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MSRTALVTGANGGIGSATVARLVKNGVEVIATDLGERSDTVPADADYVPFDLRSGDPHELFERLGGRGLD YLVNAAGVALFDRDGSMLDIDESIWDVTLGVNLHGLRKVTAAAVEHLRRGSGKSIVNVASTAGLRGMDSP LDAYQVSKAAVVSLTRALALQLAPEGIRANTVCPGAILTPMIDHLYVENPARRVDMENRTPMRRLGMPDE IASAIAFLLSDEASFVTATDLVVDGGWTAQIK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3830 | - | - | 100% (242) | 3-oxoacyl- |
| M. smegmatis MC2 155 | MSMEG_2566 | - | 8e-31 | 40.32% (253) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3262 | - | 2e-30 | 36.55% (249) | L-xylulose reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 3e-32 | 34.44% (241) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4062 | - | 7e-31 | 33.20% (244) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2857c | - | 3e-32 | 34.44% (241) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-20 | 30.86% (243) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0072c | - | 5e-27 | 35.29% (272) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_3470 | - | 2e-34 | 39.11% (248) | short chain membrane-associated dehydrogenase |
| M. avium 104 | MAV_3521 | - | 3e-34 | 39.52% (248) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_4254 | - | 1e-33 | 36.55% (249) | PUTATIVE putative 2,5-dichloro-2,5-cyclohexadiene-1,4-diol |
| M. ulcerans Agy99 | MUL_4820 | - | 1e-26 | 33.33% (249) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_0614 | - | 1e-98 | 74.17% (240) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3830|M.smegmatis_MC2_155 --------------MS-----RTALVTGANGGIGSATVARLVKNGVEVIA
Mvan_0614|M.vanbaalenii_PYR-1 --------------MT-----RTALVTGAGGGIGAATVARLAADGVHVIA
MAB_0072c|M.abscessus_ATCC_199 --------------MTGRLTGKVALVTGAARGIGRAQAVRFAQEGADIIA
Mb2882c|M.bovis_AF2122/97 -----------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
Rv2857c|M.tuberculosis_H37Rv -----------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
Mflv_4062|M.gilvum_PYR-GCK ------------MDLSQRLKDKVAVITGGASGIGLATAKRMRSEGAIVVI
TH_4254|M.thermoresistible__bu -----------MTAGSTRLAGKVVLVTGAGGGLGTAIARRLADEGARLVL
MUL_4820|M.ulcerans_Agy99 --------------------MQVAIITAATGGIGFGCAAKFAEMSMAVVG
MMAR_3470|M.marinum_M ------------ML--DHRASRTFVVTGASSGIGLATVGRLLEQGCAVVG
MAV_3521|M.avium_104 ---------MTGMVNPDRARSRTFVVTGAASGIGLATARRLLAEGGTVVG
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
: ::*.. *:* . :: . :
MSMEG_3830|M.smegmatis_MC2_155 TDLGE------RSDTVPADADYVPFDLRSGDPHELFERLGGRGL------
Mvan_0614|M.vanbaalenii_PYR-1 TDVAE------TIPALAADVDYVSFDLLTGDPQTLLSLIPGGAL------
MAB_0072c|M.abscessus_ATCC_199 LDICAPVHTTITPPATRADLDKTSELVESAGRRVIPGVVDVRNLRDVQTF
Mb2882c|M.bovis_AF2122/97 GDVDVEAGGAAADELSG-----LFVPTDVCDEDAVNGLFDGAAETYG---
Rv2857c|M.tuberculosis_H37Rv GDVDVEAGGAAADELSG-----LFVPTDVCDEDAVNGLFDGAAETYG---
Mflv_4062|M.gilvum_PYR-GCK GDLDEKTGKSVANDLNV-----TFVQVDVSDQVAVDNLFDTAFEVHG---
TH_4254|M.thermoresistible__bu ADLQESQCAALADELPAPAGAHHPLGFDVADETAWISAISTVSAQYG---
MUL_4820|M.ulcerans_Agy99 TARDERRLAELTQLPGGPD-RIATHPVDPTDDDAPGQLTRAALDRWG---
MMAR_3470|M.marinum_M ADVVT--------PPHDLGPRFTFVTADVTDEDAVAGVFDAVPDR-----
MAV_3521|M.avium_104 VDLAD--------PPGDLGPRFTFVPADVTDESAVAAVLAAVPGR-----
MLBr_01807|M.leprae_Br4923 THRAS--------VVPDW---FFGVECDVTDNDAIGAAFKAVEEHQG---
.
