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MPASEAPPGLRERKKIKTRQAIRREAFRLIEQNGYAATTVEQIAEAADVSPSTFFRYFGSKESLLLADDL DPLILDALKAQPRELSLPQAFRRAYATVLSQLPDDQLEFESTRQRLMFSIPELKAAMYDEYYRTVTVAAE AIAHRIGRAADDFEVRVFAGALTGAMMAAFDSAPTTPETIYRALDFMDAGMPLD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4894 | - | - | 100% (194) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_0474 | - | 1e-15 | 36.24% (149) | TetR-family protein transcriptional regulator |
| M. avium 104 | MAV_0350 | - | 1e-12 | 55.74% (61) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0710c | - | 1e-09 | 25.40% (189) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0350 | - | 2e-46 | 49.73% (185) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0691c | - | 1e-09 | 25.40% (189) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_01070 | - | 3e-05 | 27.33% (172) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4541 | - | 1e-10 | 28.43% (197) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0222 | - | 6e-14 | 36.21% (174) | TetR family transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5673 | - | 4e-18 | 37.21% (172) | transcriptional regulator |
| M. thermoresistible (build 8) | TH_3524 | - | 2e-12 | 33.76% (157) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4892 | - | 6e-13 | 35.06% (174) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0384 | - | 1e-47 | 51.35% (185) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0350|M.gilvum_PYR-GCK -----MEGMNPEQPGLRERKKTRT-----RETVRREAFRLFELNGYAQTT
Mvan_0384|M.vanbaalenii_PYR-1 -----MT--TGEQPSLRERKKTRT-----RETVRREAFRLFELNGYAQTT
MAV_4894|M.avium_104 -----MP-ASEAPPGLRERKKIKT-----RQAIRREAFRLIEQNGYAATT
MMAR_0222|M.marinum_M ------MSPPPAATSLAERKRTAT-----RQRIATAAAQLVADLGLAAAT
MUL_4892|M.ulcerans_Agy99 ------MSPPPAATALAERKRTAT-----RQRIATAAAQLVADLGLVAAT
Mb0710c|M.bovis_AF2122/97 ---------MPHESRVG-RRRSTT-----PHHISDVAIELFAAHGFTDVS
Rv0691c|M.tuberculosis_H37Rv ---------MPHESRVG-RRRSTT-----PHHISDVAIELFAAHGFTDVS
MSMEG_5673|M.smegmatis_MC2_155 ------MAYQTQQPGLRERKKQRT-----RATLISAAIDLCVRQGYEQTT
TH_3524|M.thermoresistible__bu ------------------VRGHRN-----REALIAAAIDLFTVNGYEQTT
MLBr_01070|M.leprae_Br4923 MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERPLGDFS
MAB_4541|M.abscessus_ATCC_1997 ---MTNLIPESETPNKRERAKADR-----RDQLLRAAARLLAMRGYARVR
: * *
Mflv_0350|M.gilvum_PYR-GCK VDQIAEAAFVSPRTFFRYFPTKESVLFS---DDLFNPIIEEFLAAPAELS
Mvan_0384|M.vanbaalenii_PYR-1 VDQIAEAADVSPRTFFRYFPTKESVLFS---DDLLTPIIEAFLAAPAELS
MAV_4894|M.avium_104 VEQIAEAADVSPSTFFRYFGSKESLLLA---DDLDPLILDALKAQPRELS
MMAR_0222|M.marinum_M VERIADTADISRATFFRYFNSKEDAVAEGMTAHWLDRIATALAAQPEHLS
MUL_4892|M.ulcerans_Agy99 VERIADTADISRATFFRYFNSKEDAVAEGMTAHWLDRIATALAAQPEHQS
Mb0710c|M.bovis_AF2122/97 VDDIARAAGIARRTLFRYYASKN-AIPWGDFSTHLAQLQGLLDNIDSRIQ
Rv0691c|M.tuberculosis_H37Rv VDDIARAAGIARRTLFRYYASKN-AIPWGDFSTHLAQLQGLLDNIDSRIQ
