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MLHHPTLADSLIDPARIDHPPRRDHGYLDVLGPESDEPVSVANRFMQSPLLAAIYERAWRPMFTRGFSYG GKSTLKAHTALMDEIAGRGDHKILDVACGPGLYTRELAAQLGTAGVCIGLDLSGPMLRRAVRDNSAERVD YIRGSAHSLPFADATFDTVVCLAALYLIPDPEQAVRELCRVAGPDGQIVVFTSLRTRAASLPGVTTAMRI GGFRAFGRDEVTGWLRAQGWTDIDQTVTGQGQFIRARRAVALRVAT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4018 | - | - | 100% (256) | similarity with UbiE/COQ5 methyltransferase |
| M. abscessus ATCC 19977 | MAB_1294c | - | 1e-12 | 40.82% (98) | hypothetical protein MAB_1294c |
| M. abscessus ATCC 19977 | MAB_1390c | - | 2e-09 | 33.62% (116) | putative UbiE/COQ5 methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3756 | - | 3e-11 | 28.02% (182) | transferase |
| M. gilvum PYR-GCK | Mflv_0738 | - | 2e-19 | 29.41% (238) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv3729 | - | 3e-11 | 28.02% (182) | transferase |
| M. leprae Br4923 | MLBr_02273 | ubiE | 7e-10 | 36.36% (99) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. marinum M | MMAR_4497 | - | 6e-39 | 39.91% (233) | methyltransferase |
| M. avium 104 | MAV_5229 | - | 4e-23 | 32.13% (249) | methyltransferase type 11 |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 2e-24 | 32.10% (243) | methyltransferase |
| M. thermoresistible (build 8) | TH_3395 | - | 4e-11 | 30.19% (159) | PUTATIVE putative ubiquinone/menaquinone biosynthesis |
| M. ulcerans Agy99 | MUL_4668 | - | 5e-40 | 40.17% (234) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0109 | - | 1e-24 | 33.89% (239) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4497|M.marinum_M --------------------------------------------------
MUL_4668|M.ulcerans_Agy99 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0738|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5229|M.avium_104 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 MFVEYTKSICPVCKVVVDAQVNIRHDKVYLRKRCREHGSFEALVYGDAQM
Rv3729|M.tuberculosis_H37Rv MFVEYTKSICPVCKVVVDAQVNIRHDKVYLRKRCREHGSFEALVYGDAQM
TH_3395|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
MMAR_4497|M.marinum_M --------------------------------------------------
MUL_4668|M.ulcerans_Agy99 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0738|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5229|M.avium_104 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 YLESARFNKPGTFPLRFQTEVRDGCPSDCGLCPDHKQHACLGLIEVNTHC
Rv3729|M.tuberculosis_H37Rv YLESARFNKPGTFPLRFQTEVRDGCPSDCGLCPDHKQHACLGLIEVNTHC
TH_3395|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
MMAR_4497|M.marinum_M --------------------------------------------------
MUL_4668|M.ulcerans_Agy99 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0738|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5229|M.avium_104 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 NLDCPICFADSGHQPDGYAITAAQCERMLDTLVAAEGEPEVVMFSGGEPT
Rv3729|M.tuberculosis_H37Rv NLDCPICFADSGHQPDGYAITAAQCERMLDTLVAAEGEPEVVMFSGGEPT
TH_3395|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
MMAR_4497|M.marinum_M --------------------------------------------------
MUL_4668|M.ulcerans_Agy99 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0738|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5229|M.avium_104 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 IHKQLLEFVDAAQARPVKTIIINTNGIRLASDRRFVDQLATRNRPGHPVH
Rv3729|M.tuberculosis_H37Rv IHKQLLEFVDAAQARPVKTVIINTNGIRLASDRRFVDQLATRNRPGHPVH
TH_3395|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
