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VDRANVAQVQAWNGDSGRAWVTLQHVLDRTLKPFEDLIVDSVAAAAGPREQILDLGCGTGATTLALAERL GAHGGCTGIDISEPMIHAARTRARDRNLPVEFVVGDAQSFPFQPNTFDVMVSRFGVMFFDDPTTAFRNLR RATRPGGRLTFVCWRDPTDNPFMSTAERAAAQLLSDLKPGIAGSPGPFAFADAHRTHSILRAGGWTAVDI RPVDVTCTMQESDLLPYLTQMGPVGRTLRAVDARTRAQVITSLREAYTEFIVDGEVRYPAACWMVDARG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4690 | - | - | 100% (280) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_4620 | - | 2e-14 | 30.45% (220) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_0983 | ubiE | 6e-14 | 28.16% (174) | ubiquinone/menaquinone biosynthesis methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0573 | ubiE | 8e-13 | 28.57% (175) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. gilvum PYR-GCK | Mflv_5258 | ubiE | 3e-13 | 27.59% (174) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. tuberculosis H37Rv | Rv0558 | ubiE | 8e-13 | 28.57% (175) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. leprae Br4923 | MLBr_00551 | - | 8e-12 | 30.71% (127) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_4018 | - | 2e-15 | 33.14% (175) | similarity with UbiE/COQ5 methyltransferase |
| M. marinum M | MMAR_0907 | ubiE | 2e-12 | 28.16% (174) | ubiquinone/menaquinone methlytransferase, MenH |
| M. avium 104 | MAV_0854 | - | 1e-13 | 36.03% (136) | methyltransferase-UbiE family protein |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 2e-14 | 39.05% (105) | methyltransferase |
| M. thermoresistible (build 8) | TH_2189 | - | 8e-13 | 28.45% (232) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0660 | ubiE | 4e-12 | 27.59% (174) | ubiquinone/menaquinone biosynthesis methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0573|M.bovis_AF2122/97 --------------------------------------------------
Rv0558|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0907|M.marinum_M --------------------------------------------------
MUL_0660|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5258|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4690|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2189|M.thermoresistible__bu VIRRLMATALTALTTAVLAGCGDAGSWVEAKPAEGWSAQYGDAANSSYTS
MLBr_00551|M.leprae_Br4923 --------------------------------------------------
Mb0573|M.bovis_AF2122/97 --------------------------------------------------
Rv0558|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0907|M.marinum_M --------------------------------------------------
MUL_0660|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5258|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4690|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2189|M.thermoresistible__bu AAGAEALTLEWSRSVKGELAAQVAVGASGYLAVNAQTPAGCSLMVWEYAN
MLBr_00551|M.leprae_Br4923 --------------------------------------------------
Mb0573|M.bovis_AF2122/97 --------------------------------------------------
Rv0558|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0907|M.marinum_M --------------------------------------------------
MUL_0660|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5258|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4690|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2189|M.thermoresistible__bu SARQRWCTRLVQGGGRTSPLLDGFDNVYIGQPGAILSFPPTQWIRWRKPV
MLBr_00551|M.leprae_Br4923 --------------------------------------------------
