For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SGHDRPQSLRERKKVRTRLAIRREAFRLFAKQGYANTTVEQIAEAADVSPRTFYRYFGVKERLLISDDKI SPIVEAFIAAPKELPIVPAYRHAVGTVFDGLTQEERDDFVAGEQMMYAIPEARGLVYTEYVRLIDLIADA LTDRPDGPTDEMERRVVAGAIVGVLIAASHNNPFPEDVLLRSLEILGRRLT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1156 | - | - | 100% (192) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1157 | - | 8e-67 | 64.58% (192) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0384 | - | 3e-49 | 53.63% (179) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3860c | - | 4e-08 | 50.00% (62) | transcriptional regulatory protein TetR-family |
| M. gilvum PYR-GCK | Mflv_5173 | - | 1e-70 | 70.43% (186) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3830c | - | 4e-08 | 50.00% (62) | transcriptional regulatory protein TetR-family |
| M. leprae Br4923 | MLBr_01070 | - | 1e-06 | 32.86% (140) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3837 | - | 3e-07 | 26.42% (159) | transcriptional regulatory protein TetR |
| M. marinum M | MMAR_0222 | - | 8e-11 | 33.94% (165) | TetR family transcriptional regulator |
| M. avium 104 | MAV_4894 | - | 5e-41 | 45.36% (183) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_5673 | - | 7e-13 | 44.09% (93) | transcriptional regulator |
| M. thermoresistible (build 8) | TH_3524 | - | 8e-10 | 47.76% (67) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4892 | - | 2e-09 | 32.12% (165) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1156|M.vanbaalenii_PYR-1 -----MSGHD-RPQSLRERKKVRT-----RLAIRREAFRLFAKQGYANTT
Mflv_5173|M.gilvum_PYR-GCK -----MPESESQPHGLRERKKVQT-----RLAIRRAAFELFDTQGYANTT
MAV_4894|M.avium_104 -----MPASE-APPGLRERKKIKT-----RQAIRREAFRLIEQNGYAATT
MMAR_0222|M.marinum_M -----MSPPP-AATSLAERKRTAT-----RQRIATAAAQLVADLGLAAAT
MUL_4892|M.ulcerans_Agy99 -----MSPPP-AATALAERKRTAT-----RQRIATAAAQLVADLGLVAAT
Mb3860c|M.bovis_AF2122/97 -----MVRPP------QTARSERT-----REALRQAALVRFLAQGVEATS
Rv3830c|M.tuberculosis_H37Rv -----MVRPP------QTARSERT-----REALRQAALVRFLAQGVEATS
MSMEG_5673|M.smegmatis_MC2_155 -----MAYQT-QQPGLRERKKQRT-----RATLISAAIDLCVRQGYEQTT
MAB_3837|M.abscessus_ATCC_1997 -----MNAQP----ARVGRRPSTT-----RDEITAVAMTLFAQHGFDEVS
TH_3524|M.thermoresistible__bu ------------------VRGHRN-----REALIAAAIDLFTVNGYEQTT
MLBr_01070|M.leprae_Br4923 MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERPLGDFS
: . : * :
Mvan_1156|M.vanbaalenii_PYR-1 VEQIAEAADVSPRTFYRYFGVKERLLIS---DDKISPIVEAFIAAPKELP
Mflv_5173|M.gilvum_PYR-GCK VDQIAEAADVSPRTLYRYFGVKEALLIS---DDQISPIVEAFADAPPDLP
MAV_4894|M.avium_104 VEQIAEAADVSPSTFFRYFGSKESLLLA---DDLDPLILDALKAQPRELS
MMAR_0222|M.marinum_M VERIADTADISRATFFRYFNSKEDAVAEGMTAHWLDRIATALAAQPEHLS
MUL_4892|M.ulcerans_Agy99 VERIADTADISRATFFRYFNSKEDAVAEGMTAHWLDRIATALAAQPEHQS
Mb3860c|M.bovis_AF2122/97 AEQIAEDAGVSLRTFYRHFRSKHDLLFAD-YDAGLHWFRAALDARPADES
