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MTSTPPVALITGVSSGIGAAIAVRLASAGFRVVGTSRAPQRLAPIPGVETLALDVTDDTAVRSVVSEVID RTGHIDVLVNNAGLGIAGAAEESSIDQARSLFDTNFFGLIRLTNEVLPHMRRRGSGRIINISSVLGFLPA PYAALYAASKHAVEGYTESLDHELREYGVRALLVEPSYTRTDFESNMWEADTPQAAYADNRAAVRAVVAN KIRNAELPAVVADATYAAAIDKRIKLRYPAGRHARQLALLKRIAPAAVLDNGIRKQTGLNSPRPTPVLAE R
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2794 | - | - | 100% (281) | short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_3423 | - | 5e-31 | 41.40% (186) | short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_2282 | - | 3e-23 | 34.70% (219) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1079 | - | 2e-28 | 36.22% (196) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_5243 | - | 1e-38 | 42.97% (249) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1050 | - | 2e-28 | 36.22% (196) | oxidoreductase |
| M. leprae Br4923 | MLBr_01094 | - | 1e-22 | 32.31% (195) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1305 | - | 2e-33 | 32.44% (262) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_3561 | - | 1e-153 | 98.93% (281) | oxidoreductase |
| M. avium 104 | MAV_2098 | - | 1e-87 | 60.22% (269) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2808 | - | 2e-38 | 44.03% (243) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3605 | - | 8e-29 | 32.06% (287) | PUTATIVE NAD dependent epimerase/dehydratase family protein |
| M. vanbaalenii PYR-1 | Mvan_1012 | - | 3e-39 | 42.86% (245) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2794|M.ulcerans_Agy99 ----MTSTPPVALITGVSSGIGAAIAVRLASAGFRVVGTSRAP-------
MMAR_3561|M.marinum_M ----MTSTPPVALITGVSSGIGAAIAVRLASAGFRVVGTSRAP-------
MAV_2098|M.avium_104 ----MTHRSPVVLVTGASSGIGRAVAKAFAAKGFEVFGTTRNP-------
Mflv_5243|M.gilvum_PYR-GCK --------MATVLITGCSSGYGRATALKFLAEGWNVVATMRNP-------
Mvan_1012|M.vanbaalenii_PYR-1 --------MTTVLITGCSSGYGLATAHRFLDEGWNVVATMRTP-------
MSMEG_2808|M.smegmatis_MC2_155 --------MAVWLITGASRGLGSAIARAALAEGHTVVAGARNVPA-----
MAB_1305|M.abscessus_ATCC_1997 -----MSEHWTVLVTGASSGIGASAARIFAERGHRVFGTSRNPDT-----
TH_3605|M.thermoresistible__bu VTDRQPAGPRSVVITGASRGLGLASATHLYRRGWRVVAAMRSVDAGMARL
Mb1079|M.bovis_AF2122/97 -MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVALAARREGALRR--
Rv1050|M.tuberculosis_H37Rv -MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVALAARREGALRR--
MLBr_01094|M.leprae_Br4923 ---MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQT-
::** . * * : * * :
MUL_2794|M.ulcerans_Agy99 ----QRLAPIPGVETLALDVTDDTAVRSVVSEVIDRTGHIDVLVNNAGLG
MMAR_3561|M.marinum_M ----QRLAPIPGVETLALDVTDDTAVRSVVSEVIDRTGRIDVLVNNAGLG
MAV_2098|M.avium_104 ----RTAEPIPGVELVELDVTDAASVDAAAKSVIERTGRIDILVNNAGSG
Mflv_5243|M.gilvum_PYR-GCK --RPDVLPASDRLRVSALDVTDPESIASAVEAAGP----LDAVVNNAGIG
Mvan_1012|M.vanbaalenii_PYR-1 --RQDVLPPSDRLRVIALDVTRPDSIAAAVAAAGP----IDVLVNNAGIG
MSMEG_2808|M.smegmatis_MC2_155 --AAAELPHSDALTVIDLDVTNSAQVSAVADATAKRHGGIDVLVNNAGYS
MAB_1305|M.abscessus_ATCC_1997 -----ITDRVPGVQYLRLDQTDKASIAECVAQAG----EVDILVNNAGES
TH_3605|M.thermoresistible__bu AETTGAAADDPRLIPVALDLTDAASITAAAKEIEGSVGAPYAVVHNAGIS
Mb1079|M.bovis_AF2122/97 -VAREIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAGVS
Rv1050|M.tuberculosis_H37Rv -VAREIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAGVS
MLBr_01094|M.leprae_Br4923 --EGQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAGIA
