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ATVLITGCSSGYGRATALKFLAEGWNVVATMRNPRPDVLPASDRLRVSALDVTDPESIASAVEAAGPLDA VVNNAGIGAVGAFEATPMSTIRELFDTNTFGVMAMTQAVVPQMRERRSGVVVNVTSSTTLAPMPLAAAYT ASKSAIEGFTGSLALELGFFGVRAKLVEPGYGPGTQFTSNGVERMAGLIPAEYQDFAAPVFEEFRSPGMV TTPDEVADVVFQAATDTSGRLRFAAGADAVALAQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5243 | - | - | 100% (245) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4152 | - | 3e-27 | 33.08% (260) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_0295 | - | 1e-25 | 40.00% (175) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1914c | - | 5e-21 | 34.55% (220) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1882c | - | 5e-21 | 34.55% (220) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-17 | 34.08% (179) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1305 | - | 1e-30 | 35.89% (248) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_3561 | - | 1e-39 | 43.37% (249) | oxidoreductase |
| M. avium 104 | MAV_2098 | - | 3e-34 | 38.43% (242) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2026 | - | 1e-31 | 36.61% (254) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3670 | - | 3e-25 | 38.62% (189) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2794 | - | 7e-39 | 42.97% (249) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1012 | - | 1e-112 | 83.67% (245) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5243|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1012|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3561|M.marinum_M --------------------------------------------------
MUL_2794|M.ulcerans_Agy99 --------------------------------------------------
MAV_2098|M.avium_104 --------------------------------------------------
MAB_1305|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2026|M.smegmatis_MC2_155 --------------------------------------------------
TH_3670|M.thermoresistible__bu --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Mflv_5243|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1012|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3561|M.marinum_M --------------------------------------------------
MUL_2794|M.ulcerans_Agy99 --------------------------------------------------
MAV_2098|M.avium_104 --------------------------------------------------
MAB_1305|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2026|M.smegmatis_MC2_155 --------------------------------------------------
TH_3670|M.thermoresistible__bu --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Mflv_5243|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1012|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3561|M.marinum_M --------------------------------------------------
MUL_2794|M.ulcerans_Agy99 --------------------------------------------------
MAV_2098|M.avium_104 --------------------------------------------------
MAB_1305|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2026|M.smegmatis_MC2_155 --------------------------------------------------
TH_3670|M.thermoresistible__bu --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Mflv_5243|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1012|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3561|M.marinum_M --------------------------------------------------
MUL_2794|M.ulcerans_Agy99 --------------------------------------------------
MAV_2098|M.avium_104 --------------------------------------------------
MAB_1305|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2026|M.smegmatis_MC2_155 --------------------------------------------------