Rv3830c|M.tuberculosis_H37Rv AEQIAEDAGVSLRTFYRHFRSKHDLLFAD-YDAGLHWFRAALDARPADES
MSMEG_5673|M.smegmatis_MC2_155 VEQIAAAAEVSARTFSRYFATKDAVMLAF-LDDVVDLVAGELAQQPPELG
MAB_3837|M.abscessus_ATCC_1997 VDDIAAAAGIARRTVFRYYSSKNAIVWGD-FDSHLGVMRALLDETADTVD
TH_3524|M.thermoresistible__bu VEQIAEAAGVAPRTFFRHFAAKEDILFHG-YADRLAEATRRFR-AARSGS
MLBr_01070|M.leprae_Br4923 VDELAKGAGISRPTFYFYFPSKNAVLLSLLDDLNMKSRSAVEALAEQLPA
.: :* * :: *. :: *. :
Mvan_1156|M.vanbaalenii_PYR-1 IVPAYRHAVGTVFDGLTQEERDD-----FVAGEQMMYAIPEARGLVYTEY
Mflv_5173|M.gilvum_PYR-GCK IVDAYRHAVATVFADLTPEERED-----AAAGQRMMYGIPEARGLIYSEY
MAV_4894|M.avium_104 LPQAFRRAYATVLSQLPDDQLEF-----ESTRQRLMFSIPELKAAMYDEY
MMAR_0222|M.marinum_M AVEAVVGAFGGLAVGFA-EMEDQ-----VRELATLTRSSETLEAWTLHIY
MUL_4892|M.ulcerans_Agy99 AVEAVVGAFGGLAVGFA-EMEDQ-----VRELATLTRSSETLEAWTLHIY
Mb3860c|M.bovis_AF2122/97 IIDSVQAAIFSFPYDVDAVTKIASLRRGELEPSRIVRHMREVEADFADAI
Rv3830c|M.tuberculosis_H37Rv IIDSVQAAIFSFPYDVDAVTKIASLRRGELEPSRIVRHMREVEADFADAI
MSMEG_5673|M.smegmatis_MC2_155 ELDAVFCAHITAFEKTRVAMPGQLTDDRLLAAARIFTSSPSLMQATMGFR
MAB_3837|M.abscessus_ATCC_1997 TSTALRQAVLTFNDFPVDETPRH------RMRMRMILEVPALQAYSMLMY
TH_3524|M.thermoresistible__bu LWKALAEASEAVATAIAENPGIF------LVRARMYGELPALRATMLRIN
MLBr_01070|M.leprae_Br4923 DPAAVWRSAITAFFEVCGTHRAV-----AVAGAAAKATSPEVRRLWSTVM
: :
Mvan_1156|M.vanbaalenii_PYR-1 VRLIDLIADALTDRPDGPTDEMER-RVVAGAIVGVLIAASHNNPFPEDV-
Mflv_5173|M.gilvum_PYR-GCK IRLIEMIAEAMVSRPDAPAAAEER-RVIAGAIVGVLIATSHETPMPDTE-
MAV_4894|M.avium_104 YRTVTVAAEAIAHRIGRAADDFEV-RVFAGALTGAMMAAFDSAPTTPET-
MMAR_0222|M.marinum_M VRYESAIADLIAPRIPNLVPQDPRPRLVGALAMAVVRIALDDWLGQGGS-
MUL_4892|M.ulcerans_Agy99 VRYESAIADLIAPRIPNLVPQDPRPRLVGALAMAVVRIALDDWLGQGGS-
Mb3860c|M.bovis_AF2122/97 QAQLRRRNCDIAGAPDARLHIAVTARCVAAAVFGAMEAWMLGSDRSLGE-
Rv3830c|M.tuberculosis_H37Rv QAQLRRRNCDIAGAPDARLHIAVTARCVAAAVFGAMEAWMLGSDRSLGE-
MSMEG_5673|M.smegmatis_MC2_155 PAPLFEVLAKRMGVSADDRKIALIASLWNAIMTTALVQLVPDVDWATVT-
MAB_3837|M.abscessus_ATCC_1997 TGWRDVIAQFVARRSGTDPGSLLPQTVAWTLLGVALAAYEQWLADESSK-
TH_3524|M.thermoresistible__bu DDWIDQMTTEVARWLGSDAAVDVRPRLAATVINGANRTAIDLWVSADGKG
MLBr_01070|M.leprae_Br4923 QQWIDYNTAAIQAERKCGVAPDTIPAEDLAVALQLMTERVMAATFSDEKP
Mvan_1156|M.vanbaalenii_PYR-1 -----LLRSLEILGRRLT-------------------
Mflv_5173|M.gilvum_PYR-GCK -----LENSLTILSKRMAR------------------
MAV_4894|M.avium_104 -----IYRALDFMDAGMPLD-----------------
MMAR_0222|M.marinum_M -----LPDRVQQGLAAIVIA-----------------
MUL_4892|M.ulcerans_Agy99 -----LPDRVQQGLAAIVIA-----------------
Mb3860c|M.bovis_AF2122/97 -----LARVCHVALESLRVGISDTWTTLTVSS-----
Rv3830c|M.tuberculosis_H37Rv -----LARVCHVALESLRVGISDTWTTLTVSS-----
MSMEG_5673|M.smegmatis_MC2_155 -----VERIVNQMRTTYAEFLEVAGRRHEFA------
MAB_3837|M.abscessus_ATCC_1997 -----LTTLLGKGFDAAEVGLRALR------------
TH_3524|M.thermoresistible__bu DLVELMADAVRLVRPTLDRIERESRTVANPVRRRDVV
MLBr_01070|M.leprae_Br4923 -----LIPDKKVIDTLVHIWLASIYGS----------
: