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TESALRMAERLLADPPEHPDVSKGYLDLLGDRPAGDAGAIQALWASRLGSLFYDNAQTVMRRVLTAWHEP TEWLNLPVGGVALDVGSGPGNVTAALGRAVGPGGLALGVDVSEPMLARAVAAEAGPNVGFLRADAQDLPL SDESVDGVVSIAMLQLIPEPARAVAEMVRVLRSGRRVAVMVPTAGPAAAALRYLPHAGAHSFGDDELADV FEGLGLTSVRANTVGTIQWVRGKKP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0738 | - | - | 100% (236) | methyltransferase type 11 |
| M. gilvum PYR-GCK | Mflv_4035 | - | 1e-08 | 30.50% (141) | methyltransferase type 11 |
| M. gilvum PYR-GCK | Mflv_1100 | - | 6e-08 | 30.57% (157) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1550 | - | 2e-09 | 30.70% (114) | methyltransferase |
| M. tuberculosis H37Rv | Rv1523 | - | 2e-09 | 30.70% (114) | methyltransferase |
| M. leprae Br4923 | MLBr_00130 | - | 2e-09 | 32.20% (118) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_4018 | - | 1e-19 | 29.41% (238) | similarity with UbiE/COQ5 methyltransferase |
| M. marinum M | MMAR_4497 | - | 5e-29 | 34.65% (228) | methyltransferase |
| M. avium 104 | MAV_5229 | - | 1e-78 | 63.14% (236) | methyltransferase type 11 |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 3e-72 | 58.90% (236) | methyltransferase |
| M. thermoresistible (build 8) | TH_0087 | - | 2e-09 | 34.21% (114) | methyltransferase type 11 |
| M. ulcerans Agy99 | MUL_4668 | - | 6e-29 | 34.63% (231) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0109 | - | 1e-109 | 80.85% (235) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0738|M.gilvum_PYR-GCK MTES------------------ALRMAERLLADPP---------------
Mvan_0109|M.vanbaalenii_PYR-1 MTHT------------------VLRMTERLLIDPP---------------
MAV_5229|M.avium_104 MTDVHTSLP------------PALRRALDLLIDPP---------------
MSMEG_0098|M.smegmatis_MC2_155 MDT-------------------ALRRAMDLLIDPP---------------
MMAR_4497|M.marinum_M MSATP-----------------DPRE--VTRGLLT---------------
MUL_4668|M.ulcerans_Agy99 MSATP-----------------DPRE--VTRGLLT---------------
MAB_4018|M.abscessus_ATCC_1997 MLHHP-----------------TLADSLIDPARID---------------
Mb1550|M.bovis_AF2122/97 MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ
Rv1523|M.tuberculosis_H37Rv MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ
MLBr_00130|M.leprae_Br4923 MAFTRIHS---------------------FLASAG---------------
TH_0087|M.thermoresistible__bu ----------------------MLTVDYDRLGIGP---------------
Mflv_0738|M.gilvum_PYR-GCK --------------------------------------------EHPDVS
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------EHPDTS
MAV_5229|M.avium_104 --------------------------------------------ADPDVS
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------AEPDFS
MMAR_4497|M.marinum_M --------------------------------------------EPCDLR
MUL_4668|M.ulcerans_Agy99 --------------------------------------------EPGDLR
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------HPPRRD
Mb1550|M.bovis_AF2122/97 IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG
Rv1523|M.tuberculosis_H37Rv IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG
MLBr_00130|M.leprae_Br4923 ---------------------------------------------NTSMY
TH_0087|M.thermoresistible__bu --------------------------------------------GVSVID
Mflv_0738|M.gilvum_PYR-GCK KGYLDLLGDRPAGDA----------GAIQALWAS-RLGSLFYDNAQTVMR
Mvan_0109|M.vanbaalenii_PYR-1 KGYLDLLGDEPDSNR----------GAIQALWAS-RLGSMFYDNAQTLAR
MAV_5229|M.avium_104 KGYLDLLGGAADEDAG----VPRNTGPIQAAWAS-PIGSLLYDNAQALSR
MSMEG_0098|M.smegmatis_MC2_155 KGYLDLLGRGDSTAP-------KNTGLIQKAWAS-PLGSKLYDRAQLLNR
MMAR_4497|M.marinum_M RGFLDVLGESTSSPVPTVAQRAMNSRFVATVYER-LWRPAAF--YLASGV
MUL_4668|M.ulcerans_Agy99 HGFLDVLGESTSSPVPTVAQRAMNSRFVATVYER-LWRPAAF--YLASGV
MAB_4018|M.abscessus_ATCC_1997 HGYLDVLGPESDEPVS-VANRFMQSPLLAAIYER-AWRPMFTRGFSYGGK
Mb1550|M.bovis_AF2122/97 KLTTKYFLPLGTRQVG------DHVVFFNFGYEEDPPMALPLSESDEPNR
Rv1523|M.tuberculosis_H37Rv KLTTKYFLPLGTRQVG------DHVVFFNFGYEEDPPMALPLSESDEPNR
MLBr_00130|M.leprae_Br4923 KRVWRFWYPLMTHKLGT-----DEIMFINWAYEEDPPMALPLEASDEPNR
TH_0087|M.thermoresistible__bu VGCG--LGRHSFEAYR--------RGAHIVAFDQ---NAEELNEVDTILQ
: .
