For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTSTPPVALITGVSSGIGAAIAVRLASAGFRVVGTSRAPQRLAPIPGVETLALDVTDDTAVRSVVSEVID RTGRIDVLVNNAGLGIAGAAEESSIDQARSLFDTNFFGLIRLTNEVLPHMRRRGSGRIINISSVLGFLPA PYAALYAASKHAVEGYTESLDHELREYGVRALLVEPSYTRTDFESNMWEADTPQAAYADNRAAVRAVVAD KIRNAELPAVVADATYAAATDKRIKLRYPAGRHARQLALLKRIAPAAVLDNGIRKQTGLNSPRPTPVLAE R
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3561 | - | - | 100% (281) | oxidoreductase |
| M. marinum M | MMAR_1614 | - | 3e-31 | 41.94% (186) | short chain dehydrogenase |
| M. marinum M | MMAR_4002 | - | 8e-27 | 31.03% (290) | dehydrogenase/decarboxylase protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1079 | - | 6e-29 | 36.73% (196) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_5243 | - | 1e-39 | 43.37% (249) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1050 | - | 6e-29 | 36.73% (196) | oxidoreductase |
| M. leprae Br4923 | MLBr_01094 | - | 6e-23 | 32.31% (195) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1305 | - | 5e-33 | 32.44% (262) | short-chain dehydrogenase/reductase |
| M. avium 104 | MAV_2098 | - | 4e-89 | 60.97% (269) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2808 | - | 1e-38 | 43.85% (244) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3670 | - | 3e-29 | 33.47% (236) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2794 | - | 1e-153 | 98.93% (281) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1012 | - | 8e-40 | 43.27% (245) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3561|M.marinum_M ---MTSTPPVALITGVSSGIGAAIAVRLASAGFRVVGTSR---APQ--RL
MUL_2794|M.ulcerans_Agy99 ---MTSTPPVALITGVSSGIGAAIAVRLASAGFRVVGTSR---APQ--RL
MAV_2098|M.avium_104 ---MTHRSPVVLVTGASSGIGRAVAKAFAAKGFEVFGTTR---NPR--TA
Mflv_5243|M.gilvum_PYR-GCK ---MAT----VLITGCSSGYGRATALKFLAEGWNVVATMR---NPRPDVL
Mvan_1012|M.vanbaalenii_PYR-1 ---MTT----VLITGCSSGYGLATAHRFLDEGWNVVATMR---TPRQDVL
MSMEG_2808|M.smegmatis_MC2_155 -------MAVWLITGASRGLGSAIARAALAEGHTVVAGAR---NVPAAAA
TH_3670|M.thermoresistible__bu MGSNVWGSKVWFITGASRGFGREWAIAALDRGDRVAATAR---DVSTLDD
MAB_1305|M.abscessus_ATCC_1997 ----MSEHWTVLVTGASSGIGASAARIFAERGHRVFGTSR---NPDTITD
Mb1079|M.bovis_AF2122/97 MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVALAARREGALRRVAR
Rv1050|M.tuberculosis_H37Rv MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVALAARREGALRRVAR
MLBr_01094|M.leprae_Br4923 --MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQTEG
.:** . * * * * :
MMAR_3561|M.marinum_M API---PGVETLALDVTDDTAVRSVVSEVIDRTGRIDVLVNNAGLGIAGA
MUL_2794|M.ulcerans_Agy99 API---PGVETLALDVTDDTAVRSVVSEVIDRTGHIDVLVNNAGLGIAGA
