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MTTWLITGCSTGIGRTLAEAVAAAGHNLVVTARDVSSVADIAETAPDRVVAAPLDVTRPEQVTAAAQLAD ERFGGVDVLVNNAGYGYRAAVEEGDDADVRTLFDTHIFGTVATIKAVLPGMRARRRGAIVNISSIGAQIT PPGSGYYAAAKAAVEGLSGSLHTELAPLGISVTVVEPGGFRTDFAGRSLKQSAAAIDDYADTAGKRRKEH DRVHGTQPGDPVKAAAAIIKAVESPEPPAFLLLGSDALSAYRRVAQARAEEIDKWADLTTSTDFDS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2026 | - | - | 100% (276) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3426 | - | 2e-59 | 43.07% (274) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2808 | - | 3e-57 | 44.60% (278) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1277c | - | 3e-24 | 30.80% (250) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_0295 | - | 2e-53 | 43.84% (276) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1245c | - | 3e-24 | 30.80% (250) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01094 | - | 2e-22 | 31.23% (253) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1305 | - | 2e-27 | 34.26% (251) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_1614 | - | 1e-111 | 72.16% (273) | short chain dehydrogenase |
| M. avium 104 | MAV_3827 | - | 3e-68 | 49.64% (274) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3670 | - | 7e-49 | 41.13% (265) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3423 | - | 1e-111 | 72.53% (273) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3508 | - | 3e-49 | 39.05% (274) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1614|M.marinum_M -------MSTWLITGCSTG-LGRALAEAVIDAGHHTVATARSVGGVADLV
MUL_3423|M.ulcerans_Agy99 -------MSTWLITGCSTG-LGRALAEAVIDAGHHTVATARSVGGVADLA
MSMEG_2026|M.smegmatis_MC2_155 -------MTTWLITGCSTG-IGRTLAEAVAAAGHNLVVTARDVSSVADIA
MAV_3827|M.avium_104 -------MARWLITGCSTG-LGREIAGAALQAGHRVVVTARRADAVRGFA
Mvan_3508|M.vanbaalenii_PYR-1 -------MRTWFITGGTPGGFGMAFADAALDAGDRVALTVRRPEELDGWA
Mflv_0295|M.gilvum_PYR-GCK ------MSKVLLISGASRG-LGRAITESALAAGHLVVAGVRATSSLSDLA
TH_3670|M.thermoresistible__bu MGSNVWGSKVWFITGASRG-FGREWAIAALDRGDRVAATARDVSTLDDLR
Mb1277c|M.bovis_AF2122/97 --MEGFAGKVAVVTGAGSG-IGQALAIELARSGAKVAISDVDTDGLADTE
Rv1245c|M.tuberculosis_H37Rv --MEGFAGKVAVVTGAGSG-IGQALAIELARSGAKVAISDVDTDGLADTE
MLBr_01094|M.leprae_Br4923 --MEGFAGKVAVVTGAGSG-IGQALAIELARSGAKLAISDVDGEGLAQTE
MAB_1305|M.abscessus_ATCC_1997 ----MSEHWTVLVTGASSG-IGASAARIFAERGHRVFGTSRNPDTITDRV
.::* * :* : * :
MMAR_1614|M.marinum_M QRSPER---VLPLALDITEPDQITAAVQAAQQRFGGIDVLVNNAGYGYRA
MUL_3423|M.ulcerans_Agy99 QRSPER---VLPLALDITEPDQITAAMQAAQQRFGGIDVLVNNAGYGYRA
MSMEG_2026|M.smegmatis_MC2_155 ETAPDR---VVAAPLDVTRPEQVTAAAQLADERFGGVDVLVNNAGYGYRA
MAV_3827|M.avium_104 EEFGEL---ALPVALDVTDRDQIAAAVAAADAAFGGIDVLVNNAGHGYLS
Mvan_3508|M.vanbaalenii_PYR-1 REHGDR---VLVVPLDVTDPEQVRVAVKATEERFGGIDVLVNNAGRAWAG
Mflv_0295|M.gilvum_PYR-GCK TREPDR---LAVVELDVTDDRHARAAVATAVERFGRLDVLVNNAGYANMS
TH_3670|M.thermoresistible__bu DRFGDA---VLAMTLDVTDRAADFAAVQRAHDHFGRLDIVVNNAGYGHFG
Mb1277c|M.bovis_AF2122/97 HRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAGIAFTG
Rv1245c|M.tuberculosis_H37Rv HRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAGIAFTG
MLBr_01094|M.leprae_Br4923 GQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAGIAFTG
MAB_1305|M.abscessus_ATCC_1997 PG-------VQYLRLDQTDK----ASIAECVAQAGEVDILVNNAGESQIG
** * . * :: : **** . .
MMAR_1614|M.marinum_M AVEEGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISSIAVAL
MUL_3423|M.ulcerans_Agy99 AVEEGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISSIAVAL
MSMEG_2026|M.smegmatis_MC2_155 AVEEGDDADVRTLFDTHIFGTVATIKAVLPGMRARRRGAIVNISSIGAQI
MAV_3827|M.avium_104 AVEEGEDAEVRKLFDVNYFGAVDMIKAVLPGMRARGCGHIVNISSMTGLV
Mvan_3508|M.vanbaalenii_PYR-1 TVEGMDESELRAMFELNFFAVLSVLRAALPGMRARRGGWIVNVSSVAGLR
Mflv_0295|M.gilvum_PYR-GCK AIEDVDVDDFRAQIETNFFGVVNLTRAALPAMRRQRDGHIVQISSVGGRL
TH_3670|M.thermoresistible__bu FVEELTETEVRDQMETNFFGALWVTQAALPYLRRQRSGHIIQVSSIGGVS
Mb1277c|M.bovis_AF2122/97 DIEVSQFKDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISSVFGLF
Rv1245c|M.tuberculosis_H37Rv DIEVSQFKDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISSVFGLF
MLBr_01094|M.leprae_Br4923 DVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSVFGLF
MAB_1305|M.abscessus_ATCC_1997 ALEDVSMDDFEKLYMTNVFGPVALTKAVLPGMRERRRGAVVMVGSMAGTL
:* :.. . :. : :* ** : * :: :.*:
MMAR_1614|M.marinum_M TPVGSGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFRT-DFAG
MUL_3423|M.ulcerans_Agy99 TPVGSGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFRT-DFAG
MSMEG_2026|M.smegmatis_MC2_155 TPPGSGYYAAAKAAVEGLSGSLHTELAPLG--ISVTVVEPGGFRT-DFAG
MAV_3827|M.avium_104 ANPPNAYYSSTKFALEAVTEALAAEVRPLG--IKVTAIEPGAFRT-DWAT
Mvan_3508|M.vanbaalenii_PYR-1 GVTGFGHYSATKFAVEAITGVLRDEVAPWG--INVMAVEPAAFRTRAYSG
Mflv_0295|M.gilvum_PYR-GCK VRPGLAAYQSAKWAVTGFSGVLAVEVAPLG--IKVTVLEPGGMRT-DWAG
TH_3670|M.thermoresistible__bu AFADLGAYHASKWALEGLSQSLSLEVAPFG--IHVTLIEPGGYAT-DWGG
Mb1277c|M.bovis_AF2122/97 SAPGQAAYNSAKFAVRGFTEALRQEMALAGHPVKVTTVHPGGVKT-----
Rv1245c|M.tuberculosis_H37Rv SAPGQAAYNSAKFAVRGFTEALRQEMALAGHPVKVTTVHPGGVKT-----
MLBr_01094|M.leprae_Br4923 SVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIKT-----
MAB_1305|M.abscessus_ATCC_1997 HVPFRSTYSSAKSALHTVADCLRYEVAPFG--ITVSTVEPGVIAT---GI
. * ::* *: .: * *: * : * : *. *
MMAR_1614|M.marinum_M RSLVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAAIITAVESPA
