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MPYPTDNPATWFVTGASRGLGAELVRQLLRRGDNVAATTRSAERLSAALAGVDTGRLLPLVVDLTDAAAV DGAVAAALDRFGRLDVVVNNAGYGFLGAVEETTDAEIRQMLDVQVSGVWNVLRSAVPHLRAARSGHIINV SSILGLTAVPGWGLYCAGKFALNGMSEALAAELAGFGIRVTIVEPGYFRTDFLTTESLALPTAAGDAYPA IREMTEQHLQLQGSQLGDPVKGAAAVIHVAVTGGGPLHQLLGSDAVSYAEAKIDALVADVKAGRDLALTT DHR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5466 | - | - | 100% (283) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0982 | - | 2e-49 | 42.91% (268) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3508 | - | 9e-39 | 36.96% (276) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1277c | - | 8e-26 | 37.43% (187) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_0930 | - | 1e-41 | 37.32% (276) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1245c | - | 8e-26 | 37.43% (187) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01094 | - | 4e-24 | 36.36% (187) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3405 | - | 2e-28 | 39.01% (182) | short chain dehydrogenase |
| M. marinum M | MMAR_1614 | - | 3e-46 | 41.13% (248) | short chain dehydrogenase |
| M. avium 104 | MAV_4982 | - | 1e-50 | 41.30% (276) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_1628 | - | 1e-123 | 75.97% (283) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3670 | - | 2e-44 | 43.39% (242) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3423 | - | 1e-46 | 41.13% (248) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5466|M.vanbaalenii_PYR-1 MPYPTDNPATWFVTGASRG-LGAELVRQLLRRGDNVAATTRSAERLSAAL
MSMEG_1628|M.smegmatis_MC2_155 MSYPTTRPATWFVTGTSKG-LGLELVRQLLARGDNVAATTRSTERLHAGL
MAV_4982|M.avium_104 ------MPKTWFITGSSRG-LGRALTTAVLDHGDHVVATARRPAQLDELV
TH_3670|M.thermoresistible__bu MGSNVWGSKVWFITGASRG-FGREWAIAALDRGDRVAATARDVSTLDDLR
MMAR_1614|M.marinum_M -------MSTWLITGCSTG-LGRALAEAVIDAGHHTVATARSVGGVADLV
MUL_3423|M.ulcerans_Agy99 -------MSTWLITGCSTG-LGRALAEAVIDAGHHTVATARSVGGVADLA
Mflv_0930|M.gilvum_PYR-GCK ------MSKRWFVTGGTPGGFGVAFAEAALEAGDRVVITSRRPHELAAWA
Mb1277c|M.bovis_AF2122/97 --MEGFAGKVAVVTGAGSG-IGQALAIELARSGAKVAISDVDTDGLADTE
Rv1245c|M.tuberculosis_H37Rv --MEGFAGKVAVVTGAGSG-IGQALAIELARSGAKVAISDVDTDGLADTE
MLBr_01094|M.leprae_Br4923 --MEGFAGKVAVVTGAGSG-IGQALAIELARSGAKLAISDVDGEGLAQTE
MAB_3405|M.abscessus_ATCC_1997 --MDKITGKNIAITGAARG-IGYATATALLRRGARVVIGDRDVEALGSAV
:** * :* . * . . :
Mvan_5466|M.vanbaalenii_PYR-1 AGVDTG--RLLPLVVDLTDAAAVDGAVAAALDRFGRLDVVVNNAGYGFLG
MSMEG_1628|M.smegmatis_MC2_155 EGVDTG--SLLPIEVDLADPSAVHKAVTATVERFGHLDVVVNNAGYGFLA
MAV_4982|M.avium_104 DRYGP---RIRACELDVTDRAAARRAIAAAVTAFGRIDVVVNNAGYANSA
TH_3670|M.thermoresistible__bu DRFGD---AVLAMTLDVTDRAADFAAVQRAHDHFGRLDIVVNNAGYGHFG
MMAR_1614|M.marinum_M QRSPE---RVLPLALDITEPDQITAAVQAAQQRFGGIDVLVNNAGYGYRA
MUL_3423|M.ulcerans_Agy99 QRSPE---RVLPLALDITEPDQITAAMQAAQQRFGGIDVLVNNAGYGYRA
Mflv_0930|M.gilvum_PYR-GCK DGYDD---RVLVVPLELTDAAQVQRVVQAAEEHFGGIDVLVNNAGRGWYG
Mb1277c|M.bovis_AF2122/97 HRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAGIAFTG
Rv1245c|M.tuberculosis_H37Rv HRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAGIAFTG
MLBr_01094|M.leprae_Br4923 GQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAGIAFTG
MAB_3405|M.abscessus_ATCC_1997 EGLKEEG-NVDAHPLDVTDPASFKRFLEAASAG-GPIDVLVNNAGVMPIG
::::: . * :: : **** .