MMAR_4497|M.marinum_M --------------------------------------------------
MUL_4668|M.ulcerans_Agy99 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0738|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5229|M.avium_104 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 IYLQFDGLDEATHRRIRGHDLRDVKQRALDNCAAAGLTVSLVAAVERGLN
Rv3729|M.tuberculosis_H37Rv IYLQFDGLDEATHRRIRGHDLRDVKQRALDNCAAAGLTVSLVAAVERGLN
TH_3395|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
MMAR_4497|M.marinum_M --------------------------------------------------
MUL_4668|M.ulcerans_Agy99 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0738|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5229|M.avium_104 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 EHELGAVIRHGMAQPGVQSVVFQPVTHAGRHVQFDPLTRLTNSDIIACIT
Rv3729|M.tuberculosis_H37Rv EHELGAVIRHGMAQPGVQPVVFQPVTHAGRHVQFDPLTRLTNSDIIACIT
TH_3395|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
MMAR_4497|M.marinum_M --------------------------------------------------
MUL_4668|M.ulcerans_Agy99 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0738|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5229|M.avium_104 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 AQLPEWFRPGDFFPVPCCFPSCRSITYLLTDGEHVVPIPRLLNVEDYLDY
Rv3729|M.tuberculosis_H37Rv AQLPEWFRPGDFFPVPCCFPSCRSITYLLTDGEHVVPIPRLLNVEDYLDY
TH_3395|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
MMAR_4497|M.marinum_M --------------------------------------------------
MUL_4668|M.ulcerans_Agy99 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0738|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5229|M.avium_104 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 VSNRVIPDLAIREALENLWSASAVPGTDTMTAQLQRATAALNCAEGCGIN
Rv3729|M.tuberculosis_H37Rv VSNRVIPDLAIREALENLWSASAVPGTDTMTAQLQRATAALNCAEGCGIN
TH_3395|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
MMAR_4497|M.marinum_M --------------------------------------------MSATP-
MUL_4668|M.ulcerans_Agy99 --------------------------------------------MSATP-
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------MLHHP-
Mflv_0738|M.gilvum_PYR-GCK --------------------------------------------MTES--
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------MTHT--
MAV_5229|M.avium_104 --------------------------------------------MTDVHT
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------MDT---
Mb3756|M.bovis_AF2122/97 LPEALTHLTDRVFAIVIQDFQDPYTLNVKQLMKCCVQQITPDGRLIPFCA
Rv3729|M.tuberculosis_H37Rv LPEALTHLTDRVFAIVIQDFQDPYTLNVKQLMKCCVQQITPDGRLIPFCA
TH_3395|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
MMAR_4497|M.marinum_M ----DPRE--VTRGLLTEPCDLRRGFLDVLGESTSSPVPT----------
MUL_4668|M.ulcerans_Agy99 ----DPRE--VTRGLLTEPGDLRHGFLDVLGESTSSPVPT----------
MAB_4018|M.abscessus_ATCC_1997 ----TLADSLIDPARIDHPPRRDHGYLDVLGPESDEPVS-----------
Mflv_0738|M.gilvum_PYR-GCK ----ALRMAERLLADPPEHPDVSKGYLDLLGDRPAGDA------------
Mvan_0109|M.vanbaalenii_PYR-1 ----VLRMTERLLIDPPEHPDTSKGYLDLLGDEPDSNR------------
MAV_5229|M.avium_104 SLPPALRRALDLLIDPPADPDVSKGYLDLLGGAADEDAGVP---------
MSMEG_0098|M.smegmatis_MC2_155 ----ALRRAMDLLIDPPAEPDFSKGYLDLLGRGDSTAP------------
Mb3756|M.bovis_AF2122/97 YNSVGYREQVREQLTGVPVPDIVPNAIPLAGLLADAPHGSKQANTGGSIA
Rv3729|M.tuberculosis_H37Rv YNSVGYREQVREQLTGVPVPDIVPNAIPLAGLLADAPHGSKQANTGGSIA
TH_3395|M.thermoresistible__bu ------------------MADVAANWAGRGGRFAGGLYDFG---------
MLBr_02273|M.leprae_Br4923 --------MPPGSVDVVSRAALDKDPRDVVAMFDDVAH------------
. .
