For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MDLGLSGKRFVVSGGTRGIGRAVVEGLLAEGASVAFCARTPAAVEQAQAELSANGAAVAGAVVDVGDAAA VEAWVTQAAGMFSGLDGVVANVSALAIPETHENWRTTFEVDLMGTVGMVDAAMPYLLESDAGSIVTVSSV SGREVDFAAGPYGTMKAAIIHYTQGLAFKYAGQGVRANTVSPGNTYFPGGVWTSIEENDPQLFATALALN PTGRMATPQEVANAVVFLSSPAASFITGTNLLVDGALTRGVQF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5148 | - | - | 100% (253) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4818 | - | 2e-27 | 32.53% (249) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1829 | - | 3e-26 | 32.03% (256) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0950c | - | 4e-26 | 33.60% (250) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0927c | - | 4e-26 | 33.60% (250) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-15 | 26.83% (246) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0833 | - | 4e-33 | 34.14% (249) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0587 | - | 8e-26 | 33.88% (245) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_3019 | - | 2e-28 | 35.45% (268) | carveol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4382 | - | 1e-114 | 79.45% (253) | dehydrogenase/reductase SDR family protein member 10 |
| M. thermoresistible (build 8) | TH_2589 | - | 4e-34 | 36.55% (249) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4042 | - | 6e-25 | 31.09% (267) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1185 | - | 1e-111 | 80.16% (252) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0950c|M.bovis_AF2122/97 -----------MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLI
Rv0927c|M.tuberculosis_H37Rv -----------MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLI
MAB_0833|M.abscessus_ATCC_1997 -------MNRETFSRLFDLTGRTAIVTGGTRGIGRALAEGYACAGANVVV
TH_2589|M.thermoresistible__bu -------VDRQTFDKLFDMTGRTVVVTGGTRGIGLALAEGYVLAGARVVV
MMAR_0587|M.marinum_M ---------------MGQLEGKTALVTGGNSGIGLAAAQRLAAEGAHVFL
Mflv_5148|M.gilvum_PYR-GCK --------------MDLGLSGKRFVVSGGTRGIGRAVVEGLLAEGASVAF
Mvan_1185|M.vanbaalenii_PYR-1 --------------MELGLEGKRFAVTGGTRGIGRAVVEGLLAEGASVAY
MSMEG_4382|M.smegmatis_MC2_155 --------------MDLGLTGKRFVVTGGTRGIGRAVVEGLLAEGAAVAF
MAV_3019|M.avium_104 ---------------MSGLRGRVVLVTGAGRGIGRSHCQRFAEEGADVIA
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MUL_4042|M.ulcerans_Agy99 --------------MQLSFQDRTYLVTGGGSGIGKGVAAGLVAAGASVMI
: .: ::*. *:* . * *
Mb0950c|M.bovis_AF2122/97 ASRTSSELDAVAEQIRAA---GRRAHTVAADLAHPEVTAQLAGQAVGAFG
Rv0927c|M.tuberculosis_H37Rv ASRTSSELDAVAEQIRAA---GRRAHTVAADLAHPEVTAQLAGQAVGAFG
MAB_0833|M.abscessus_ATCC_1997 ASRKPEACTEAVERLRSL---GARALGVPTHTGDIHSLEELVRATAEEFG
TH_2589|M.thermoresistible__bu ASRKSDACERAAAHLRAL---GGDAIGVPTHLGDIDACEALVRRTVDEFG
MMAR_0587|M.marinum_M TGRNQATIDAAVASI------GSRAHGIRADVSNIEDLARVADAIAAAGR
Mflv_5148|M.gilvum_PYR-GCK CARTPAAVEQAQAELSAN---GAAVAGAVVDVGDAAAVEAWVTQAAGMFS
Mvan_1185|M.vanbaalenii_PYR-1 CARTYEPVP--------------GAVGTAVDVGDGAALATWVDATADAFS
MSMEG_4382|M.smegmatis_MC2_155 CARTPEAVTATQQELAAD---GVTVVGTPVDVGDGAAVADWVAQSAETLG
MAV_3019|M.avium_104 VDVPAAAPDLAQTAAAVQQR-GVRAATALADVSDFAALAAAVDEAVGRLG
MLBr_01807|M.leprae_Br4923 THRASVVPD--------------WFFGVECDVTDNDAIGAAFKAVEEHQG
MUL_4042|M.ulcerans_Agy99 VGRNPDKLAGAVQELEALGANGGAIRYEPTDITNEDETARAVDAVTAWHG
. .
