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M. gilvum PYR-GCK Mflv_0738 (-)

annotation: methyltransferase type 11
coordinates: 757932 - 758642
length: 236

TESALRMAERLLADPPEHPDVSKGYLDLLGDRPAGDAGAIQALWASRLGSLFYDNAQTVMRRVLTAWHEP
TEWLNLPVGGVALDVGSGPGNVTAALGRAVGPGGLALGVDVSEPMLARAVAAEAGPNVGFLRADAQDLPL
SDESVDGVVSIAMLQLIPEPARAVAEMVRVLRSGRRVAVMVPTAGPAAAALRYLPHAGAHSFGDDELADV
FEGLGLTSVRANTVGTIQWVRGKKP*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_0738--100% (236)methyltransferase type 11
M. gilvum PYR-GCKMflv_4035-1e-0830.50% (141) methyltransferase type 11
M. gilvum PYR-GCKMflv_1100-6e-0830.57% (157) methyltransferase type 11

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1550-2e-0930.70% (114) methyltransferase
M. tuberculosis H37RvRv1523-2e-0930.70% (114) methyltransferase
M. leprae Br4923MLBr_00130-2e-0932.20% (118) hypothetical protein MLBr_00130
M. abscessus ATCC 19977MAB_4018-1e-1929.41% (238) similarity with UbiE/COQ5 methyltransferase
M. marinum MMMAR_4497-5e-2934.65% (228) methyltransferase
M. avium 104MAV_5229-1e-7863.14% (236) methyltransferase type 11
M. smegmatis MC2 155MSMEG_0098-3e-7258.90% (236) methyltransferase
M. thermoresistible (build 8)TH_0087-2e-0934.21% (114) methyltransferase type 11
M. ulcerans Agy99MUL_4668-6e-2934.63% (231) methyltransferase
M. vanbaalenii PYR-1Mvan_0109-1e-10980.85% (235) methyltransferase type 11

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0738|M.gilvum_PYR-GCK          MTES------------------ALRMAERLLADPP---------------
Mvan_0109|M.vanbaalenii_PYR-1       MTHT------------------VLRMTERLLIDPP---------------
MAV_5229|M.avium_104                MTDVHTSLP------------PALRRALDLLIDPP---------------
MSMEG_0098|M.smegmatis_MC2_155      MDT-------------------ALRRAMDLLIDPP---------------
MMAR_4497|M.marinum_M               MSATP-----------------DPRE--VTRGLLT---------------
MUL_4668|M.ulcerans_Agy99           MSATP-----------------DPRE--VTRGLLT---------------
MAB_4018|M.abscessus_ATCC_1997      MLHHP-----------------TLADSLIDPARID---------------
Mb1550|M.bovis_AF2122/97            MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ
Rv1523|M.tuberculosis_H37Rv         MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ
MLBr_00130|M.leprae_Br4923          MAFTRIHS---------------------FLASAG---------------
TH_0087|M.thermoresistible__bu      ----------------------MLTVDYDRLGIGP---------------
                                                                                      

Mflv_0738|M.gilvum_PYR-GCK          --------------------------------------------EHPDVS
Mvan_0109|M.vanbaalenii_PYR-1       --------------------------------------------EHPDTS
MAV_5229|M.avium_104                --------------------------------------------ADPDVS
MSMEG_0098|M.smegmatis_MC2_155      --------------------------------------------AEPDFS
MMAR_4497|M.marinum_M               --------------------------------------------EPCDLR
MUL_4668|M.ulcerans_Agy99           --------------------------------------------EPGDLR
MAB_4018|M.abscessus_ATCC_1997      --------------------------------------------HPPRRD
Mb1550|M.bovis_AF2122/97            IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG
Rv1523|M.tuberculosis_H37Rv         IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG
MLBr_00130|M.leprae_Br4923          ---------------------------------------------NTSMY
TH_0087|M.thermoresistible__bu      --------------------------------------------GVSVID
                                                                                      