MSMEG_3830|M.smegmatis_MC2_155 --DYLVNAAGVALFDRDG------SMLDIDESIWDVTLGVNLHGLRKVTA
Mvan_0614|M.vanbaalenii_PYR-1 --DYLVNAAGVALFDRDG------STLDVSESVWELTLGVNLHGMRRLTV
MAB_0072c|M.abscessus_ATCC_199 TQDAVTEFGGLDIVCATAGITSRRMLLDMPESDWQTMLDVNLTGVWHTTR
Mb2882c|M.bovis_AF2122/97 RIDIAFNNAGISPPEDNL-------IENTELAAWQRVQDVNLKSVYLCCR
Rv2857c|M.tuberculosis_H37Rv RIDIAFNNAGISPPEDNL-------IENTELAAWQRVQDVNLKSVYLCCR
Mflv_4062|M.gilvum_PYR-GCK GVDIAFNNAGISPPEDDL-------IENTGIDAWDRVQDINLKSVFFCCK
TH_4254|M.thermoresistible__bu ALHALVNNAAIGALGN---------VAEERLERWDRILDVGATGVWLGMK
MUL_4820|M.ulcerans_Agy99 RIDFLINAAGEGSPKS---------VHETDDESLDYVLSLMLRAPFRLTR
MMAR_3470|M.marinum_M -LDGVVHSAGVAGGGP---------VHLLARAEWDRVIGVNLTGTFLVAK
MAV_3521|M.avium_104 -LDGVFHAAGVAGGGP---------VHLLDRSEWDRVIGVNLTGTFLVAK
MLBr_01807|M.leprae_Br4923 PVEVLVANAGITSDML---------IMRMSEEQFQKVIDVNLTGVFRVAK
. .. : .: .
MSMEG_3830|M.smegmatis_MC2_155 AAVEHLRRGS-----GKSIVNVASTAGLRGMDSPLDAYQVSKAAVVSLTR
Mvan_0614|M.vanbaalenii_PYR-1 AAVPYLRAGQ-----GKSIVNVASIAGLRNMDSPLDAYQVSKAAVVSLTR
MAB_0072c|M.abscessus_ATCC_199 AATPHLIARG-----GGAMVLVSSIAGLRGLVG-VSHYVAAKHGVVGLMR
Mb2882c|M.bovis_AF2122/97 AALRHMVLAG-----KGSIVNTASFVAVMGSATSQISYTASKGGVLAMSR
Rv2857c|M.tuberculosis_H37Rv AALRHMVLAG-----KGSIVNTASFVAVMGSATSQISYTASKGGVLAMSR
Mflv_4062|M.gilvum_PYR-GCK AALRHMVPAQ-----KGSIVNTASFVAVNGSATSQISYTASKGGVLAMSR
TH_4254|M.thermoresistible__bu HAVPLIRRSG-----GGSVVNICSIFGTVGGFGDSAAYHAAKGAVRTLTK
MUL_4820|M.ulcerans_Agy99 EVLPHLRP-------GSAIINITSTFAVVGGLR-GGAYSAAKGGLAALTT
MMAR_3470|M.marinum_M AALARMIEQPRVDGERGSIVTLASIEGLEGTAG-GSSYNAAKGGVVLLTK
MAV_3521|M.avium_104 AALARMIDQPRVDGERGSLVTVASVEGLEGTAG-GSSYNAAKGGVVLLTK
MLBr_01807|M.leprae_Br4923 LASRNMIKQR-----FGRYIFMGSVVGLSGVPG-QANYAASKSGLIGMAR
. : : * . . * .:* .: :
MSMEG_3830|M.smegmatis_MC2_155 ALALQLAPEGIRANTVCPGAILTPMIDHLYV--------ENPARRVDMEN
Mvan_0614|M.vanbaalenii_PYR-1 SLALQLAPEGIRVNTVCPGAILTPMIEPLYL--------ENPARRTNMEQ
MAB_0072c|M.abscessus_ATCC_199 SLAIELAPHKIRVNTVHPTNVDTPMIQNEFVRTLFRPDLEQPTREDFAAA
