For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. bovis AF2122 / 97 Mb1976 (-)

annotation: short-chain type dehydrogenase/reductase
coordinates: 2185298 - 2186068
length: 256

LNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADIDGDAADAAATKIGCGAAACRVDVSDEQQII
AMVDACVAAFGGVDKLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERGGGAIVNLS
SLAGQVAVGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTLLPAFVDTPMQQTAMAMFDGALGAGGARS
MIARLQGRMAAPEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1976--100% (256)short-chain type dehydrogenase/reductase
M. bovis AF2122 / 97Mb1385fabG2e-3835.89% (248) 3-ketoacyl-(acyl-carrier-protein) reductase
M. bovis AF2122 / 97Mb0792-2e-3740.64% (251) short chain dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_4505-4e-3936.25% (251) short-chain dehydrogenase/reductase SDR
M. tuberculosis H37RvRv1941-1e-142100.00% (256) short-chain type dehydrogenase/reductase
M. leprae Br4923MLBr_01807fabG15e-2934.41% (247) 3-oxoacyl-
M. abscessus ATCC 19977MAB_4680c-7e-3839.36% (249) putative short-chain dehydrogenase/reductase
M. marinum MMMAR_2869-1e-11277.73% (256) short-chain type dehydrogenase/reductase
M. avium 104MAV_5088fabG2e-4444.76% (248) 3-ketoacyl-(acyl-carrier-protein) reductase
M. smegmatis MC2 155MSMEG_3607-4e-4240.73% (248) short chain dehydrogenase
M. thermoresistible (build 8)TH_4254-8e-4137.30% (252) PUTATIVE putative 2,5-dichloro-2,5-cyclohexadiene-1,4-diol
M. ulcerans Agy99MUL_2885-1e-11176.95% (256) short-chain type dehydrogenase/reductase
M. vanbaalenii PYR-1Mvan_3999-1e-10876.17% (256) short-chain dehydrogenase/reductase SDR

CLUSTAL 2.0.9 multiple sequence alignment


Mb1976|M.bovis_AF2122/97            MNHPD-------------LAGKVAIVTGAGAGIGLAVARRLADEGCHVLC
Rv1941|M.tuberculosis_H37Rv         MNHPD-------------LAGKVAIVTGAGAGIGLAVARRLADEGCHVLC
MMAR_2869|M.marinum_M               MRYPD-------------LAGKATIVTGAGAGIGLAIAERLAAEGAAVLC
MUL_2885|M.ulcerans_Agy99           MRYPD-------------LAGKATIVTGAGAGIGLAIAERLAAEGAAVLC
Mvan_3999|M.vanbaalenii_PYR-1       MTYPD-------------LADKAVIVTGAAAGIGLAIAERLAAERCRVVC
MAV_5088|M.avium_104                MAESL-------------LLGKVAVVTGAGQGIGREIARALHRHGARVVL
Mflv_4505|M.gilvum_PYR-GCK          MTGR--------------LAGKVALISGAARGMGASHARVMAGHGAKVVC
MAB_4680c|M.abscessus_ATCC_199      MNGNSAL-----------LQGKNVIVTGGARGLGAAFSRHIVSQGGRVVI
TH_4254|M.thermoresistible__bu      MTAGSTR-----------LAGKVVLVTGAGGGLGTAIARRLADEGARLVL
MSMEG_3607|M.smegmatis_MC2_155      MTQAQELSVDFDFR----LDGKVALVTGAASGIGAAIASAYATKGARIAA
MLBr_01807|M.leprae_Br4923          MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
                                    *                 : .:  :::*.  *:*   :     .   :  