Mb0950c|M.bovis_AF2122/97 KLDIVVNNVG-GTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLE
Rv0927c|M.tuberculosis_H37Rv KLDIVVNNVG-GTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLE
MAB_0833|M.abscessus_ATCC_1997 GIDIVVNNAA-NALTEPVGAFTVDGWDKSFGVNLRGPVFLVQAALPHLVA
TH_2589|M.thermoresistible__bu GIDVLVNNAA-NALTQPLGELTVDAWTKSFEVNLRGPVFLVQAALPHLKT
MMAR_0587|M.marinum_M GLDVLFANAG-GGEFVLLGDITIEHFTNGFMTNVAGTLFTVQTMLPLLNS
Mflv_5148|M.gilvum_PYR-GCK GLDGVVAN-----VSALAIPETHENWRTTFEVDLMGTVGMVDAAMPYLLE
Mvan_1185|M.vanbaalenii_PYR-1 GLDGVVAN-----VSALAIPETHENWHTSFDVDLMGTVNLVDAALPYLLE
MSMEG_4382|M.smegmatis_MC2_155 GLDGVVAN-----VSALAIPESPENWRTSFEVDMMGTVGLVDAALPHLLK
MAV_3019|M.avium_104 RLDVLVGNAGIHPAAAPAWEITPQNWQQTLDVNLTGVWHTVKAGVPHMSR
MLBr_01807|M.leprae_Br4923 PVEVLVANAG-ITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIK
MUL_4042|M.ulcerans_Agy99 RLHGVVHCAGGSENIGPITQVDSEAWRRTVDLNVNGTMYVLKHAAREMVR
:. :. . . :: :
Mb0950c|M.bovis_AF2122/97 HSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR-VRV
Rv0927c|M.tuberculosis_H37Rv HSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR-VRV
MAB_0833|M.abscessus_ATCC_1997 SP-HAAVLNVVSVGAFMFGQGVSMYSAAKAALVSYTRSAAAELASRGVRV
TH_2589|M.thermoresistible__bu SP-HAAVLNMVSVGAFLFSPGTAMYSAGKAALMSFTRSMAAQFAPLGIRV
MMAR_0587|M.marinum_M GA---SIVLTGSTAAYNGSPAFSVYAATKAAIRSFGRTWAAELVSRNIRV
Mflv_5148|M.gilvum_PYR-GCK SD-AGSIVTVSSVSGREVDFAAGPYGTMKAAIIHYTQGLAFKYAGQGVRA
Mvan_1185|M.vanbaalenii_PYR-1 AD-SGSIVTISSVSGREIDFAAGPYGTMKAAIIHYTQGLAFKLAAQGVRA
MSMEG_4382|M.smegmatis_MC2_155 SD-AGSIVTISSVSGREIDFAAGPYGTFKAAIIHYTQGLAYQLAAKGVRA
MAV_3019|M.avium_104 TARGGSIVIISSTSGIRGTPGAAPYSASKHAVVGLARTLANELGPQGIRV
MLBr_01807|M.leprae_Br4923 QR-FGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITA
MUL_4042|M.ulcerans_Agy99 GG-GGSFVGISSIAASNTHRWFGAYGVTKSAVDHLMQLAADELGASWVRV
: * . . *.. * .: : * . : .
