLAG-----
MMAR_0587|M.marinum_M ---------------MGQLEGKTALVTGGNSGIGLAAAQRLAAEG-----
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADG-----
. .: ::*. *:* : . *
Mb1976|M.bovis_AF2122/97 -------CHVLCADIDGDAADAAATKIGCG-----AAACRVDVSDEQQII
Rv1941|M.tuberculosis_H37Rv -------CHVLCADIDGDAADAAATKIGCG-----AAACRVDVSDEQQII
Mvan_1185|M.vanbaalenii_PYR-1 -------ASVAYCARTYEPVP-------------GAVGTAVDVGDGAALA
Mflv_5148|M.gilvum_PYR-GCK -------ASVAFCARTPAAVEQAQAELSAN--GAAVAGAVVDVGDAAAVE
MSMEG_4382|M.smegmatis_MC2_155 -------AAVAFCARTPEAVTATQQELAAD--GVTVVGTPVDVGDGAAVA
MAV_3551|M.avium_104 VDICCTPTGLDYPLATEEDLNETVRLVEKH--GRRAVPKIVDVRDEAAMK
MUL_4041|M.ulcerans_Agy99 -------ATVVGADIDADGLSRTQARTAEAGTGARLTTCQIDVADEKSVV
MAB_0833|M.abscessus_ATCC_1997 -------ANVVVASRKPEACTEAVERLRSLG--ARALGVPTHTGDIHSLE
TH_2589|M.thermoresistible__bu -------ARVVVASRKSDACERAAAHLRALG--GDAIGVPTHLGDIDACE
MMAR_0587|M.marinum_M -------AHVFLTGRNQATIDAAVA---SIG--SRAHGIRADVSNIEDLA
MLBr_01807|M.leprae_Br4923 -------HRVAVTHRASVVPD-------------WFFGVECDVTDNDAIG
: . :
Mb1976|M.bovis_AF2122/97 AMVDACVAAFGGVDKLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLC
Rv1941|M.tuberculosis_H37Rv AMVDACVAAFGGVDKLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLC
Mvan_1185|M.vanbaalenii_PYR-1 TWVDATADAFSGLDGVVANVSALAIP----ETHENWHTSFDVDLMGTVNL
Mflv_5148|M.gilvum_PYR-GCK AWVTQAAGMFSGLDGVVANVSALAIP----ETHENWRTTFEVDLMGTVGM
MSMEG_4382|M.smegmatis_MC2_155 DWVAQSAETLGGLDGVVANVSALAIP----ESPENWRTSFEVDMMGTVGL
MAV_3551|M.avium_104 AAVDAAVDELGGLDGAVANAGVLTVGTWDTTTAEQWRLVLDVNLIGAWNT
MUL_4041|M.ulcerans_Agy99 DGVGAAVQALGGLDALVNAAGMLRAAHTHQTSIQQWNQIIAVNLTGTFLV
MAB_0833|M.abscessus_ATCC_1997 ELVRATAEEFGGIDIVVNNAANALTEPVGAFTVDGWDKSFGVNLRGPVFL
TH_2589|M.thermoresistible__bu ALVRRTVDEFGGIDVLVNNAANALTQPLGELTVDAWTKSFEVNLRGPVFL
MMAR_0587|M.marinum_M RVADAIAAAGRGLDVLFANAGGGEFVLLGDITIEHFTNGFMTNVAGTLFT
MLBr_01807|M.leprae_Br4923 AAFKAVEEHQGPVEVLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRV
:: . .. : : : : :: *
Mb1976|M.bovis_AF2122/97 TKHAAPRMIERGGGAIVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAA
Rv1941|M.tuberculosis_H37Rv TKHAAPRMIERGGGAIVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAA
Mvan_1185|M.vanbaalenii_PYR-1 VDAALPYLLEADSGSIVTISSVSGREIDFAAGPYGTMKAAIIHYTQGLAF
Mflv_5148|M.gilvum_PYR-GCK VDAAMPYLLESDAGSIVTVSSVSGREVDFAAGPYGTMKAAIIHYTQGLAF