Mflv_0738|M.gilvum_PYR-GCK          KGYLDLLGDRPAGDA----------GAIQALWAS-RLGSLFYDNAQTVMR
Mvan_0109|M.vanbaalenii_PYR-1       KGYLDLLGDEPDSNR----------GAIQALWAS-RLGSMFYDNAQTLAR
MAV_5229|M.avium_104                KGYLDLLGGAADEDAG----VPRNTGPIQAAWAS-PIGSLLYDNAQALSR
MSMEG_0098|M.smegmatis_MC2_155      KGYLDLLGRGDSTAP-------KNTGLIQKAWAS-PLGSKLYDRAQLLNR
MMAR_4497|M.marinum_M               RGFLDVLGESTSSPVPTVAQRAMNSRFVATVYER-LWRPAAF--YLASGV
MUL_4668|M.ulcerans_Agy99           HGFLDVLGESTSSPVPTVAQRAMNSRFVATVYER-LWRPAAF--YLASGV
MAB_4018|M.abscessus_ATCC_1997      HGYLDVLGPESDEPVS-VANRFMQSPLLAAIYER-AWRPMFTRGFSYGGK
Mb1550|M.bovis_AF2122/97            KLTTKYFLPLGTRQVG------DHVVFFNFGYEEDPPMALPLSESDEPNR
Rv1523|M.tuberculosis_H37Rv         KLTTKYFLPLGTRQVG------DHVVFFNFGYEEDPPMALPLSESDEPNR
MLBr_00130|M.leprae_Br4923          KRVWRFWYPLMTHKLGT-----DEIMFINWAYEEDPPMALPLEASDEPNR
TH_0087|M.thermoresistible__bu      VGCG--LGRHSFEAYR--------RGAHIVAFDQ---NAEELNEVDTILQ
                                                                   :      .           

Mflv_0738|M.gilvum_PYR-GCK          RVLTAWHEPTEWLNLPVGGVALDVGSGPGNVTAALGRAVGPGGLALGVDV
Mvan_0109|M.vanbaalenii_PYR-1       RLMTAWQQPTEWLNVPVGGTALDVGSGPGNVTGALGRAVGPGGLALGVDI
MAV_5229|M.avium_104                RWISAWQLPLEWLQIPRGGVALDVGSGPGNVTASLARAAGPDGLALGIDI
MSMEG_0098|M.smegmatis_MC2_155      RLVASTRPPVEWLRIPPGGTVLDIGCGPGNITAQLARAAGLDGLALGVDI
MMAR_4497|M.marinum_M               TTRAEQHRAAAALHLSTAHRLLDVACGPGNFTAPLVKQLPAGSLAVGLDI
MUL_4668|M.ulcerans_Agy99           TTRAEQHRAAAALHLSTAHRLLDVACGPGNFTAPLVKQLPAGSLAVGLDI
MAB_4018|M.abscessus_ATCC_1997      STLKAHTALMDEIAGRGDHKILDVACGPGLYTRELAAQLGTAGVCIGLDL
Mb1550|M.bovis_AF2122/97            YCIQLYHQTASQVDLT-GKEVLEVSCGAGGGASYIARNLGP-ASYTGLDL
Rv1523|M.tuberculosis_H37Rv         YCIQLYHQTASQVDLT-GKEVLEVSCGAGGGASYIARNLGP-ASYTGLDL
MLBr_00130|M.leprae_Br4923          AHINLYHRTATQVNLS-GKRILEVSCGHGGGASYLTRALHP-ASYTGLDL
TH_0087|M.thermoresistible__bu      AMAEQREAPAGARAEVVKGDALDLPYADGTFDRVIASEILEHVPEDDRAI
                                                         *::  . *     :           .  :

Mflv_0738|M.gilvum_PYR-GCK          SEPMLARAVAAEAGPNVGFLRADAQDLPLSDESVDGVVSIAMLQLIPEPA
Mvan_0109|M.vanbaalenii_PYR-1       SEPMLARAVRAEAGPNVGFIRADAQHLPFRDESFDAVVSIAMLQLIPDPA
MAV_5229|M.avium_104                SEPMLARAVRNEAGPQVGFIKADAQRLPLRDNTVDAAVSTAVLQLVPNPQ
MSMEG_0098|M.smegmatis_MC2_155      SEPMLARAVAAEAGRQVGFVRADAQQLPFRDEVFDAATSLAVFQLIPDPV
MMAR_4497|M.marinum_M               SEPMLTRAVLDNSGPQTCYVRGDARMLPFDDETFDAVCCFGALYLMPEPF
MUL_4668|M.ulcerans_Agy99           SEPMLTRAVLDNSGPQTCYVRGDARMLPFDDETFDAVCCFGALYLMPEPF
MAB_4018|M.abscessus_ATCC_1997      SGPMLRRAVRDNSAERVDYIRGSAHSLPFADATFDTVVCLAALYLIPDPE
Mb1550|M.bovis_AF2122/97            NPASIDLCRAKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPDFR
Rv1523|M.tuberculosis_H37Rv         NPASIDLCRAKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPDFR
MLBr_00130|M.leprae_Br4923          NPAGIKLCQKRHQLPGLEFVRGDAENLPFDNESFDVVINIEASHCYPHFP
TH_0087|M.thermoresistible__bu      AELVRVLKPGGKLVVTVPRWLPERICWLLSDEYHANEGGHVRIYRADELR
                                               .          .     : :                .  