MUL_3423|M.ulcerans_Agy99 RSLVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAAIITAVESPA
MSMEG_2026|M.smegmatis_MC2_155 RSLKQSAAAIDDYADTAGKRRKEHDRVHGTQPGDPVKAAAAIIKAVESPE
MAV_3827|M.avium_104 RSMKESGTPIADYTDVAA-RKDLIKQFADHLPGDPRKVAEAVLMVTGLDE
Mvan_3508|M.vanbaalenii_PYR-1 FADEPLREPVSEYRALLQGVREAMIAQDGMQPGDPRRGARAVLAAMAQDP
Mflv_0295|M.gilvum_PYR-GCK SSMR-IAPVREEYAATVGAAASLS-DPNVLGASDPAKVAGLLLDVIGMPD
TH_3670|M.thermoresistible__bu SSAR-RSATMPEYAESRAEADRVR-SQRVARPGDPKASAAALLKVVDAEK
Mb1277c|M.bovis_AF2122/97 -----AIARNATAAEGLDQAELAETFDKRVAHLSPQRAAQIILTGVAKNK
Rv1245c|M.tuberculosis_H37Rv -----AIARNATAAEGLDQAELAETFDKRVAHLSPQRAAQIILTGVAKNK
MLBr_01094|M.leprae_Br4923 -----AIARNATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVRKKK
MAB_1305|M.abscessus_ATCC_1997 ETRRNRIVPDGSPYRDAFRTVDAAMAAREEHGTATDELGRLVVDVALSPS
. . ::
MMAR_1614|M.marinum_M PPAFLLLGPDALMAYRHIAQRRDVEITDWEQLTAGTNLTP----------
MUL_3423|M.ulcerans_Agy99 PPAFLLLGPDALMAYRHIAQRRDVEITDWEQLTAGTNLTP----------
MSMEG_2026|M.smegmatis_MC2_155 PPAFLLLGSDALSAYRRVAQARAEEIDKWADLTTSTDFDS----------
MAV_3827|M.avium_104 PPLRLLLGRDVLKAMRDKIAAMSASIDEWEAVTKDVNFPGA---------
Mvan_3508|M.vanbaalenii_PYR-1 PPHRLVLGGDGFDAVKAELEAALAELHENETLSRGADFPH----------
Mflv_0295|M.gilvum_PYR-GCK PPRRLLVGPDAYRYATAAGRDLLAVDERWRTLSMSTAADDVSPEQLDPLG
TH_3670|M.thermoresistible__bu PPLRVFFGELPLQIVNADYQSRLQTWEEWQPIAVLAQG------------
Mb1277c|M.bovis_AF2122/97 --ARVLVGVDAKVLDLVVRLTG-SGYQRIFPIITGRLIPRPR--------
Rv1245c|M.tuberculosis_H37Rv --ARVLVGVDAKVLDLVVRLTG-SGYQRIFPIITGRLIPRPR--------
MLBr_01094|M.leprae_Br4923 --ARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR--------
MAB_1305|M.abscessus_ATCC_1997 PKPLYAKGSNAPIIMTAQRLLPARLFLKFLARMHGLKVR-----------
*
MMAR_1614|M.marinum_M ----
MUL_3423|M.ulcerans_Agy99 ----
MSMEG_2026|M.smegmatis_MC2_155 ----
MAV_3827|M.avium_104 ----
Mvan_3508|M.vanbaalenii_PYR-1 ----
Mflv_0295|M.gilvum_PYR-GCK SASR
TH_3670|M.thermoresistible__bu ----
Mb1277c|M.bovis_AF2122/97 ----
Rv1245c|M.tuberculosis_H37Rv ----
MLBr_01094|M.leprae_Br4923 ----
MAB_1305|M.abscessus_ATCC_1997 ----