Mb0573|M.bovis_AF2122/97 -------------------------------------------------M
Rv0558|M.tuberculosis_H37Rv -------------------------------------------------M
MMAR_0907|M.marinum_M -------------------------------------------------M
MUL_0660|M.ulcerans_Agy99 -------------------------------------------------M
Mflv_5258|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_4690|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0854|M.avium_104 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 -----------------------------MDTALRRAMDLLIDPPAEPDF
MAB_4018|M.abscessus_ATCC_1997 ---------------------------MLHHPTLADSLIDPARIDHPPRR
TH_2189|M.thermoresistible__bu IGMPTTPRILAPGELLVVTHLGQVLLFDAHRGTVTGTPLDLVAGVDPTDS
MLBr_00551|M.leprae_Br4923 --------------------------------------------------
Mb0573|M.bovis_AF2122/97 SRAALDKDPRDV-------------ASMFDG---------VARKYDLTNT
Rv0558|M.tuberculosis_H37Rv SRAALDKDPRDV-------------ASMFDG---------VARKYDLTNT
MMAR_0907|M.marinum_M SRAALDKDPRDV-------------ASMFDG---------VARRYDLTNT
MUL_0660|M.ulcerans_Agy99 SRAALDKDPRDV-------------ASMFDG---------VARRYDLTNT
Mflv_5258|M.gilvum_PYR-GCK NRASLEKNPHEV-------------ASMFDG---------VARRYDLTNT
Mvan_4690|M.vanbaalenii_PYR-1 ---MVDRANVAQ-------------VQAWNGD--------SGRAWVTLQH
MAV_0854|M.avium_104 ------MNDQHR-------------ATYTHG---------------HHES
MSMEG_0098|M.smegmatis_MC2_155 SKGYLDLLGRGD-------------STAPKNTGLIQKAWASPLGSKLYDR
MAB_4018|M.abscessus_ATCC_1997 DHGYLDVLGPESD-------EPVSVANRFMQSPLLAAIYERAWRPMFTRG
TH_2189|M.thermoresistible__bu ERGLADCAGARXXXCWPPPRPPSTVTPRARDAARHPTARLPAMTETTEPG
MLBr_00551|M.leprae_Br4923 MNLYTPIHEDQS-------------LAAIHR-----------AMWALGDY
Mb0573|M.bovis_AF2122/97 VLSLGQDRYWRRATR-SALRIGPGQK------------------------
Rv0558|M.tuberculosis_H37Rv VLSLGQDRYWRRATR-SALRIGPGQK------------------------
MMAR_0907|M.marinum_M VLSLGQDRYWRRATR-SALRIGPGDK------------------------
MUL_0660|M.ulcerans_Agy99 VLSLGQDRYWRRATR-SALRIGPGDK------------------------
Mflv_5258|M.gilvum_PYR-GCK VLSLGQDRFWRRATR-EALQLSPADK------------------------
Mvan_4690|M.vanbaalenii_PYR-1 VLDRTLKPFEDLIVDSVAAAAGPREQ------------------------
MAV_0854|M.avium_104 VLRSHRRRTAEDSAGYLLAHLTPGLS------------------------
MSMEG_0098|M.smegmatis_MC2_155 AQLLNRRLVASTRPPVEWLRIPPGGT------------------------
MAB_4018|M.abscessus_ATCC_1997 FSYGGKSTLKAHTALMDEIAGRGDHK------------------------
TH_2189|M.thermoresistible__bu IGSEGAGDLPAPNPHATAEQVEAAMRDSKLAQILYHDWEAESYDDKWSIS
MLBr_00551|M.leprae_Br4923 ALMAEEVMAPLGPILVTATGIRPGMQ------------------------
Mb0573|M.bovis_AF2122/97 -----------------------------VLDLAAGTAVSTVELTK---S
Rv0558|M.tuberculosis_H37Rv -----------------------------VLDLAAGTAVSTVELTK---S
MMAR_0907|M.marinum_M -----------------------------VLDLAAGTAVSTVELAK---S
MUL_0660|M.ulcerans_Agy99 -----------------------------VLDLAAGTAVSSVELAK---S
Mflv_5258|M.gilvum_PYR-GCK -----------------------------VLDLAAGTAVSTVELAS---S
Mvan_4690|M.vanbaalenii_PYR-1 -----------------------------ILDLGCGTGATTLALAERLGA
MAV_0854|M.avium_104 -----------------------------VLDVGCGPGTITADLAAR-VA
MSMEG_0098|M.smegmatis_MC2_155 -----------------------------VLDIGCGPGNITAQLARAAGL
MAB_4018|M.abscessus_ATCC_1997 -----------------------------ILDVACGPGLYTRELAAQLGT
TH_2189|M.thermoresistible__bu YDQRCVDYARGRFDAIVPDHVQRELPYDNALELGCGTGFFLLNLIQS-GV
MLBr_00551|M.leprae_Br4923 -----------------------------VLDVAAGSGNISLPAAK---T
*::..*..