Mvan_5466|M.vanbaalenii_PYR-1 AVEETTDAEIRQMLDVQVSGVWNVLRSAVPHLRAARSGHIINVSSILG-L
MSMEG_1628|M.smegmatis_MC2_155 SVEDTTDADIRQMLDVQVIGTWNVLRAAIPHLRAARSGHIVNVSSILG-L
MAV_4982|M.avium_104 PVEEVSDDDFRAQVETNFFGVVNVTKAALPVLHRQRAGHIVQISSVGGRV
TH_3670|M.thermoresistible__bu FVEELTETEVRDQMETNFFGALWVTQAALPYLRRQRSGHIIQVSSIGG-V
MMAR_1614|M.marinum_M AVEEGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISSIAVAL
MUL_3423|M.ulcerans_Agy99 AVEEGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISSIAVAL
Mflv_0930|M.gilvum_PYR-GCK SIEGMDESSLRAMFELNFFAVLSVTRAVLPGMRARGSGWIVNVSSVAG-L
Mb1277c|M.bovis_AF2122/97 DIEVSQFKDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISSVFG-L
Rv1245c|M.tuberculosis_H37Rv DIEVSQFKDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISSVFG-L
MLBr_01094|M.leprae_Br4923 DVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSVFG-L
MAB_3405|M.abscessus_ATCC_1997 PFLSTSDRAIRSMLEVNLYGVINGCQLALPEMVARRRGQVVNIASVAG-L
. .. .: . .. : :* : * :::::*: :
Mvan_5466|M.vanbaalenii_PYR-1 TAVPGWGLYCAGKFALNGMSEALAAELAGFG--IRVTIVEPGYFRT-DFL
MSMEG_1628|M.smegmatis_MC2_155 TAMPGWGLYCAGKFALNGMSEALAGEMAEFG--VNVSIVEPGYFRT-SFL
MAV_4982|M.avium_104 GGSPGIAAYQASKFAVAGFSEALAAEVAPLG--IKVTIAEPGALRT-EWA
TH_3670|M.thermoresistible__bu SAFADLGAYHASKWALEGLSQSLSLEVAPFG--IHVTLIEPGGYAT-DWG
MMAR_1614|M.marinum_M TPVG-SGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFRT-DFA
MUL_3423|M.ulcerans_Agy99 TPVG-SGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFRT-DFA
Mflv_0930|M.gilvum_PYR-GCK VAAPGFGYYSATKFAIEAVTDALRDEVSTHG--ISVLAVEPGAFRTNAYA
Mb1277c|M.bovis_AF2122/97 FSAPGQAAYNSAKFAVRGFTEALRQEMALAGHPVKVTTVHPGGVKT----
Rv1245c|M.tuberculosis_H37Rv FSAPGQAAYNSAKFAVRGFTEALRQEMALAGHPVKVTTVHPGGVKT----
MLBr_01094|M.leprae_Br4923 FSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIKT----
MAB_3405|M.abscessus_ATCC_1997 MAVPGMAVYNASKFGVVGLSRALSDEFAPQG--VQVSAVLPTFTNTELIA
. * : * .: ..: :* *.: * : * * *
Mvan_5466|M.vanbaalenii_PYR-1 TTESLALPTAAGDAYPAIREMTEQHLQLQGSQLGDPVKGAAAVIHVAVTG