Mb1976|M.bovis_AF2122/97            ADIDGDAADAAATKIG-CGA--AACRVDVSDEQQIIAMVDACVAAFGGVD
Rv1941|M.tuberculosis_H37Rv         ADIDGDAADAAATKIG-CGA--AACRVDVSDEQQIIAMVDACVAAFGGVD
MMAR_2869|M.marinum_M               ADIDGASAEQAAAKIG-SGA--VGYQVDVSAEEQVAGMVEACVTSFGGLD
MUL_2885|M.ulcerans_Agy99           ADIDGASAEQAAAKIG-SGA--VGYQVDVSAEEQVAGMVEACVTSFGGLD
Mvan_3999|M.vanbaalenii_PYR-1       ADIDGAAADAAAAAIG-NGA--VGYAVDVSDEPQVVGMVEACVAAFGGVD
MAV_5088|M.avium_104                ADLDGSAARSAAAQIDDSGANCTGLACDVTSEEQVGALVAGTVREHGGLD
Mflv_4505|M.gilvum_PYR-GCK          GDILDSDGEAVAAELGDAARYVH---LDVTSPDDWDRAVAAAVADFGGLD
MAB_4680c|M.abscessus_ATCC_199      ADVLDGDGRQLAAELGDAARFTH---LDVTDAEQWRELIDTTLAGFGTIT
TH_4254|M.thermoresistible__bu      ADLQESQCAALADELPAPAGAHHPLGFDVADETAWISAISTVSAQYGALH
MSMEG_3607|M.smegmatis_MC2_155      VDLNAEGAEALAAQLGGDRGAHRGFACDVADAASVQAAADAVAAEFGRID
MLBr_01807|M.leprae_Br4923          THRASVVP-----------DWFFGVECDVTDNDAIGAAFKAVEEHQGPVE
                                     .                         **:                * : 

Mb1976|M.bovis_AF2122/97            KLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERGGG
Rv1941|M.tuberculosis_H37Rv         KLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERGGG
MMAR_2869|M.marinum_M               KLVANAGVVHLAPILDTAVEDFDRVIGINLRGAWLCTKHAAPKMVERGGG
MUL_2885|M.ulcerans_Agy99           KLVANAGVVHLAPILDTAVEDFDRVIGINLRGAWLCTKHAAPKMVERGGG
Mvan_3999|M.vanbaalenii_PYR-1       KLVANAGVVHFAPLTETTVDDFDRIIGINLRGAWLCTKHAAPRMAERGGG
MAV_5088|M.avium_104                VFVNNAGITRDASLKRMTVADFDAVIAVHLRGTWLGVREAAAVMRERKTG
Mflv_4505|M.gilvum_PYR-GCK          VLVNNAGILNIGTVEDYELSEWHRILDVNLTGVFLGIRAATPTMKAAGRG
MAB_4680c|M.abscessus_ATCC_199      GLVNNAGISSAAMVADEPLEHFRKVIEINLVGVFIGMQAVIPAMRAHGCG
TH_4254|M.thermoresistible__bu      ALVNNAAIGALGNVAEERLERWDRILDVGATGVWLGMKHAVPLIRRSGGG
MSMEG_3607|M.smegmatis_MC2_155      ILVNSAGVARLAPAEELSLQDWDSTLAINLSGTFLMCQAVGKRMLEAGGG
MLBr_01807|M.leprae_Br4923          VLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRFG
                                     :* .*.:             :   : :   *.:   : .   :     *

Mb1976|M.bovis_AF2122/97            AIVNLSSLAGQVA-VGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTLL
Rv1941|M.tuberculosis_H37Rv         AIVNLSSLAGQVA-VGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTLL
MMAR_2869|M.marinum_M               AIVNMSSLAGHIG-VGGTAAYGMSKAGISHLSRVTAAELRSANVRSNALL
MUL_2885|M.ulcerans_Agy99           AIVNMSSLAGHIG-VGGTAAYGMSKAGISHLSRVTAAELRSANVRSNALL
Mvan_3999|M.vanbaalenii_PYR-1       AIVNMSSLGGLVA-AAGTAAYGMSKAGIIHLSRITAAEMRSANIRSNALL
MAV_5088|M.avium_104                SIVNMSSLSGKAG-NPGQTNYSAAKAGIVGLTKAAAKELAHHNVRVNAIQ
Mflv_4505|M.gilvum_PYR-GCK          SIINIASIEGMAG-TVGCHGYTATKFAVRGLTKSTALELGPFGIRVNSVH
MAB_4680c|M.abscessus_ATCC_199      SIVNISSAAGLVG-LALTSGYGASKWGVRGLSKVAAIELGRERIRVNSVH
TH_4254|M.thermoresistible__bu      SVVNICSIFGTVGGFGDSAAYHAAKGAVRTLTKNAALHWAPDGVRVNSLH
MSMEG_3607|M.smegmatis_MC2_155      AIVNMASQAATVA-LDQHVAYCASKFGVVGVSKVLAAEWGGRGVRVNTIS
MLBr_01807|M.leprae_Br4923          RYIFMGSVVGLSG-VPGQANYAASKSGLIGMARSLARELGSRSITANVVA
                                      : : *  .  .       *  :* .:  :::  * .     :  * : 

