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MTDVHTSLPPALRRALDLLIDPPADPDVSKGYLDLLGGAADEDAGVPRNTGPIQAAWASPIGSLLYDNAQ ALSRRWISAWQLPLEWLQIPRGGVALDVGSGPGNVTASLARAAGPDGLALGIDISEPMLARAVRNEAGPQ VGFIKADAQRLPLRDNTVDAAVSTAVLQLVPNPQAALVEIARVLRPGGRLAVMVPTAGRLARYWRLLPNV GAHAFDDDEIGDILEENGFASVRVKNFGTFQWVRAKLS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5229 | - | - | 100% (248) | methyltransferase type 11 |
| M. avium 104 | MAV_2988 | - | 1e-12 | 31.80% (217) | ubiquinone/menaquinone biosynthesis methyltransferases |
| M. avium 104 | MAV_0854 | - | 2e-11 | 43.00% (100) | methyltransferase-UbiE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0573 | ubiE | 7e-10 | 34.23% (149) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. gilvum PYR-GCK | Mflv_0738 | - | 1e-78 | 63.14% (236) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv0558 | ubiE | 7e-10 | 34.23% (149) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. leprae Br4923 | MLBr_01723 | - | 6e-09 | 37.11% (97) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_4018 | - | 4e-23 | 32.13% (249) | similarity with UbiE/COQ5 methyltransferase |
| M. marinum M | MMAR_4497 | - | 3e-23 | 38.31% (154) | methyltransferase |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 3e-80 | 64.10% (234) | methyltransferase |
| M. thermoresistible (build 8) | TH_3395 | - | 1e-11 | 39.66% (116) | PUTATIVE putative ubiquinone/menaquinone biosynthesis |
| M. ulcerans Agy99 | MUL_4668 | - | 2e-23 | 38.31% (154) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0109 | - | 5e-83 | 64.56% (237) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0738|M.gilvum_PYR-GCK MTES------ALRMAERLLADPPEHPDVSKGYLDLLGDRPAGDA------
Mvan_0109|M.vanbaalenii_PYR-1 MTHT------VLRMTERLLIDPPEHPDTSKGYLDLLGDEPDSNR------
MAV_5229|M.avium_104 MTDVHTSLPPALRRALDLLIDPPADPDVSKGYLDLLGGAADEDAGVPRNT
MSMEG_0098|M.smegmatis_MC2_155 MDT-------ALRRAMDLLIDPPAEPDFSKGYLDLLGRGDSTAP---KNT
MMAR_4497|M.marinum_M MSATP-----DPRE--VTRGLLTEPCDLRRGFLDVLGESTSSPVPT----
MUL_4668|M.ulcerans_Agy99 MSATP-----DPRE--VTRGLLTEPGDLRHGFLDVLGESTSSPVPT----
MAB_4018|M.abscessus_ATCC_1997 MLHHP-----TLADSLIDPARIDHPPRRDHGYLDVLGPESDEPVS-----
Mb0573|M.bovis_AF2122/97 ----------------MSRAALDKDPRDVASMFDGVAR------------
Rv0558|M.tuberculosis_H37Rv ----------------MSRAALDKDPRDVASMFDGVAR------------
TH_3395|M.thermoresistible__bu -------------MADVAANWAGRGGRFAGGLYDFGVER-----------
MLBr_01723|M.leprae_Br4923 ----------MTRSTEISANAVPNPHATAEQVAAARKDSKLAQVLY----
Mflv_0738|M.gilvum_PYR-GCK GAIQALWASRLGSLFYDNAQTVMRR---------VLTAWHEPTEWLNLPV