Mb0950c|M.bovis_AF2122/97 NAIAPG------SILTSALEVVAAN---DELRAPMEQATPLRRLGD----
Rv0927c|M.tuberculosis_H37Rv NAIAPG------SILTSALEVVAAN---DELRAPMEQATPLRRLGD----
MAB_0833|M.abscessus_ATCC_1997 NALAPG------AIDTDMVRKTPP-----AEVERMANTNHLKRLGL----
TH_2589|M.thermoresistible__bu NALAPG------PVDTDMMRNNPQ-----EVVDMMAGATLMKRLAT----
MMAR_0587|M.marinum_M NTVVPG------PVETPGLKGLAPEGQEQQLLEGEAAKVPMGRLGK----
Mflv_5148|M.gilvum_PYR-GCK NTVSPG----NTYFPGGVWTSIE--ENDPQLFATALALNPTGRMAT----
Mvan_1185|M.vanbaalenii_PYR-1 NTVSPG----NTYFPGGVWPSIE--QSDPELFATALALNPTGRMAT----
MSMEG_4382|M.smegmatis_MC2_155 NSVSPG----NTYFEGGVWPTIE--KDDPELFASALALNPTGRMGT----
MAV_3019|M.avium_104 NTVHPGAVATAMVLNEATFRRLRPDLDNPTADDAAEALSARHLLPVPWVE
MLBr_01807|M.leprae_Br4923 NVVAPG------FIDTEMTRAMDS-----KYQEAALQAIPLGRIGA----
MUL_4042|M.ulcerans_Agy99 NSIRPG------LIRTDLVAAITES---AELSSDYAMCTPLPRQGE----
* : ** .
Mb0950c|M.bovis_AF2122/97 PVDIAAAAVYLASPAGSFLTGKTLEVDGGLTFPNLDLPIPDL--------
Rv0927c|M.tuberculosis_H37Rv PVDIAAAAVYLASPAGSFLTGKTLEVDGGLTFPNLDLPIPDL--------
MAB_0833|M.abscessus_ATCC_1997 PDEMVGTALLLTSDAGSYITGQTIIADGGLVAR-----------------
TH_2589|M.thermoresistible__bu PDEMVGAALLLTSDAGSYITGTVLIADGGGTPR-----------------
MMAR_0587|M.marinum_M PAEIAAAVLFLASDQSSFMTGSEMFVDGGTEQL-----------------
Mflv_5148|M.gilvum_PYR-GCK PQEVANAVVFLSSPAASFITGTNLLVDGALTRGVQF--------------
Mvan_1185|M.vanbaalenii_PYR-1 PQEVANAVVFLSSAAASFITGTNLLVDGALTRGVQL--------------
MSMEG_4382|M.smegmatis_MC2_155 PREVANAVVFLSSPVASFITGTNLVVDGALTRGVQF--------------
MAV_3019|M.avium_104 PVDVSNAVVFLASDQARYITGTQIVVDAGLLAKA----------------
MLBr_01807|M.leprae_Br4923 VEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH----------------
MUL_4042|M.ulcerans_Agy99 VEDVANMAMFLLSDAASFVTGQVINVDGGQMLRRGPDFSAMLEPVFGRDA
:: . * * . :::* : .*..
Mb0950c|M.bovis_AF2122/97 -----
Rv0927c|M.tuberculosis_H37Rv -----
MAB_0833|M.abscessus_ATCC_1997 -----
TH_2589|M.thermoresistible__bu -----
MMAR_0587|M.marinum_M -----
Mflv_5148|M.gilvum_PYR-GCK -----
Mvan_1185|M.vanbaalenii_PYR-1 -----
MSMEG_4382|M.smegmatis_MC2_155 -----
MAV_3019|M.avium_104 -----
MLBr_01807|M.leprae_Br4923 -----
MUL_4042|M.ulcerans_Agy99 LRGLV