Mb1976|M.bovis_AF2122/97            PAFVDTPMQQTAMAMFDGALGAGGARSMIARLQGRMAAPEEMAGIVVFLL
Rv1941|M.tuberculosis_H37Rv         PAFVDTPMQQTAMAMFDGALGAGGARSMIARLQGRMAAPEEMAGIVVFLL
MMAR_2869|M.marinum_M               PAFVDTPMQQSAMAMFDEALGTGGANTMIARLQGRMARPEEMASIVAFLL
MUL_2885|M.ulcerans_Agy99           PAFVDTPMQQSAMAMFDEVLGTGGANTMIARLQGRMARPEEMARIVAFLL
Mvan_3999|M.vanbaalenii_PYR-1       PAFVDTPMQQTAMTMFDEALGDGGAATMIGRLQGRMAGPAEMAGVVAFLL
MAV_5088|M.avium_104                PGLIRTPMTA---AMPPDVFAEREAAVPMKRAG----EPEEVAGAVVFLA
Mflv_4505|M.gilvum_PYR-GCK          PGLVKTPMADWV------------PEDIFQSALGRIAQPHEVSNLVVYLA
MAB_4680c|M.abscessus_ATCC_199      PGVIYTPMTAKEGF--R-----EGEGNMPIAAMGRVGNADEVAGAVAYLL
TH_4254|M.thermoresistible__bu      PGFIETPQLRELYKGTE-----RYERMLAGTPLGRLGRPDEIAAVVAFLV
MSMEG_3607|M.smegmatis_MC2_155      PTVVLTELGHKAWDG-P-----RGDALKKLIPTGRFAYPDEIAAAAVFLA
MLBr_01807|M.leprae_Br4923          PGFIDTEMTRAMDSKYQ-------EAALQAIPLGRIGAVEEIAGAVSFLA
                                    * .: *                                  *::  . :* 

Mb1976|M.bovis_AF2122/97            SDDASMITGTTQIADGGTIAALW-----------------
Rv1941|M.tuberculosis_H37Rv         SDDASMITGTTQIADGGTIAALW-----------------
MMAR_2869|M.marinum_M               SDDSSMITGTTQIADGGTIAALW-----------------
MUL_2885|M.ulcerans_Agy99           PDDSSMITGTTQIADGGTIAALW-----------------
Mvan_3999|M.vanbaalenii_PYR-1       SDAASMVNGTAQLADGGTLAALW-----------------
MAV_5088|M.avium_104                SELSSYITGTVLGVGGGRYM--------------------
Mflv_4505|M.gilvum_PYR-GCK          SDESSYSTGAEFVVDGGTLAGLAHKDFSAVDVDQQPEWIT
MAB_4680c|M.abscessus_ATCC_199      SDAASYVTGAELAVDGGWTAGPTLTTITGQ----------
TH_4254|M.thermoresistible__bu      SDDASFITGSEVYADGGWTAR-------------------
MSMEG_3607|M.smegmatis_MC2_155      SDAAAMINGADLVIDGGYTIK-------------------
MLBr_01807|M.leprae_Br4923          SEDAGYISGAVIPVDGGLGMGH------------------
                                    .: :.  .*:    .**