MAV_2098|M.avium_104 EPI---PGVELVELDVTDAASVDAAAKSVIERTGRIDILVNNAGSGILGA
Mflv_5243|M.gilvum_PYR-GCK PAS---DRLRVSALDVTDPESIASAV----EAAGPLDAVVNNAGIGAVGA
Mvan_1012|M.vanbaalenii_PYR-1 PPS---DRLRVIALDVTRPDSIAAAV----AAAGPIDVLVNNAGIGAVGA
MSMEG_2808|M.smegmatis_MC2_155 ELP-HSDALTVIDLDVTNSAQVSAVADATAKRHGGIDVLVNNAGYSVLGA
TH_3670|M.thermoresistible__bu LRDRFGDAVLAMTLDVTDRAADFAAVQRAHDHFGRLDIVVNNAGYGHFGF
MAB_1305|M.abscessus_ATCC_1997 RVP----GVQYLRLDQTDKASIAECV----AQAGEVDILVNNAGESQIGA
Mb1079|M.bovis_AF2122/97 EIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAGVSLVGP
Rv1050|M.tuberculosis_H37Rv EIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAGVSLVGP
MLBr_01094|M.leprae_Br4923 QLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAGIAFTGD
** : . * :: : **** . *
MMAR_3561|M.marinum_M AE-ESSIDQARSLFDTNFFGLIRLTNEVLPHMRRRGSGRIINISSVLGFL
MUL_2794|M.ulcerans_Agy99 AE-ESSIDQARSLFDTNFFGLIRLTNEVLPHMRRRGSGRIINISSVLGFL
MAV_2098|M.avium_104 AE-ERSVAQAQRLIDTNFLGLVRLTNAVLPYLRAQGGGRVINIGSVLGFL
Mflv_5243|M.gilvum_PYR-GCK FE-ATPMSTIRELFDTNTFGVMAMTQAVVPQMRERRSGVVVNVTSSTTLA
Mvan_1012|M.vanbaalenii_PYR-1 FE-ATPMQTVRELFDTNTFGVMAMTQAVVPQMRARRSGVVVNVTSSVTLA
MSMEG_2808|M.smegmatis_MC2_155 VE-ELTDTETRDMFEVNVFGLHRMTRAVLPHMRARGRGRILNIGSVGGFA
TH_3670|M.thermoresistible__bu VE-ELTETEVRDQMETNFFGALWVTQAALPYLRRQRSGHIIQVSSIGGVS
MAB_1305|M.abscessus_ATCC_1997 LE-DVSMDDFEKLYMTNVFGPVALTKAVLPGMRERRRGAVVMVGSMAGTL
Mb1079|M.bovis_AF2122/97 VDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMSSVVGRK
Rv1050|M.tuberculosis_H37Rv VDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMSSVVGRK
MLBr_01094|M.leprae_Br4923 VE-VSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSVFGLF
: . : * .. :* : * :: : *
MMAR_3561|M.marinum_M PAPYAALYAASKHAVEGYTESLDHELREYG--VRALLVEPSYTR--TDFE
MUL_2794|M.ulcerans_Agy99 PAPYAALYAASKHAVEGYTESLDHELREYG--VRALLVEPSYTR--TDFE
MAV_2098|M.avium_104 PQPYGALYAGSKHAVEGYSESLDHETREFG--VRVSVVEPAYTR--TSFE
Mflv_5243|M.gilvum_PYR-GCK PMPLAAAYTASKSAIEGFTGSLALELGFFG--VRAKLVEPGYGPG-TQFT
Mvan_1012|M.vanbaalenii_PYR-1 AMPLAAAYTASKAAIEGFTGSLALELGFFG--VRAKLVEPGYGPG-TQFA
MSMEG_2808|M.smegmatis_MC2_155 AVASSGLYGATKFAVEAITEALALELRGSG--VSATVIEPGAFR--TDFL
TH_3670|M.thermoresistible__bu AFADLGAYHASKWALEGLSQSLSLEVAPFG--IHVTLIEPGGYA--TDWG
MAB_1305|M.abscessus_ATCC_1997 HVPFRSTYSSAKSALHTVADCLRYEVAPFG--ITVSTVEPGVIATGIETR
Mb1079|M.bovis_AF2122/97 AFARFAGYSSAMHAIAGFSDALRQELRGSG--IAVSVIHPALTQ--TPLL
Rv1050|M.tuberculosis_H37Rv AFARFAGYSSAMHAIAGFSDALRQELRGSG--IAVSVIHPALTQ--TPLL
MLBr_01094|M.leprae_Br4923 SVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIK------
. . * .: *: : .* * * : . : *.