TH_3670|M.thermoresistible__bu --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mflv_5243|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1012|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3561|M.marinum_M --------------------------------------------------
MUL_2794|M.ulcerans_Agy99 --------------------------------------------------
MAV_2098|M.avium_104 --------------------------------------------------
MAB_1305|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2026|M.smegmatis_MC2_155 --------------------------------------------------
TH_3670|M.thermoresistible__bu --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mflv_5243|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1012|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3561|M.marinum_M --------------------------------------------------
MUL_2794|M.ulcerans_Agy99 --------------------------------------------------
MAV_2098|M.avium_104 --------------------------------------------------
MAB_1305|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2026|M.smegmatis_MC2_155 --------------------------------------------------
TH_3670|M.thermoresistible__bu --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mflv_5243|M.gilvum_PYR-GCK -----------------------MAT----VLITGCSSGYGRATALKFLA
Mvan_1012|M.vanbaalenii_PYR-1 -----------------------MTT----VLITGCSSGYGLATAHRFLD
MMAR_3561|M.marinum_M -----------------------MTSTPPVALITGVSSGIGAAIAVRLAS
MUL_2794|M.ulcerans_Agy99 -----------------------MTSTPPVALITGVSSGIGAAIAVRLAS
MAV_2098|M.avium_104 -----------------------MTHRSPVVLVTGASSGIGRAVAKAFAA
MAB_1305|M.abscessus_ATCC_1997 ------------------------MSEHWTVLVTGASSGIGASAARIFAE
MSMEG_2026|M.smegmatis_MC2_155 ---------------------------MTTWLITGCSTGIGRTLAEAVAA
TH_3670|M.thermoresistible__bu --------------------MGSNVWGSKVWFITGASRGFGREWAIAALD
Mb1914c|M.bovis_AF2122/97 ---------------------------MKAIFITGAGSGMGREGATLFHA
Rv1882c|M.tuberculosis_H37Rv ---------------------------MKAIFITGAGSGMGREGATLFHA
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
:** . * * *
Mflv_5243|M.gilvum_PYR-GCK EGWNVVATMRNPRPD----VLPASDR--LRVSALDVTDPESIASAV----
Mvan_1012|M.vanbaalenii_PYR-1 EGWNVVATMRTPRQD----VLPPSDR--LRVIALDVTRPDSIAAAV----
MMAR_3561|M.marinum_M AGFRVVGTSRAPQR------LAPIPG--VETLALDVTDDTAVRSVVS--E
MUL_2794|M.ulcerans_Agy99 AGFRVVGTSRAPQR------LAPIPG--VETLALDVTDDTAVRSVVS--E
MAV_2098|M.avium_104 KGFEVFGTTRNPRT------AEPIPG--VELVELDVTDAASVDAAAK--S
MAB_1305|M.abscessus_ATCC_1997 RGHRVFGTSRNPDT-----ITDRVPG--VQYLRLDQTDKASIAECV----
MSMEG_2026|M.smegmatis_MC2_155 AGHNLVVTARDVSSVADI-AETAPDR--VVAAPLDVTRPEQVTAAAQ--L
TH_3670|M.thermoresistible__bu RGDRVAATARDVSTLDDL-RDRFGDA--VLAMTLDVTDRAADFAAVQ--R
Mb1914c|M.bovis_AF2122/97 NGWRVGAIDRNEDGLAALRVQLGAER--LWARAVDVTDKAALEGALADFC
Rv1882c|M.tuberculosis_H37Rv NGWRVGAIDRNEDGLAALRVQLGAER--LWARAVDVTDKAALEGALADFC
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQ--
* .: :* :
Mflv_5243|M.gilvum_PYR-GCK --EAAGPLDAVVNNAGIGAVGAFEATPMSTIRELFDTNTFGVMAMTQAVV
Mvan_1012|M.vanbaalenii_PYR-1 --AAAGPIDVLVNNAGIGAVGAFEATPMQTVRELFDTNTFGVMAMTQAVV
MMAR_3561|M.marinum_M VIDRTGRIDVLVNNAGLGIAGAAEESSIDQARSLFDTNFFGLIRLTNEVL
MUL_2794|M.ulcerans_Agy99 VIDRTGHIDVLVNNAGLGIAGAAEESSIDQARSLFDTNFFGLIRLTNEVL
MAV_2098|M.avium_104 VIERTGRIDILVNNAGSGILGAAEERSVAQAQRLIDTNFLGLVRLTNAVL
MAB_1305|M.abscessus_ATCC_1997 --AQAGEVDILVNNAGESQIGALEDVSMDDFEKLYMTNVFGPVALTKAVL
MSMEG_2026|M.smegmatis_MC2_155 ADERFGGVDVLVNNAGYGYRAAVEEGDDADVRTLFDTHIFGTVATIKAVL
