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MTTVLITGCSSGYGLATAHRFLDEGWNVVATMRTPRQDVLPPSDRLRVIALDVTRPDSIAAAVAAAGPID VLVNNAGIGAVGAFEATPMQTVRELFDTNTFGVMAMTQAVVPQMRARRSGVVVNVTSSVTLAAMPLAAAY TASKAAIEGFTGSLALELGFFGVRAKLVEPGYGPGTQFASNGSHRMADLIPDEYQDFAAPIMESFGSPAA VTTPDDVAEVVYLAATDASDRLRYAAGADAVALAQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1012 | - | - | 100% (245) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_5466 | - | 6e-28 | 34.65% (254) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0982 | - | 3e-27 | 40.84% (191) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1079 | - | 4e-20 | 34.83% (178) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_5243 | - | 1e-112 | 83.67% (245) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1050 | - | 4e-20 | 34.83% (178) | oxidoreductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 5e-18 | 34.48% (174) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_1305 | - | 3e-30 | 35.48% (248) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_3561 | - | 7e-40 | 43.27% (245) | oxidoreductase |
| M. avium 104 | MAV_2098 | - | 1e-33 | 39.18% (245) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2026 | - | 5e-33 | 43.90% (205) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3670 | - | 1e-24 | 38.22% (191) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2794 | - | 2e-39 | 42.86% (245) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1079|M.bovis_AF2122/97 -------------MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVAL
Rv1050|M.tuberculosis_H37Rv -------------MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVAL
Mvan_1012|M.vanbaalenii_PYR-1 ----------------MTT----VLITGCSSGYGLATAHRFLDEGWNVVA
Mflv_5243|M.gilvum_PYR-GCK ----------------MAT----VLITGCSSGYGRATALKFLAEGWNVVA
MMAR_3561|M.marinum_M ----------------MTSTPPVALITGVSSGIGAAIAVRLASAGFRVVG
MUL_2794|M.ulcerans_Agy99 ----------------MTSTPPVALITGVSSGIGAAIAVRLASAGFRVVG
MAV_2098|M.avium_104 ----------------MTHRSPVVLVTGASSGIGRAVAKAFAAKGFEVFG
MSMEG_2026|M.smegmatis_MC2_155 --------------------MTTWLITGCSTGIGRTLAEAVAAAGHNLVV
TH_3670|M.thermoresistible__bu -------------MGSNVWGSKVWFITGASRGFGREWAIAALDRGDRVAA
MAB_1305|M.abscessus_ATCC_1997 -----------------MSEHWTVLVTGASSGIGASAARIFAERGHRVFG
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
::** . * * * * :
Mb1079|M.bovis_AF2122/97 AARREGALRRVAREIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRID
Rv1050|M.tuberculosis_H37Rv AARREGALRRVAREIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRID
Mvan_1012|M.vanbaalenii_PYR-1 TMR---TPRQD---VLPPSDRLRVIALDVTRPDSIAAAV----AAAGPID
Mflv_5243|M.gilvum_PYR-GCK TMR---NPRPD---VLPASDRLRVSALDVTDPESIASAV----EAAGPLD
MMAR_3561|M.marinum_M TSR---APQ-----RLAPIPGVETLALDVTDDTAVRSVVSEVIDRTGRID
MUL_2794|M.ulcerans_Agy99 TSR---APQ-----RLAPIPGVETLALDVTDDTAVRSVVSEVIDRTGHID
MAV_2098|M.avium_104 TTR---NPR-----TAEPIPGVELVELDVTDAASVDAAAKSVIERTGRID
MSMEG_2026|M.smegmatis_MC2_155 TAR---DVSSVADIAETAPDRVVAAPLDVTRPEQVTAAAQLADERFGGVD
TH_3670|M.thermoresistible__bu TAR---DVSTLDDLRDRFGDAVLAMTLDVTDRAADFAAVQRAHDHFGRLD
MAB_1305|M.abscessus_ATCC_1997 TSR---NPD----TITDRVPGVQYLRLDQTDKASIAECV----AQAGEVD
MLBr_01807|M.leprae_Br4923 THR-----------ASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPVE
: * * : * ::
Mb1079|M.bovis_AF2122/97 VVFNNAGVSLVGPVDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRS
Rv1050|M.tuberculosis_H37Rv VVFNNAGVSLVGPVDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRS
Mvan_1012|M.vanbaalenii_PYR-1 VLVNNAGIGAVGAFE-ATPMQTVRELFDTNTFGVMAMTQAVVPQMRARRS
Mflv_5243|M.gilvum_PYR-GCK AVVNNAGIGAVGAFE-ATPMSTIRELFDTNTFGVMAMTQAVVPQMRERRS
MMAR_3561|M.marinum_M VLVNNAGLGIAGAAE-ESSIDQARSLFDTNFFGLIRLTNEVLPHMRRRGS