MSMEG_5673|M.smegmatis_MC2_155 VEQIAAAAEVSARTFSRYFATKDAVMLA-FLDDVVDLVAGELAQQPPELG
TH_3524|M.thermoresistible__bu VEQIAEAAGVAPRTFFRHFAAKEDILFHGYADRLAEATRRFRAARSG--S
MLBr_01070|M.leprae_Br4923 VDELAKGAGISRPTFYFYFPSKNAVLLSLLDDLNMKSRSAVEALAEQLPA
MAB_4541|M.abscessus_ATCC_1997 LEDLGSAVGISGPAIYRHFPNKEALLVDLLTDVSRRLLEGGMTVAAAASS
:: :. . :: :: :: *: :
Mflv_0350|M.gilvum_PYR-GCK PVAAYRHAAARVFETMAGSD-----YDYIIARQRLLYDLPEAKGALWNEH
Mvan_0384|M.vanbaalenii_PYR-1 PVAAYRHAAAQVFAAMAGPD-----FDYVIARQRLLYALPEAKGALWNEH
MAV_4894|M.avium_104 LPQAFRRAYATVLSQLPDDQ-----LEFESTRQRLMFSIPELKAAMYDEY
MMAR_0222|M.marinum_M AVEAVVGAFG-GLAVGFAEM-----EDQVRELATLTRSSETLEAWTLHIY
MUL_4892|M.ulcerans_Agy99 AVEAVVGAFG-GLAVGFAEM-----EDQVRELATLTRSSETLEAWTLHIY
Mb0710c|M.bovis_AF2122/97 LRDALRAALL-AFNTFDESE-----TIRHRKRMRVILQTPELQAYSMTMY
Rv0691c|M.tuberculosis_H37Rv LRDALRAALL-AFNTFDESE-----TIRHRKRMRVILQTPELQAYSMTMY
MSMEG_5673|M.smegmatis_MC2_155 ELDAVFCAHITAFEKTRVAMPGQLTDDRLLAAARIFTSSPSLMQATMGFR
TH_3524|M.thermoresistible__bu LWKALAEASEAVATAIAENP------GIFLVRARMYGELPALRATMLRIN
MLBr_01070|M.leprae_Br4923 DPAAVWRSAITAFFEVCGTH-----RAVAVAGAAAKATSPEVRRLWSTVM
MAB_4541|M.abscessus_ATCC_1997 PAEALDGLIDFHLDFALNES------DLIRVQDRDLDSLPENARRQVRQY
*
Mflv_0350|M.gilvum_PYR-GCK VGAIRRLTSAIAKRLG-RPEDDYQARVTAGAIIGVFMAASD------DEP
Mvan_0384|M.vanbaalenii_PYR-1 VKAIRVLTTAIAERLD-RPEDD-QVRVTAGAIIGVFMAASD------DAP
MAV_4894|M.avium_104 YRTVTVAAEAIAHRIG-RAADDFEVRVFAGALTGAMMAAFD------SAP
MMAR_0222|M.marinum_M VRYESAIADLIAPRIPNLVPQDPRPRLVGALAMAVVRIALDDWLG--QGG
MUL_4892|M.ulcerans_Agy99 VRYESAIADLIAPRIPNLVPQDPRPRLVGALAMAVVRIALDDWLG--QGG
Mb0710c|M.bovis_AF2122/97 AGWREVIAKFVARRSGGKTT-DFMPQTVAWTMLGVALSAYEHWLRD-ESV
Rv0691c|M.tuberculosis_H37Rv AGWREVIAKFVARRSGGKTT-DFMPQTVAWTMLGVALSAYEHWLRD-ESV
MSMEG_5673|M.smegmatis_MC2_155 P---APLFEVLAKRMG-VSADDRKIALIASLWNAIMTTALVQLVP--DVD
TH_3524|M.thermoresistible__bu DDWIDQMTTEVARWLGSDAAVDVRPRLAATVINGANRTAIDLWVSADGKG
MLBr_01070|M.leprae_Br4923 QQWIDYNTAAIQAERKCGVAPDTIPAEDLAVALQLMTERVMAATFSDEKP
MAB_4541|M.abscessus_ATCC_1997 QRRYVEAWVQVLCRSQ-QGLDESDARIKAHAAFGLMNSTPYS-----AGR
: :
Mflv_0350|M.gilvum_PYR-GCK MSG--EAFLEALDLLDQALPR------------------
Mvan_0384|M.vanbaalenii_PYR-1 LDG--EAFLQALDILETGLPE------------------
MAV_4894|M.avium_104 TTP--ETIYRALDFMDAGMPLD-----------------
MMAR_0222|M.marinum_M SLP--DRVQQGLAAIVIA---------------------
MUL_4892|M.ulcerans_Agy99 SLP--DRVQQGLAAIVIA---------------------
Mb0710c|M.bovis_AF2122/97 SLT--EALGAAFDVVGAGLDRLNQ---------------
Rv0691c|M.tuberculosis_H37Rv SLT--EALGAAFDVVGAGLDRLNQ---------------
MSMEG_5673|M.smegmatis_MC2_155 WAT--VTVERIVNQMRTTYAEFLEVAGRRHEFA------
TH_3524|M.thermoresistible__bu DLV--ELMADAVRLVRPTLDRIERESRTVANPVRRRDVV
MLBr_01070|M.leprae_Br4923 LIPDKKVIDTLVHIWLASIYGS-----------------
MAB_4541|M.abscessus_ATCC_1997 SAP--SQTRTVLRQMVVAALRS-----------------
.