MSMEG_1628|M.smegmatis_MC2_155 TTDSLALPEATSDAYPGIHEMTQNHLALQGSQLGDPVKGAEAIIDIAVAG
MAV_4982|M.avium_104 GSSMAVATVSP-DYESTVGAMNRRRAGFNRNAPGDPARAAHAIIEVVIAD
TH_3670|M.thermoresistible__bu GSSARRSATMP-EYAESRAEADRVRS-QRVARPGDPKASAAALLKVVDAE
MMAR_1614|M.marinum_M GRSLVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAAIITAVESP
MUL_3423|M.ulcerans_Agy99 GRSLVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAAIITAVESP
Mflv_0930|M.gilvum_PYR-GCK GFANKPVAETIPSYHDMLEEVRAAFVEMDGVQPGDPRRGARAVIAAMAQD
Mb1277c|M.bovis_AF2122/97 ------AIARNATAAEGLDQAELAETFDKRVAHLSPQRAAQIILTGVAKN
Rv1245c|M.tuberculosis_H37Rv ------AIARNATAAEGLDQAELAETFDKRVAHLSPQRAAQIILTGVAKN
MLBr_01094|M.leprae_Br4923 ------AIARNATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVRKK
MAB_3405|M.abscessus_ATCC_1997 GTDSTGAQKPVEPEDIAAAVVRIIEKPRVQVTVPKPLGAVTTIVNSLPTG
.* .. ::
Mvan_5466|M.vanbaalenii_PYR-1 GGPLHQLLG---------SDAVSYAEAKIDALVADVKAGRDLALTTDHR-
MSMEG_1628|M.smegmatis_MC2_155 QGPLHQLLG---------SDSYEYAQAKVAALSGDIEAGRELAFTTDHR-
MAV_4982|M.avium_104 DPPLRLLLGSDALSAALAKSHQQIAEANRWAELSKSIDYPPVATPHRAAR
TH_3670|M.thermoresistible__bu KPPLRVFFG---------ELPLQIVNADYQSRLQTWEEWQPIAVLAQG--
MMAR_1614|M.marinum_M APPAFLLLG------PDALMAYRHIAQRRDVEITDWEQLTAGTNLTP---
MUL_3423|M.ulcerans_Agy99 APPAFLLLG------PDALMAYRHIAQRRDVEITDWEQLTAGTNLTP---
Mflv_0930|M.gilvum_PYR-GCK PPPRRLVLG---------NSGYDAVIDALEQSLGDIRANETLSRSADFPT
Mb1277c|M.bovis_AF2122/97 K--ARVLVG--------VDAKVLDLVVRLTG-SGYQRIFPIITGRLIPRP
Rv1245c|M.tuberculosis_H37Rv K--ARVLVG--------VDAKVLDLVVRLTG-SGYQRIFPIITGRLIPRP
MLBr_01094|M.leprae_Br4923 K--ARVLVG--------PDAKVANVVVRFSGGAGYQRLFAQVASRLILNQ
MAB_3405|M.abscessus_ATCC_1997 VRRFMSKKTG--------TDRVFLDFDTSARTAYENRAGSSLGVTKPDGE
Mvan_5466|M.vanbaalenii_PYR-1 --
MSMEG_1628|M.smegmatis_MC2_155 --
MAV_4982|M.avium_104 SR
TH_3670|M.thermoresistible__bu --
MMAR_1614|M.marinum_M --
MUL_3423|M.ulcerans_Agy99 --
Mflv_0930|M.gilvum_PYR-GCK --
Mb1277c|M.bovis_AF2122/97 R-
Rv1245c|M.tuberculosis_H37Rv R-
MLBr_01094|M.leprae_Br4923 R-
MAB_3405|M.abscessus_ATCC_1997 --