** : . . : :*** .
MUL_2794|M.ulcerans_Agy99 IAGAAE-ESSIDQARSLFDTNFFGLIRLTNEVLPHMRRRGSGRIINISSV
MMAR_3561|M.marinum_M IAGAAE-ESSIDQARSLFDTNFFGLIRLTNEVLPHMRRRGSGRIINISSV
MAV_2098|M.avium_104 ILGAAE-ERSVAQAQRLIDTNFLGLVRLTNAVLPYLRAQGGGRVINIGSV
Mflv_5243|M.gilvum_PYR-GCK AVGAFE-ATPMSTIRELFDTNTFGVMAMTQAVVPQMRERRSGVVVNVTSS
Mvan_1012|M.vanbaalenii_PYR-1 AVGAFE-ATPMQTVRELFDTNTFGVMAMTQAVVPQMRARRSGVVVNVTSS
MSMEG_2808|M.smegmatis_MC2_155 VLGAVE-ELTDTETRDMFEVNVFGLHRMTRAVLPHMRARGRGRILNIGSV
MAB_1305|M.abscessus_ATCC_1997 QIGALE-DVSMDDFEKLYMTNVFGPVALTKAVLPGMRERRRGAVVMVGSM
TH_3605|M.thermoresistible__bu AAGMVE-ETPLSLWEQMFATTVFGPVALTRELLPGMRRAGRGRIVLVSSQ
Mb1079|M.bovis_AF2122/97 LVGPVDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMSSV
Rv1050|M.tuberculosis_H37Rv LVGPVDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMSSV
MLBr_01094|M.leprae_Br4923 FTGDVE-VSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSV
* : . : * .. .:* : * :: : *
MUL_2794|M.ulcerans_Agy99 LGFLPAPYAALYAASKHAVEGYTESLDHELREYG--VRALLVEPS-YTRT
MMAR_3561|M.marinum_M LGFLPAPYAALYAASKHAVEGYTESLDHELREYG--VRALLVEPS-YTRT
MAV_2098|M.avium_104 LGFLPQPYGALYAGSKHAVEGYSESLDHETREFG--VRVSVVEPA-YTRT
Mflv_5243|M.gilvum_PYR-GCK TTLAPMPLAAAYTASKSAIEGFTGSLALELGFFG--VRAKLVEPGYGPGT
Mvan_1012|M.vanbaalenii_PYR-1 VTLAAMPLAAAYTASKAAIEGFTGSLALELGFFG--VRAKLVEPGYGPGT
MSMEG_2808|M.smegmatis_MC2_155 GGFAAVASSGLYGATKFAVEAITEALALELRGSG--VSATVIEPG-AFRT
MAB_1305|M.abscessus_ATCC_1997 AGTLHVPFRSTYSSAKSALHTVADCLRYEVAPFG--ITVSTVEPG-VIAT
TH_3605|M.thermoresistible__bu QGVWGMPSTAPYSAAKGALERWAEAMAGEVNPFG--IGVTVLVTG-VYDT
Mb1079|M.bovis_AF2122/97 VGRKAFARFAGYSSAMHAIAGFSDALRQELRGSG--IAVSVIHPA-LTQT
Rv1050|M.tuberculosis_H37Rv VGRKAFARFAGYSSAMHAIAGFSDALRQELRGSG--IAVSVIHPA-LTQT
MLBr_01094|M.leprae_Br4923 FGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPG-GIKT
. . * .: *: : .: * * : . : .. *
MUL_2794|M.ulcerans_Agy99 DFESN--MWEADTPQAAYADNRAAVRAVVANKIR-NAELPAVVADATYAA
MMAR_3561|M.marinum_M DFESN--MWEADTPQAAYADNRAAVRAVVADKIR-NAELPAVVADATYAA
MAV_2098|M.avium_104 SFEAN--MADADAPIDAYAASREHARRRMAELMK-TADDPAIVAEVVLKA