MUL_2794|M.ulcerans_Agy99 VLVNNAGLGIAGAAE-ESSIDQARSLFDTNFFGLIRLTNEVLPHMRRRGS
MAV_2098|M.avium_104 ILVNNAGSGILGAAE-ERSVAQAQRLIDTNFLGLVRLTNAVLPYLRAQGG
MSMEG_2026|M.smegmatis_MC2_155 VLVNNAGYGYRAAVE-EGDDADVRTLFDTHIFGTVATIKAVLPGMRARRR
TH_3670|M.thermoresistible__bu IVVNNAGYGHFGFVE-ELTETEVRDQMETNFFGALWVTQAALPYLRRQRS
MAB_1305|M.abscessus_ATCC_1997 ILVNNAGESQIGALE-DVSMDDFEKLYMTNVFGPVALTKAVLPGMRERRR
MLBr_01807|M.leprae_Br4923 VLVANAGIT-SDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRF
:. *** . . * . . . : :
Mb1079|M.bovis_AF2122/97 GRIMNMSSVVGRKAFARFAGYSSAMHAIAGFSDALRQELRGSGIAVSVIH
Rv1050|M.tuberculosis_H37Rv GRIMNMSSVVGRKAFARFAGYSSAMHAIAGFSDALRQELRGSGIAVSVIH
Mvan_1012|M.vanbaalenii_PYR-1 GVVVNVTSSVTLAAMPLAAAYTASKAAIEGFTGSLALELGFFGVRAKLVE
Mflv_5243|M.gilvum_PYR-GCK GVVVNVTSSTTLAPMPLAAAYTASKSAIEGFTGSLALELGFFGVRAKLVE
MMAR_3561|M.marinum_M GRIINISSVLGFLPAPYAALYAASKHAVEGYTESLDHELREYGVRALLVE
MUL_2794|M.ulcerans_Agy99 GRIINISSVLGFLPAPYAALYAASKHAVEGYTESLDHELREYGVRALLVE
MAV_2098|M.avium_104 GRVINIGSVLGFLPQPYGALYAGSKHAVEGYSESLDHETREFGVRVSVVE
MSMEG_2026|M.smegmatis_MC2_155 GAIVNISSIGAQITPPGSGYYAAAKAAVEGLSGSLHTELAPLGISVTVVE
TH_3670|M.thermoresistible__bu GHIIQVSSIGGVSAFADLGAYHASKWALEGLSQSLSLEVAPFGIHVTLIE
MAB_1305|M.abscessus_ATCC_1997 GAVVMVGSMAGTLHVPFRSTYSSAKSALHTVADCLRYEVAPFGITVSTVE
MLBr_01807|M.leprae_Br4923 GRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITANVVA
* : : * . . * .: .: : .* * .: . :
Mb1079|M.bovis_AF2122/97 PALTQTPLLANVDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARVVVP
Rv1050|M.tuberculosis_H37Rv PALTQTPLLANVDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARVVVP
Mvan_1012|M.vanbaalenii_PYR-1 PGYGPGTQFASNGSHRMADLIPDEYQDF----AAPIMESFGSPA-AVTTP
Mflv_5243|M.gilvum_PYR-GCK PGYGPGTQFTSNGVERMAGLIPAEYQDF----AAPVFEEFRSPG-MVTTP
MMAR_3561|M.marinum_M PSYTR-TDFESN--MWEADTPQAAYADN----RAAVRAVVADKIRNAELP
MUL_2794|M.ulcerans_Agy99 PSYTR-TDFESN--MWEADTPQAAYADN----RAAVRAVVANKIRNAELP
MAV_2098|M.avium_104 PAYTR-TSFEAN--MADADAPIDAYAAS----REHARRRMAELMKTADDP
MSMEG_2026|M.smegmatis_MC2_155 PGGFR-TDFAGR-SLKQSAAAIDDYADTAGKRRKEHDRVHG---TQPGDP
TH_3670|M.thermoresistible__bu PGGYA-TDWGGS-SARR-SATMPEYAES----RAEADRVRSQRVARPGDP
MAB_1305|M.abscessus_ATCC_1997 PGVIA-TGIETR--RNRIVPDGSPYRDA----FRTVDAAMAAREEHGTAT
MLBr_01807|M.leprae_Br4923 PGFID---------TEMTRAMDSKYQEA---------ALQAIPLGRIGAV
*.
Mb1079|M.bovis_AF2122/97 FQPRLLMVGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTESAK
Rv1050|M.tuberculosis_H37Rv FQPRLLMVGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTESAK
Mvan_1012|M.vanbaalenii_PYR-1 DDVAEVVYLAATDASDRLRYAAGADAVALAQ-------------------
Mflv_5243|M.gilvum_PYR-GCK DEVADVVFQAATDTSGRLRFAAGADAVALAQ-------------------
MMAR_3561|M.marinum_M AVVADATYAAATDKRIKLRYPAGRHARQLALLKRIAPAAVLDNGIRKQTG
MUL_2794|M.ulcerans_Agy99 AVVADATYAAAIDKRIKLRYPAGRHARQLALLKRIAPAAVLDNGIRKQTG
MAV_2098|M.avium_104 AIVAEVVLKAATARKPKLRYPAGPLARRLSLLKKFAPEAVLDRGIRKTNG
MSMEG_2026|M.smegmatis_MC2_155 VKAAAAIIKAVESPEPPAFLLLGSDALSAYRRVAQARAEEIDKWADLTTS
TH_3670|M.thermoresistible__bu KASAAALLKVVDAEKPPLRVFFGELPLQIVNADYQSRLQTWEEWQPIAVL
MAB_1305|M.abscessus_ATCC_1997 DELGRLVVDVALSPSPKPLYAKGSNAPIIMTAQRLLPARLFLKFLARMHG
MLBr_01807|M.leprae_Br4923 EEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH-----------------
.
Mb1079|M.bovis_AF2122/97 AQAAQPERGYSSAR
Rv1050|M.tuberculosis_H37Rv AQAAQPERGYSSAR
Mvan_1012|M.vanbaalenii_PYR-1 --------------
Mflv_5243|M.gilvum_PYR-GCK --------------
MMAR_3561|M.marinum_M LNSP-RPTPVLAER
MUL_2794|M.ulcerans_Agy99 LNSP-RPTPVLAER
MAV_2098|M.avium_104 LPAASRPHSHLQL-
MSMEG_2026|M.smegmatis_MC2_155 TDFDS---------
TH_3670|M.thermoresistible__bu AQG-----------
MAB_1305|M.abscessus_ATCC_1997 LKVR----------
MLBr_01807|M.leprae_Br4923 --------------