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TESALRMAERLLADPPEHPDVSKGYLDLLGDRPAGDAGAIQALWASRLGSLFYDNAQTVMRRVLTAWHEP TEWLNLPVGGVALDVGSGPGNVTAALGRAVGPGGLALGVDVSEPMLARAVAAEAGPNVGFLRADAQDLPL SDESVDGVVSIAMLQLIPEPARAVAEMVRVLRSGRRVAVMVPTAGPAAAALRYLPHAGAHSFGDDELADV FEGLGLTSVRANTVGTIQWVRGKKP*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_0738 | - | - | 100% (236) | methyltransferase type 11 |
M. gilvum PYR-GCK | Mflv_4035 | - | 1e-08 | 30.50% (141) | methyltransferase type 11 |
M. gilvum PYR-GCK | Mflv_1100 | - | 6e-08 | 30.57% (157) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1550 | - | 2e-09 | 30.70% (114) | methyltransferase |
M. tuberculosis H37Rv | Rv1523 | - | 2e-09 | 30.70% (114) | methyltransferase |
M. leprae Br4923 | MLBr_00130 | - | 2e-09 | 32.20% (118) | hypothetical protein MLBr_00130 |
M. abscessus ATCC 19977 | MAB_4018 | - | 1e-19 | 29.41% (238) | similarity with UbiE/COQ5 methyltransferase |
M. marinum M | MMAR_4497 | - | 5e-29 | 34.65% (228) | methyltransferase |
M. avium 104 | MAV_5229 | - | 1e-78 | 63.14% (236) | methyltransferase type 11 |
M. smegmatis MC2 155 | MSMEG_0098 | - | 3e-72 | 58.90% (236) | methyltransferase |
M. thermoresistible (build 8) | TH_0087 | - | 2e-09 | 34.21% (114) | methyltransferase type 11 |
M. ulcerans Agy99 | MUL_4668 | - | 6e-29 | 34.63% (231) | methyltransferase |
M. vanbaalenii PYR-1 | Mvan_0109 | - | 1e-109 | 80.85% (235) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0738|M.gilvum_PYR-GCK MTES------------------ALRMAERLLADPP--------------- Mvan_0109|M.vanbaalenii_PYR-1 MTHT------------------VLRMTERLLIDPP--------------- MAV_5229|M.avium_104 MTDVHTSLP------------PALRRALDLLIDPP--------------- MSMEG_0098|M.smegmatis_MC2_155 MDT-------------------ALRRAMDLLIDPP--------------- MMAR_4497|M.marinum_M MSATP-----------------DPRE--VTRGLLT--------------- MUL_4668|M.ulcerans_Agy99 MSATP-----------------DPRE--VTRGLLT--------------- MAB_4018|M.abscessus_ATCC_1997 MLHHP-----------------TLADSLIDPARID--------------- Mb1550|M.bovis_AF2122/97 MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ Rv1523|M.tuberculosis_H37Rv MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ MLBr_00130|M.leprae_Br4923 MAFTRIHS---------------------FLASAG--------------- TH_0087|M.thermoresistible__bu ----------------------MLTVDYDRLGIGP--------------- Mflv_0738|M.gilvum_PYR-GCK --------------------------------------------EHPDVS Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------EHPDTS MAV_5229|M.avium_104 --------------------------------------------ADPDVS MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------AEPDFS MMAR_4497|M.marinum_M --------------------------------------------EPCDLR