Mflv_0738|M.gilvum_PYR-GCK          RAVAEMVRVLRSGRRVAVMVPTAGPAAAALRYLPHAG------AHSFGDD
Mvan_0109|M.vanbaalenii_PYR-1       VALAEMVRVLRPGRRMAVMVPTAGPAAGLLRYLPNAG------AHAFGDD
MAV_5229|M.avium_104                AALVEIARVLRPGGRLAVMVPTAGRLARYWRLLPNVG------AHAFDDD
MSMEG_0098|M.smegmatis_MC2_155      AAVSEIVRVLKPGGRVAIMVPTAG-AVKPVTFLARGG------ARIFGDD
MMAR_4497|M.marinum_M               RIAREMVRVLGPGGRIAILTTYSGQRAPIRHALDAAAGA--IGLTMFDQD
MUL_4668|M.ulcerans_Agy99           RIAREMVRVLGPGGRIAILTTYSGQRAPIRHALDAAAGA--IGLTMFDQD
MAB_4018|M.abscessus_ATCC_1997      QAVRELCRVAGPDGQIVVFTSLR-TRAASLPGVTTAMRI--GGFRAFGRD
Mb1550|M.bovis_AF2122/97            GFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQ
Rv1523|M.tuberculosis_H37Rv         GFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQ
MLBr_00130|M.leprae_Br4923          RFLAEVVRVLRPGGHLAYADLRPSNKVGEWEVDFANSRLQQLSQREINAE
TH_0087|M.thermoresistible__bu      DKITRHGLRLTHRHHAHALHSPFWWLKCAVGTNNDRHFAVRAYHQLLVWD
                                        .         :                               :  :

Mflv_0738|M.gilvum_PYR-GCK          ELADVFEGLGLTSVRANTVGTIQWVRGKKP--------------------
Mvan_0109|M.vanbaalenii_PYR-1       ELGDTFESLGLAGVRINTVGTIQWVRGRKS--------------------
MAV_5229|M.avium_104                EIGDILEENGFASVRVKNFGTFQWVRAKLS--------------------
MSMEG_0098|M.smegmatis_MC2_155      ELGDIFENVGLVGVRVKTHGFIQWVRGTKL--------------------
MMAR_4497|M.marinum_M               SFVDLFSSAGLVDIDQQTQRGLQFVVAAKPK-------------------
MUL_4668|M.ulcerans_Agy99           SFVDLFSSAGLVDIDQQTQRGLQFVVAAKPK-------------------
MAB_4018|M.abscessus_ATCC_1997      EVTGWLRAQGWTDIDQTVTGQGQFIRARRAVALRVAT-------------
Mb1550|M.bovis_AF2122/97            AKRGLDANTARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRR---GGGFSY
Rv1523|M.tuberculosis_H37Rv         AKRGLDANTARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRR---GGGFSY
MLBr_00130|M.leprae_Br4923          VLRGIASNSQKSRDLVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSY
TH_0087|M.thermoresistible__bu      MVRRPWVTRWAEEMLNPLIGKSVALYFDKPEVAGADS-------------
                                                                                      

Mflv_0738|M.gilvum_PYR-GCK          --------
Mvan_0109|M.vanbaalenii_PYR-1       --------
MAV_5229|M.avium_104                --------
MSMEG_0098|M.smegmatis_MC2_155      --------
MMAR_4497|M.marinum_M               --------
MUL_4668|M.ulcerans_Agy99           --------
MAB_4018|M.abscessus_ATCC_1997      --------
Mb1550|M.bovis_AF2122/97            RIYLFAKD
Rv1523|M.tuberculosis_H37Rv         RIYLFAKD
MLBr_00130|M.leprae_Br4923          RMYSFAKD
TH_0087|M.thermoresistible__bu      --------