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MTHTVLRMTERLLIDPPEHPDTSKGYLDLLGDEPDSNRGAIQALWASRLGSMFYDNAQTLARRLMTAWQQ PTEWLNVPVGGTALDVGSGPGNVTGALGRAVGPGGLALGVDISEPMLARAVRAEAGPNVGFIRADAQHLP FRDESFDAVVSIAMLQLIPDPAVALAEMVRVLRPGRRMAVMVPTAGPAAGLLRYLPNAGAHAFGDDELGD TFESLGLAGVRINTVGTIQWVRGRKS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0109 | - | - | 100% (236) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_2948 | - | 2e-15 | 42.14% (140) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_4690 | - | 3e-12 | 37.61% (109) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1550 | - | 5e-12 | 38.54% (96) | methyltransferase |
| M. gilvum PYR-GCK | Mflv_0738 | - | 1e-109 | 80.85% (235) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1523 | - | 5e-12 | 38.54% (96) | methyltransferase |
| M. leprae Br4923 | MLBr_00130 | - | 1e-11 | 37.00% (100) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_4018 | - | 1e-24 | 33.89% (239) | similarity with UbiE/COQ5 methyltransferase |
| M. marinum M | MMAR_4497 | - | 4e-29 | 36.67% (240) | methyltransferase |
| M. avium 104 | MAV_5229 | - | 4e-83 | 64.56% (237) | methyltransferase type 11 |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 3e-78 | 62.98% (235) | methyltransferase |
| M. thermoresistible (build 8) | TH_3395 | - | 2e-11 | 33.97% (156) | PUTATIVE putative ubiquinone/menaquinone biosynthesis |
| M. ulcerans Agy99 | MUL_4668 | - | 5e-29 | 36.67% (240) | methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0109|M.vanbaalenii_PYR-1 MTHT------------------VLRMTERLLIDPP---------------
Mflv_0738|M.gilvum_PYR-GCK MTES------------------ALRMAERLLADPP---------------
MAV_5229|M.avium_104 MTDVHTSLPP------------ALRRALDLLIDPP---------------
MSMEG_0098|M.smegmatis_MC2_155 MDT-------------------ALRRAMDLLIDPP---------------
MMAR_4497|M.marinum_M MSATP-----------------DPRE--VTRGLLT---------------
MUL_4668|M.ulcerans_Agy99 MSATP-----------------DPRE--VTRGLLT---------------
MAB_4018|M.abscessus_ATCC_1997 MLHHP-----------------TLADSLIDPARID---------------
Mb1550|M.bovis_AF2122/97 MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ
Rv1523|M.tuberculosis_H37Rv MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ
MLBr_00130|M.leprae_Br4923 MAFTRIHS---------------------FLASAG---------------
TH_3395|M.thermoresistible__bu --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------EHPDTS
Mflv_0738|M.gilvum_PYR-GCK --------------------------------------------EHPDVS
MAV_5229|M.avium_104 --------------------------------------------ADPDVS
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------AEPDFS
MMAR_4497|M.marinum_M --------------------------------------------EPCDLR