MMAR_4497|M.marinum_M -----------VAQRAMNSRFVATVYERLWRPAAF--YLASGVTTRAEQH
MUL_4668|M.ulcerans_Agy99 -----------VAQRAMNSRFVATVYERLWRPAAF--YLASGVTTRAEQH
MAB_4018|M.abscessus_ATCC_1997 -----------VANRFMQSPLLAAIYERAWRPMFTRGFSYGGKSTLKAHT
Mflv_0738|M.gilvum_PYR-GCK ----------GAIQALWASRLGSLFYDNAQTVMRR---------VLTAWH
Mvan_0109|M.vanbaalenii_PYR-1 ----------GAIQALWASRLGSMFYDNAQTLARR---------LMTAWQ
MAV_5229|M.avium_104 -------RNTGPIQAAWASPIGSLLYDNAQALSRR---------WISAWQ
MSMEG_0098|M.smegmatis_MC2_155 -------KNTGLIQKAWASPLGSKLYDRAQLLNRR---------LVASTR
Mb3756|M.bovis_AF2122/97 RLAGPTRGAPMALPPQQIKACCADAYSRDIVALLLGDSFHPGGATLTRRL
Rv3729|M.tuberculosis_H37Rv RLAGPTRGAPMALPPQQIKACCADAYSRDIVALLLGDSFHPGGATLTRRL
TH_3395|M.thermoresistible__bu -----------VEREVLARPAGLLMWGTDTRLLFD---------------
MLBr_02273|M.leprae_Br4923 -------------RYDLTNTVLSLGQDRYWRRATR---------------
MMAR_4497|M.marinum_M RAAAALHLSTA-HRLLDVACGPGNFTAPLVKQLPAGSLAVGLDISEPMLT
MUL_4668|M.ulcerans_Agy99 RAAAALHLSTA-HRLLDVACGPGNFTAPLVKQLPAGSLAVGLDISEPMLT
MAB_4018|M.abscessus_ATCC_1997 ALMDEIAGRGD-HKILDVACGPGLYTRELAAQLGTAGVCIGLDLSGPMLR
Mflv_0738|M.gilvum_PYR-GCK EPTEWLNLPVG-GVALDVGSGPGNVTAALGRAVGPGGLALGVDVSEPMLA
Mvan_0109|M.vanbaalenii_PYR-1 QPTEWLNVPVG-GTALDVGSGPGNVTGALGRAVGPGGLALGVDISEPMLA
MAV_5229|M.avium_104 LPLEWLQIPRG-GVALDVGSGPGNVTASLARAAGPDGLALGIDISEPMLA
MSMEG_0098|M.smegmatis_MC2_155 PPVEWLRIPPG-GTVLDIGCGPGNITAQLARAAGLDGLALGVDISEPMLA
Mb3756|M.bovis_AF2122/97 ADQLGLRSTGDPRRVADIAAGPGASARLLASDYG--VAVDGVDISEINVK
Rv3729|M.tuberculosis_H37Rv ADQLGLRSTGDPRRVADIAAGPGASARLLASDYG--VAVDGVDISEINVK
TH_3395|M.thermoresistible__bu -SIRRIGDLPDGTAVLDIPCGGGLALRGLR--HGRRLRYVAADISADMLA
MLBr_02273|M.leprae_Br4923 ---SALRIGPG-QKVLDLAAGTAVSTAELSK---SGAWCVAADFSVRMLA
: *: .* . * . *.* :
MMAR_4497|M.marinum_M RAVLDNSGP----QTCYVRGDARMLPFDDETFDAVCCFGALYLMPEPFRI
MUL_4668|M.ulcerans_Agy99 RAVLDNSGP----QTCYVRGDARMLPFDDETFDAVCCFGALYLMPEPFRI
MAB_4018|M.abscessus_ATCC_1997 RAVRDNSAE----RVDYIRGSAHSLPFADATFDTVVCLAALYLIPDPEQA
Mflv_0738|M.gilvum_PYR-GCK RAVAAEAGP----NVGFLRADAQDLPLSDESVDGVVSIAMLQLIPEPARA
Mvan_0109|M.vanbaalenii_PYR-1 RAVRAEAGP----NVGFIRADAQHLPFRDESFDAVVSIAMLQLIPDPAVA
MAV_5229|M.avium_104 RAVRNEAGP----QVGFIKADAQRLPLRDNTVDAAVSTAVLQLVPNPQAA
MSMEG_0098|M.smegmatis_MC2_155 RAVAAEAGR----QVGFVRADAQQLPFRDEVFDAATSLAVFQLIPDPVAA
Mb3756|M.bovis_AF2122/97 RAQAAVAQTGLTERVRFHLGDAESVPLPDDTFDALVCECAFCTFPDKNAA
Rv3729|M.tuberculosis_H37Rv RAQAAVAQTGLTERVRFHLGDAESVPLPDDTFDALVCECAFCTFPDKNAA
TH_3395|M.thermoresistible__bu RAQRRAATLG-RTDVRFVVADIERMPFGDGEFDCCVTFNGLHCVPDPAAA