TH_3670|M.thermoresistible__bu AHDHFGRLDIVVNNAGYGHFGFVEELTETEVRDQMETNFFGALWVTQAAL
Mb1914c|M.bovis_AF2122/97 AGNVGGGLDMMWNNAGIGEGGWFEDVPYEAAVRVVDVNFKAVLTGAYAAL
Rv1882c|M.tuberculosis_H37Rv AGNVGGGLDMMWNNAGIGEGGWFEDVPYEAAVRVVDVNFKAVLTGAYAAL
MLBr_00862|M.leprae_Br4923 VSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFG
* * : **** . . .: . :
Mflv_5243|M.gilvum_PYR-GCK PQMRER-RSGVVVNVTSSTTLAPMPLAAAYTASKSAIEGFTGSLALELGF
Mvan_1012|M.vanbaalenii_PYR-1 PQMRAR-RSGVVVNVTSSVTLAAMPLAAAYTASKAAIEGFTGSLALELGF
MMAR_3561|M.marinum_M PHMRRR-GSGRIINISSVLGFLPAPYAALYAASKHAVEGYTESLDHELRE
MUL_2794|M.ulcerans_Agy99 PHMRRR-GSGRIINISSVLGFLPAPYAALYAASKHAVEGYTESLDHELRE
MAV_2098|M.avium_104 PYLRAQ-GGGRVINIGSVLGFLPQPYGALYAGSKHAVEGYSESLDHETRE
MAB_1305|M.abscessus_ATCC_1997 PGMRER-RRGAVVMVGSMAGTLHVPFRSTYSSAKSALHTVADCLRYEVAP
MSMEG_2026|M.smegmatis_MC2_155 PGMRAR-RRGAIVNISSIGAQITPPGSGYYAAAKAAVEGLSGSLHTELAP
TH_3670|M.thermoresistible__bu PYLRRQ-RSGHIIQVSSIGGVSAFADLGAYHASKWALEGLSQSLSLEVAP
Mb1914c|M.bovis_AF2122/97 PYLKKA-PGSLMFSTSSSSGTYGMPRIAVYSATKHAVKGLTEALSVEWQR
Rv1882c|M.tuberculosis_H37Rv PYLKKA-PGSLMFSTSSSSGTYGMPRIAVYSATKHAVKGLTEALSVEWQR
MLBr_00862|M.leprae_Br4923 QRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDA
: . :. * . * :* * : .* *
Mflv_5243|M.gilvum_PYR-GCK FGVRAKLVEPGYGPGTQFTSNGVERMAGLIPAEYQDF----AAPVFEEFR
Mvan_1012|M.vanbaalenii_PYR-1 FGVRAKLVEPGYGPGTQFASNGSHRMADLIPDEYQDF----AAPIMESFG
MMAR_3561|M.marinum_M YGVRALLVEPSYTR-TDFESN--MWEADTPQAAYADN----RAAVRAVVA
MUL_2794|M.ulcerans_Agy99 YGVRALLVEPSYTR-TDFESN--MWEADTPQAAYADN----RAAVRAVVA
MAV_2098|M.avium_104 FGVRVSVVEPAYTR-TSFEAN--MADADAPIDAYAAS----REHARRRMA
MAB_1305|M.abscessus_ATCC_1997 FGITVSTVEPGVIA-TGIETR--RNRIVPDGSPYRDA----FRTVDAAMA
MSMEG_2026|M.smegmatis_MC2_155 LGISVTVVEPGGFR-TDFAGR-SLKQSAAAIDDYADTAGKRRKEHDRVHG
TH_3670|M.thermoresistible__bu FGIHVTLIEPGGYA-TDWGGS-SARR-SATMPEYAES----RAEADRVRS
Mb1914c|M.bovis_AF2122/97 HGVRVADVLPGLIDTAILTST----RQHSDEGPYTIS----AEQIRAAAP
Rv1882c|M.tuberculosis_H37Rv HGVRVADVLPGLIDTAILTST----RQHSDEGPYTIS----AEQIRAAAP
MLBr_00862|M.leprae_Br4923 VGVGLTTICPGVIDTNIIQST----RIDTPTAKQERV----RDRRGQLDM
*: : *.
Mflv_5243|M.gilvum_PYR-GCK SPG-MVTTPDEVADVVFQAATDTSGRLRFAAGADAVALAQ----------
Mvan_1012|M.vanbaalenii_PYR-1 SPA-AVTTPDDVAEVVYLAATDASDRLRYAAGADAVALAQ----------
MMAR_3561|M.marinum_M DKIRNAELPAVVADATYAAATDKRIKLRYPAGRHARQLALLKRIAPAAVL
MUL_2794|M.ulcerans_Agy99 NKIRNAELPAVVADATYAAAIDKRIKLRYPAGRHARQLALLKRIAPAAVL
MAV_2098|M.avium_104 ELMKTADDPAIVAEVVLKAATARKPKLRYPAGPLARRLSLLKKFAPEAVL
MAB_1305|M.abscessus_ATCC_1997 AREEHGTATDELGRLVVDVALSPSPKPLYAKGSNAPIIMTAQRLLPARLF
MSMEG_2026|M.smegmatis_MC2_155 ---TQPGDPVKAAAAIIKAVESPEPPAFLLLGSDALSAYRRVAQARAEEI
TH_3670|M.thermoresistible__bu QRVARPGDPKASAAALLKVVDAEKPPLRVFFGELPLQIVNADYQSRLQTW
Mb1914c|M.bovis_AF2122/97 KKGMFRLMPSSSVAEAAWRAYQHPTRLHWYVPRSIRWIDRLKGVSPEFVR
Rv1882c|M.tuberculosis_H37Rv KKGMFRLMPSSSVAEAAWRAYQHPTRLHWYVPRSIRWIDRLKGVSPEFVR
MLBr_00862|M.leprae_Br4923 MFRLRRYGPDKVADTILSAIKKNKP--IRPVAPEAYALYGISRVLPQVLR
.
Mflv_5243|M.gilvum_PYR-GCK -----------------------
Mvan_1012|M.vanbaalenii_PYR-1 -----------------------
MMAR_3561|M.marinum_M DNGIRKQTGLNSP-RPTPVLAER
MUL_2794|M.ulcerans_Agy99 DNGIRKQTGLNSP-RPTPVLAER
MAV_2098|M.avium_104 DRGIRKTNGLPAASRPHSHLQL-
MAB_1305|M.abscessus_ATCC_1997 LKFLARMHGLKVR----------
MSMEG_2026|M.smegmatis_MC2_155 DKWADLTTSTDFDS---------
TH_3670|M.thermoresistible__bu EEWQPIAVLAQG-----------
Mb1914c|M.bovis_AF2122/97 RHIAKSLATLEPKRK--------
Rv1882c|M.tuberculosis_H37Rv RHIAKSLATLEPKRK--------
MLBr_00862|M.leprae_Br4923 STARIRVI---------------