MUL_4668|M.ulcerans_Agy99 --------------------------------------------EPGDLR
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------HPPRRD
Mb1550|M.bovis_AF2122/97 IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG
Rv1523|M.tuberculosis_H37Rv IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG
MLBr_00130|M.leprae_Br4923 ---------------------------------------------NTSMY
TH_3395|M.thermoresistible__bu ------------------------------------------------MA
Mvan_0109|M.vanbaalenii_PYR-1 KGYLDLLGDEPDSNR----------GAIQALWAS-RLGSMFYDNAQTLAR
Mflv_0738|M.gilvum_PYR-GCK KGYLDLLGDRPAGDA----------GAIQALWAS-RLGSLFYDNAQTVMR
MAV_5229|M.avium_104 KGYLDLLGGAADEDAG----VPRNTGPIQAAWAS-PIGSLLYDNAQALSR
MSMEG_0098|M.smegmatis_MC2_155 KGYLDLLGRGDSTAP-------KNTGLIQKAWAS-PLGSKLYDRAQLLNR
MMAR_4497|M.marinum_M RGFLDVLGESTSSPVPTVAQRAMNSRFVATVYER-LWRPAAF--YLASGV
MUL_4668|M.ulcerans_Agy99 HGFLDVLGESTSSPVPTVAQRAMNSRFVATVYER-LWRPAAF--YLASGV
MAB_4018|M.abscessus_ATCC_1997 HGYLDVLGPESDEPVS-VANRFMQSPLLAAIYER-AWRPMFTRGFSYGGK
Mb1550|M.bovis_AF2122/97 KLTTKYFLPLGTRQVG------DHVVFFNFGYEEDPPMALPLSESDEPNR
Rv1523|M.tuberculosis_H37Rv KLTTKYFLPLGTRQVG------DHVVFFNFGYEEDPPMALPLSESDEPNR
MLBr_00130|M.leprae_Br4923 KRVWRFWYPLMTHKLGT-----DEIMFINWAYEEDPPMALPLEASDEPNR
TH_3395|M.thermoresistible__bu DVAANWAGRGGRFAGG----------LYDFGVER--EVLARPAGLLMWGT
Mvan_0109|M.vanbaalenii_PYR-1 RLMTAWQQPTEWLNVPVGGTALDVGSGPGNVTGALGRAVGPGGLALGVDI
Mflv_0738|M.gilvum_PYR-GCK RVLTAWHEPTEWLNLPVGGVALDVGSGPGNVTAALGRAVGPGGLALGVDV
MAV_5229|M.avium_104 RWISAWQLPLEWLQIPRGGVALDVGSGPGNVTASLARAAGPDGLALGIDI
MSMEG_0098|M.smegmatis_MC2_155 RLVASTRPPVEWLRIPPGGTVLDIGCGPGNITAQLARAAGLDGLALGVDI
MMAR_4497|M.marinum_M TTRAEQHRAAAALHLSTAHRLLDVACGPGNFTAPLVKQLPAGSLAVGLDI
MUL_4668|M.ulcerans_Agy99 TTRAEQHRAAAALHLSTAHRLLDVACGPGNFTAPLVKQLPAGSLAVGLDI
MAB_4018|M.abscessus_ATCC_1997 STLKAHTALMDEIAGRGDHKILDVACGPGLYTRELAAQLGTAGVCIGLDL
Mb1550|M.bovis_AF2122/97 YCIQLYHQTASQVDLT-GKEVLEVSCGAGGGASYIARNLGP-ASYTGLDL
Rv1523|M.tuberculosis_H37Rv YCIQLYHQTASQVDLT-GKEVLEVSCGAGGGASYIARNLGP-ASYTGLDL
MLBr_00130|M.leprae_Br4923 AHINLYHRTATQVNLS-GKRILEVSCGHGGGASYLTRALHP-ASYTGLDL
TH_3395|M.thermoresistible__bu DTRLLFDSIRRIGDLPDGTAVLDIPCGGG--LALRGLRHGRRLRYVAADI
*:: .* * . *:
Mvan_0109|M.vanbaalenii_PYR-1 SEPMLARAVRAEAGP---NVGFIRADAQHLPFRDESFDAVVSIAMLQLIP
Mflv_0738|M.gilvum_PYR-GCK SEPMLARAVAAEAGP---NVGFLRADAQDLPLSDESVDGVVSIAMLQLIP
MAV_5229|M.avium_104 SEPMLARAVRNEAGP---QVGFIKADAQRLPLRDNTVDAAVSTAVLQLVP
MSMEG_0098|M.smegmatis_MC2_155 SEPMLARAVAAEAGR---QVGFVRADAQQLPFRDEVFDAATSLAVFQLIP
MMAR_4497|M.marinum_M SEPMLTRAVLDNSGP---QTCYVRGDARMLPFDDETFDAVCCFGALYLMP
MUL_4668|M.ulcerans_Agy99 SEPMLTRAVLDNSGP---QTCYVRGDARMLPFDDETFDAVCCFGALYLMP