Mvan_0109|M.vanbaalenii_PYR-1 GAIQALWASRLGSMFYDNAQTLARR---------LMTAWQQPTEWLNVPV
MAV_5229|M.avium_104 GPIQAAWASPIGSLLYDNAQALSRR---------WISAWQLPLEWLQIPR
MSMEG_0098|M.smegmatis_MC2_155 GLIQKAWASPLGSKLYDRAQLLNRR---------LVASTRPPVEWLRIPP
MMAR_4497|M.marinum_M -VAQRAMNSRFVATVYERLWRPAAF--YLASGVTTRAEQHRAAAALHLST
MUL_4668|M.ulcerans_Agy99 -VAQRAMNSRFVATVYERLWRPAAF--YLASGVTTRAEQHRAAAALHLST
MAB_4018|M.abscessus_ATCC_1997 -VANRFMQSPLLAAIYERAWRPMFTRGFSYGGKSTLKAHTALMDEIAGRG
Mb0573|M.bovis_AF2122/97 ---KYDLTNTVLSLGQDRYWRRATR------------------SALRIGP
Rv0558|M.tuberculosis_H37Rv ---KYDLTNTVLSLGQDRYWRRATR------------------SALRIGP
TH_3395|M.thermoresistible__bu ----EVLARPAGLLMWGTDTRLLFD---------------SIRRIGDLPD
MLBr_01723|M.leprae_Br4923 HDWEAENYDEKWSISYDQRCVDYVR---------HCFDAIVPDELFTELP
Mflv_0738|M.gilvum_PYR-GCK GGVALDVGSGPGNVTAALGRAVGPGGLALGVDVSEPMLARAVAAEAGP--
Mvan_0109|M.vanbaalenii_PYR-1 GGTALDVGSGPGNVTGALGRAVGPGGLALGVDISEPMLARAVRAEAGP--
MAV_5229|M.avium_104 GGVALDVGSGPGNVTASLARAAGPDGLALGIDISEPMLARAVRNEAGP--
MSMEG_0098|M.smegmatis_MC2_155 GGTVLDIGCGPGNITAQLARAAGLDGLALGVDISEPMLARAVAAEAGR--
MMAR_4497|M.marinum_M AHRLLDVACGPGNFTAPLVKQLPAGSLAVGLDISEPMLTRAVLDNSGP--
MUL_4668|M.ulcerans_Agy99 AHRLLDVACGPGNFTAPLVKQLPAGSLAVGLDISEPMLTRAVLDNSGP--
MAB_4018|M.abscessus_ATCC_1997 DHKILDVACGPGLYTRELAAQLGTAGVCIGLDLSGPMLRRAVRDNSAE--
Mb0573|M.bovis_AF2122/97 GQKVLDLAAGTAVSTVELTKSG---AWCVAADFSVGMLA----AGAAR--
Rv0558|M.tuberculosis_H37Rv GQKVLDLAAGTAVSTVELTKSG---AWCVAADFSVGMLA----AGAAR--
TH_3395|M.thermoresistible__bu GTAVLDIPCGGGLALRGLRHGR--RLRYVAADISADMLARAQRRAATLGR
MLBr_01723|M.leprae_Br4923 YDCALELGCGTGFFLLNLIQSG-VARRGSVTDLSPGMVKIATRNGQSLG-
*:: .* . * *.* *:
Mflv_0738|M.gilvum_PYR-GCK -NVGFLRADAQDLPLSDESVDGVVSIAMLQLIPEPARAVAEMVRVLRSGR
Mvan_0109|M.vanbaalenii_PYR-1 -NVGFIRADAQHLPFRDESFDAVVSIAMLQLIPDPAVALAEMVRVLRPGR
MAV_5229|M.avium_104 -QVGFIKADAQRLPLRDNTVDAAVSTAVLQLVPNPQAALVEIARVLRPGG
MSMEG_0098|M.smegmatis_MC2_155 -QVGFVRADAQQLPFRDEVFDAATSLAVFQLIPDPVAAVSEIVRVLKPGG
MMAR_4497|M.marinum_M -QTCYVRGDARMLPFDDETFDAVCCFGALYLMPEPFRIAREMVRVLGPGG
MUL_4668|M.ulcerans_Agy99 -QTCYVRGDARMLPFDDETFDAVCCFGALYLMPEPFRIAREMVRVLGPGG
MAB_4018|M.abscessus_ATCC_1997 -RVDYIRGSAHSLPFADATFDTVVCLAALYLIPDPEQAVRELCRVAGPDG
Mb0573|M.bovis_AF2122/97 -KVPKVAGDATRLPFGDDVFDAVTISFGLRNVANQQAALREMARVTRPGG
Rv0558|M.tuberculosis_H37Rv -KVPKVAGDATRLPFGDDVFDAVTISFGLRNVANQQAALREMARVTRPGG
TH_3395|M.thermoresistible__bu TDVRFVVADIERMPFGDGEFDCCVTFNGLHCVPDPAAAVAEIARCVKPGG
MLBr_01723|M.leprae_Br4923 LDINGRVADAEGIPYDDNTFDLVVGHAVLHHIPDVELSLREVLRVLKPGG
.. :* * .* : :.: *: * ..
