For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTHRSPVVLVTGASSGIGRAVAKAFAAKGFEVFGTTRNPRTAEPIPGVELVELDVTDAASVDAAAKSVIE RTGRIDILVNNAGSGILGAAEERSVAQAQRLIDTNFLGLVRLTNAVLPYLRAQGGGRVINIGSVLGFLPQ PYGALYAGSKHAVEGYSESLDHETREFGVRVSVVEPAYTRTSFEANMADADAPIDAYAASREHARRRMAE LMKTADDPAIVAEVVLKAATARKPKLRYPAGPLARRLSLLKKFAPEAVLDRGIRKTNGLPAASRPHSHLQ L
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2098 | - | - | 100% (281) | short chain dehydrogenase |
| M. avium 104 | MAV_3827 | - | 7e-34 | 37.34% (241) | short chain dehydrogenase |
| M. avium 104 | MAV_4982 | - | 4e-32 | 33.70% (276) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1079 | - | 1e-30 | 39.20% (199) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_5243 | - | 4e-34 | 38.43% (242) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1050 | - | 1e-30 | 39.20% (199) | oxidoreductase |
| M. leprae Br4923 | MLBr_01094 | - | 9e-24 | 31.70% (265) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1305 | - | 3e-37 | 35.53% (273) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_3561 | - | 4e-89 | 60.97% (269) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_2808 | - | 1e-39 | 41.32% (242) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3670 | - | 7e-35 | 35.66% (272) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2794 | - | 1e-87 | 60.22% (269) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5466 | - | 7e-36 | 37.72% (228) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3561|M.marinum_M ---MTSTPPVALITGVSSGIGAAIAVRLASAGFRVVGTSRAPQRLAPIP-
MUL_2794|M.ulcerans_Agy99 ---MTSTPPVALITGVSSGIGAAIAVRLASAGFRVVGTSRAPQRLAPIP-
MAV_2098|M.avium_104 ---MTHRSPVVLVTGASSGIGRAVAKAFAAKGFEVFGTTRNPRTAEPIP-
Mflv_5243|M.gilvum_PYR-GCK -------MATVLITGCSSGYGRATALKFLAEGWNVVATMRNP-RPDVLP-
TH_3670|M.thermoresistible__bu MGSNVWGSKVWFITGASRGFGREWAIAALDRGDRVAATARDVSTLDDLRD
Mvan_5466|M.vanbaalenii_PYR-1 MPYPTDNPATWFVTGASRGLGAELVRQLLRRGDNVAATTRSAERLSAALA
MSMEG_2808|M.smegmatis_MC2_155 -------MAVWLITGASRGLGSAIARAALAEGHTVVAGARNVPAAAAELP
MAB_1305|M.abscessus_ATCC_1997 ----MSEHWTVLVTGASSGIGASAARIFAERGHRVFGTSRNPDTITDRVP
Mb1079|M.bovis_AF2122/97 MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVALAARREGALRRVAR
Rv1050|M.tuberculosis_H37Rv MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVALAARREGALRRVAR
MLBr_01094|M.leprae_Br4923 --MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQTEG
. .:** . * * . * :
MMAR_3561|M.marinum_M -------GVETLALDVTDDTAVRSVVSEVIDRTGRIDVLVNNAGLGIAGA
MUL_2794|M.ulcerans_Agy99 -------GVETLALDVTDDTAVRSVVSEVIDRTGHIDVLVNNAGLGIAGA