MMAR_3561|M.marinum_M SN--MWEADTPQAAYADNRAAVRAVVADKIR-NAELPAVVADATYAAATD
MUL_2794|M.ulcerans_Agy99 SN--MWEADTPQAAYADNRAAVRAVVANKIR-NAELPAVVADATYAAAID
MAV_2098|M.avium_104 AN--MADADAPIDAYAASREHARRRMAELMK-TADDPAIVAEVVLKAATA
Mflv_5243|M.gilvum_PYR-GCK SNGVERMAGLIPAEYQDFAAPVFEEFRSPG--MVTTPDEVADVVFQAATD
Mvan_1012|M.vanbaalenii_PYR-1 SNGSHRMADLIPDEYQDFAAPIMESFGSPA--AVTTPDDVAEVVYLAATD
MSMEG_2808|M.smegmatis_MC2_155 SPRSVRFAATEIDAYADTAGAARTAFAALDGHQPGDPDKAAAAILAVAAA
TH_3670|M.thermoresistible__bu GS-SARRSATMPEYAESRAEADRVRSQRVA--RPGDPKASAAALLKVVDA
MAB_1305|M.abscessus_ATCC_1997 RNRIVPDGSPYRDAFRTVDAAMAAREEHG-----TATDELGRLVVDVALS
Mb1079|M.bovis_AF2122/97 AN--VDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARVVVPFQPRLLM
Rv1050|M.tuberculosis_H37Rv AN--VDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARVVVPFQPRLLM
MLBr_01094|M.leprae_Br4923 -------TAIARNATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVR
MMAR_3561|M.marinum_M KRIKLRYPAGRHARQLALLKRIAPAAVLDNGIRKQTGLNSP-RPTPVLAE
MUL_2794|M.ulcerans_Agy99 KRIKLRYPAGRHARQLALLKRIAPAAVLDNGIRKQTGLNSP-RPTPVLAE
MAV_2098|M.avium_104 RKPKLRYPAGPLARRLSLLKKFAPEAVLDRGIRKTNGLPAASRPHSHLQL
Mflv_5243|M.gilvum_PYR-GCK TSGRLRFAAGADAVALAQ--------------------------------
Mvan_1012|M.vanbaalenii_PYR-1 ASDRLRYAAGADAVALAQ--------------------------------
MSMEG_2808|M.smegmatis_MC2_155 DPAPLRVQLGRDCVARVERKLLDVCQELGRWRAIAESTDFSTSPAESTSG
TH_3670|M.thermoresistible__bu EKPPLRVFFGELPLQIVNADYQSRLQTWEEWQPIAVLAQG----------
MAB_1305|M.abscessus_ATCC_1997 PSPKPLYAKGSNAPIIMTAQRLLPARLFLKFLARMHGLKVR---------
Mb1079|M.bovis_AF2122/97 VGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTESAKAQAAQPE
Rv1050|M.tuberculosis_H37Rv VGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTESAKAQAAQPE
MLBr_01094|M.leprae_Br4923 KK-KARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR------
*
MMAR_3561|M.marinum_M R------
MUL_2794|M.ulcerans_Agy99 R------
MAV_2098|M.avium_104 -------
Mflv_5243|M.gilvum_PYR-GCK -------
Mvan_1012|M.vanbaalenii_PYR-1 -------
MSMEG_2808|M.smegmatis_MC2_155 TRTVGAA
TH_3670|M.thermoresistible__bu -------
MAB_1305|M.abscessus_ATCC_1997 -------
Mb1079|M.bovis_AF2122/97 RGYSSAR
Rv1050|M.tuberculosis_H37Rv RGYSSAR
MLBr_01094|M.leprae_Br4923 -------