MUL_4668|M.ulcerans_Agy99 --------------------------------------------EPGDLR MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------HPPRRD Mb1550|M.bovis_AF2122/97 IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG Rv1523|M.tuberculosis_H37Rv IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG MLBr_00130|M.leprae_Br4923 ---------------------------------------------NTSMY TH_0087|M.thermoresistible__bu --------------------------------------------GVSVID Mflv_0738|M.gilvum_PYR-GCK KGYLDLLGDRPAGDA----------GAIQALWAS-RLGSLFYDNAQTVMR Mvan_0109|M.vanbaalenii_PYR-1 KGYLDLLGDEPDSNR----------GAIQALWAS-RLGSMFYDNAQTLAR MAV_5229|M.avium_104 KGYLDLLGGAADEDAG----VPRNTGPIQAAWAS-PIGSLLYDNAQALSR MSMEG_0098|M.smegmatis_MC2_155 KGYLDLLGRGDSTAP-------KNTGLIQKAWAS-PLGSKLYDRAQLLNR MMAR_4497|M.marinum_M RGFLDVLGESTSSPVPTVAQRAMNSRFVATVYER-LWRPAAF--YLASGV MUL_4668|M.ulcerans_Agy99 HGFLDVLGESTSSPVPTVAQRAMNSRFVATVYER-LWRPAAF--YLASGV MAB_4018|M.abscessus_ATCC_1997 HGYLDVLGPESDEPVS-VANRFMQSPLLAAIYER-AWRPMFTRGFSYGGK Mb1550|M.bovis_AF2122/97 KLTTKYFLPLGTRQVG------DHVVFFNFGYEEDPPMALPLSESDEPNR Rv1523|M.tuberculosis_H37Rv KLTTKYFLPLGTRQVG------DHVVFFNFGYEEDPPMALPLSESDEPNR MLBr_00130|M.leprae_Br4923 KRVWRFWYPLMTHKLGT-----DEIMFINWAYEEDPPMALPLEASDEPNR TH_0087|M.thermoresistible__bu VGCG--LGRHSFEAYR--------RGAHIVAFDQ---NAEELNEVDTILQ : . Mflv_0738|M.gilvum_PYR-GCK RVLTAWHEPTEWLNLPVGGVALDVGSGPGNVTAALGRAVGPGGLALGVDV Mvan_0109|M.vanbaalenii_PYR-1 RLMTAWQQPTEWLNVPVGGTALDVGSGPGNVTGALGRAVGPGGLALGVDI MAV_5229|M.avium_104 RWISAWQLPLEWLQIPRGGVALDVGSGPGNVTASLARAAGPDGLALGIDI MSMEG_0098|M.smegmatis_MC2_155 RLVASTRPPVEWLRIPPGGTVLDIGCGPGNITAQLARAAGLDGLALGVDI MMAR_4497|M.marinum_M TTRAEQHRAAAALHLSTAHRLLDVACGPGNFTAPLVKQLPAGSLAVGLDI MUL_4668|M.ulcerans_Agy99 TTRAEQHRAAAALHLSTAHRLLDVACGPGNFTAPLVKQLPAGSLAVGLDI MAB_4018|M.abscessus_ATCC_1997 STLKAHTALMDEIAGRGDHKILDVACGPGLYTRELAAQLGTAGVCIGLDL Mb1550|M.bovis_AF2122/97 YCIQLYHQTASQVDLT-GKEVLEVSCGAGGGASYIARNLGP-ASYTGLDL Rv1523|M.tuberculosis_H37Rv YCIQLYHQTASQVDLT-GKEVLEVSCGAGGGASYIARNLGP-ASYTGLDL MLBr_00130|M.leprae_Br4923 AHINLYHRTATQVNLS-GKRILEVSCGHGGGASYLTRALHP-ASYTGLDL TH_0087|M.thermoresistible__bu AMAEQREAPAGARAEVVKGDALDLPYADGTFDRVIASEILEHVPEDDRAI *:: . * : . : Mflv_0738|M.gilvum_PYR-GCK SEPMLARAVAAEAGPNVGFLRADAQDLPLSDESVDGVVSIAMLQLIPEPA Mvan_0109|M.vanbaalenii_PYR-1 SEPMLARAVRAEAGPNVGFIRADAQHLPFRDESFDAVVSIAMLQLIPDPA MAV_5229|M.avium_104 SEPMLARAVRNEAGPQVGFIKADAQRLPLRDNTVDAAVSTAVLQLVPNPQ MSMEG_0098|M.smegmatis_MC2_155 SEPMLARAVAAEAGRQVGFVRADAQQLPFRDEVFDAATSLAVFQLIPDPV MMAR_4497|M.marinum_M SEPMLTRAVLDNSGPQTCYVRGDARMLPFDDETFDAVCCFGALYLMPEPF MUL_4668|M.ulcerans_Agy99 SEPMLTRAVLDNSGPQTCYVRGDARMLPFDDETFDAVCCFGALYLMPEPF