MLBr_02273|M.leprae_Br4923 TGGAR--------KVPKVAADATQLPFSDGVFDAVTISFGLRNIADYQAA
. . .. :*: * .* : ..:
MMAR_4497|M.marinum_M AREMVRVLGPGGRIAILTTYSGQRAPIRHALDAAAGAI---GLTMFDQDS
MUL_4668|M.ulcerans_Agy99 AREMVRVLGPGGRIAILTTYSGQRAPIRHALDAAAGAI---GLTMFDQDS
MAB_4018|M.abscessus_ATCC_1997 VRELCRVAGPDGQIVVFTSLR-TRAASLPGVTTAMRIG---GFRAFGRDE
Mflv_0738|M.gilvum_PYR-GCK VAEMVRVLRSGRRVAVMVPTAGPAAAALRYLPHAG-------AHSFGDDE
Mvan_0109|M.vanbaalenii_PYR-1 LAEMVRVLRPGRRMAVMVPTAGPAAGLLRYLPNAG-------AHAFGDDE
MAV_5229|M.avium_104 LVEIARVLRPGGRLAVMVPTAGRLARYWRLLPNVG-------AHAFDDDE
MSMEG_0098|M.smegmatis_MC2_155 VSEIVRVLKPGGRVAIMVPTAG-AVKPVTFLARGG-------ARIFGDDE
Mb3756|M.bovis_AF2122/97 AQQFARILRPGGLAGITDVTVGDGGLPAELTPLAAWVAC--IADARTVTD
Rv3729|M.tuberculosis_H37Rv AQQFARILRPGGLAGITDVTVGDGGLPAELTPLAAWVAC--IADARTVTD
TH_3395|M.thermoresistible__bu VAEIARCVKPGGRLIGDAVVRGAGRRQDALIAVFRRAGV--FGPGGTTDE
MLBr_02273|M.leprae_Br4923 LREMARVTRPGGQLVVCEFSTPTNALVANVYTEYLMRALPQVARLVSSNP
:: * ..
MMAR_4497|M.marinum_M FVDLFSSAGLVDIDQQTQRG-----LQFVVAAKPK---------------
MUL_4668|M.ulcerans_Agy99 FVDLFSSAGLVDIDQQTQRG-----LQFVVAAKPK---------------
MAB_4018|M.abscessus_ATCC_1997 VTGWLRAQGWTDIDQTVTGQ-----GQFIRARRAVALRVAT---------
Mflv_0738|M.gilvum_PYR-GCK LADVFEGLGLTSVRANTVGT-----IQWVRGKKP----------------
Mvan_0109|M.vanbaalenii_PYR-1 LGDTFESLGLAGVRINTVGT-----IQWVRGRKS----------------
MAV_5229|M.avium_104 IGDILEENGFASVRVKNFGT-----FQWVRAKLS----------------
MSMEG_0098|M.smegmatis_MC2_155 LGDIFENVGLVGVRVKTHGF-----IQWVRGTKL----------------
Mb3756|M.bovis_AF2122/97 YTDILEGAGLRTRHIESHDESLLDMIDRIDARITALHVAAPEILADNGIR
Rv3729|M.tuberculosis_H37Rv YTDILEGAGLRTRHIESHDESLLDMIDRIDARITALHVAAPEILADNGIR
TH_3395|M.thermoresistible__bu LQGWLTRAGFEVEDFRRSGA-----VAHFTAVRS----------------
MLBr_02273|M.leprae_Br4923 DAYIYLAESIRAWPDQVTLACQLSRTGWASPRWRNLTGGIVALHAADKPV
.
MMAR_4497|M.marinum_M ------------------------------
MUL_4668|M.ulcerans_Agy99 ------------------------------
MAB_4018|M.abscessus_ATCC_1997 ------------------------------
Mflv_0738|M.gilvum_PYR-GCK ------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 ------------------------------
MAV_5229|M.avium_104 ------------------------------
MSMEG_0098|M.smegmatis_MC2_155 ------------------------------
Mb3756|M.bovis_AF2122/97 HDSVRDFTALARAAVQTGRIGYTLMIAEKP
Rv3729|M.tuberculosis_H37Rv HDSVRDFTALARAAVQTGRIGYTLMIAEKP
TH_3395|M.thermoresistible__bu ------------------------------
MLBr_02273|M.leprae_Br4923 R-----------------------------