MSMEG_4382|M.smegmatis_MC2_155 VDAALPHLLKSDAGSIVTISSVSGREIDFAAGPYGTFKAAIIHYTQGLAY
MAV_3551|M.avium_104 CAAALPHLIGGGGGSLVNISSSAGIKGTPLHLPYTASKHGIVGMTLALAN
MUL_4041|M.ulcerans_Agy99 VREALPALLDNQRSTVVNFSSTSAAFAHPYMAAYAASKGGVQAFTHSLAL
MAB_0833|M.abscessus_ATCC_1997 VQAALPHLVASPHAAVLNVVSVGAFMFGQGVSMYSAAKAALVSYTRSAAA
TH_2589|M.thermoresistible__bu VQAALPHLKTSPHAAVLNMVSVGAFLFSPGTAMYSAGKAALMSFTRSMAA
MMAR_0587|M.marinum_M VQTMLPLLNSG--ASIVLTGSTAAYNGSPAFSVYAATKAAIRSFGRTWAA
MLBr_01807|M.leprae_Br4923 AKLASRNMIKQRFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLAR
: . : * . * * .: *
Mb1976|M.bovis_AF2122/97 ELRSSGIRSNTLLPAFVDTPMQQTAMAMFDGALGAGGARSMIARLQGR--
Rv1941|M.tuberculosis_H37Rv ELRSSGIRSNTLLPAFVDTPMQQTAMAMFDGALGAGGARSMIARLQGR--
Mvan_1185|M.vanbaalenii_PYR-1 KLAAQGVRANTVSPG---NTYFPGGVWPSIEQSDPELFATALALNPTGR-
Mflv_5148|M.gilvum_PYR-GCK KYAGQGVRANTVSPG---NTYFPGGVWTSIEENDPQLFATALALNPTGR-
MSMEG_4382|M.smegmatis_MC2_155 QLAAKGVRANSVSPG---NTYFEGGVWPTIEKDDPELFASALALNPTGR-
MAV_3551|M.avium_104 ELAAQNIRVNTVHPTGVATGMAPPGMHALIAEQRPDLVPIFLNALPAP--
MUL_4041|M.ulcerans_Agy99 EYARDGLRAVCVAPGSIKSGITDATGGYIPADANWSLFTRLMPILPTTET
MAB_0833|M.abscessus_ATCC_1997 ELASRGVRVNALAPG---AIDTDMVR-----KTPPAEVERMANTNHLKR-
TH_2589|M.thermoresistible__bu QFAPLGIRVNALAPG---PVDTDMMR-----NNPQEVVDMMAGATLMKR-
MMAR_0587|M.marinum_M ELVSRNIRVNTVVPG---PVETPGLKGLAPEGQEQQLLEGEAAKVPMGR-
MLBr_01807|M.leprae_Br4923 ELGSRSITANVVAPG---FIDTEMTR-----AMDSKYQEAALQAIPLGR-
: .: : *
Mb1976|M.bovis_AF2122/97 -----MAAPEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW-
Rv1941|M.tuberculosis_H37Rv -----MAAPEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW-
Mvan_1185|M.vanbaalenii_PYR-1 -----MATPQEVANAVVFLSSAAASFITGTNLLVDGALTRGVQL
Mflv_5148|M.gilvum_PYR-GCK -----MATPQEVANAVVFLSSPAASFITGTNLLVDGALTRGVQF
MSMEG_4382|M.smegmatis_MC2_155 -----MGTPREVANAVVFLSSPVASFITGTNLVVDGALTRGVQF
MAV_3551|M.avium_104 -----LIEASDVSNAVLYLISDESRYVTGLELKVDAGVTIR---
MUL_4041|M.ulcerans_Agy99 SSGAGMADPSVVAGVIAMLVSEDGAFITGTEIRIDGGTHA----
MAB_0833|M.abscessus_ATCC_1997 -----LGLPDEMVGTALLLTSDAGSYITGQTIIADGGLVAR---
TH_2589|M.thermoresistible__bu -----LATPDEMVGAALLLTSDAGSYITGTVLIADGGGTPR---
MMAR_0587|M.marinum_M -----LGKPAEIAAAVLFLASDQSSFMTGSEMFVDGGTEQL---
MLBr_01807|M.leprae_Br4923 -----IGAVEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH--
: : * * . ::* *..