Mb2882c|M.bovis_AF2122/97 ELGVQFARQGIRVNALCPGPVNTPLLQELFA--------KNPERAARRMV
Rv2857c|M.tuberculosis_H37Rv ELGVQFARQGIRVNALCPGPVNTPLLQELFA--------KNPERAARRMV
Mflv_4062|M.gilvum_PYR-GCK ELGIQYARQGIRVNALCPGPVNTPLLQELFA--------KDPERAARRLV
TH_4254|M.thermoresistible__bu NAALHWAPDGVRVNSLHPGFIETPQLRELY---------KGTERYERMLA
MUL_4820|M.ulcerans_Agy99 HIACQYGAQGIRCNAVAPGVIQTAMTQHRLA---------DERFRRLNVE
MMAR_3470|M.marinum_M NIALDYGPSGIRANAICPGFIATPLAEGVFGMP------GMEGPRASITN
MAV_3521|M.avium_104 NIALDYGPSGIRANVICPGFIETPMAHNVFSIP------GMEAPLASITR
MLBr_01807|M.leprae_Br4923 SLARELGSRSITANVVAPGFIDTEMTR-AMDSK------YQEAALQAIP-
. . . : * : * : *
MSMEG_3830|M.smegmatis_MC2_155 RTPMRRLGMP----DEIASAIAFLLSDEASFVTATDLVVDGGWTAQIK--
Mvan_0614|M.vanbaalenii_PYR-1 RTPLGRMGFP----VDIANAIRFLLSDEASFITATDLVVDGGWIAQTV--
MAB_0072c|M.abscessus_ATCC_199 AKTMNLLDLPWVEPLDIANASLFLASDEARYITSVSLPVDAGSTQR----
Mb2882c|M.bovis_AF2122/97 HVPLGRFAEP----DEIAAAVAFLASDDASFITASTFLVDGGISSAYVTP
Rv2857c|M.tuberculosis_H37Rv HVPLGRFAEP----DEIAAAVAFLASDDASFITASTFLVDGGISSAYVTP
Mflv_4062|M.gilvum_PYR-GCK HVPMGRFAEP----EELAAAVAFLASDDASFITGSSFLVDGGITGHYVTP
TH_4254|M.thermoresistible__bu GTPLGRLGRP----DEIAAVVAFLVSDDASFITGSEVYADGGWTAR----
MUL_4820|M.ulcerans_Agy99 ITPHQRLGTV----DDVANTVAFLCSEGGAFINGQTIVVDGG--------
MMAR_3470|M.marinum_M EHALQRLGKP----EEIAAMAAFLLSPDASFVTGQAIAVDGGYTAGRDHG
MAV_3521|M.avium_104 EHALQRLGRP----EEIAAMAAFLLSTDASFVSGQAIAVDGGYTAGRDHG
MLBr_01807|M.leprae_Br4923 ---LGRIGAV----EEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH---
: ::* ** * . ::.. . .*.*
MSMEG_3830|M.smegmatis_MC2_155 ---------
Mvan_0614|M.vanbaalenii_PYR-1 ---------
MAB_0072c|M.abscessus_ATCC_199 ---------
Mb2882c|M.bovis_AF2122/97 L--------
Rv2857c|M.tuberculosis_H37Rv L--------
Mflv_4062|M.gilvum_PYR-GCK L--------
TH_4254|M.thermoresistible__bu ---------
MUL_4820|M.ulcerans_Agy99 ---------
MMAR_3470|M.marinum_M VVRLFGLPQ
MAV_3521|M.avium_104 VVELFGFPS
MLBr_01807|M.leprae_Br4923 ---------