Mflv_0738|M.gilvum_PYR-GCK RVLTAWHEPTEWLNLPVGGVALDVGSGPGNVTAALGRAVGPGGLALGVDV
Mvan_0109|M.vanbaalenii_PYR-1 RLMTAWQQPTEWLNVPVGGTALDVGSGPGNVTGALGRAVGPGGLALGVDI
MAV_5229|M.avium_104 RWISAWQLPLEWLQIPRGGVALDVGSGPGNVTASLARAAGPDGLALGIDI
MSMEG_0098|M.smegmatis_MC2_155 RLVASTRPPVEWLRIPPGGTVLDIGCGPGNITAQLARAAGLDGLALGVDI
MMAR_4497|M.marinum_M TTRAEQHRAAAALHLSTAHRLLDVACGPGNFTAPLVKQLPAGSLAVGLDI
MUL_4668|M.ulcerans_Agy99 TTRAEQHRAAAALHLSTAHRLLDVACGPGNFTAPLVKQLPAGSLAVGLDI
MAB_4018|M.abscessus_ATCC_1997 STLKAHTALMDEIAGRGDHKILDVACGPGLYTRELAAQLGTAGVCIGLDL
Mb1550|M.bovis_AF2122/97 YCIQLYHQTASQVDLT-GKEVLEVSCGAGGGASYIARNLGP-ASYTGLDL
Rv1523|M.tuberculosis_H37Rv YCIQLYHQTASQVDLT-GKEVLEVSCGAGGGASYIARNLGP-ASYTGLDL
MLBr_00130|M.leprae_Br4923 AHINLYHRTATQVNLS-GKRILEVSCGHGGGASYLTRALHP-ASYTGLDL
TH_0087|M.thermoresistible__bu AMAEQREAPAGARAEVVKGDALDLPYADGTFDRVIASEILEHVPEDDRAI
*:: . * : . :
Mflv_0738|M.gilvum_PYR-GCK SEPMLARAVAAEAGPNVGFLRADAQDLPLSDESVDGVVSIAMLQLIPEPA
Mvan_0109|M.vanbaalenii_PYR-1 SEPMLARAVRAEAGPNVGFIRADAQHLPFRDESFDAVVSIAMLQLIPDPA
MAV_5229|M.avium_104 SEPMLARAVRNEAGPQVGFIKADAQRLPLRDNTVDAAVSTAVLQLVPNPQ
MSMEG_0098|M.smegmatis_MC2_155 SEPMLARAVAAEAGRQVGFVRADAQQLPFRDEVFDAATSLAVFQLIPDPV
MMAR_4497|M.marinum_M SEPMLTRAVLDNSGPQTCYVRGDARMLPFDDETFDAVCCFGALYLMPEPF
MUL_4668|M.ulcerans_Agy99 SEPMLTRAVLDNSGPQTCYVRGDARMLPFDDETFDAVCCFGALYLMPEPF
MAB_4018|M.abscessus_ATCC_1997 SGPMLRRAVRDNSAERVDYIRGSAHSLPFADATFDTVVCLAALYLIPDPE
Mb1550|M.bovis_AF2122/97 NPASIDLCRAKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPDFR
Rv1523|M.tuberculosis_H37Rv NPASIDLCRAKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPDFR
MLBr_00130|M.leprae_Br4923 NPAGIKLCQKRHQLPGLEFVRGDAENLPFDNESFDVVINIEASHCYPHFP
TH_0087|M.thermoresistible__bu AELVRVLKPGGKLVVTVPRWLPERICWLLSDEYHANEGGHVRIYRADELR
. . : : .