MAB_4018|M.abscessus_ATCC_1997 SGPMLRRAVRDNSAE---RVDYIRGSAHSLPFADATFDTVVCLAALYLIP
Mb1550|M.bovis_AF2122/97 NPASIDLCRAKHRLP---GLQFVQGDAQNLPFPDESFDAVVNVEASHQYP
Rv1523|M.tuberculosis_H37Rv NPASIDLCRAKHRLP---GLQFVQGDAQNLPFPDESFDAVVNVEASHQYP
MLBr_00130|M.leprae_Br4923 NPAGIKLCQKRHQLP---GLEFVRGDAENLPFDNESFDVVINIEASHCYP
TH_3395|M.thermoresistible__bu SADMLARAQRRAATLGRTDVRFVVADIERMPFGDGEFDCCVTFNGLHCVP
. : . :: .. . :*: : .* *
Mvan_0109|M.vanbaalenii_PYR-1 DPAVALAEMVRVLRPGRRMAVMVPTAGPAAGLLRYLPNAG------AHAF
Mflv_0738|M.gilvum_PYR-GCK EPARAVAEMVRVLRSGRRVAVMVPTAGPAAAALRYLPHAG------AHSF
MAV_5229|M.avium_104 NPQAALVEIARVLRPGGRLAVMVPTAGRLARYWRLLPNVG------AHAF
MSMEG_0098|M.smegmatis_MC2_155 DPVAAVSEIVRVLKPGGRVAIMVPTAG-AVKPVTFLARGG------ARIF
MMAR_4497|M.marinum_M EPFRIAREMVRVLGPGGRIAILTTYSGQRAPIRHALDAAAGA--IGLTMF
MUL_4668|M.ulcerans_Agy99 EPFRIAREMVRVLGPGGRIAILTTYSGQRAPIRHALDAAAGA--IGLTMF
MAB_4018|M.abscessus_ATCC_1997 DPEQAVRELCRVAGPDGQIVVFTSLR-TRAASLPGVTTAMRI--GGFRAF
Mb1550|M.bovis_AF2122/97 DFRGFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQRDI
Rv1523|M.tuberculosis_H37Rv DFRGFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQRDI
MLBr_00130|M.leprae_Br4923 HFPRFLAEVVRVLRPGGHLAYADLRPSNKVGEWEVDFANSRLQQLSQREI
TH_3395|M.thermoresistible__bu DPAAAVAEIARCVKPGGRLIGDAVVRGAGRRQDALIAVFRRAG-VFGPGG
. *: * .. :.
Mvan_0109|M.vanbaalenii_PYR-1 GDDELGDTFESLGLAGVRINTVGTIQWVRGRKS-----------------
Mflv_0738|M.gilvum_PYR-GCK GDDELADVFEGLGLTSVRANTVGTIQWVRGKKP-----------------
MAV_5229|M.avium_104 DDDEIGDILEENGFASVRVKNFGTFQWVRAKLS-----------------
MSMEG_0098|M.smegmatis_MC2_155 GDDELGDIFENVGLVGVRVKTHGFIQWVRGTKL-----------------
MMAR_4497|M.marinum_M DQDSFVDLFSSAGLVDIDQQTQRGLQFVVAAKPK----------------
MUL_4668|M.ulcerans_Agy99 DQDSFVDLFSSAGLVDIDQQTQRGLQFVVAAKPK----------------
MAB_4018|M.abscessus_ATCC_1997 GRDEVTGWLRAQGWTDIDQTVTGQGQFIRARRAVALRVAT----------
Mb1550|M.bovis_AF2122/97 GAQAKRGLDANTARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRR---GGG
Rv1523|M.tuberculosis_H37Rv GAQAKRGLDANTARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRR---GGG
MLBr_00130|M.leprae_Br4923 NAEVLRGIASNSQKSRDLVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGE
TH_3395|M.thermoresistible__bu TTDELQGWLTRAGFEVEDFRRSGAVAHFTAVRS-----------------
: .
Mvan_0109|M.vanbaalenii_PYR-1 -----------
Mflv_0738|M.gilvum_PYR-GCK -----------
MAV_5229|M.avium_104 -----------
MSMEG_0098|M.smegmatis_MC2_155 -----------
MMAR_4497|M.marinum_M -----------
MUL_4668|M.ulcerans_Agy99 -----------
MAB_4018|M.abscessus_ATCC_1997 -----------
Mb1550|M.bovis_AF2122/97 FSYRIYLFAKD
Rv1523|M.tuberculosis_H37Rv FSYRIYLFAKD
MLBr_00130|M.leprae_Br4923 LSYRMYSFAKD
TH_3395|M.thermoresistible__bu -----------