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M. thermoresistible (build 8) TH_4254 (-)

annotation: putative 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase
coordinates: 4583839 - 4584606
length: 256

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4254--100% (256)putative 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase
M. thermoresistible (build 8)TH_3912-3e-3840.08% (237) PUTATIVE short-chain dehydrogenase/reductase SDR
M. thermoresistible (build 8)TH_3954-1e-3538.06% (247) PUTATIVE 3-oxoacyl-[acyl-carrier-protein] reductase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2025fabG36e-4640.40% (250) 20-beta-hydroxysteroid dehydrogenase
M. gilvum PYR-GCKMflv_4505-3e-4641.53% (248) short-chain dehydrogenase/reductase SDR
M. tuberculosis H37RvRv2002fabG36e-4640.40% (250) 20-beta-hydroxysteroid dehydrogenase
M. leprae Br4923MLBr_01094-2e-2435.98% (189) short chain alcohol dehydrogenase
M. abscessus ATCC 19977MAB_4680c-1e-4640.16% (254) putative short-chain dehydrogenase/reductase
M. marinum MMMAR_2981fabG3_12e-4741.94% (248) 20-beta-hydroxysteroid dehydrogenase FabG3_1
M. avium 104MAV_2509-1e-4641.53% (248) 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
M. smegmatis MC2 155MSMEG_3009-1e-4844.40% (250) 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase
M. ulcerans Agy99MUL_1037fabG32e-4541.63% (245) 20-beta-hydroxysteroid dehydrogenase FabG3
M. vanbaalenii PYR-1Mvan_3000-8e-4740.73% (248) short-chain dehydrogenase/reductase SDR

CLUSTAL 2.0.9 multiple sequence alignment


Mb2025|M.bovis_AF2122/97            MSGR---LIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAV
Rv2002|M.tuberculosis_H37Rv         MSGR---LIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAV
MMAR_2981|M.marinum_M               MAGR---LTGKVALVSGGARGMGASHVRALVAEGAHVVLGDILDDEGRAV
MAV_2509|M.avium_104                MAER---LAGKVALVSGGARGMGASHVRSLVAEGAKVVFGDILDDEGKAV
Mflv_4505|M.gilvum_PYR-GCK          MTGR---LAGKVALISGAARGMGASHARVMAGHGAKVVCGDILDSDGEAV
MUL_1037|M.ulcerans_Agy99           -MGR---VDGKVALISGGARGMGASHARLLVQEGAKVVIGDILDEEGKAL
Mvan_3000|M.vanbaalenii_PYR-1       -MGR---VDGKVALISGGAQGMGAADARALIAEGAKVVIGDILDDKGKAL
MAB_4680c|M.abscessus_ATCC_199      MNGNSALLQGKNVIVTGGARGLGAAFSRHIVSQGGRVVIADVLDGDGRQL
MSMEG_3009|M.smegmatis_MC2_155      -MNR---LDGKVAIVTGTCRGIGHAIADALAREGAITVATGRSKTD-EAL
TH_4254|M.thermoresistible__bu      MTAGSTRLAGKVVLVTGAGGGLGTAIARRLADEGARLVLADLQESQCAAL
MLBr_01094|M.leprae_Br4923          -MEG---FAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQT
                                           . ** .:::*   *:* :    :   *.  .  .         

Mb2025|M.bovis_AF2122/97            AAELA----DAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILN
Rv2002|M.tuberculosis_H37Rv         AAELA----DAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILN
MMAR_2981|M.marinum_M               AAELG----DAARYVHLDVTQPEQWTAAVDTAVNEFGGLHVLVNNAGILN
MAV_2509|M.avium_104                AAEVG----EATRYLHLDVTKPEDWDAAVATALAEFGRIDVLVNNAGIIN
Mflv_4505|M.gilvum_PYR-GCK          AAELG----DAARYVHLDVTSPDDWDRAVAAAVADFGGLDVLVNNAGILN
MUL_1037|M.ulcerans_Agy99           AEEIG----DAARYVHLDVTQPDQWEAAVATAVDEFGKLDVLVNNVGIVA
Mvan_3000|M.vanbaalenii_PYR-1       ADEINAETPDSIRYVHLDVTQADQWEAAVATAVDAFGKLNVLVNNAGTVA
MAB_4680c|M.abscessus_ATCC_199      AAELG----DAARFTHLDVTDAEQWRELIDTTLAGFGTITGLVNNAGISS
MSMEG_3009|M.smegmatis_MC2_155      GPRSA-----EVEYRQLDVASEEDWDSVVTETVERYGRIDVLVNNAGIIA
TH_4254|M.thermoresistible__bu      ADELPAP-AGAHHPLGFDVADETAWISAISTVSAQYGALHALVNNAAIGA
MLBr_01094|M.leprae_Br4923          EGQLKAIG-ASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAGIAF
                                      .         .   :**:.   :      .   :* :  : **..   