Mflv_0738|M.gilvum_PYR-GCK RAVAEMVRVLRSGRRVAVMVPTAGPAAAALRYLPHAG------AHSFGDD
Mvan_0109|M.vanbaalenii_PYR-1 VALAEMVRVLRPGRRMAVMVPTAGPAAGLLRYLPNAG------AHAFGDD
MAV_5229|M.avium_104 AALVEIARVLRPGGRLAVMVPTAGRLARYWRLLPNVG------AHAFDDD
MSMEG_0098|M.smegmatis_MC2_155 AAVSEIVRVLKPGGRVAIMVPTAG-AVKPVTFLARGG------ARIFGDD
MMAR_4497|M.marinum_M RIAREMVRVLGPGGRIAILTTYSGQRAPIRHALDAAAGA--IGLTMFDQD
MUL_4668|M.ulcerans_Agy99 RIAREMVRVLGPGGRIAILTTYSGQRAPIRHALDAAAGA--IGLTMFDQD
MAB_4018|M.abscessus_ATCC_1997 QAVRELCRVAGPDGQIVVFTSLR-TRAASLPGVTTAMRI--GGFRAFGRD
Mb1550|M.bovis_AF2122/97 GFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQ
Rv1523|M.tuberculosis_H37Rv GFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQ
MLBr_00130|M.leprae_Br4923 RFLAEVVRVLRPGGHLAYADLRPSNKVGEWEVDFANSRLQQLSQREINAE
TH_0087|M.thermoresistible__bu DKITRHGLRLTHRHHAHALHSPFWWLKCAVGTNNDRHFAVRAYHQLLVWD
. : : :
Mflv_0738|M.gilvum_PYR-GCK ELADVFEGLGLTSVRANTVGTIQWVRGKKP--------------------
Mvan_0109|M.vanbaalenii_PYR-1 ELGDTFESLGLAGVRINTVGTIQWVRGRKS--------------------
MAV_5229|M.avium_104 EIGDILEENGFASVRVKNFGTFQWVRAKLS--------------------
MSMEG_0098|M.smegmatis_MC2_155 ELGDIFENVGLVGVRVKTHGFIQWVRGTKL--------------------
MMAR_4497|M.marinum_M SFVDLFSSAGLVDIDQQTQRGLQFVVAAKPK-------------------
MUL_4668|M.ulcerans_Agy99 SFVDLFSSAGLVDIDQQTQRGLQFVVAAKPK-------------------
MAB_4018|M.abscessus_ATCC_1997 EVTGWLRAQGWTDIDQTVTGQGQFIRARRAVALRVAT-------------
Mb1550|M.bovis_AF2122/97 AKRGLDANTARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRR---GGGFSY
Rv1523|M.tuberculosis_H37Rv AKRGLDANTARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRR---GGGFSY
MLBr_00130|M.leprae_Br4923 VLRGIASNSQKSRDLVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSY
TH_0087|M.thermoresistible__bu MVRRPWVTRWAEEMLNPLIGKSVALYFDKPEVAGADS-------------
Mflv_0738|M.gilvum_PYR-GCK --------
Mvan_0109|M.vanbaalenii_PYR-1 --------
MAV_5229|M.avium_104 --------
MSMEG_0098|M.smegmatis_MC2_155 --------
MMAR_4497|M.marinum_M --------
MUL_4668|M.ulcerans_Agy99 --------
MAB_4018|M.abscessus_ATCC_1997 --------
Mb1550|M.bovis_AF2122/97 RIYLFAKD
Rv1523|M.tuberculosis_H37Rv RIYLFAKD
MLBr_00130|M.leprae_Br4923 RMYSFAKD
TH_0087|M.thermoresistible__bu --------