Mb0573|M.bovis_AF2122/97 GAWCVAADFSVGMLAAGAARK-------VPKVAGDATRLPFGDDVFDAVT
Rv0558|M.tuberculosis_H37Rv GAWCVAADFSVGMLAAGAARK-------VPKVAGDATRLPFGDDVFDAVT
MMAR_0907|M.marinum_M GAWCVAADFSVGMLAAGHERK-------VCKVAGDATRLPFADDVFDAVT
MUL_0660|M.ulcerans_Agy99 GAWCVAADFSVGMLAAGHERR-------VCKVAGDATRLPFADDVFDAVT
Mflv_5258|M.gilvum_PYR-GCK GAWCVAADFSVGMLAAGASRR-------VPKVAGDATRLPFDDGVFDAVT
Mvan_4690|M.vanbaalenii_PYR-1 HGGCTGIDISEPMIHAARTRARDRNLP-VEFVVGDAQSFPFQPNTFDVMV
MAV_0854|M.avium_104 PGQVTAVDQAADVLEVARAEAEQRNLSNVSFGTADVHRLDFADDTFDVVH
MSMEG_0098|M.smegmatis_MC2_155 DGLALGVDISEPMLARAVAAEAG---RQVGFVRADAQQLPFRDEVFDAAT
MAB_4018|M.abscessus_ATCC_1997 AGVCIGLDLSGPMLRRAVRDNSAER---VDYIRGSAHSLPFADATFDTVV
TH_2189|M.thermoresistible__bu ARRGSVTDLSPGMVRVATRNGRSLG-LDVDGRVADAEGIPYDDNTFDLVV
MLBr_00551|M.leprae_Br4923 GATIVSTDLTPELLQRSQARATELG-LTLEYREADAQALPFGDGEFDVVM
* : :: . : ... : : **
Mb0573|M.bovis_AF2122/97 ISFGLRNVANQQAALREMARVTRPGGRLLVCEFSTPTNALFATAYKEYLM
Rv0558|M.tuberculosis_H37Rv ISFGLRNVANQQAALREMARVTRPGGRLLVCEFSTPTNALFATAYKEYLM
MMAR_0907|M.marinum_M ISFGLRNVVDFSAALREMARVTRPGGRLVVCEFSTPVSALFATVYKEYLM
MUL_0660|M.ulcerans_Agy99 ISFGLRNVVDFSAALREMARVTRPGGRLVVCEFSTPVSALFATVYKEYLM
Mflv_5258|M.gilvum_PYR-GCK ISFGLRNVVDFSAGLREMARVTRPGGRLVVCEFSTPTNGLFSTVYKEYLM
Mvan_4690|M.vanbaalenii_PYR-1 SRFGVMFFDDPTTAFRNLRRATRPGGRLTFVCWRDPTDNPFMSTAERAAA
MAV_0854|M.avium_104 AHQVLQHLSDPVAALREMRRVCRPGGIVAVRDADYAGFIWYPELPALDLW
MSMEG_0098|M.smegmatis_MC2_155 SLAVFQLIPDPVAAVSEIVRVLKPGGRVAIMVPTAGAVKPVTFLARGGAR
MAB_4018|M.abscessus_ATCC_1997 CLAALYLIPDPEQAVRELCRVAGPDGQIVVFTSLRTRAASLPGVTTAMRI
TH_2189|M.thermoresistible__bu GHAVLHHIPDVELSLREVVRVLRPGGRFVFAGEPTTVGNSYARALSTLTW
MLBr_00551|M.leprae_Br4923 SAIGVMFAPDHRRAASELVRVCRPNGTIGVISWTQEGFFGRMLATIRPYR
. : . :: *. *.* . .
