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MDLTQRLAGRVAVITGAGGGIGLAAARRMHAEGATIVVADIDADAGAAAADELSGLFVPTDVADEDAVNA LFDTAVRRYGRIDIAFNNAGISPPDDDVIENTEPPAWQRVQDVNLKSVYLCCRAALRHMVSARRGSIINT ASFVAVMGSATSQISYTAAKGGVLALSRELGVQFARQGIRVNALCPGPVNTPLLQELFAKDPQRAARRLV HVPVGRFAEPGEIAAAAAFLASDDASFITASTFLVDGGISAAYVTPL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3714 | - | - | 100% (258) | short chain dehydrogenase |
| M. avium 104 | MAV_1832 | - | 8e-43 | 39.51% (243) | 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase |
| M. avium 104 | MAV_2509 | - | 7e-38 | 37.45% (251) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 1e-125 | 86.82% (258) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4062 | - | 1e-106 | 73.15% (257) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2857c | - | 1e-125 | 86.82% (258) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 3e-30 | 32.79% (244) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0598 | - | 2e-31 | 36.18% (246) | short chain dehydrogenase |
| M. marinum M | MMAR_4033 | fabG | 9e-38 | 36.84% (247) | 3-oxoacyl- |
| M. smegmatis MC2 155 | MSMEG_2598 | - | 1e-119 | 81.71% (257) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4254 | - | 1e-43 | 41.83% (251) | PUTATIVE putative 2,5-dichloro-2,5-cyclohexadiene-1,4-diol |
| M. ulcerans Agy99 | MUL_1037 | fabG3 | 3e-36 | 36.99% (246) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
| M. vanbaalenii PYR-1 | Mvan_2281 | - | 1e-110 | 76.26% (257) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2882c|M.bovis_AF2122/97 -----------MMDLSQRLAGRVAVITGGG-SGIGLAAGRRMRAEGATIV
Rv2857c|M.tuberculosis_H37Rv -----------MMDLSQRLAGRVAVITGGG-SGIGLAAGRRMRAEGATIV
MAV_3714|M.avium_104 -----------MMDLTQRLAGRVAVITGAG-GGIGLAAARRMHAEGATIV
Mflv_4062|M.gilvum_PYR-GCK ------------MDLSQRLKDKVAVITGGA-SGIGLATAKRMRSEGAIVV
Mvan_2281|M.vanbaalenii_PYR-1 ------------MDLGQRLKDKVAVITGGA-SGIGLATAKRMQAEGAIVV
MSMEG_2598|M.smegmatis_MC2_155 ------------MDLTQRLAGKVAVITGGA-SGIGLATGRRLRAEGATVV
TH_4254|M.thermoresistible__bu -----------MTAGSTRLAGKVVLVTGAG-GGLGTAIARRLADEGARLV
MUL_1037|M.ulcerans_Agy99 -------------MG--RVDGKVALISGGA-RGMGASHARLLVQEGAKVV
MAB_0598|M.abscessus_ATCC_1997 ---MNLAEAPTEIEGHGLLKGKAVVVTAAAGTGIGSSTARRALVEGADVV
MMAR_4033|M.marinum_M ---MSVS----------LLNGQIAVVTGGA-QGLGLAIAERFVSEGARVV
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGN-RGIGLAVARRLVADGHRVA
. .: :::.. *:* : .. :* :.
Mb2882c|M.bovis_AF2122/97 VGDVDVEAGGAAADELSGLF-------VPTDVCDEDAVNGLFDGAAETYG
Rv2857c|M.tuberculosis_H37Rv VGDVDVEAGGAAADELSGLF-------VPTDVCDEDAVNGLFDGAAETYG
MAV_3714|M.avium_104 VADIDADAGAAAADELSGLF-------VPTDVADEDAVNALFDTAVRRYG
Mflv_4062|M.gilvum_PYR-GCK IGDLDEKTGKSVANDLNVTF-------VQVDVSDQVAVDNLFDTAFEVHG
Mvan_2281|M.vanbaalenii_PYR-1 IGDVDASTGKSVANDMNVTF-------VQVDVADQVAVDHLFDTAFEVHG
MSMEG_2598|M.smegmatis_MC2_155 VGDIDPTTGKAAADELEGLF-------VPVDVSEQEAVDNLFDTAASTFG
TH_4254|M.thermoresistible__bu LADLQESQCAALADELPAPAG--AHHPLGFDVADETAWISAISTVSAQYG
MUL_1037|M.ulcerans_Agy99 IGDILDEEGKALAEEIGDAAR--YVH---LDVTQPDQWEAAVATAVDEFG
MAB_0598|M.abscessus_ATCC_1997 VSDYHERRLTETRDELAALGLGKVAAVV-CDVTSTEAVDALITESVAALG
MMAR_4033|M.marinum_M LGDVN---LEATEAAAKQLGGGEVAVAVRCDVTKADEVETLLQTALERFG
MLBr_01807|M.leprae_Br4923 VTHRASVVPDWFFG-------------VECDVTDNDAIGAAFKAVEEHQG
: . ** . . *
Mb2882c|M.bovis_AF2122/97 RIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMV
Rv2857c|M.tuberculosis_H37Rv RIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMV
MAV_3714|M.avium_104 RIDIAFNNAGISPPDDDVIENTEPPAWQRVQDVNLKSVYLCCRAALRHMV
Mflv_4062|M.gilvum_PYR-GCK GVDIAFNNAGISPPEDDLIENTGIDAWDRVQDINLKSVFFCCKAALRHMV
Mvan_2281|M.vanbaalenii_PYR-1 GVDIAFNNAGISPPEDDLIENTGVDAWDRVQDINLKSVFFCCKAALRHMV
MSMEG_2598|M.smegmatis_MC2_155 RVDIAFNNAGISPPEDDLIENTDLPAWQRVQDINLKSVYLSCRAALRHMV
TH_4254|M.thermoresistible__bu ALHALVNNAAIGALGN--VAEERLERWDRILDVGATGVWLGMKHAVPLIR
MUL_1037|M.ulcerans_Agy99 KLDVLVNNVGIVALGQ--LKKFDLGKWQKVIDVNLTGTFLGMRAAVEPMT
MAB_0598|M.abscessus_ATCC_1997 RIDVLVNNAGLG--GETPVADMTDDQWDRVLDVTLTSTFRATRAALRYFR
MMAR_4033|M.marinum_M GLDIMVNNAGIT--RDATMRKMTEEQFDQVIDVHLKGTWNGIRLAAAIMR
MLBr_01807|M.leprae_Br4923 PVEVLVANAGIT--SDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMI
:. . *..: : : :::: *: ...: : * :
Mb2882c|M.bovis_AF2122/97 LAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFARQGIR
Rv2857c|M.tuberculosis_H37Rv LAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFARQGIR
MAV_3714|M.avium_104 SARRGSIINTASFVAVMGSATSQISYTAAKGGVLALSRELGVQFARQGIR
Mflv_4062|M.gilvum_PYR-GCK PAQKGSIVNTASFVAVNGSATSQISYTASKGGVLAMSRELGIQYARQGIR
Mvan_2281|M.vanbaalenii_PYR-1 PAQKGSIINTASFVAVMGSATSQISYTASKGGVLAMSRELGVQYARQGIR
MSMEG_2598|M.smegmatis_MC2_155 PAGKGSIINTASFVAVMGSATSQISYTASKGGVLAMSRELGVQYARQGIR
TH_4254|M.thermoresistible__bu RSGGGSVVNICSIFGTVGGFGDSAAYHAAKGAVRTLTKNAALHWAPDGVR
MUL_1037|M.ulcerans_Agy99 AAGSGSIINVSSIEG-LRGAPAVHPYVASKWAVRGLTKSAALELAPLNIR
MAB_0598|M.abscessus_ATCC_1997 EAGHGGVIVNNASVLGWRAQYGQSHYAAAKAGVMALTRCSAIEAVEHGVR
MMAR_4033|M.marinum_M EN-KRGAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHVGVR
MLBr_01807|M.leprae_Br4923 KQRFGRYIFMGSVVG-LSGVPGQANYAASKSGLIGMARSLARELGSRSIT
: : . * *:* .: ::: . . .:
Mb2882c|M.bovis_AF2122/97 VNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAAAVAFL
Rv2857c|M.tuberculosis_H37Rv VNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAAAVAFL
MAV_3714|M.avium_104 VNALCPGPVNTPLLQELFAKDPQRAARRLVHVPVGRFAEPGEIAAAAAFL
Mflv_4062|M.gilvum_PYR-GCK VNALCPGPVNTPLLQELFAKDPERAARRLVHVPMGRFAEPEELAAAVAFL
Mvan_2281|M.vanbaalenii_PYR-1 VNALCPGPVNTPLLQELFAKDPERAARRLVHVPVGRFAEPEELAAAVAFL
MSMEG_2598|M.smegmatis_MC2_155 VNALCPGPVNTPLLQELFAKDPERAARRLVHIPLGRFAEPEELAAAVAFL
TH_4254|M.thermoresistible__bu VNSLHPGFIETPQLRELYK-GTERYERMLAGTPLGRLGRPDEIAAVVAFL
MUL_1037|M.ulcerans_Agy99 VNSIHPGFIRTPMTANLP-------DDMVT-IPLGRPAESREVSTFVVFL
MAB_0598|M.abscessus_ATCC_1997 VNAVAPSIARHKFLDKVTS--SDLLDKLSSDEAFGRAAEPWEVAATIAFL
MMAR_4033|M.marinum_M VNAIAPGLIRSAMTEAMP---QRIWDQKLAEVPMGRAGEPSEVASVALFL
MLBr_01807|M.leprae_Br4923 ANVVAPGFIDTEMTRAMDS---KYQEAALQAIPLGRIGAVEEIAGAVSFL
.* : *. : ..** . *:: **
Mb2882c|M.bovis_AF2122/97 ASDDASFITASTFLVDGGISSAYVTPL-
Rv2857c|M.tuberculosis_H37Rv ASDDASFITASTFLVDGGISSAYVTPL-
MAV_3714|M.avium_104 ASDDASFITASTFLVDGGISAAYVTPL-
Mflv_4062|M.gilvum_PYR-GCK ASDDASFITGSSFLVDGGITGHYVTPL-
Mvan_2281|M.vanbaalenii_PYR-1 ASDDASFITASSFLVDGGISGHYVTPL-
MSMEG_2598|M.smegmatis_MC2_155 ASDDASFITGSTFLVDGGISSAYVTPL-
TH_4254|M.thermoresistible__bu VSDDASFITGSEVYADGGWTAR------
MUL_1037|M.ulcerans_Agy99 ASDDASYATGSEFVMDGGLVTDVPHKQF
MAB_0598|M.abscessus_ATCC_1997 ASDYSSYLTGEVISVSSQRA--------
MMAR_4033|M.marinum_M ACDLSSYMTGTVLDVTGGRFI-------
MLBr_01807|M.leprae_Br4923 ASEDAGYISGAVIPVDGGLGMGH-----
..: :.: :. . .