Mflv_5243|M.gilvum_PYR-GCK QFTSNGVERMAGLIPAEYQDFAAPVFEEFRSPG--MVTTPDEVADVVFQA
Mvan_1012|M.vanbaalenii_PYR-1 QFASNGSHRMADLIPDEYQDFAAPIMESFGSPA--AVTTPDDVAEVVYLA
MSMEG_2808|M.smegmatis_MC2_155 DFLSPRSVRFAATEIDAYADTAGAARTAFAALDGHQPGDPDKAAAAILAV
MAB_1305|M.abscessus_ATCC_1997 GIETRRNRIVPDGSP--YRDAFRTVDAAMAAREEHGTATDELGRLVVDVA
TH_3605|M.thermoresistible__bu EIITDAGTTDCRDLQGVYARHHRTMDKRGRAAVAKAARPPEKFALALSKA
Mb1079|M.bovis_AF2122/97 PLLAN--VDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARVVVPFQPR
Rv1050|M.tuberculosis_H37Rv PLLAN--VDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARVVVPFQPR
MLBr_01094|M.leprae_Br4923 AIARN----------ATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKA
:
MUL_2794|M.ulcerans_Agy99 AIDKRIKLRYPAGRHARQLALLKRIAPAAVLDNG--IRKQTGLNSP-RPT
MMAR_3561|M.marinum_M ATDKRIKLRYPAGRHARQLALLKRIAPAAVLDNG--IRKQTGLNSP-RPT
MAV_2098|M.avium_104 ATARKPKLRYPAGPLARRLSLLKKFAPEAVLDRG--IRKTNGLPAASRPH
Mflv_5243|M.gilvum_PYR-GCK ATDTSGRLRFAAGADAVALAQ-----------------------------
Mvan_1012|M.vanbaalenii_PYR-1 ATDASDRLRYAAGADAVALAQ-----------------------------
MSMEG_2808|M.smegmatis_MC2_155 AAADPAPLRVQLGRDCVARVERKLLDVCQELGRWRAIAESTDFSTSPAES
MAB_1305|M.abscessus_ATCC_1997 LS-PSPKPLYAKGSNAPIIMTAQRLLPARLFLKFLARMHGLKVR------
TH_3605|M.thermoresistible__bu LDNPQPFVKRPAGPSARMLMIANRILPPATLHQMIRLSLGLPRFGRLTTR
Mb1079|M.bovis_AF2122/97 LLMVGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTESAKAQAA
Rv1050|M.tuberculosis_H37Rv LLMVGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTESAKAQAA
MLBr_01094|M.leprae_Br4923 VRKKKAR--VLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR---
*
MUL_2794|M.ulcerans_Agy99 PVLAER----
MMAR_3561|M.marinum_M PVLAER----
MAV_2098|M.avium_104 SHLQL-----
Mflv_5243|M.gilvum_PYR-GCK ----------
Mvan_1012|M.vanbaalenii_PYR-1 ----------
MSMEG_2808|M.smegmatis_MC2_155 TSGTRTVGAA
MAB_1305|M.abscessus_ATCC_1997 ----------
TH_3605|M.thermoresistible__bu EDTHA-----
Mb1079|M.bovis_AF2122/97 QPERGYSSAR
Rv1050|M.tuberculosis_H37Rv QPERGYSSAR
MLBr_01094|M.leprae_Br4923 ----------