Mb0573|M.bovis_AF2122/97 RALP-RVARAVSSNPEA----YEYLAES--------------------IR
Rv0558|M.tuberculosis_H37Rv RALP-RVARAVSSNPEA----YEYLAES--------------------IR
MMAR_0907|M.marinum_M RALP-RVARAVSSNPEA----YVYLAES--------------------IR
MUL_0660|M.ulcerans_Agy99 RALP-RVARAVSSNPEA----YVYLAES--------------------IR
Mflv_5258|M.gilvum_PYR-GCK KALP-AMATAVSSNPDA----YVYLAES--------------------IR
Mvan_4690|M.vanbaalenii_PYR-1 QLLS-DLKPGIAGSPGP----FAFADAHRTHSILRAGGWTAVDIRPVDVT
MAV_0854|M.avium_104 RDLYRRVARANRGEPDAGRRLLSWARQAGFDDITPTG--------SLWCY
MSMEG_0098|M.smegmatis_MC2_155 ------------------------------------------------IF
MAB_4018|M.abscessus_ATCC_1997 GGFR--------------------------------------------AF
TH_2189|M.thermoresistible__bu HVATTVTRLPGLQGWRRPQAELDESSRAAALEAVVDLHTFE----PSDLE
MLBr_00551|M.leprae_Br4923 PSLSAALPPAALWGREAYIRGLLDDTVTN-------------------VK
Mb0573|M.bovis_AF2122/97 AWPDQAVLAHQISRAG-----WSGVRWRNLTGG-----------------
Rv0558|M.tuberculosis_H37Rv AWPDQAVLAHQISRAG-----WSGVRWRNLTGG-----------------
MMAR_0907|M.marinum_M AWPDQAALAQQMSRAG-----WSAVRWRNLTGG-----------------
MUL_0660|M.ulcerans_Agy99 AWPDQAALAQQMSRAG-----WSAVRWRNLTGG-----------------
Mflv_5258|M.gilvum_PYR-GCK AWPDQRALARRIEAAG-----WSDVRWRNLTGG-----------------
Mvan_4690|M.vanbaalenii_PYR-1 CTMQESDLLPYLTQMGPVGRTLRAVDARTRAQV-----------------
MAV_0854|M.avium_104 ATPETRDWWGGMWADR----ILHSTVARDLVSLGLAARE-----------
MSMEG_0098|M.smegmatis_MC2_155 GDDELGDIFENVGLVG----------VRVKTHG-----------------
MAB_4018|M.abscessus_ATCC_1997 GRDEVTGWLRAQGWTD--------IDQTVTGQG-----------------
TH_2189|M.thermoresistible__bu RMARNAGAVEVATASEEFTAAMLGWPVRTFEAAVPPGKLGWNWAKFAFGS
MLBr_00551|M.leprae_Br4923 TERRQLEVKRFNSAEGVHNYFKNHYGPTIEAYTNIGDNS-------VLAA
Mb0573|M.bovis_AF2122/97 --IVALHAGYKPGKQTPQ--------------
Rv0558|M.tuberculosis_H37Rv --IVALHAGYKPGKQTPQ--------------
MMAR_0907|M.marinum_M --IVALHAGYKP---QPV--------------
MUL_0660|M.ulcerans_Agy99 --IVALHAGYKP---QPV--------------
Mflv_5258|M.gilvum_PYR-GCK --IVALHAATKP--------------------
Mvan_4690|M.vanbaalenii_PYR-1 --ITSLREAYTEFIVDGEVRYPAACWMVDARG
MAV_0854|M.avium_104 -QLEEISAAWREWAAAPDGWIAIPHGEIICRA
MSMEG_0098|M.smegmatis_MC2_155 --FIQWVRGTKL--------------------
MAB_4018|M.abscessus_ATCC_1997 -QFIRARRAVALRVAT----------------
TH_2189|M.thermoresistible__bu WTALSWVDANVWRRVMPKGWFYNVMVTGVKPS
MLBr_00551|M.leprae_Br4923 ELDAQLTELAQKYLTNSTMGWEYLLLTAQKH-