MAV_2098|M.avium_104 -------GVELVELDVTDAASVDAAAKSVIERTGRIDILVNNAGSGILGA
Mflv_5243|M.gilvum_PYR-GCK -------ASDRLRVSALDVTDPESIAS-AVEAAGPLDAVVNNAGIGAVGA
TH_3670|M.thermoresistible__bu RFG-D--AVLAMTLDVTDRAADFAAVQRAHDHFGRLDIVVNNAGYGHFGF
Mvan_5466|M.vanbaalenii_PYR-1 GVDTG--RLLPLVVDLTDAAAVDGAVAAALDRFGRLDVVVNNAGYGFLGA
MSMEG_2808|M.smegmatis_MC2_155 HSD----ALTVIDLDVTNSAQVSAVADATAKRHGGIDVLVNNAGYSVLGA
MAB_1305|M.abscessus_ATCC_1997 -------GVQYLRLDQTDKAS----IAECVAQAGEVDILVNNAGESQIGA
Mb1079|M.bovis_AF2122/97 EIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAGVSLVGP
Rv1050|M.tuberculosis_H37Rv EIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAGVSLVGP
MLBr_01094|M.leprae_Br4923 QLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAGIAFTGD
:. . * :: : **** . *
MMAR_3561|M.marinum_M AE-ESSIDQARSLFDTNFFGLIRLTNEVLPHMRRRGSGRIINISSVLGFL
MUL_2794|M.ulcerans_Agy99 AE-ESSIDQARSLFDTNFFGLIRLTNEVLPHMRRRGSGRIINISSVLGFL
MAV_2098|M.avium_104 AE-ERSVAQAQRLIDTNFLGLVRLTNAVLPYLRAQGGGRVINIGSVLGFL
Mflv_5243|M.gilvum_PYR-GCK FE-ATPMSTIRELFDTNTFGVMAMTQAVVPQMRERRSGVVVNVTSSTTLA
TH_3670|M.thermoresistible__bu VE-ELTETEVRDQMETNFFGALWVTQAALPYLRRQRSGHIIQVSSIGGVS
Mvan_5466|M.vanbaalenii_PYR-1 VE-ETTDAEIRQMLDVQVSGVWNVLRSAVPHLRAARSGHIINVSSILGLT
MSMEG_2808|M.smegmatis_MC2_155 VE-ELTDTETRDMFEVNVFGLHRMTRAVLPHMRARGRGRILNIGSVGGFA
MAB_1305|M.abscessus_ATCC_1997 LE-DVSMDDFEKLYMTNVFGPVALTKAVLPGMRERRRGAVVMVGSMAGTL
Mb1079|M.bovis_AF2122/97 VDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMSSVVGRK
Rv1050|M.tuberculosis_H37Rv VDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMSSVVGRK
MLBr_01094|M.leprae_Br4923 VE-VSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSVFGLF
: . : * . :* : * :: : *
MMAR_3561|M.marinum_M PAPYAALYAASKHAVEGYTESLDHELREYG--VRALLVEPSYTR-TDFES
MUL_2794|M.ulcerans_Agy99 PAPYAALYAASKHAVEGYTESLDHELREYG--VRALLVEPSYTR-TDFES
MAV_2098|M.avium_104 PQPYGALYAGSKHAVEGYSESLDHETREFG--VRVSVVEPAYTR-TSFEA
Mflv_5243|M.gilvum_PYR-GCK PMPLAAAYTASKSAIEGFTGSLALELGFFG--VRAKLVEPGYGPGTQFTS
TH_3670|M.thermoresistible__bu AFADLGAYHASKWALEGLSQSLSLEVAPFG--IHVTLIEPGGYATDWGGS
Mvan_5466|M.vanbaalenii_PYR-1 AVPGWGLYCAGKFALNGMSEALAAELAGFG--IRVTIVEPGYFRTDFLTT
MSMEG_2808|M.smegmatis_MC2_155 AVASSGLYGATKFAVEAITEALALELRGSG--VSATVIEPGAFRTDFLSP
MAB_1305|M.abscessus_ATCC_1997 HVPFRSTYSSAKSALHTVADCLRYEVAPFG--ITVSTVEPGVIATGIETR
Mb1079|M.bovis_AF2122/97 AFARFAGYSSAMHAIAGFSDALRQELRGSG--IAVSVIHPALTQTPLLAN
Rv1050|M.tuberculosis_H37Rv AFARFAGYSSAMHAIAGFSDALRQELRGSG--IAVSVIHPALTQTPLLAN
MLBr_01094|M.leprae_Br4923 SVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIKTAIARN
. . * . *: : .* * * : . : *.