Mb2025|M.bovis_AF2122/97            IGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEG
Rv2002|M.tuberculosis_H37Rv         IGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEG
MMAR_2981|M.marinum_M               IGTIEDYALSEWQRILDINVTGVFLGIRAAVKPMKEAGRGSIINISSIEG
MAV_2509|M.avium_104                IGTLEDYALSEWQRILDINLTGVFLGIRAVVKPMKKAGRGSIINISSIEG
Mflv_4505|M.gilvum_PYR-GCK          IGTVEDYELSEWHRILDVNLTGVFLGIRAATPTMKAAGRGSIINIASIEG
MUL_1037|M.ulcerans_Agy99           LGQLKKFDLGKWQKVIDVNLTGTFLGMRAAVEPMTAAGSGSIINVSSIEG
Mvan_3000|M.vanbaalenii_PYR-1       LGQIGQFDMAKWQKVIDVNLTGTFLGMQASVEAMKTAGGGSIINISSIEG
MAB_4680c|M.abscessus_ATCC_199      AAMVADEPLEHFRKVIEINLVGVFIGMQAVIPAMRAHGCGSIVNISSAAG
MSMEG_3009|M.smegmatis_MC2_155      YQGLHELTVPEWNRVVATNQTGTWLGMRAVIPHMVSQHGGSIINISSIWG
TH_4254|M.thermoresistible__bu      LGNVAEERLERWDRILDVGATGVWLGMKHAVPLIRRSGGGSVVNICSIFG
MLBr_01094|M.leprae_Br4923          TGDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSVFG
                                       :    .    :::  .  *.  * :     :     * ::*:.*  *

Mb2025|M.bovis_AF2122/97            LAG-TVACHGYTATKFAVRGLTKSTALELGPSG--IRVNSIHPGLVKTPM
Rv2002|M.tuberculosis_H37Rv         LAG-TVACHGYTATKFAVRGLTKSTALELGPSG--IRVNSIHPGLVKTPM
MMAR_2981|M.marinum_M               LAG-TIASHGYTVSKFAVRGLTKSTALELGPSG--IRVNSIHPGLVKTPM
MAV_2509|M.avium_104                MAG-TIACHGYTATKFAVRGLTKSAALELGPSG--IRVNSIHPGLIKTPM
Mflv_4505|M.gilvum_PYR-GCK          MAG-TVGCHGYTATKFAVRGLTKSTALELGPFG--IRVNSVHPGLVKTPM
MUL_1037|M.ulcerans_Agy99           LRG-APAVHPYVASKWAVRGLTKSAALELAPLN--IRVNSIHPGFIRTPM
Mvan_3000|M.vanbaalenii_PYR-1       LRG-AVMVHPYVASKWAVRGLTKSAALELGSHN--IRVNSVHPGFIRTPM
MAB_4680c|M.abscessus_ATCC_199      LVG-LALTSGYGASKWGVRGLSKVAAIELGRER--IRVNSVHPGVIYTPM
MSMEG_3009|M.smegmatis_MC2_155      SAA-VAGAHAYHATKGAVRNMSKSAAISYAKDN--VRVNSVHPGFIRTPL
TH_4254|M.thermoresistible__bu      TVGGFGDSAAYHAAKGAVRTLTKNAALHWAPDG--VRVNSLHPGFIETPQ
MLBr_01094|M.leprae_Br4923          LFS-VPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIKTAI
                                      .       *  :* .** :::      .     :.*.:::** : *. 

Mb2025|M.bovis_AF2122/97            TDWV----------PEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGA
Rv2002|M.tuberculosis_H37Rv         TDWV----------PEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGA
MMAR_2981|M.marinum_M               TEWV----------PEDLFQTALGRAAEPMEVSNLVVYLASDESSYSTGA
MAV_2509|M.avium_104                TEWV----------PEDIFQSALGRAAEPKEVSNLVVYLASDESSYSTGS
Mflv_4505|M.gilvum_PYR-GCK          ADWV----------PEDIFQSALGRIAQPHEVSNLVVYLASDESSYSTGA
MUL_1037|M.ulcerans_Agy99           TANL----------PDDMVTIPLGRPAESREVSTFVVFLASDDASYATGS
Mvan_3000|M.vanbaalenii_PYR-1       TKHF----------PDNMLRIPLGRPGQPEEVATFVVFLASDESRYATGA
MAB_4680c|M.abscessus_ATCC_199      TAKEGF-----REGEGNMPIAAMGRVGNADEVAGAVAYLLSDAASYVTGA
MSMEG_3009|M.smegmatis_MC2_155      TDAQET-----TINDYVVSQTPMGRAGTPDEIANGVVFLASDEASFVTGS
TH_4254|M.thermoresistible__bu      LRELYKGT---ERYERMLAGTPLGRLGRPDEIAAVVAFLVSDDASFITGS
MLBr_01094|M.leprae_Br4923          ARNATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVRKKKARVLVGP
                                                          :.: .        :  : .. :   .*.

Mb2025|M.bovis_AF2122/97            EFVVDGGTVAGLAHNDFGAVEVSSQPEWVT---
Rv2002|M.tuberculosis_H37Rv         EFVVDGGTVAGLAHNDFGAVEVSSQPEWVT---
MMAR_2981|M.marinum_M               EFVVDGGTVAGLAHKDFSAVDVAAQPEWVT---
MAV_2509|M.avium_104                EFVVDGGTTAGLGHKDFSNVETDAQPDWVT---
Mflv_4505|M.gilvum_PYR-GCK          EFVVDGGTLAGLAHKDFSAVDVDQQPEWIT---
MUL_1037|M.ulcerans_Agy99           EFVMDGGLVTDVPHKQF----------------
Mvan_3000|M.vanbaalenii_PYR-1       EFVMDGGLTNDVPHK------------------
MAB_4680c|M.abscessus_ATCC_199      ELAVDGGWTAGPTLTTITGQ-------------
MSMEG_3009|M.smegmatis_MC2_155      ELVIDGGYLAQ----------------------
TH_4254|M.thermoresistible__bu      EVYADGGWTAR----------------------
MLBr_01094|M.leprae_Br4923          DAKVANVVVRFSGGAGYQRLFAQVASRLILNQR
                                    :    .