MAB_4018|M.abscessus_ATCC_1997 SGPMLRRAVRDNSAERVDYIRGSAHSLPFADATFDTVVCLAALYLIPDPE Mb1550|M.bovis_AF2122/97 NPASIDLCRAKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPDFR Rv1523|M.tuberculosis_H37Rv NPASIDLCRAKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPDFR MLBr_00130|M.leprae_Br4923 NPAGIKLCQKRHQLPGLEFVRGDAENLPFDNESFDVVINIEASHCYPHFP TH_0087|M.thermoresistible__bu AELVRVLKPGGKLVVTVPRWLPERICWLLSDEYHANEGGHVRIYRADELR . . : : . Mflv_0738|M.gilvum_PYR-GCK RAVAEMVRVLRSGRRVAVMVPTAGPAAAALRYLPHAG------AHSFGDD Mvan_0109|M.vanbaalenii_PYR-1 VALAEMVRVLRPGRRMAVMVPTAGPAAGLLRYLPNAG------AHAFGDD MAV_5229|M.avium_104 AALVEIARVLRPGGRLAVMVPTAGRLARYWRLLPNVG------AHAFDDD MSMEG_0098|M.smegmatis_MC2_155 AAVSEIVRVLKPGGRVAIMVPTAG-AVKPVTFLARGG------ARIFGDD MMAR_4497|M.marinum_M RIAREMVRVLGPGGRIAILTTYSGQRAPIRHALDAAAGA--IGLTMFDQD MUL_4668|M.ulcerans_Agy99 RIAREMVRVLGPGGRIAILTTYSGQRAPIRHALDAAAGA--IGLTMFDQD MAB_4018|M.abscessus_ATCC_1997 QAVRELCRVAGPDGQIVVFTSLR-TRAASLPGVTTAMRI--GGFRAFGRD Mb1550|M.bovis_AF2122/97 GFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQ Rv1523|M.tuberculosis_H37Rv GFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQ MLBr_00130|M.leprae_Br4923 RFLAEVVRVLRPGGHLAYADLRPSNKVGEWEVDFANSRLQQLSQREINAE TH_0087|M.thermoresistible__bu DKITRHGLRLTHRHHAHALHSPFWWLKCAVGTNNDRHFAVRAYHQLLVWD . : : : Mflv_0738|M.gilvum_PYR-GCK ELADVFEGLGLTSVRANTVGTIQWVRGKKP-------------------- Mvan_0109|M.vanbaalenii_PYR-1 ELGDTFESLGLAGVRINTVGTIQWVRGRKS-------------------- MAV_5229|M.avium_104 EIGDILEENGFASVRVKNFGTFQWVRAKLS-------------------- MSMEG_0098|M.smegmatis_MC2_155 ELGDIFENVGLVGVRVKTHGFIQWVRGTKL-------------------- MMAR_4497|M.marinum_M SFVDLFSSAGLVDIDQQTQRGLQFVVAAKPK------------------- MUL_4668|M.ulcerans_Agy99 SFVDLFSSAGLVDIDQQTQRGLQFVVAAKPK------------------- MAB_4018|M.abscessus_ATCC_1997 EVTGWLRAQGWTDIDQTVTGQGQFIRARRAVALRVAT------------- Mb1550|M.bovis_AF2122/97 AKRGLDANTARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRR---GGGFSY Rv1523|M.tuberculosis_H37Rv AKRGLDANTARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRR---GGGFSY MLBr_00130|M.leprae_Br4923 VLRGIASNSQKSRDLVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSY TH_0087|M.thermoresistible__bu MVRRPWVTRWAEEMLNPLIGKSVALYFDKPEVAGADS------------- Mflv_0738|M.gilvum_PYR-GCK -------- Mvan_0109|M.vanbaalenii_PYR-1 -------- MAV_5229|M.avium_104 -------- MSMEG_0098|M.smegmatis_MC2_155 -------- MMAR_4497|M.marinum_M -------- MUL_4668|M.ulcerans_Agy99 -------- MAB_4018|M.abscessus_ATCC_1997 -------- Mb1550|M.bovis_AF2122/97 RIYLFAKD Rv1523|M.tuberculosis_H37Rv RIYLFAKD MLBr_00130|M.leprae_Br4923 RMYSFAKD TH_0087|M.thermoresistible__bu --------