Mflv_0738|M.gilvum_PYR-GCK RVAVMVPTAGP---------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 RMAVMVPTAGP---------------------------------------
MAV_5229|M.avium_104 RLAVMVPTAGR---------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 RVAIMVPTAG----------------------------------------
MMAR_4497|M.marinum_M RIAILTTYSGQ---------------------------------------
MUL_4668|M.ulcerans_Agy99 RIAILTTYSGQ---------------------------------------
MAB_4018|M.abscessus_ATCC_1997 QIVVFTSLR-T---------------------------------------
Mb0573|M.bovis_AF2122/97 RLLVCEFSTPTNALFA----------------------------------
Rv0558|M.tuberculosis_H37Rv RLLVCEFSTPTNALFA----------------------------------
TH_3395|M.thermoresistible__bu RLIGDAVVRGAGR-------------------------------------
MLBr_01723|M.leprae_Br4923 RFVFAGEPTDVGNRYARVFADLTWKVTIRVVQLPGLSAWRRTQVEIDENS
:.
Mflv_0738|M.gilvum_PYR-GCK --------------AAAALRYLPHAG----AHSFGDDELADVFEGL----
Mvan_0109|M.vanbaalenii_PYR-1 --------------AAGLLRYLPNAG----AHAFGDDELGDTFESL----
MAV_5229|M.avium_104 --------------LARYWRLLPNVG----AHAFDDDEIGDILEEN----
MSMEG_0098|M.smegmatis_MC2_155 --------------AVKPVTFLARGG----ARIFGDDELGDIFENV----
MMAR_4497|M.marinum_M --------------RAPIRHALDAAAGAIGLTMFDQDSFVDLFSSA----
MUL_4668|M.ulcerans_Agy99 --------------RAPIRHALDAAAGAIGLTMFDQDSFVDLFSSA----
MAB_4018|M.abscessus_ATCC_1997 --------------RAASLPGVTTAMRIGGFRAFGRDEVTGWLRAQ----
Mb0573|M.bovis_AF2122/97 -----------TAYKEYLMRALPRVARAVSSNPEAYEYLAESIRAWPDQA
Rv0558|M.tuberculosis_H37Rv -----------TAYKEYLMRALPRVARAVSSNPEAYEYLAESIRAWPDQA
TH_3395|M.thermoresistible__bu -------------RQDALIAVFRRAG------VFGPGGTTDELQGWLTR-
MLBr_01723|M.leprae_Br4923 RAAALEWVVDLHTFEPKVLETMATNAGAVQVKTVTEEFTAAMLGWPLRTF
. :
Mflv_0738|M.gilvum_PYR-GCK ---------GLTSVRAN--TVGTIQWVRGKKP------------------
Mvan_0109|M.vanbaalenii_PYR-1 ---------GLAGVRIN--TVGTIQWVRGRKS------------------
MAV_5229|M.avium_104 ---------GFASVRVK--NFGTFQWVRAKLS------------------
MSMEG_0098|M.smegmatis_MC2_155 ---------GLVGVRVK--THGFIQWVRGTKL------------------
MMAR_4497|M.marinum_M ---------GLVDIDQQ--TQRGLQFVVAAKPK-----------------
MUL_4668|M.ulcerans_Agy99 ---------GLVDIDQQ--TQRGLQFVVAAKPK-----------------
MAB_4018|M.abscessus_ATCC_1997 ---------GWTDIDQT--VTGQGQFIRARRAVALRVAT-----------
Mb0573|M.bovis_AF2122/97 VLAHQISRAGWSGVRWRNLTGGIVALHAGYKPGKQTPQ------------
Rv0558|M.tuberculosis_H37Rv VLAHQISRAGWSGVRWRNLTGGIVALHAGYKPGKQTPQ------------
TH_3395|M.thermoresistible__bu --------AGFEVEDFR--RSGAVAHFTAVRS------------------
MLBr_01723|M.leprae_Br4923 ESTMPPSKLGWGWARFAFTSWKTLSWVDANVWRRVIPKSWFYNIIITGVK
* .
Mflv_0738|M.gilvum_PYR-GCK --
Mvan_0109|M.vanbaalenii_PYR-1 --
MAV_5229|M.avium_104 --
MSMEG_0098|M.smegmatis_MC2_155 --
MMAR_4497|M.marinum_M --
MUL_4668|M.ulcerans_Agy99 --
MAB_4018|M.abscessus_ATCC_1997 --
Mb0573|M.bovis_AF2122/97 --
Rv0558|M.tuberculosis_H37Rv --
TH_3395|M.thermoresistible__bu --
MLBr_01723|M.leprae_Br4923 PS