MMAR_3561|M.marinum_M NMWEADTPQAAYADNRAAVRAVVADKIRN--AELPAVVADATYAAATDKR
MUL_2794|M.ulcerans_Agy99 NMWEADTPQAAYADNRAAVRAVVANKIRN--AELPAVVADATYAAAIDKR
MAV_2098|M.avium_104 NMADADAPIDAYAASREHARRRMAELMKT--ADDPAIVAEVVLKAATARK
Mflv_5243|M.gilvum_PYR-GCK NGVERMAGLIP-AEYQDFAAPVFEEFRSPGMVTTPDEVADVVFQAATDTS
TH_3670|M.thermoresistible__bu S--ARRSATMPEYAESR-AEADRVRSQRVARPGDPKASAAALLKVVDAEK
Mvan_5466|M.vanbaalenii_PYR-1 ESLALPTAAGDAYPAIR-EMTEQHLQLQGSQLGDPVKGAAAVIHVAVTGG
MSMEG_2808|M.smegmatis_MC2_155 RSVRFAATEIDAYADTAGAARTAFAALDGHQPGDPDKAAAAILAVAAADP
MAB_1305|M.abscessus_ATCC_1997 RNRIVPDGSPYRDAFRTVDAAMAAREEHG---TATDELGRLVVDVALSPS
Mb1079|M.bovis_AF2122/97 VDPADMP--PPFRSLTPIPVHWVAAAVLDGVARRRARVVVPFQPRLLMVG
Rv1050|M.tuberculosis_H37Rv VDPADMP--PPFRSLTPIPVHWVAAAVLDGVARRRARVVVPFQPRLLMVG
MLBr_01094|M.leprae_Br4923 ATAAEGLDVSKIASRFDTWVAHTS----------PQHAARIILKAVRKK-
MMAR_3561|M.marinum_M IKLRYPAGRHARQLALLKRIAPAAVLDNGIRKQTGLNSP-RPTPVLAER-
MUL_2794|M.ulcerans_Agy99 IKLRYPAGRHARQLALLKRIAPAAVLDNGIRKQTGLNSP-RPTPVLAER-
MAV_2098|M.avium_104 PKLRYPAGPLARRLSLLKKFAPEAVLDRGIRKTNGLPAASRPHSHLQL--
Mflv_5243|M.gilvum_PYR-GCK GRLRFAAGADAVALAQ----------------------------------
TH_3670|M.thermoresistible__bu PPLRVFFGELPLQIVNADYQSRLQTWEEWQPIAVLAQG------------
Mvan_5466|M.vanbaalenii_PYR-1 GPLHQLLGSDAVSYAEAKIDALVADVKAGRDLALTTDHR-----------
MSMEG_2808|M.smegmatis_MC2_155 APLRVQLGRDCVARVERKLLDVCQELGRWRAIAESTDFSTSPAESTSGTR
MAB_1305|M.abscessus_ATCC_1997 PKPLYAKGSNAPIIMTAQRLLPARLFLKFLARMHGLKVR-----------
Mb1079|M.bovis_AF2122/97 DAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTESAKAQAAQPERG
Rv1050|M.tuberculosis_H37Rv DAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTESAKAQAAQPERG
MLBr_01094|M.leprae_Br4923 -KARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR--------
*
MMAR_3561|M.marinum_M -----
MUL_2794|M.ulcerans_Agy99 -----
MAV_2098|M.avium_104 -----
Mflv_5243|M.gilvum_PYR-GCK -----
TH_3670|M.thermoresistible__bu -----
Mvan_5466|M.vanbaalenii_PYR-1 -----
MSMEG_2808|M.smegmatis_MC2_155 TVGAA
MAB_1305|M.abscessus_ATCC_1997 -----
Mb1079|M.bovis_AF2122/97 YSSAR
Rv1050|M.tuberculosis_H37Rv YSSAR
MLBr_01094|M.leprae_Br4923 -----